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Conserved domains on  [gi|1622942103|ref|XP_028704735|]
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ankyrin repeat and SOCS box protein 5 isoform X1 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-284 8.95e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.54  E-value: 8.95e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  35 LAILSHFYIVKGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGD 114
Cdd:COG0666    19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 115 HVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKA-QLESCLPSPTHEAASKGHHECLDILISWGID 193
Cdd:COG0666    99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 194 VDQDIPHLGTPLYVACMSQQFHCIWKLLYAGADV-QKGKYWDTPLHAAAQQSSTEIVNLLLEFGADTNAKNTELLRPIDV 272
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVnAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258

                         250
                  ....*....|..
gi 1622942103 273 ATSSSMVERILL 284
Cdd:COG0666   259 AAAAGAALIVKL 270
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 288-329 1.77e-23

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239694  Cd Length: 42  Bit Score: 91.09  E-value: 1.77e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622942103 288 ATPRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
Cdd:cd03724     1 ATPSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-284 8.95e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.54  E-value: 8.95e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  35 LAILSHFYIVKGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGD 114
Cdd:COG0666    19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 115 HVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKA-QLESCLPSPTHEAASKGHHECLDILISWGID 193
Cdd:COG0666    99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 194 VDQDIPHLGTPLYVACMSQQFHCIWKLLYAGADV-QKGKYWDTPLHAAAQQSSTEIVNLLLEFGADTNAKNTELLRPIDV 272
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVnAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258

                         250
                  ....*....|..
gi 1622942103 273 ATSSSMVERILL 284
Cdd:COG0666   259 AAAAGAALIVKL 270
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 288-329 1.77e-23

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 91.09  E-value: 1.77e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622942103 288 ATPRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
Cdd:cd03724     1 ATPSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 72-291 1.05e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 87.04  E-value: 1.05e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  72 SPLHEAASQGRLLAL-RTLLSQGYNVNAVTLDHVTPLH-EACLGDHVACARTLLEAGANVNAITIDGVTPLFNACS-QGS 148
Cdd:PHA02876  275 TPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYlMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTlDRN 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 149 PSCAELLLEYGAKAQL-ESCLPSPTHEAASKGHHECLDILISWGIDVDQDIPHLGTPLYVA-CMSQQFHCIWKLLYAGAD 226
Cdd:PHA02876  355 KDIVITLLELGANVNArDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGAN 434

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622942103 227 VQ-KGKYWDTPLHAAAQQS-STEIVNLLLEFGADTNAKNTELLRPIDVATSSSMVERILLQHEATPR 291
Cdd:PHA02876  435 VNsKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALEYHGIVNILLHYGAELR 501
Ank_2 pfam12796
Ankyrin repeats (3 copies);
173-263 6.37e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.77  E-value: 6.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 173 HEAASKGHHECLDILISWGIDVDQDIPHLGTPLYVACMSQQFHCIwKLLYAGADVQKGKYWDTPLHAAAQQSSTEIVNLL 252
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIV-KLLLEHADVNLKDNGRTALHYAARSGHLEIVKLL 80

                          90
                  ....*....|.
gi 1622942103 253 LEFGADTNAKN 263
Cdd:pfam12796  81 LEKGADINVKD 91
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 289-327 1.92e-12

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 60.64  E-value: 1.92e-12
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622942103 289 TPRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQ 327
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 291-329 5.29e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.48  E-value: 5.29e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1622942103  291 RSLYQLCRLCIRSYIGKprlhlIPQLQLPTLLKNFLQYR 329
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 203-264 2.80e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 2.80e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622942103 203 TPLYVACMSQQFHCIWKLLYAGADVQKGK---------------YWDTPLHAAAQQSSTEIVNLLLEFGADTNAKNT 264
Cdd:cd22192    91 TALHIAVVNQNLNLVRELIARGADVVSPRatgtffrpgpknliyYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDS 167
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 102-131 3.97e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 3.97e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1622942103  102 DHVTPLHEACLGDHVACARTLLEAGANVNA 131
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 128-262 4.91e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 38.52  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 128 NVNAITIDGVTPLFNACSQGSP-SCAELLLEYGAKAQL-ESCLpsptHeAASKGHHECLDILISWGIDVDQDipHLGTPL 205
Cdd:TIGR00870  44 NINCPDRLGRSALFVAAIENENlELTELLLNLSCRGAVgDTLL----H-AISLEYVDAVEAILLHLLAAFRK--SGPLEL 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622942103 206 YVACMSQQFhciwkllYAGAdvqkgkywdTPLHAAAQQSSTEIVNLLLEFGADTNAK 262
Cdd:TIGR00870 117 ANDQYTSEF-------TPGI---------TALHLAAHRQNYEIVKLLLERGASVPAR 157
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-284 8.95e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.54  E-value: 8.95e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  35 LAILSHFYIVKGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGD 114
Cdd:COG0666    19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 115 HVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKA-QLESCLPSPTHEAASKGHHECLDILISWGID 193
Cdd:COG0666    99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 194 VDQDIPHLGTPLYVACMSQQFHCIWKLLYAGADV-QKGKYWDTPLHAAAQQSSTEIVNLLLEFGADTNAKNTELLRPIDV 272
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVnAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258

                         250
                  ....*....|..
gi 1622942103 273 ATSSSMVERILL 284
Cdd:COG0666   259 AAAAGAALIVKL 270
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
40-270 5.62e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 131.61  E-value: 5.62e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  40 HFYIVKGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACA 119
Cdd:COG0666    57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 120 RTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCL-PSPTHEAASKGHHECLDILISWGIDVDQDI 198
Cdd:COG0666   137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDgETPLHLAAENGHLEIVKLLLEAGADVNAKD 216

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622942103 199 PHLGTPLYVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADTNAKNTELLRPI 270
Cdd:COG0666   217 NDGKTALDLAAENGNLEIVKLLLEAGADLNaKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 288-329 1.77e-23

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 91.09  E-value: 1.77e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622942103 288 ATPRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
Cdd:cd03724     1 ATPSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 72-291 1.05e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 87.04  E-value: 1.05e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  72 SPLHEAASQGRLLAL-RTLLSQGYNVNAVTLDHVTPLH-EACLGDHVACARTLLEAGANVNAITIDGVTPLFNACS-QGS 148
Cdd:PHA02876  275 TPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYlMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTlDRN 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 149 PSCAELLLEYGAKAQL-ESCLPSPTHEAASKGHHECLDILISWGIDVDQDIPHLGTPLYVA-CMSQQFHCIWKLLYAGAD 226
Cdd:PHA02876  355 KDIVITLLELGANVNArDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGAN 434

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622942103 227 VQ-KGKYWDTPLHAAAQQS-STEIVNLLLEFGADTNAKNTELLRPIDVATSSSMVERILLQHEATPR 291
Cdd:PHA02876  435 VNsKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALEYHGIVNILLHYGAELR 501
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 73-283 1.13e-18

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 85.87  E-value: 1.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  73 PLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVA-----CARTLLEAGANVNAITIDGVTPLFNACSQ- 146
Cdd:PHA03100   38 PLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGITPLLYAISKk 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 147 -GSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHEcLDI---LISWGIDVDQ--------------DIPHL--GTPL 205
Cdd:PHA03100  118 sNSYSIVEYLLDNGANVNIKNSDGeNLLHLYLESNKID-LKIlklLIDKGVDINAknrvnyllsygvpiNIKDVygFTPL 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 206 YVACMSQQFHCIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADTNAKNTELL----RPIDVATSSSMVE 280
Cdd:PHA03100  197 HYAVYNNNPEFVKYLLDLGANPNlVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIETLLyfkdKDLNTITKIKMLK 276


                  ...
gi 1622942103 281 RIL 283
Cdd:PHA03100  277 KSI 279
Ank_2 pfam12796
Ankyrin repeats (3 copies);
173-263 6.37e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.77  E-value: 6.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 173 HEAASKGHHECLDILISWGIDVDQDIPHLGTPLYVACMSQQFHCIwKLLYAGADVQKGKYWDTPLHAAAQQSSTEIVNLL 252
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIV-KLLLEHADVNLKDNGRTALHYAARSGHLEIVKLL 80

                          90
                  ....*....|.
gi 1622942103 253 LEFGADTNAKN 263
Cdd:pfam12796  81 LEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
74-161 7.65e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.38  E-value: 7.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEaGANVNAITiDGVTPLFNACSQGSPSCAE 153
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ....*...
gi 1622942103 154 LLLEYGAK 161
Cdd:pfam12796  79 LLLEKGAD 86
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 288-329 1.98e-16

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 71.76  E-value: 1.98e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622942103 288 ATPRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 73-307 3.30e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 79.15  E-value: 3.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  73 PLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEAC-----------LGDHVACA---------------------- 119
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICkepnklgmkemIRSINKCSvfytlvaikdafnnrnveifki 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 120 -------------------------------RTLLEAGANVNAITID-GVTPLFNACSQGSPSCAELLLEYGAKAQ-LES 166
Cdd:PHA02878  120 iltnrykniqtidlvyidkkskddiieaeitKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNiPDK 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 167 CLPSPTHEAASKGHHECLDILISWGIDVDQDIPHLGTPLYVACMSQQFHCIWK-LLYAGADVQKGKYWD--TPLHAAAQq 243
Cdd:PHA02878  200 TNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDYDILKlLLEHGVDVNAKSYILglTALHSSIK- 278

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622942103 244 sSTEIVNLLLEFGADTNAKNTELLRPIDVATSSsmverillqheatpRSLYQLCR-----LCIRSYIGK 307
Cdd:PHA02878  279 -SERKLKLLLEYGADINSLNSYKLTPLSSAVKQ--------------YLCINIGRilisnICLLKRIKP 332
Ank_2 pfam12796
Ankyrin repeats (3 copies);
107-196 8.35e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 8.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 107 LHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYgAKAQLESCLPSPTHEAASKGHHECLDI 186
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|
gi 1622942103 187 LISWGIDVDQ 196
Cdd:pfam12796  80 LLEKGADINV 89
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 289-329 4.21e-15

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 68.27  E-value: 4.21e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622942103 289 TPRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
Cdd:cd03587     1 NPRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 71-261 2.50e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 73.56  E-value: 2.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  71 RSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACART----------------------------- 121
Cdd:PHA02876  179 ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAiidnrsninkndlsllkairnedletsll 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 122 LLEAGANVNAITIDGVTPLFNACSqgSPSCAEL---LLEYGAKAQLESCL-PSPTHEAASKGHH-ECLDILISWGIDVDQ 196
Cdd:PHA02876  259 LYDAGFSVNSIDDCKNTPLHHASQ--APSLSRLvpkLLERGADVNAKNIKgETPLYLMAKNGYDtENIRTLIMLGADVNA 336

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622942103 197 DIPHLGTPLYVACMSQQFH-CIWKLLYAGADVQKGKYWD-TPLHAAAQQSSTEIVNLLLEFGADTNA 261
Cdd:PHA02876  337 ADRLYITPLHQASTLDRNKdIVITLLELGANVNARDYCDkTPIHYAAVRNNVVIINTLLDYGADIEA 403
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 289-327 1.92e-12

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 60.64  E-value: 1.92e-12
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622942103 289 TPRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQ 327
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 71-292 2.55e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 64.24  E-value: 2.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  71 RSPLHEAASQGRLLALRTLLSQGYNVNAVTL-DHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSP 149
Cdd:PHA02875   69 ESELHDAVEEGDVKAVEELLDLGKFADDVFYkDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 150 SCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILISWGIDVDqdiphlgtplYVAcmsqQFHCIWKLLYagadvq 228
Cdd:PHA02875  149 KGIELLIDHKACLDIEDCCGcTPLIIAMAKGDIAICKMLLDSGANID----------YFG----KNGCVAALCY------ 208

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622942103 229 kgkywdtplhaAAQQSSTEIVNLLLEFGADTNAKNT---------ELLRPIDVATSSSMV-----ERILLQHEATPRS 292
Cdd:PHA02875  209 -----------AIENNKIDIVRLFIKRGADCNIMFMiegeectilDMICNMCTNLESEAIdaliaDIAIRIHKKTIRR 275
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 81-270 2.70e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.21  E-value: 2.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  81 GRLLALRTLLSQGYNVNAVTLDH-VTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYG 159
Cdd:PHA02874   12 GDIEAIEKIIKNKGNCINISVDEtTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 160 AKAqleSCLPSPTHEaaskghHECLDILISWGIDVDQDIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ----KGKYwdt 235
Cdd:PHA02874   92 VDT---SILPIPCIE------KDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNieddNGCY--- 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1622942103 236 PLHAAAQQSSTEIVNLLLEFGADTNAKNTELLRPI 270
Cdd:PHA02874  160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 74-295 2.83e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 64.31  E-value: 2.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVT--------------- 138
Cdd:PHA02876  149 IKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSvlecavdsknidtik 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 139 --------------PLFNACSQGSPSCAELLLEYGAKAQ-LESCLPSPTHEAA-SKGHHECLDILISWGIDVDQDIPHLG 202
Cdd:PHA02876  229 aiidnrsninkndlSLLKAIRNEDLETSLLLYDAGFSVNsIDDCKNTPLHHASqAPSLSRLVPKLLERGADVNAKNIKGE 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 203 TPLYV-ACMSQQFHCIWKLLYAGADVQKG-KYWDTPLHAAAQ-QSSTEIVNLLLEFGADTNAKNTELLRPIDVAT--SSS 277
Cdd:PHA02876  309 TPLYLmAKNGYDTENIRTLIMLGADVNAAdRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAvrNNV 388

                         250
                  ....*....|....*...
gi 1622942103 278 MVERILLQHEATPRSLYQ 295
Cdd:PHA02876  389 VIINTLLDYGADIEALSQ 406
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 86-273 4.18e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 63.44  E-value: 4.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  86 LRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLE 165
Cdd:PHA02874  107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 166 S-CLPSPTHEAASKGHHECLDILISWGIDVDQDIPHLGTPLYVACMSQQfhCIWKLLYAGADVQKGKY-WDTPLHAAAQ- 242
Cdd:PHA02874  187 DnNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR--SAIELLINNASINDQDIdGSTPLHHAINp 264

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1622942103 243 QSSTEIVNLLLEFGADTNAKNTELLRPIDVA 273
Cdd:PHA02874  265 PCDIDIIDILLYHKADISIKDNKGENPIDTA 295
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 290-329 6.23e-11

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 56.54  E-value: 6.23e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622942103 290 PRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
Cdd:cd03718     3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 122-288 2.30e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.13  E-value: 2.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 122 LLEAGANVNAITID-GVTPLFNACSQGSPSCAELLLEYGAKA-QLESCLPSPTHEAASKGHHECLDILISWGIDVdqdip 199
Cdd:PHA02874   20 IIKNKGNCINISVDeTTTPLIDAIRSGDAKIVELFIKHGADInHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDT----- 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 200 hlgTPLYVACMSQQFhcIWKLLYAGADVQ-KGKYWDTPLHAAAQQSSTEIVNLLLEFGADTNAKNTELLRPIDVATSSSM 278
Cdd:PHA02874   95 ---SILPIPCIEKDM--IKTILDCGIDVNiKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNF 169

                         170
                  ....*....|..
gi 1622942103 279 VE--RILLQHEA 288
Cdd:PHA02874  170 FDiiKLLLEKGA 181
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 74-158 3.21e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 61.07  E-value: 3.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAE 153
Cdd:PTZ00322   86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165


                  ....*
gi 1622942103 154 LLLEY 158
Cdd:PTZ00322  166 LLSRH 170
PHA03095 PHA03095
ankyrin-like protein; Provisional
 76-292 3.36e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.81  E-value: 3.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  76 EAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACA---RTLLEAGANVNAITIDGVTPLFnacsqgspsca 152
Cdd:PHA03095   20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKdivRLLLEAGADVNAPERCGFTPLH----------- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 153 eLLLEYGAKAQLesclpsptheaaskghhecldiliswgIDVdqdiphlgtplyvacmsqqfhciwkLLYAGADVQ-KGK 231
Cdd:PHA03095   89 -LYLYNATTLDV---------------------------IKL-------------------------LIKAGADVNaKDK 115

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622942103 232 YWDTPLHA--AAQQSSTEIVNLLLEFGADTNAKNTELLRPIDVATSSSMVE----RILLQHEATPRS 292
Cdd:PHA03095  116 VGRTPLHVylSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANvellRLLIDAGADVYA 182
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 103-290 4.12e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 4.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 103 HVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESC-LPSPTHEAASKGHH 181
Cdd:PHA02875    2 DQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPdIESELHDAVEEGDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 182 ECLDILISWGIDVDQDIPHLG-TPLYVACMSQQFHCIWKLLYAGADV---QKGKYwdTPLHAAAQQSSTEIVNLLLEFGA 257
Cdd:PHA02875   82 KAVEELLDLGKFADDVFYKDGmTPLHLATILKKLDIMKLLIARGADPdipNTDKF--SPLHLAVMMGDIKGIELLIDHKA 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1622942103 258 DTNAKNTELLRPIDVATSSSMVE--RILLQHEATP 290
Cdd:PHA02875  160 CLDIEDCCGCTPLIIAMAKGDIAicKMLLDSGANI 194
Ank_4 pfam13637
Ankyrin repeats (many copies);
103-156 5.13e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.51  E-value: 5.13e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622942103 103 HVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLL 156
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 70-260 9.35e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.15  E-value: 9.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  70 DRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSP 149
Cdd:PHA02875    2 DQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 150 SCAELLLEYGAKAQ--LESCLPSPTHEAASKGHHECLDILISWGIDVDQDIPHLGTPLYVACMSQQFHCIWKLL--YAGA 225
Cdd:PHA02875   82 KAVEELLDLGKFADdvFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIdhKACL 161

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1622942103 226 DVQKGkYWDTPLHAAAQQSSTEIVNLLLEFGADTN 260
Cdd:PHA02875  162 DIEDC-CGCTPLIIAMAKGDIAICKMLLDSGANID 195
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 94-270 1.38e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 56.23  E-value: 1.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  94 YNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTH 173
Cdd:PHA02876  136 YDKINESIEYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVL 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 174 EAASKGHHecLDIlISWGIDVDQDIPHLGTPLYVACMSQQFHCIWKLLYAGADVQK-GKYWDTPLHAAAQQSS-TEIVNL 251
Cdd:PHA02876  216 ECAVDSKN--IDT-IKAIIDNRSNINKNDLSLLKAIRNEDLETSLLLYDAGFSVNSiDDCKNTPLHHASQAPSlSRLVPK 292

                         170
                  ....*....|....*....
gi 1622942103 252 LLEFGADTNAKNTELLRPI 270
Cdd:PHA02876  293 LLERGADVNAKNIKGETPL 311
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 68-194 2.79e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 55.07  E-value: 2.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  68 WADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDH-VACARTLLEAGANVNAITIDGVTPLFNACSQ 146
Cdd:PHA02876  373 YCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNpYMSVKTLIDRGANVNSKNKDLSTPLHYACKK 452

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622942103 147 G-SPSCAELLLEYGAKA---QLESCLPSptheAASKGHHECLDILISWGIDV 194
Cdd:PHA02876  453 NcKLDVIEMLLDNGADVnaiNIQNQYPL----LIALEYHGIVNILLHYGAEL 500
Ank_4 pfam13637
Ankyrin repeats (many copies);
71-123 3.08e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 3.08e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622942103  71 RSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLL 123
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 289-329 3.34e-08

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 49.01  E-value: 3.34e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622942103 289 TPRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
Cdd:cd03729     2 TPLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSYN 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 72-163 4.47e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 54.29  E-value: 4.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  72 SPLHEAASQGR--LLALRTLLSQGYNVNAVT-----LDHV-----------TPLHEACLGDHVACARTLLEAGANVNAIT 133
Cdd:PHA03100  143 NLLHLYLESNKidLKILKLLIDKGVDINAKNrvnylLSYGvpinikdvygfTPLHYAVYNNNPEFVKYLLDLGANPNLVN 222

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622942103 134 IDGVTPLFNACSQGSPSCAELLLEYGAKAQ 163
Cdd:PHA03100  223 KYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 70-160 5.14e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.12  E-value: 5.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  70 DRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEA---CLGDHVacARTLLEAGANVNA-ITIDGVTPLFNACS 145
Cdd:PHA02878  201 NNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvgyCKDYDI--LKLLLEHGVDVNAkSYILGLTALHSSIK 278

                          90
                  ....*....|....*
gi 1622942103 146 qgSPSCAELLLEYGA 160
Cdd:PHA02878  279 --SERKLKLLLEYGA 291
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 290-329 6.07e-08

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 48.41  E-value: 6.07e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622942103 290 PRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
Cdd:cd03743     3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
71-131 8.29e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.34  E-value: 8.29e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622942103  71 RSPLHEAASQGRLLALRTLLSQGyNVNaVTLDHVTPLHEACLGDHVACARTLLEAGANVNA 131
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLEHA-DVN-LKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 290-329 1.57e-07

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 47.09  E-value: 1.57e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622942103 290 PRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
Cdd:cd03728     3 PPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 290-328 3.01e-07

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 46.40  E-value: 3.01e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622942103 290 PRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQY 328
Cdd:cd03721     3 PRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNH 41
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 291-329 5.29e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 45.48  E-value: 5.29e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1622942103  291 RSLYQLCRLCIRSYIGKprlhlIPQLQLPTLLKNFLQYR 329
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG-----IDKLPLPPRLKDYLLYY 34
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 289-326 8.53e-07

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 45.12  E-value: 8.53e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1622942103 289 TPRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFL 326
Cdd:cd03723     2 TPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYL 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
205-288 1.10e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.26  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 205 LYVACMSQQFHCIWKLLYAGADV-QKGKYWDTPLHAAAQQSSTEIVNLLLEFgADTNAKNtELLRPIDVATSSSMVE--R 281
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADAnLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEivK 78


                  ....*..
gi 1622942103 282 ILLQHEA 288
Cdd:pfam12796  79 LLLEKGA 85
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 288-328 1.22e-06

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 44.72  E-value: 1.22e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622942103 288 ATPRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQY 328
Cdd:cd03720     1 GNPRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLH 41
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 77-312 1.49e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.87  E-value: 1.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  77 AASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLL 156
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 157 EYGAKAQLES-----CLpsptheAASKGHHECLDILISWGIDVDQDIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGK 231
Cdd:PLN03192  612 HFASISDPHAagdllCT------AAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 232 YWDtplhaaaQQSSTEIVNLLlefgadtnaKNTELLRPIDVATSSSMVERILLQHEATprslyQLCRLCIRSYIGK--PR 309
Cdd:PLN03192  686 TDD-------DFSPTELRELL---------QKRELGHSITIVDSVPADEPDLGRDGGS-----RPGRLQGTSSDNQcrPR 744


                  ...
gi 1622942103 310 LHL 312
Cdd:PLN03192  745 VSI 747
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 108-164 4.89e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.97  E-value: 4.89e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622942103 108 HEACLGDHVAcARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQL 164
Cdd:PTZ00322   88 QLAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTL 143
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 289-329 6.27e-06

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 42.53  E-value: 6.27e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622942103 289 TPRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
Cdd:cd03726     2 QPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHK 42
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 290-329 1.46e-05

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 41.51  E-value: 1.46e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622942103 290 PRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
Cdd:cd03744     3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 290-329 1.57e-05

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 41.43  E-value: 1.57e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622942103 290 PRSLYQLCRLCIRSYIGKprlHLIPQLQLPTLLKNFLQYR 329
Cdd:cd03717     3 VRSLQHLCRFVIRQCTRR---DLIDQLPLPRRLKDYLKEY 39
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 288-329 2.72e-05

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 40.77  E-value: 2.72e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622942103 288 ATPRSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR 329
Cdd:cd03719     1 AEPHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 72-132 2.76e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.43  E-value: 2.76e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622942103  72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAI 132
Cdd:PHA03100  194 TPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTI 254
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 234-263 4.22e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 4.22e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1622942103 234 DTPLHAAAQQS-STEIVNLLLEFGADTNAKN 263
Cdd:pfam00023   3 NTPLHLAAGRRgNLEIVKLLLSKGADVNARD 33
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 291-328 5.71e-05

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 40.08  E-value: 5.71e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1622942103 291 RSLYQLCRLCIRSYIgkpRLHLIPQLQLPTLLKNFLQY 328
Cdd:cd03741     4 QSLQHLCRFVIRKLV---RRDHIPALPLPRRLIDYLRE 38
Ank_5 pfam13857
Ankyrin repeats (many copies);
231-273 7.58e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.02  E-value: 7.58e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622942103 231 KYWDTPLHAAAQQSSTEIVNLLLEFGADTNAKNTELLRPIDVA 273
Cdd:pfam13857  14 GEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 71-162 8.38e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.86  E-value: 8.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103  71 RSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAI--TIDGVTP-LFNACSQG 147
Cdd:PHA03095  258 QTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVaaTLNTASVaGGDIPSDA 337

                          90
                  ....*....|....*.
gi 1622942103 148 SPSC-AELLLEYGAKA 162
Cdd:PHA03095  338 TRLCvAKVVLRGAFSL 353
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 72-143 1.33e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.41  E-value: 1.33e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622942103  72 SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLgdHVACARTLLEAGANVNAITIDGVTPLFNA 143
Cdd:PHA02874  192 SPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPLHHA 261
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 74-135 2.63e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.55  E-value: 2.63e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622942103  74 LHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITID 135
Cdd:PLN03192  626 LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 288-328 2.70e-04

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 38.23  E-value: 2.70e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622942103 288 ATPRSLYQLCRLCIRSYIGKPRLH---LIPQLQLPTLLKNFLQY 328
Cdd:cd03722     1 ASVPSLTHLCRLEIRSSLKSERLRsdsFICQLPLPRSLQDYLLY 44
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 203-264 2.80e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 2.80e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622942103 203 TPLYVACMSQQFHCIWKLLYAGADVQKGK---------------YWDTPLHAAAQQSSTEIVNLLLEFGADTNAKNT 264
Cdd:cd22192    91 TALHIAVVNQNLNLVRELIARGADVVSPRatgtffrpgpknliyYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDS 167
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 290-329 2.91e-04

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 38.29  E-value: 2.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622942103 290 PRSLYQLCRLCIRSYIGKPRLH---LIPQLQLPTLLKNFLQYR 329
Cdd:cd03730     3 PRSLKHLCRLKIRACMGRLRLRcpvFMSFLPLPNRLKAYILYK 45
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 105-133 3.01e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 3.01e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1622942103 105 TPLHEACL-GDHVACARTLLEAGANVNAIT 133
Cdd:pfam00023   4 TPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 102-131 3.97e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 3.97e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1622942103  102 DHVTPLHEACLGDHVACARTLLEAGANVNA 131
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 220-286 4.45e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.81  E-value: 4.45e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 220 LLYAGADVQKGKY-WDTPLHAAAQQSSTEIVNLLLEFGADTNAKNTELLRPIDVATSSSM--VERILLQH 286
Cdd:PTZ00322  101 LLTGGADPNCRDYdGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFreVVQLLSRH 170
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 291-327 9.81e-04

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 36.24  E-value: 9.81e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622942103 291 RSLYQLCRLCIRSYIgkpRLHLIPQLQLPTLLKNFLQ 327
Cdd:cd03740     4 RSLQYLCRFVIRQYT---RIDLIQKLPLPNKMKGYLL 37
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 290-329 1.01e-03

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 36.51  E-value: 1.01e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622942103  290 PRSLYQLCRLCIRSYIgkpRLHLIPQLQLPTLLKNFLQYR 329
Cdd:smart00253   7 VPSLQHLCRFTIRRCT---RTDQIKTLPLPPKLKDYLSYY 43
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 290-329 1.71e-03

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 35.96  E-value: 1.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622942103 290 PRSLYQLCRLCIRSYIGKPRLHL---IPQLQLPTLLKNFLQYR 329
Cdd:cd03731     3 PRPLKHLCRLKIRKLMGLQKLQQpssMKKLPLPPALKRYILYK 45
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 232-261 1.73e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 1.73e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1622942103  232 YWDTPLHAAAQQSSTEIVNLLLEFGADTNA 261
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
95-140 1.99e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 1.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1622942103  95 NVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPL 140
Cdd:pfam13857   8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 103-160 4.66e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 38.43  E-value: 4.66e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622942103 103 HVTPLHEACLGDHVACARTLLEAGANVNAITIDGV-TPLFNACSQGSPSCAELLLEYGA 160
Cdd:PHA02884   70 KTNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKiTPLYISVLHGCLKCLEILLSYGA 128
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 128-262 4.91e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 38.52  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 128 NVNAITIDGVTPLFNACSQGSP-SCAELLLEYGAKAQL-ESCLpsptHeAASKGHHECLDILISWGIDVDQDipHLGTPL 205
Cdd:TIGR00870  44 NINCPDRLGRSALFVAAIENENlELTELLLNLSCRGAVgDTLL----H-AISLEYVDAVEAILLHLLAAFRK--SGPLEL 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622942103 206 YVACMSQQFhciwkllYAGAdvqkgkywdTPLHAAAQQSSTEIVNLLLEFGADTNAK 262
Cdd:TIGR00870 117 ANDQYTSEF-------TPGI---------TALHLAAHRQNYEIVKLLLERGASVPAR 157
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 186-266 5.36e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 38.34  E-value: 5.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622942103 186 ILISWGIDVDQDIPHLGTPLYVACMSQQFHCIWKLLYAGADV----QKGKywdTPLHAAAQQSSTEIVNLLL-----EFG 256
Cdd:PTZ00322  100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPtlldKDGK---TPLELAEENGFREVVQLLSrhsqcHFE 176

                          90
                  ....*....|
gi 1622942103 257 ADTNAKNTEL 266
Cdd:PTZ00322  177 LGANAKPDSF 186
PHA03095 PHA03095
ankyrin-like protein; Provisional
 86-155 9.48e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 37.70  E-value: 9.48e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622942103  86 LRTLLSQGYNVNAVTLDHVTPLHEacLGDHVACART----LLEAGANVNAITIDGVTPL-FNACSQGSPSCAELL 155
Cdd:PHA03095  205 VRELIRAGCDPAATDMLGNTPLHS--MATGSSCKRSlvlpLLIAGISINARNRYGQTPLhYAAVFNNPRACRRLI 277
Ank_5 pfam13857
Ankyrin repeats (many copies);
122-160 9.64e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 33.86  E-value: 9.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622942103 122 LLEAG-ANVNAITIDGVTPLFNACSQGSPSCAELLLEYGA 160
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGV 40
Ank_4 pfam13637
Ankyrin repeats (many copies);
203-253 9.76e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 33.79  E-value: 9.76e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622942103 203 TPLYVACMSQQFHCIWKLLYAGADVQK-GKYWDTPLHAAAQQSSTEIVNLLL 253
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAvDGNGETALHFAASNGNVEVLKLLL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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