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Conserved domains on  [gi|1622941912|ref|XP_028704702|]
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kelch-like protein 2 isoform X5 [Macaca mulatta]

Protein Classification

kelch-like protein; Kelch-like protein 36( domain architecture ID 13335506)

kelch-like protein may act as substrate adaptors for Cullin 3 ubiquitin ligases| Kelch-like protein 36 (KLHL36) is a probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 56-185 1.54e-98

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


:

Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 292.70  E-value: 1.54e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18512     1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622941912 136 VRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYH 185
Cdd:cd18512    81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
PHA03098 super family cl33709
kelch-like protein; Provisional
 32-476 3.77e-56

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 195.76  E-value: 3.77e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  32 LLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISS 111
Cdd:PHA03098   81 ILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSD 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 112 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLvqrveeEALVKNSSACKDYLIeamkyhllpTEQ 191
Cdd:PHA03098  161 DKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGI------KKLKRWKLRIKKKKI---------VFN 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 192 RILMKSVRTRLRT----PMNLPKLMVVVGGQAP--KAIRSVECYDFKEERWHQVAELPSRRCrAGMVYMAGLVFAVGGFN 265
Cdd:PHA03098  226 KRCIKIIYSKKYNlnkiLPRSSTFGSIIYIHITmsIFTYNYITNYSPLSEINTIIDIHYVYC-FGSVVLNNVIYFIGGMN 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 266 GS-LRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVG 344
Cdd:PHA03098  305 KNnLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPC 384

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 345 VGVVGGLLYAVGG---YDgasrQCLSTVECYNATTNEWSYIAEMSTRRSGAGVGVLNNLLYAVGGH---DGPLVRKSVEV 418
Cdd:PHA03098  385 VVNVNNLIYVIGGiskND----ELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVES 460

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622941912 419 YDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVV 476
Cdd:PHA03098  461 YNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLF 518
 
Name Accession Description Interval E-value
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 56-185 1.54e-98

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 292.70  E-value: 1.54e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18512     1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622941912 136 VRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYH 185
Cdd:cd18512    81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
PHA03098 PHA03098
kelch-like protein; Provisional
 32-476 3.77e-56

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 195.76  E-value: 3.77e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  32 LLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISS 111
Cdd:PHA03098   81 ILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSD 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 112 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLvqrveeEALVKNSSACKDYLIeamkyhllpTEQ 191
Cdd:PHA03098  161 DKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGI------KKLKRWKLRIKKKKI---------VFN 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 192 RILMKSVRTRLRT----PMNLPKLMVVVGGQAP--KAIRSVECYDFKEERWHQVAELPSRRCrAGMVYMAGLVFAVGGFN 265
Cdd:PHA03098  226 KRCIKIIYSKKYNlnkiLPRSSTFGSIIYIHITmsIFTYNYITNYSPLSEINTIIDIHYVYC-FGSVVLNNVIYFIGGMN 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 266 GS-LRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVG 344
Cdd:PHA03098  305 KNnLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPC 384

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 345 VGVVGGLLYAVGG---YDgasrQCLSTVECYNATTNEWSYIAEMSTRRSGAGVGVLNNLLYAVGGH---DGPLVRKSVEV 418
Cdd:PHA03098  385 VVNVNNLIYVIGGiskND----ELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVES 460

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622941912 419 YDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVV 476
Cdd:PHA03098  461 YNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLF 518
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
236-493 3.73e-52

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 178.04  E-value: 3.73e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 236 WHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANM-RDRRSTLGAAVLNGLLYAVGGFDG- 313
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGa 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 314 ---STGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRqcLSTVECYNATTNEWSYIAEMSTRRS 390
Cdd:COG3055    83 npsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGN--VAWVEVYDPATGTWTQLAPLPTPRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 391 GAGVGVL-NNLLYAVGGHDGplvrksvevyDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGscNLASVEYYNPT 469
Cdd:COG3055   161 HLAAAVLpDGKILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPA 228

                         250       260
                  ....*....|....*....|....
gi 1622941912 470 TDKWTVVSScMSTGRSYAGVTVID 493
Cdd:COG3055   229 TNTWTALGE-LPTPRHGHAAVLTD 251
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 61-163 3.98e-44

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 150.77  E-value: 3.98e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  61 CLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEF 140
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 1622941912 141 MARLMEHVRLPLLPREYLVQRVE 163
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 61-161 1.48e-40

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 141.32  E-value: 1.48e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912   61 CLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEF 140
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 1622941912  141 MARLMEHVRLPLLPREYLVQR 161
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
Kelch smart00612
Kelch domain;
400-446 2.02e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 69.89  E-value: 2.02e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622941912  400 LLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNG 446
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-58 5.23e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 71.26  E-value: 5.23e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1622941912  12 LLIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHP 58
Cdd:cd18338    75 MLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 388-433 1.80e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 64.56  E-value: 1.80e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1622941912 388 RRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMN 433
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
 
Name Accession Description Interval E-value
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 56-185 1.54e-98

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 292.70  E-value: 1.54e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18512     1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622941912 136 VRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYH 185
Cdd:cd18512    81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 56-185 4.06e-81

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 248.06  E-value: 4.06e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18513     1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622941912 136 VRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYH 185
Cdd:cd18513    81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 56-169 2.23e-77

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 237.52  E-value: 2.23e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18445     1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622941912 136 VRQEFMARLMEHVRLPLLPREYLVQRVEEEALVK 169
Cdd:cd18445    81 NRKEHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
PHA03098 PHA03098
kelch-like protein; Provisional
 32-476 3.77e-56

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 195.76  E-value: 3.77e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  32 LLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISS 111
Cdd:PHA03098   81 ILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSD 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 112 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLvqrveeEALVKNSSACKDYLIeamkyhllpTEQ 191
Cdd:PHA03098  161 DKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGI------KKLKRWKLRIKKKKI---------VFN 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 192 RILMKSVRTRLRT----PMNLPKLMVVVGGQAP--KAIRSVECYDFKEERWHQVAELPSRRCrAGMVYMAGLVFAVGGFN 265
Cdd:PHA03098  226 KRCIKIIYSKKYNlnkiLPRSSTFGSIIYIHITmsIFTYNYITNYSPLSEINTIIDIHYVYC-FGSVVLNNVIYFIGGMN 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 266 GS-LRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVG 344
Cdd:PHA03098  305 KNnLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPC 384

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 345 VGVVGGLLYAVGG---YDgasrQCLSTVECYNATTNEWSYIAEMSTRRSGAGVGVLNNLLYAVGGH---DGPLVRKSVEV 418
Cdd:PHA03098  385 VVNVNNLIYVIGGiskND----ELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVES 460

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622941912 419 YDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVV 476
Cdd:PHA03098  461 YNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLF 518
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
236-493 3.73e-52

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 178.04  E-value: 3.73e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 236 WHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANM-RDRRSTLGAAVLNGLLYAVGGFDG- 313
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGa 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 314 ---STGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRqcLSTVECYNATTNEWSYIAEMSTRRS 390
Cdd:COG3055    83 npsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGN--VAWVEVYDPATGTWTQLAPLPTPRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 391 GAGVGVL-NNLLYAVGGHDGplvrksvevyDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGscNLASVEYYNPT 469
Cdd:COG3055   161 HLAAAVLpDGKILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPA 228

                         250       260
                  ....*....|....*....|....
gi 1622941912 470 TDKWTVVSScMSTGRSYAGVTVID 493
Cdd:COG3055   229 TNTWTALGE-LPTPRHGHAAVLTD 251
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 56-188 1.89e-48

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 163.34  E-value: 1.89e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18452     1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622941912 136 VRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLP 188
Cdd:cd18452    81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRP 133
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
214-453 6.90e-45

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 158.78  E-value: 6.90e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 214 VVGGQAP-KAIRSVECYDFKEERWHQVAELP-SRRCRAGMVYMAGLVFAVGGFNGSLRVRT----VDSYDPVKDQWTSVA 287
Cdd:COG3055    27 VAGGLSGgSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGFTGANPSSTplndVYVYDPATNTWTKLA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 288 NMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG-LLYAVGGYDGasrqcl 366
Cdd:COG3055   107 PMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDgKILVIGGRNG------ 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 367 stvecyNATTNEWSYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLvrKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNG 446
Cdd:COG3055   181 ------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFS--DEVEAYDPATNTWTALGELPTPRHGHAAVLTDG 252


                  ....*..
gi 1622941912 447 LLYVVGG 453
Cdd:COG3055   253 KVYVIGG 259
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 61-163 3.98e-44

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 150.77  E-value: 3.98e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  61 CLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEF 140
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 1622941912 141 MARLMEHVRLPLLPREYLVQRVE 163
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 55-158 2.86e-43

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 148.63  E-value: 2.86e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  55 QLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDK 134
Cdd:cd18444     1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                          90       100
                  ....*....|....*....|....
gi 1622941912 135 DVRQEFMARLMEHVRLPLLPREYL 158
Cdd:cd18444    81 PERKKHLAKLLALIRLPLLTPQFL 104
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 56-162 4.47e-42

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 145.53  E-value: 4.47e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18457     1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                          90       100
                  ....*....|....*....|....*..
gi 1622941912 136 VRQEFMARLMEHVRLPLLPREYLVQRV 162
Cdd:cd18457    81 NREEYLPELLSKVRLPLLRPQFLTDRV 107
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 61-161 1.48e-40

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 141.32  E-value: 1.48e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912   61 CLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEF 140
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 1622941912  141 MARLMEHVRLPLLPREYLVQR 161
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
214-420 1.90e-38

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 141.45  E-value: 1.90e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 214 VVGG-----QAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVAN 288
Cdd:COG3055    75 VFGGftganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAP 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 289 MRDRRSTLGAAVL-NGLLYAVGGFDGSTGlssveaynikSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASrqclS 367
Cdd:COG3055   155 LPTPRDHLAAAVLpDGKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFS----D 220

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622941912 368 TVECYNATTNEWSYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKS----VEVYD 420
Cdd:COG3055   221 EVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGVRTPlvtsAEVYD 277
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 55-153 2.35e-33

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 121.77  E-value: 2.35e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  55 QLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDK 134
Cdd:cd18459     1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                          90
                  ....*....|....*....
gi 1622941912 135 DVRQEFMARLMEHVRLPLL 153
Cdd:cd18459    81 QERRPHLPQVLQHVRLPLL 99
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 60-133 3.42e-33

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 120.59  E-value: 3.42e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622941912  60 NCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHD 133
Cdd:cd18508     4 NCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 55-151 3.64e-33

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 121.26  E-value: 3.64e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  55 QLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDK 134
Cdd:cd18448     1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                          90
                  ....*....|....*..
gi 1622941912 135 DVRQEFMARLMEHVRLP 151
Cdd:cd18448    81 QHRKRHLDDLLSQVRLP 97
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 55-158 5.03e-32

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 118.48  E-value: 5.03e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  55 QLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDK 134
Cdd:cd18510     1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                          90       100
                  ....*....|....*....|....
gi 1622941912 135 DVRQEFMARLMEHVRLPLLPREYL 158
Cdd:cd18510    81 QNRQKDLGMLLSYIRLPLLPPQLL 104
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 56-157 6.08e-32

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 118.18  E-value: 6.08e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18456     1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                          90       100
                  ....*....|....*....|..
gi 1622941912 136 VRQEFMARLMEHVRLPLLPREY 157
Cdd:cd18456    81 GRRQHVPRLMKCVRLPLLSRDF 102
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 55-158 1.43e-31

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 117.09  E-value: 1.43e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  55 QLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDK 134
Cdd:cd18511     1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                          90       100
                  ....*....|....*....|....
gi 1622941912 135 DVRQEFMARLMEHVRLPLLPREYL 158
Cdd:cd18511    81 EQRRKDLSKLLAYIRLPLLAPQFL 104
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 56-158 1.29e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 112.04  E-value: 1.29e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18509     2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                          90       100
                  ....*....|....*....|...
gi 1622941912 136 VRQEFMARLMEHVRLPLLPREYL 158
Cdd:cd18509    82 RRCSDLSMLLAYIRLPLLPPQLL 104
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 55-145 3.18e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 110.08  E-value: 3.18e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  55 QLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDK 134
Cdd:cd18458     1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                          90
                  ....*....|.
gi 1622941912 135 DVRQEFMARLM 145
Cdd:cd18458    81 ENRRQYLEALL 91
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 57-158 8.27e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 109.42  E-value: 8.27e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  57 HPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDV 136
Cdd:cd18468     1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                          90       100
                  ....*....|....*....|..
gi 1622941912 137 RQEFMARLMEHVRLPLLPREYL 158
Cdd:cd18468    81 RKQHIAELLAVVRLPFIHPSYL 102
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 56-163 1.81e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 108.71  E-value: 1.81e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18446     1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                          90       100
                  ....*....|....*....|....*...
gi 1622941912 136 VRQEFMARLMEHVRLPLLPREYLVQRVE 163
Cdd:cd18446    81 ERLPLLPRVLENVRLPLLDPWYFVETVE 108
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 55-132 1.67e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 102.09  E-value: 1.67e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622941912  55 QLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNH 132
Cdd:cd18463     1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 56-133 4.34e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 95.76  E-value: 4.34e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVV-LSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHD 133
Cdd:cd18450     1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAkDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 58-145 8.87e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 95.46  E-value: 8.87e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  58 PVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVR 137
Cdd:cd18455     2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81


                  ....*...
gi 1622941912 138 QEFMARLM 145
Cdd:cd18455    82 KVHLKDLM 89
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 56-153 1.60e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 94.63  E-value: 1.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18467     1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                          90
                  ....*....|....*...
gi 1622941912 136 VRQEFMARLMEHVRLPLL 153
Cdd:cd18467    81 ERQKYLAQLLHCVRLPLL 98
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 56-152 1.40e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 92.10  E-value: 1.40e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18485     1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                          90
                  ....*....|....*..
gi 1622941912 136 VRQEFMARLMEHVRLPL 152
Cdd:cd18485    81 SRVQHLVELLKQVRLEL 97
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 55-152 8.72e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 89.72  E-value: 8.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  55 QLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDK 134
Cdd:cd18447     1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                          90
                  ....*....|....*...
gi 1622941912 135 DVRQEFMARLMEHVRLPL 152
Cdd:cd18447    81 PNRQPYMVDILAKVRFPL 98
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 58-158 6.61e-21

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 87.53  E-value: 6.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  58 PVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVR 137
Cdd:cd18466     3 PANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKR 82

                          90       100
                  ....*....|....*....|.
gi 1622941912 138 QEFMARLMEHVRLPLLPREYL 158
Cdd:cd18466    83 KKHVVEVLEPVRFPLLPPQRL 103
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 55-157 8.46e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 87.12  E-value: 8.46e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  55 QLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDK 134
Cdd:cd18469     2 QIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDP 81

                          90       100
                  ....*....|....*....|...
gi 1622941912 135 DVRQEFMARLMEHVRLPLLPREY 157
Cdd:cd18469    82 QARAAHLPELLSLVHLSLLTDQY 104
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 56-154 3.20e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 85.28  E-value: 3.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18514     1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                          90
                  ....*....|....*....
gi 1622941912 136 VRQEFMARLMEHVRLPLLP 154
Cdd:cd18514    81 KRKDYLPELLRNVRLALLP 99
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 57-154 9.60e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 81.39  E-value: 9.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  57 HPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDV 136
Cdd:cd18464     1 HPSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPR 80

                          90
                  ....*....|....*...
gi 1622941912 137 RQEFMARLMEHVRLPLLP 154
Cdd:cd18464    81 RHEVLPELLRSVRLALLP 98
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
210-373 1.68e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 85.59  E-value: 1.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 210 KLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCR-AGMVYMAGLVFAVGGFNGSLRVrtvdsydpvkDQWTSVAN 288
Cdd:COG3055   123 KIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHlAAAVLPDGKILVIGGRNGSGFS----------NTWTTLAP 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 289 MRDRRSTLGAAVLNGLLYAVGGFDGStgLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYD--GASRQCL 366
Cdd:COG3055   193 LPTARAGHAAAVLGGKILVFGGESGF--SDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETkpGVRTPLV 270


                  ....*..
gi 1622941912 367 STVECYN 373
Cdd:COG3055   271 TSAEVYD 277
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 56-151 6.49e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 79.01  E-value: 6.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLtISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18476     1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                          90
                  ....*....|....*.
gi 1622941912 136 VRQEFMARLMEHVRLP 151
Cdd:cd18476    80 ARKGYIHDLFKKVRLQ 95
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 57-154 6.79e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 78.86  E-value: 6.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  57 HPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDV 136
Cdd:cd18515     1 HPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKK 80

                          90
                  ....*....|....*...
gi 1622941912 137 RQEFMARLMEHVRLPLLP 154
Cdd:cd18515    81 RHCYLSELLQTVRLALLP 98
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 59-137 7.70e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 75.05  E-value: 7.70e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622941912  59 VNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVR 137
Cdd:cd18480     4 SNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLEAR 82
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 60-154 3.06e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 74.02  E-value: 3.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  60 NCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQE 139
Cdd:cd18516     5 NCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERTK 84

                          90
                  ....*....|....*
gi 1622941912 140 FMARLMEHVRLPLLP 154
Cdd:cd18516    85 ALPVLLESIRFRLMP 99
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 60-150 3.85e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 73.94  E-value: 3.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  60 NCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQE 139
Cdd:cd18479     5 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQ 84

                          90
                  ....*....|.
gi 1622941912 140 FMARLMEHVRL 150
Cdd:cd18479    85 YLSSVLSQIRI 95
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 56-152 4.31e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 73.61  E-value: 4.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18462     1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                          90
                  ....*....|....*..
gi 1622941912 136 VRQEFMARLMEHVRLPL 152
Cdd:cd18462    81 KRIECAYDLLSSIKLDL 97
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 56-154 7.29e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 72.95  E-value: 7.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18477     1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                          90
                  ....*....|....*....
gi 1622941912 136 VRQEFMARLMEHVRLPLLP 154
Cdd:cd18477    81 NRQKALPTVFESIRFRLLP 99
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 56-154 1.04e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 72.50  E-value: 1.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18517     1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                          90
                  ....*....|....*....
gi 1622941912 136 VRQEFMARLMEHVRLPLLP 154
Cdd:cd18517    81 NRVKSLGEIFDCIRFRLMP 99
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 56-151 1.27e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 72.20  E-value: 1.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18483     1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                          90
                  ....*....|....*..
gi 1622941912 136 VRQEFMARLMEH-VRLP 151
Cdd:cd18483    81 KREMHLPEIFAKcIRMP 97
Kelch smart00612
Kelch domain;
400-446 2.02e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 69.89  E-value: 2.02e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622941912  400 LLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNG 446
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-58 5.23e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 71.26  E-value: 5.23e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1622941912  12 LLIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHP 58
Cdd:cd18338    75 MLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 57-111 5.93e-15

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 68.84  E-value: 5.93e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622941912  57 HPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISS 111
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 56-130 6.81e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 69.34  E-value: 6.81e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWV 130
Cdd:cd18472     1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 56-155 7.68e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 70.21  E-value: 7.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18460     1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                          90       100
                  ....*....|....*....|
gi 1622941912 136 VRQEFMARLMEHVRLPLLPR 155
Cdd:cd18460    81 HRQHFWPELLQHVRLPFVRR 100
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 56-148 2.69e-14

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 68.42  E-value: 2.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNL---GIEQVCSliSSDKLTISSEEKVFEAVIAWVNH 132
Cdd:cd18502     1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLprlQIEVILE--SNQELESINERKLCQLVLEWVQR 78

                          90
                  ....*....|....*.
gi 1622941912 133 DKDVRQEFMARLMEHV 148
Cdd:cd18502    79 SIEEGGLDLDDLTEKV 94
Kelch smart00612
Kelch domain;
447-494 3.74e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 66.43  E-value: 3.74e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1622941912  447 LLYVVGGDDGSCNLASVEYYNPTTDKWTVVSScMSTGRSYAGVTVIDK 494
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPS-MPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
257-303 4.09e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 66.43  E-value: 4.09e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622941912  257 LVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNG 303
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-58 1.22e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 67.45  E-value: 1.22e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622941912  11 SLLIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHP 58
Cdd:cd18235    74 LLLIDYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 388-433 1.80e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 64.56  E-value: 1.80e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1622941912 388 RRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMN 433
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
351-399 2.72e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 64.12  E-value: 2.72e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1622941912  351 LLYAVGGYDGAsrQCLSTVECYNATTNEWSYIAEMSTRRSGAGVGVLNN 399
Cdd:smart00612   1 KIYVVGGFDGG--QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 436-480 7.57e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 62.63  E-value: 7.57e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1622941912 436 RRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCM 480
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 292-337 4.89e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 60.32  E-value: 4.89e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1622941912 292 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMN 337
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-63 2.12e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 61.31  E-value: 2.12e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622941912  12 LLIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLG 63
Cdd:cd18249    77 LLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 60-151 2.51e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 60.13  E-value: 2.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  60 NCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDvRQE 139
Cdd:cd18449     5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHEDD-RMQ 83

                          90
                  ....*....|..
gi 1622941912 140 FMARLMEHVRLP 151
Cdd:cd18449    84 FAAKLMENIRFP 95
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 60-133 3.15e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 59.06  E-value: 3.15e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622941912  60 NCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHD 133
Cdd:cd18474     5 NCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-58 4.33e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 60.12  E-value: 4.33e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622941912  11 SLLIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHP 58
Cdd:cd18339    74 SKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 121
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 245-290 4.37e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 57.62  E-value: 4.37e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1622941912 245 RRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMR 290
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
304-341 5.32e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 57.57  E-value: 5.32e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1622941912  304 LLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRS 341
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRS 38
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 68-163 1.90e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 57.72  E-value: 1.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  68 ADMHACTDLLNKANTYaeqhftdvvLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEH 147
Cdd:cd18453    13 AALHGLEETKKLANKY---------LVEDVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKR 83

                          90
                  ....*....|....*.
gi 1622941912 148 VRLPLLPREYLVQRVE 163
Cdd:cd18453    84 LRFALIPAPELVERVQ 99
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-58 2.28e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 57.93  E-value: 2.28e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622941912   7 KTWKSLLIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHP 58
Cdd:cd18257    67 ETALQAIVEYAYTGTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-61 2.84e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 57.84  E-value: 2.84e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622941912  13 LIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNC 61
Cdd:cd18242    76 LLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 56-140 3.29e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 56.51  E-value: 3.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 135
Cdd:cd18451     1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                  ....*
gi 1622941912 136 VRQEF 140
Cdd:cd18451    81 ERERY 85
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 35-158 1.24e-09

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 55.31  E-value: 1.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  35 AAGLLQLQDVKKTCCEFLesqlhpvnclgirafaDMHActdllnkantyaeqhfTDVVLSEEFLNLGIEQVCSLISSDKL 114
Cdd:cd14822    12 VASLYSLDDLCQTCCQFM----------------DRNA----------------QEVLSSEGFLTLSKSALKELLSRDSF 59

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622941912 115 tISSEEKVFEAVIAWVNHDKDVRQEfMARLMEHVRLPLLPREYL 158
Cdd:cd14822    60 -CAPEVDIFNAVRRWCEHNPDSKED-AKEILEAVRLPLMSLTEL 101
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 61-153 1.47e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 54.91  E-value: 1.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  61 CLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDkDVRQEF 140
Cdd:cd18465     6 CLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHD-PSRRAS 84

                          90
                  ....*....|...
gi 1622941912 141 MARLMEHVRLPLL 153
Cdd:cd18465    85 ASHVLCHIRFPLM 97
PLN02193 PLN02193
nitrile-specifier protein
 352-478 1.51e-09

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 59.97  E-value: 1.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 352 LYAVGGYDgASRQcLSTVECYNATTNEWSY---IAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQ 428
Cdd:PLN02193  231 LYVFGGRD-ASRQ-YNGFYSFDTTTNEWKLltpVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFH 308

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622941912 429 VA---DMNMCRRNAGVCAVNGLLYVVGGDDGsCNLASVEYYNPTTDKWTVVSS 478
Cdd:PLN02193  309 CStpgDSFSIRGGAGLEVVQGKVWVVYGFNG-CEVDDVHYYDPVQDKWTQVET 360
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-63 3.56e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 54.72  E-value: 3.56e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622941912  30 QVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLG 63
Cdd:cd18256    92 QELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-64 7.21e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 54.61  E-value: 7.21e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622941912  12 LLIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGI 64
Cdd:cd18267    95 LLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-65 7.46e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 53.90  E-value: 7.46e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622941912  13 LIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIR 65
Cdd:cd18336    74 LVHYAYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGIR 126
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 60-132 1.56e-08

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 51.58  E-value: 1.56e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622941912  60 NCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNH 132
Cdd:cd18503     5 NCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
PHA02790 PHA02790
Kelch-like protein; Provisional
 304-475 4.43e-08

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 55.43  E-value: 4.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 304 LLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASrqclsTVECYNATTNEWSYIA 383
Cdd:PHA02790  273 VVYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNPT-----SVERWFHGDAAWVNMP 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 384 EMSTRRSGAGVGVLNNLLYAVGGHD------------------GP-------------------LVRKSVEVYDPTTNAW 426
Cdd:PHA02790  348 SLLKPRCNPAVASINNVIYVIGGHSetdttteyllpnhdqwqfGPstyyphykscalvfgrrlfLVGRNAEFYCESSNTW 427

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1622941912 427 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTV 475
Cdd:PHA02790  428 TLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSWNI 476
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-63 5.49e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 51.14  E-value: 5.49e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622941912  30 QVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLG 63
Cdd:cd18238    87 QSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 60-153 1.19e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 49.76  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  60 NCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWvnH------D 133
Cdd:cd18461     5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLY--HytpeqvE 82

                          90       100
                  ....*....|....*....|.
gi 1622941912 134 KD-VRQEFMARLMEHVRLPLL 153
Cdd:cd18461    83 KDqVSLQEPPKLLEAVRFPLM 103
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-62 1.34e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 49.67  E-value: 1.34e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1622941912  30 QVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCL 62
Cdd:cd18234    73 ESLLATACLLQLSEVVEACCGFLMKQLHPSNCL 105
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 351-386 2.31e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 47.22  E-value: 2.31e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1622941912 351 LLYAVGGYDGasRQCLSTVECYNATTNEWSYIAEMS 386
Cdd:pfam01344  13 KIYVIGGFDG--NQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-63 3.15e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 49.41  E-value: 3.15e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622941912  11 SLLIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLG 63
Cdd:cd18237    74 ELLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126
PHA02713 PHA02713
hypothetical protein; Provisional
 385-467 4.23e-07

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 52.32  E-value: 4.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 385 MSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVE 464
Cdd:PHA02713  338 MIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHIDYTSVH 417


                  ...
gi 1622941912 465 YYN 467
Cdd:PHA02713  418 HMN 420
Kelch smart00612
Kelch domain;
214-256 5.54e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 46.01  E-value: 5.54e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1622941912  214 VVGGQAPK-AIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAG 256
Cdd:smart00612   4 VVGGFDGGqRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KBTBD4 cd18481
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 60-140 6.19e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also termed BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates.


Pssm-ID: 350556  Cd Length: 88  Bit Score: 47.19  E-value: 6.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  60 NCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDkltISSEEKVFEAVIAWVNHDKDVRQE 139
Cdd:cd18481     5 NCLQVMWLADQHSDQELYTAAKHCAKTHLSQLHQTEEFLNLPLRLLTDIIKDG---VPCSQNPTAAIEAWINHNKEEREG 81


                  .
gi 1622941912 140 F 140
Cdd:cd18481    82 F 82
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-63 7.35e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 48.08  E-value: 7.35e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622941912  12 LLIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLG 63
Cdd:cd18254    77 LLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-65 8.00e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 48.13  E-value: 8.00e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622941912  29 LQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIR 65
Cdd:cd18337    94 IECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIR 130
PHA02713 PHA02713
hypothetical protein; Provisional
 298-481 8.40e-07

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 51.55  E-value: 8.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 298 AAVLNGLLYAVGGFD-GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQclSTVECYNATT 376
Cdd:PHA02713  299 SAIVDNEIIIAGGYNfNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVE--RTIECYTMGD 376

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 377 NEWSYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEV------------------YDPTTNAWRQVADMNMCRRN 438
Cdd:PHA02713  377 DKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHIDYTSVHHmnsidmeedthssnkvirYDTVNNIWETLPNFWTGTIR 456

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1622941912 439 AGVCAVNGLLYVVGG--DDGSCNLASVEYYNPTTDKWTVVSSCMS 481
Cdd:PHA02713  457 PGVVSHKDDIYVVCDikDEKNVKTCIFRYNTNTYNGWELITTTES 501
PHA02713 PHA02713
hypothetical protein; Provisional
 233-324 9.99e-07

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 51.16  E-value: 9.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 233 EERWHqvAELP---SRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVG 309
Cdd:PHA02713  328 ENKIH--VELPpmiKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIG 405

                          90
                  ....*....|....*
gi 1622941912 310 GFDGSTGLSSVEAYN 324
Cdd:PHA02713  406 GRTEHIDYTSVHHMN 420
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-65 2.42e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 46.58  E-value: 2.42e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622941912  18 WPPVVLIFMPCLQV-------LLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIR 65
Cdd:cd18335    72 WDLVQFAYTGCLELkedtienLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGIR 126
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-61 3.80e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 45.91  E-value: 3.80e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622941912  11 SLLIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNC 61
Cdd:cd18250    74 GLLLDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 60-150 4.46e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 45.25  E-value: 4.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  60 NCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDvRQE 139
Cdd:cd18470     5 NCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFDQK-RVK 83

                          90
                  ....*....|.
gi 1622941912 140 FMARLMEHVRL 150
Cdd:cd18470    84 YAADLLSNIRF 94
PLN02153 PLN02153
epithiospecifier protein
 352-478 5.29e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 48.44  E-value: 5.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 352 LYAVGGYDgaSRQCLSTVECYNATTNEWSYIAEMSTR-----RSGAGVGVLNNLLYAVGG------HDGPLVRKSVEVYD 420
Cdd:PLN02153   88 LYIFGGRD--EKREFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGvskgglMKTPERFRTIEAYN 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622941912 421 PTTNAWRQVAD--MNMCRRN-AGVCAVNGLLYVV----------GGDDGSCNlaSVEYYNPTTDKWTVVSS 478
Cdd:PLN02153  166 IADGKWVQLPDpgENFEKRGgAGFAVVQGKIWVVygfatsilpgGKSDYESN--AVQFFDPASGKWTEVET 234
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 56-153 5.48e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 44.89  E-value: 5.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLS--EEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHd 133
Cdd:cd18471     1 LNSFNYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKShpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEH- 79

                          90       100
                  ....*....|....*....|
gi 1622941912 134 kDVRQEFMARLMEHVRLPLL 153
Cdd:cd18471    80 -NCRYQYMDELLQYVRFGLM 98
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 88-130 1.49e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 42.95  E-value: 1.49e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622941912  88 FTDVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWV 130
Cdd:cd18493    32 FEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-58 1.60e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 44.64  E-value: 1.60e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1622941912  13 LIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHP 58
Cdd:cd18246    94 LVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDP 139
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 86-155 1.93e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 43.29  E-value: 1.93e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622941912  86 QHFTDVVLSEEFL-NLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDvRQEFMARLMEHVRLPLLPR 155
Cdd:cd18475    31 QNFGTLSFTPDFLqNVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQSPE-RENEAYQVLSNIHFPLIPK 100
Kelch_6 pfam13964
Kelch motif;
298-340 2.75e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.55  E-value: 2.75e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622941912 298 AAVLNGLLYAVGGF-DGSTGLSSVEAYNIKSNEWFHVAPMNTRR 340
Cdd:pfam13964   7 VVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-61 4.06e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 43.08  E-value: 4.06e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622941912  11 SLLIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNC 61
Cdd:cd18240    70 ELIIEYAYTRTVPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
PLN02193 PLN02193
nitrile-specifier protein
 229-394 4.82e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 45.72  E-value: 4.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 229 YDFKEERWH---QVAELPSRRCRA-GMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQW---TSVANMRDRRSTLGAAVL 301
Cdd:PLN02193  198 FDLETRTWSispATGDVPHLSCLGvRMVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWkllTPVEEGPTPRSFHSMAAD 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 302 NGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVA-PMN--TRRSSVGVGVVGGLLYAVGGYDGASrqcLSTVECYNATTNE 378
Cdd:PLN02193  278 EENVYVFGGVSATARLKTLDSYNIVDKKWFHCStPGDsfSIRGGAGLEVVQGKVWVVYGFNGCE---VDDVHYYDPVQDK 354

                         170
                  ....*....|....*.
gi 1622941912 379 WSYIAEMSTRRSGAGV 394
Cdd:PLN02193  355 WTQVETFGVRPSERSV 370
PLN02193 PLN02193
nitrile-specifier protein
 211-341 6.49e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 45.33  E-value: 6.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 211 LMVVVGGQAPKAIRSVECYDFKEERWH---QVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVA 287
Cdd:PLN02193  231 LYVFGGRDASRQYNGFYSFDTTTNEWKlltPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCS 310

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622941912 288 NMRDRRSTLGAA---VLNGLLYAVGGFDGSTgLSSVEAYNIKSNEWFHVAPMNTRRS 341
Cdd:PLN02193  311 TPGDSFSIRGGAgleVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKWTQVETFGVRPS 366
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 56-158 6.71e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 42.03  E-value: 6.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  56 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSE----EFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVN 131
Cdd:cd18473     1 LSPENCCFSANIAARFGLPDALKAAEKYIISNLWRLLASDaddaGLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLN 80

                          90       100
                  ....*....|....*....|....*..
gi 1622941912 132 HDKDvRQEFMARLMEHVRLPLLPREYL 158
Cdd:cd18473    81 QDES-RLAYANALLSRIRYGLVPVEEL 106
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-55 8.64e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 41.88  E-value: 8.64e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622941912  13 LIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQ 55
Cdd:cd18247    74 LINFAYSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-64 1.29e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 42.12  E-value: 1.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622941912  11 SLLIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGI 64
Cdd:cd18273    87 ALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 60-149 1.71e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 40.56  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912  60 NCLGIRAFADMHACTDLLNKANTYAEQHFTDVVLSEEFL-NLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQ 138
Cdd:cd18482     5 NCAGILKFADAFDNRELKSKALAFIARNFQQLLAKEEELcELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKERA 84

                          90
                  ....*....|.
gi 1622941912 139 EFMARLMEHVR 149
Cdd:cd18482    85 ASAAEVLKCVR 95
Kelch_3 pfam13415
Galactose oxidase, central domain;
352-394 3.41e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.43  E-value: 3.41e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622941912 352 LYAVGGYDGASRQCLSTVECYNATTNEWSYIAEMSTRRSGAGV 394
Cdd:pfam13415   4 LYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSA 46
Kelch_3 pfam13415
Galactose oxidase, central domain;
398-444 3.68e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.43  E-value: 3.68e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622941912 398 NNLLYAVGG--HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAV 444
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-63 4.07e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 40.53  E-value: 4.07e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622941912  11 SLLIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLG 63
Cdd:cd18265    76 EVLLDYMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 388-432 4.31e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 38.09  E-value: 4.31e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1622941912 388 RRSGAGVGVLNNLLYAVGGHD--GPLVRKSVEVYDPTTNAWRQVADM 432
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDglGDLSSSDVLVYDPETNVWTEVPRL 47
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-63 4.85e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 40.19  E-value: 4.85e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1622941912  29 LQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLG 63
Cdd:cd18252    93 VQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127
PRK14131 PRK14131
N-acetylneuraminate epimerase;
232-313 8.12e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.54  E-value: 8.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 232 KEERWHQVAELPS-RRCRAGMVYMAGLVFAVGGF-----NGSLRV-RTVDSYDPVKDQWTSVaNMRDRRSTLGAAVL--- 301
Cdd:PRK14131   60 PSKGWTKIAAFPGgPREQAVAAFIDGKLYVFGGIgktnsEGSPQVfDDVYKYDPKTNSWQKL-DTRSPVGLAGHVAVslh 138

                          90
                  ....*....|....*..
gi 1622941912 302 NGLLYAVGG-----FDG 313
Cdd:PRK14131  139 NGKAYITGGvnkniFDG 155
PRK14131 PRK14131
N-acetylneuraminate epimerase;
373-453 1.02e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.54  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622941912 373 NATTNEWSYIAEM-STRRSGAGVGVLNNLLYAVGG-----HDGPL-VRKSVEVYDPTTNAWRQVadmnMCRR------NA 439
Cdd:PRK14131   58 NAPSKGWTKIAAFpGGPREQAVAAFIDGKLYVFGGigktnSEGSPqVFDDVYKYDPKTNSWQKL----DTRSpvglagHV 133

                          90
                  ....*....|....
gi 1622941912 440 GVCAVNGLLYVVGG 453
Cdd:PRK14131  134 AVSLHNGKAYITGG 147
Kelch_3 pfam13415
Galactose oxidase, central domain;
445-492 1.34e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.88  E-value: 1.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622941912 445 NGLLYVVGGDDGSCNLASVEY--YNPTTDKWTVVSScMSTGRSYAGVTVI 492
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLyvYDLDTNTWTQIGD-LPPPRSGHSATYI 49
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-63 1.34e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 38.80  E-value: 1.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622941912  12 LLIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLG 63
Cdd:cd18258    74 LLLEFVYTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-56 1.69e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 38.51  E-value: 1.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1622941912  11 SLLIEWCWPPVVLIFMPCLQVLLPAAGLLQLQDVKKTCCEFLESQL 56
Cdd:cd18248    78 SRLIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
Kelch_3 pfam13415
Galactose oxidase, central domain;
302-342 1.82e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.50  E-value: 1.82e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622941912 302 NGLLYAVGG--FDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSS 342
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSG 43
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 211-243 2.33e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.05  E-value: 2.33e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622941912 211 LMVVVGGQ-APKAIRSVECYDFKEERWHQVAELP 243
Cdd:pfam01344  13 KIYVIGGFdGNQSLNSVEVYDPETNTWSKLPSMP 46
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
201-263 3.72e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 39.37  E-value: 3.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622941912 201 RLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGG 263
Cdd:COG3055   197 RAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGG 259
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-61 5.29e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 37.12  E-value: 5.29e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1622941912  29 LQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNC 61
Cdd:cd18253    89 VQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
Kelch_6 pfam13964
Kelch motif;
435-484 5.55e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.00  E-value: 5.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622941912 435 CRRNAGVCAVNGLLYVVGGDDGSCN-LASVEYYNPTTDKWTVVSScMSTGR 484
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPaLNKLEVYNPLTKSWEELPP-LPTPR 50
Kelch_6 pfam13964
Kelch motif;
396-433 6.50e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.62  E-value: 6.50e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622941912 396 VLNNLLYAVGGHDGPLVRKS-VEVYDPTTNAWRQVADMN 433
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPALNkLEVYNPLTKSWEELPPLP 47
BACK_KLHL15 cd18454
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...
 79-153 7.36e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.


Pssm-ID: 350529  Cd Length: 108  Bit Score: 36.41  E-value: 7.36e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622941912  79 KANTYAEQHFTDVVLSEEFLN-LGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDvRQEFMARLMEHVRLPLL 153
Cdd:cd18454    26 KLDSFLLENFVPLMSRPDFLSyLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLRHDRR-RWRHTDTIIQNIRFCLM 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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