NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622942927|ref|XP_028704953|]
View 

tetraspanin-17 isoform X3 [Macaca mulatta]

Protein Classification

TM4SF9_like_LEL domain-containing protein( domain architecture ID 10123576)

TM4SF9_like_LEL domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TM4SF9_like_LEL cd03159
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. ...
 77-181 1.02e-57

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 9 (TM4SF9) or Tetraspanin-5 and related proteins. TM4SF9 is strongly expressed witin the central nervous system, and expression levels appear to correlate with differentiation status of particular neurons, hinting at a role in neuronal maturation.


:

Pssm-ID: 239412 [Multi-domain]  Cd Length: 121  Bit Score: 180.31  E-value: 1.02e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942927  77 LGFAGCIGALRENT-------FLLKFWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDV 149
Cdd:cd03159    13 EFLNNNIRAYRDDIdlqnlidFLQEYWQCCGARGPDDWNLNIYFNCTDSNPSRERCGVPFSCCVKDPAEDVVNTQCGYDV 92

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622942927 150 RLKLvrgELEQQGFIHTKGCVGQFEKWLQDNL 181
Cdd:cd03159    93 RKKP---ELELQHHIHTKGCVQAFEKWLQDNL 121
 
Name Accession Description Interval E-value
TM4SF9_like_LEL cd03159
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. ...
 77-181 1.02e-57

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 9 (TM4SF9) or Tetraspanin-5 and related proteins. TM4SF9 is strongly expressed witin the central nervous system, and expression levels appear to correlate with differentiation status of particular neurons, hinting at a role in neuronal maturation.


Pssm-ID: 239412 [Multi-domain]  Cd Length: 121  Bit Score: 180.31  E-value: 1.02e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942927  77 LGFAGCIGALRENT-------FLLKFWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDV 149
Cdd:cd03159    13 EFLNNNIRAYRDDIdlqnlidFLQEYWQCCGARGPDDWNLNIYFNCTDSNPSRERCGVPFSCCVKDPAEDVVNTQCGYDV 92

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622942927 150 RLKLvrgELEQQGFIHTKGCVGQFEKWLQDNL 181
Cdd:cd03159    93 RKKP---ELELQHHIHTKGCVQAFEKWLQDNL 121
Tetraspanin pfam00335
Tetraspanin family;
18-206 3.63e-19

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 82.37  E-value: 3.63e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942927  18 KYFLFGFNIVFWVLGALFLAIGLWAwgeKGVLSNISALTDLGGLDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFWS 97
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGVWL---LSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942927  98 CC-----------GArgpndwnlnIYFNCTDLNPSRERCGVPFSccVRDPAEDVLNTQCGYDVRLKLVrgeleQQGFIHT 166
Cdd:pfam00335  79 VLllllflaelaaGI---------LAFVYRDKLSGLLSNWLKKS--LEDGYRDWLDLYSCLNSALDSL-----QSEFGCC 142

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1622942927 167 KGCVGQFEKWLQDNLIVVAGVFVGIALLQIFGICLAQNLV 206
Cdd:pfam00335 143 GGCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLC 182
 
Name Accession Description Interval E-value
TM4SF9_like_LEL cd03159
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. ...
 77-181 1.02e-57

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 9 (TM4SF9) or Tetraspanin-5 and related proteins. TM4SF9 is strongly expressed witin the central nervous system, and expression levels appear to correlate with differentiation status of particular neurons, hinting at a role in neuronal maturation.


Pssm-ID: 239412 [Multi-domain]  Cd Length: 121  Bit Score: 180.31  E-value: 1.02e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942927  77 LGFAGCIGALRENT-------FLLKFWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDV 149
Cdd:cd03159    13 EFLNNNIRAYRDDIdlqnlidFLQEYWQCCGARGPDDWNLNIYFNCTDSNPSRERCGVPFSCCVKDPAEDVVNTQCGYDV 92

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622942927 150 RLKLvrgELEQQGFIHTKGCVGQFEKWLQDNL 181
Cdd:cd03159    93 RKKP---ELELQHHIHTKGCVQAFEKWLQDNL 121
penumbra_like_LEL cd03158
Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. ...
 97-181 7.98e-27

Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Human Penumbra exhibits growth-suppressive activity in vitro and has been associated with myeloid malignancies.


Pssm-ID: 239411  Cd Length: 119  Bit Score: 100.84  E-value: 7.98e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942927  97 SCCGARGPNDWNLNIYFNCTDLNPsrERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLVrgeLEQQGFIHTKGCVGQFEKW 176
Cdd:cd03158    40 KCCGGDDYRDWSKNMYFNCSSPNP--EACGVPYSCCIRAKDQEVINTMCGYGVQNLER---LEASKLIYTRGCIDAVVLW 114


                  ....*
gi 1622942927 177 LQDNL 181
Cdd:cd03158   115 IEDNL 119
Tetraspanin pfam00335
Tetraspanin family;
18-206 3.63e-19

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 82.37  E-value: 3.63e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942927  18 KYFLFGFNIVFWVLGALFLAIGLWAwgeKGVLSNISALTDLGGLDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFWS 97
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGVWL---LSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942927  98 CC-----------GArgpndwnlnIYFNCTDLNPSRERCGVPFSccVRDPAEDVLNTQCGYDVRLKLVrgeleQQGFIHT 166
Cdd:pfam00335  79 VLllllflaelaaGI---------LAFVYRDKLSGLLSNWLKKS--LEDGYRDWLDLYSCLNSALDSL-----QSEFGCC 142

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1622942927 167 KGCVGQFEKWLQDNLIVVAGVFVGIALLQIFGICLAQNLV 206
Cdd:pfam00335 143 GGCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLC 182
oculospanin_like_LEL cd03167
Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. ...
 98-181 6.28e-15

Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contains sequences similar to oculospanin, which is found to be expressed in retinal pigment epithelium, iris, ciliary body, and retinal ganglion cells.


Pssm-ID: 239420  Cd Length: 120  Bit Score: 69.41  E-value: 6.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942927  98 CCGARGPNDWNLNIYFNCTdlNPSRERCGVPFSCCVrDPAED--VLNTQCGYDVrlkLVRGELEQQGFIHTKGCVGQFEK 175
Cdd:cd03167    41 CCGASSYQDWQQNLYFNCS--SPGVQACSLPASCCI-DPREDgaVVNDQCGFGA---LGLDEDAAQRVVHLGGCGPPLRR 114


                  ....*.
gi 1622942927 176 WLQDNL 181
Cdd:cd03167   115 WLRGNL 120
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 98-181 5.73e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 49.43  E-value: 5.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942927  98 CCGARGPNDWNLNiyfnctdlnpsreRCGVPFSCCVRDPAEDVLNtqcgydvrlklvrgeleqqgfIHTKGCVGQFEKWL 177
Cdd:cd03127    41 CCGVNGPTDYLDL-------------RLLVPSSCCKGTDGNCGLN---------------------LYTEGCLEKLVDFL 86


                  ....
gi 1622942927 178 QDNL 181
Cdd:cd03127    87 RSNL 90
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 89-180 5.56e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 47.14  E-value: 5.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942927  89 NTFLLKFwSCCGARGPNDWNLNIYFNCTDLNPSRErcgVPFSCCVRDPAEDVLNTQCgydvrlklvrGELEQQGFIHTKG 168
Cdd:cd03156    36 NRVMIEL-KCCGVNGPTDFVDSTSFFRQKNEPNSP---YPESCCKRNSNSQIVDLDC----------PKLGSPNSYNKKG 101

                          90
                  ....*....|..
gi 1622942927 169 CVGQFEKWLQDN 180
Cdd:cd03156   102 CYEKLSNPIERY 113
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 98-181 4.92e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 44.65  E-value: 4.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942927  98 CCGARGPNDWNLNIYFNctdlNPSRERCGVPFSCCVRdpaedvLNTQCGydvrlklVRGELEQQGFIHTKGCVGQFEKWL 177
Cdd:cd03155    44 CCGSNNYTDWQDSEWIN----SNEANGRLVPDSCCKT------VVDRCG-------CLRDHPSNIYKVEGGCIPKLEDFL 106


                  ....
gi 1622942927 178 QDNL 181
Cdd:cd03155   107 YDHL 110
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 98-181 7.03e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 40.92  E-value: 7.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942927  98 CCGARGPNDWNlNIYFNCTDlnpsrercGVPFSCCVRdpaedvLNTQCGYDVRLKLvrgeleqqgfIHTKGCVGQFEKWL 177
Cdd:cd03166    41 CCGANNYTDWE-NIPSLDTD--------SVPDSCCIN------VTKGCGINFDEKV----------IHLEGCVTKIEGWL 95


                  ....
gi 1622942927 178 QDNL 181
Cdd:cd03166    96 KKNI 99
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 87-182 8.84e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 41.21  E-value: 8.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942927  87 RENTFLLKFWS-------CCGARGPNDWNLNIyfnctdLNPSRERCGVPFSCCV---RDPAEDVLNTQCGYDVRLKLvrg 156
Cdd:cd03160    27 PENKTAEEAWDyvqfqlqCCGWTGPQDWTDNS------LIKNSSEPLYPCSCCNssaTADSPRPSKGFCEAPASLDW--- 97

                          90       100
                  ....*....|....*....|....*.
gi 1622942927 157 eleqqgFIHTKGCVGQFEKWLQDNLI 182
Cdd:cd03160    98 ------PVYQEGCMEKLQSWLNENLG 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH