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Conserved domains on  [gi|1622943461|ref|XP_028705095|]
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bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X3 [Macaca mulatta]

Protein Classification

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase( domain architecture ID 10572471)

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 8-351 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


:

Pssm-ID: 463450  Cd Length: 429  Bit Score: 736.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461   8 ANENSLLSAQLKGFPLFLHSNLGLKDCSINPKSPLLYVTRPSEVEKGVLPGEDWTVFQSNHSTYEPVLLAKTRSSESIPH 87
Cdd:pfam12062  90 ANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLLAKVKSGEESPS 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461  88 LGadagLHAALHATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVAFLTGKRLSLPLDRYILVDIDDIFVGKEGTRMK 167
Cdd:pfam12062 170 PG----LDAALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFVGKEGTRMK 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 168 VEDVKALFDTQNELRAHIPNFTFNLGYSGKFFHTGTDAEDAGDDLLLSYVKEFWWFPHMWSHMQPHLFHNQSVLAEQMAL 247
Cdd:pfam12062 246 VEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFHNQTVLEEQMLL 325

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 248 NKKFAVEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKQVWSIRVTSTEEYPHLKPARYRRGFIHNGIMVLPRQTCGLFTH 327
Cdd:pfam12062 326 NKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPRQTCGLFTH 405

                         330       340
                  ....*....|....*....|....
gi 1622943461 328 TIFYNEYPGGSSELDKIINGGELF 351
Cdd:pfam12062 406 TIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
441-691 3.01e-43

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 156.73  E-value: 3.01e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 441 PKLLIIGPQKTGTTALYLFLGMHPDLSSNypssETFEEIQFFNGHNYHKGIDWYmeffpipsnttsdfyfeKSANYFDSE 520
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDF----EKSEEPHLFNNHNRSPFLEWY-----------------PGDTYFDVA 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 521 VAPRRAAAL--------------------LPKAKVLTILINPADRAYSWYQHQRAHDDPVALKYTFHEVitagsdasskl 580
Cdd:pfam00685  61 EGPVRLNALpspriikthlplhllpkslwDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV----------- 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 581 RALQNRCLVPGWYATHIERWLSAYHANQILVLDGKLLRTEPAKVMDMVQKFLGVTNT----IDYHKTLAFDPKKGFWCQL 656
Cdd:pfam00685 130 EDFLNGKVNCGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTeeelDKIVKHLSFENMKGNPCLN 209

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1622943461 657 L-------EGGKTKCLGKSkgrKYPEMDLDSRAFLKDYYRDH 691
Cdd:pfam00685 210 YsklpkevSPFFRKGLVGD---WKNYFTPEQAEKFDEIYQEK 248
 
Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 8-351 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


Pssm-ID: 463450  Cd Length: 429  Bit Score: 736.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461   8 ANENSLLSAQLKGFPLFLHSNLGLKDCSINPKSPLLYVTRPSEVEKGVLPGEDWTVFQSNHSTYEPVLLAKTRSSESIPH 87
Cdd:pfam12062  90 ANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLLAKVKSGEESPS 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461  88 LGadagLHAALHATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVAFLTGKRLSLPLDRYILVDIDDIFVGKEGTRMK 167
Cdd:pfam12062 170 PG----LDAALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFVGKEGTRMK 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 168 VEDVKALFDTQNELRAHIPNFTFNLGYSGKFFHTGTDAEDAGDDLLLSYVKEFWWFPHMWSHMQPHLFHNQSVLAEQMAL 247
Cdd:pfam12062 246 VEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFHNQTVLEEQMLL 325

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 248 NKKFAVEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKQVWSIRVTSTEEYPHLKPARYRRGFIHNGIMVLPRQTCGLFTH 327
Cdd:pfam12062 326 NKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPRQTCGLFTH 405

                         330       340
                  ....*....|....*....|....
gi 1622943461 328 TIFYNEYPGGSSELDKIINGGELF 351
Cdd:pfam12062 406 TIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
441-691 3.01e-43

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 156.73  E-value: 3.01e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 441 PKLLIIGPQKTGTTALYLFLGMHPDLSSNypssETFEEIQFFNGHNYHKGIDWYmeffpipsnttsdfyfeKSANYFDSE 520
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDF----EKSEEPHLFNNHNRSPFLEWY-----------------PGDTYFDVA 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 521 VAPRRAAAL--------------------LPKAKVLTILINPADRAYSWYQHQRAHDDPVALKYTFHEVitagsdasskl 580
Cdd:pfam00685  61 EGPVRLNALpspriikthlplhllpkslwDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV----------- 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 581 RALQNRCLVPGWYATHIERWLSAYHANQILVLDGKLLRTEPAKVMDMVQKFLGVTNT----IDYHKTLAFDPKKGFWCQL 656
Cdd:pfam00685 130 EDFLNGKVNCGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTeeelDKIVKHLSFENMKGNPCLN 209

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1622943461 657 L-------EGGKTKCLGKSkgrKYPEMDLDSRAFLKDYYRDH 691
Cdd:pfam00685 210 YsklpkevSPFFRKGLVGD---WKNYFTPEQAEKFDEIYQEK 248
 
Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 8-351 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


Pssm-ID: 463450  Cd Length: 429  Bit Score: 736.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461   8 ANENSLLSAQLKGFPLFLHSNLGLKDCSINPKSPLLYVTRPSEVEKGVLPGEDWTVFQSNHSTYEPVLLAKTRSSESIPH 87
Cdd:pfam12062  90 ANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLLAKVKSGEESPS 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461  88 LGadagLHAALHATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVAFLTGKRLSLPLDRYILVDIDDIFVGKEGTRMK 167
Cdd:pfam12062 170 PG----LDAALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFVGKEGTRMK 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 168 VEDVKALFDTQNELRAHIPNFTFNLGYSGKFFHTGTDAEDAGDDLLLSYVKEFWWFPHMWSHMQPHLFHNQSVLAEQMAL 247
Cdd:pfam12062 246 VEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFHNQTVLEEQMLL 325

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 248 NKKFAVEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKQVWSIRVTSTEEYPHLKPARYRRGFIHNGIMVLPRQTCGLFTH 327
Cdd:pfam12062 326 NKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPRQTCGLFTH 405

                         330       340
                  ....*....|....*....|....
gi 1622943461 328 TIFYNEYPGGSSELDKIINGGELF 351
Cdd:pfam12062 406 TIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
441-691 3.01e-43

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 156.73  E-value: 3.01e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 441 PKLLIIGPQKTGTTALYLFLGMHPDLSSNypssETFEEIQFFNGHNYHKGIDWYmeffpipsnttsdfyfeKSANYFDSE 520
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDF----EKSEEPHLFNNHNRSPFLEWY-----------------PGDTYFDVA 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 521 VAPRRAAAL--------------------LPKAKVLTILINPADRAYSWYQHQRAHDDPVALKYTFHEVitagsdasskl 580
Cdd:pfam00685  61 EGPVRLNALpspriikthlplhllpkslwDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV----------- 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 581 RALQNRCLVPGWYATHIERWLSAYHANQILVLDGKLLRTEPAKVMDMVQKFLGVTNT----IDYHKTLAFDPKKGFWCQL 656
Cdd:pfam00685 130 EDFLNGKVNCGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTeeelDKIVKHLSFENMKGNPCLN 209

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1622943461 657 L-------EGGKTKCLGKSkgrKYPEMDLDSRAFLKDYYRDH 691
Cdd:pfam00685 210 YsklpkevSPFFRKGLVGD---WKNYFTPEQAEKFDEIYQEK 248
Sulfotransfer_3 pfam13469
Sulfotransferase family;
443-635 1.03e-08

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 55.37  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 443 LLIIGPQKTGTTALYLFLGMHPDLSSNYpssETFEEIQFFNGHnYHKGIDWYMEFFPIPSNTtsDFYFEKSANYFdseVA 522
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLAAHPDVRPPE---ETWFVIPRILAL-LQAWGKSLEALARVPSYA--RWLCDKSPSHL---FH 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943461 523 PRRAAALLPKAKVLTILINPADRAYSWYQHQRAHDdpvalkytfhevitaGSDASSKLRALQNRCLVpgWYATHIERWLS 602
Cdd:pfam13469  72 LDLLLKAFPDAKFIHLHRDPVDTVISSYCSLFGFT---------------LSSYSTAFLRDIGLALA--RWSRAYERLMA 134

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1622943461 603 AYH---ANQILVLDGKLLRTEPAKVMDMVQKFLGVT 635
Cdd:pfam13469 135 ARArvpPGRFLDVRYEDLVADPEGTLRRILEFLGLP 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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