NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622938759|ref|XP_028704171|]
View 

limbin isoform X2 [Macaca mulatta]

Protein Classification

kinesin family protein; PEPP family PH domain-containing protein( domain architecture ID 13780468)

kinesin family protein is a microtubule-dependent molecular motor that plays an important role in intracellular transport and in cell division and has an ATPase-containing motor domain; similar to N-type kinesins that are (+) end-directed motors and have an N-terminal motor domain| PEPP (phosphoinositol 3-phosphate-binding protein) family PH (pleckstrin homology) domain-containing protein similar to PH domain region of vertebrate pleckstrin homology domain-containing family A member 4/5/6/7

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
EVC2_like pfam12297
Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. ...
237-641 0e+00

Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. Proteins in this family are typically between 571 and 1310 amino acids in length. There are two conserved sequence motifs: LPA and ELH. EVC2 is implicated in Ellis van Creveld chondrodysplastic dwarfism in humans. Mutations in this protein can give rise to this congenital condition. LIMBIN is a protein which shares around 80% sequence homology with EVC2 and it is implicated in a similar condition in bovine chondrodysplastic dwarfism.


:

Pssm-ID: 463525 [Multi-domain]  Cd Length: 428  Bit Score: 627.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  237 GDAFAVSYAATLQAGDLGNGESLKLPAQLTFQSSSQ----------------------VLPHHGLHAAGFFIAFLLSLVL 294
Cdd:pfam12297    1 GEEYAVSYTAELDAKERGKGESLTLPAQLTFQNSSQnnrtqlgpltanltltveektkVLPNHGLHAAGFFIGFLVSLVL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  295 TWAALFLMVHYQCLKGSMLTRHQVWQYDSKLEPLPFTSADGVNEDLSLNDQMIDILSSEDPGSMLQALEELEIATLNRAD 374
Cdd:pfam12297   81 TLLAFFLLGRTRCLQGSLLSRNRRLSQESKLEYSQFTSAEGVKEDLAFEDQMIDILTFEDPGSMLQALENLEIATLLRAD 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  375 ADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSDVFKKQFMLLENEIQEEYDRKMVALTAECDLETRKKMENQYQR 454
Cdd:pfam12297  161 ADLEACRTQISKDIIAILLKNLRSSGHLSPQAEKRMSSVFNKQFLAMEGRLQEEYERKMAALAAECNLETREKMEAQHQR 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  455 EMMAMEEAEELLKRASERSAVECNSLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHRIFFTQIKSAILKG 534
Cdd:pfam12297  241 EMAEKEEAEELLKHADEQEALECSSLLDKLHKLEQEHLQRSLLLRQEEDFAKAQRQLAVFQRVELHKIFFTQLKEATRKG 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  535 ELKPEAAKTLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGY 614
Cdd:pfam12297  321 ELKPEAAKRLLQDYSKIQEQIEELMDFFQANQRYHLSERFAQREYLVQSLQSLETRVSGLLNTAATQLTSLIQKMERAGY 400
                          410       420
                   ....*....|....*....|....*..
gi 1622938759  615 LDEDQMEMLLERAQTEVFSIKQKLDND 641
Cdd:pfam12297  401 LDEEQMEMLLERAQKELLSVKQKLDND 427
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
493-1059 1.94e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.63  E-value: 1.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  493 RKSLALQQEEDFAKAhrQLAVFQRNELHRifftQIKSAILKGELKPEAAKTLLQNYSKIQENVEELmdffqASKRYHLSK 572
Cdd:COG1196    213 ERYRELKEELKELEA--ELLLLKLRELEA----ELEELEAELEELEAELEELEAELAELEAELEEL-----RLELEELEL 281
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  573 RFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLQQK 652
Cdd:COG1196    282 ELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA 361
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  653 LITKRRRELLQKHREQRREQLSISEAFQAVEDAGQYLRQRRSLMEEQGAALEELQERLDQAALDDLRALTLSLFEKATDE 732
Cdd:COG1196    362 EAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE 441
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  733 LRRLQNSAMTQELLKRSvpwLFLQQILEEHGKEMAVRAEQLEGEERDRDQEgvQSVRQRLKDDAPEAATEEQAELRRWEH 812
Cdd:COG1196    442 EALEEAAEEEAELEEEE---EALLELLAELLEEAALLEAALAELLEELAEA--AARLLLLLEAEADYEGFLEGVKAALLL 516
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  813 lvfmklcsSVFSLSEEELLRMRQEVHGCFAQMDRSLALpkIRARVLLQQFQTAWREAEFLKLDQALAAPEL------QQQ 886
Cdd:COG1196    517 --------AGLRGLAGAVAVLIGVEAAYEAALEAALAA--ALQNIVVEDDEVAAAAIEYLKAAKAGRATFLpldkirARA 586
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  887 SKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKV-------------RGELLRERVQRLEAQEGGFAQSLVALQ 953
Cdd:COG1196    587 ALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTlvaarleaalrraVTLAGRLREVTLEGEGGSAGGSLTGGS 666
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  954 FQKAARVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQALASWQQWV 1033
Cdd:COG1196    667 RRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEE 746
                          570       580
                   ....*....|....*....|....*.
gi 1622938759 1034 ADGPGILNEPGEVDSERQVSTVLQQA 1059
Cdd:COG1196    747 LLEEEALEELPEPPDLEELERELERL 772
 
Name Accession Description Interval E-value
EVC2_like pfam12297
Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. ...
237-641 0e+00

Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. Proteins in this family are typically between 571 and 1310 amino acids in length. There are two conserved sequence motifs: LPA and ELH. EVC2 is implicated in Ellis van Creveld chondrodysplastic dwarfism in humans. Mutations in this protein can give rise to this congenital condition. LIMBIN is a protein which shares around 80% sequence homology with EVC2 and it is implicated in a similar condition in bovine chondrodysplastic dwarfism.


Pssm-ID: 463525 [Multi-domain]  Cd Length: 428  Bit Score: 627.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  237 GDAFAVSYAATLQAGDLGNGESLKLPAQLTFQSSSQ----------------------VLPHHGLHAAGFFIAFLLSLVL 294
Cdd:pfam12297    1 GEEYAVSYTAELDAKERGKGESLTLPAQLTFQNSSQnnrtqlgpltanltltveektkVLPNHGLHAAGFFIGFLVSLVL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  295 TWAALFLMVHYQCLKGSMLTRHQVWQYDSKLEPLPFTSADGVNEDLSLNDQMIDILSSEDPGSMLQALEELEIATLNRAD 374
Cdd:pfam12297   81 TLLAFFLLGRTRCLQGSLLSRNRRLSQESKLEYSQFTSAEGVKEDLAFEDQMIDILTFEDPGSMLQALENLEIATLLRAD 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  375 ADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSDVFKKQFMLLENEIQEEYDRKMVALTAECDLETRKKMENQYQR 454
Cdd:pfam12297  161 ADLEACRTQISKDIIAILLKNLRSSGHLSPQAEKRMSSVFNKQFLAMEGRLQEEYERKMAALAAECNLETREKMEAQHQR 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  455 EMMAMEEAEELLKRASERSAVECNSLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHRIFFTQIKSAILKG 534
Cdd:pfam12297  241 EMAEKEEAEELLKHADEQEALECSSLLDKLHKLEQEHLQRSLLLRQEEDFAKAQRQLAVFQRVELHKIFFTQLKEATRKG 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  535 ELKPEAAKTLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGY 614
Cdd:pfam12297  321 ELKPEAAKRLLQDYSKIQEQIEELMDFFQANQRYHLSERFAQREYLVQSLQSLETRVSGLLNTAATQLTSLIQKMERAGY 400
                          410       420
                   ....*....|....*....|....*..
gi 1622938759  615 LDEDQMEMLLERAQTEVFSIKQKLDND 641
Cdd:pfam12297  401 LDEEQMEMLLERAQKELLSVKQKLDND 427
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
493-1059 1.94e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.63  E-value: 1.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  493 RKSLALQQEEDFAKAhrQLAVFQRNELHRifftQIKSAILKGELKPEAAKTLLQNYSKIQENVEELmdffqASKRYHLSK 572
Cdd:COG1196    213 ERYRELKEELKELEA--ELLLLKLRELEA----ELEELEAELEELEAELEELEAELAELEAELEEL-----RLELEELEL 281
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  573 RFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLQQK 652
Cdd:COG1196    282 ELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA 361
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  653 LITKRRRELLQKHREQRREQLSISEAFQAVEDAGQYLRQRRSLMEEQGAALEELQERLDQAALDDLRALTLSLFEKATDE 732
Cdd:COG1196    362 EAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE 441
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  733 LRRLQNSAMTQELLKRSvpwLFLQQILEEHGKEMAVRAEQLEGEERDRDQEgvQSVRQRLKDDAPEAATEEQAELRRWEH 812
Cdd:COG1196    442 EALEEAAEEEAELEEEE---EALLELLAELLEEAALLEAALAELLEELAEA--AARLLLLLEAEADYEGFLEGVKAALLL 516
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  813 lvfmklcsSVFSLSEEELLRMRQEVHGCFAQMDRSLALpkIRARVLLQQFQTAWREAEFLKLDQALAAPEL------QQQ 886
Cdd:COG1196    517 --------AGLRGLAGAVAVLIGVEAAYEAALEAALAA--ALQNIVVEDDEVAAAAIEYLKAAKAGRATFLpldkirARA 586
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  887 SKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKV-------------RGELLRERVQRLEAQEGGFAQSLVALQ 953
Cdd:COG1196    587 ALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTlvaarleaalrraVTLAGRLREVTLEGEGGSAGGSLTGGS 666
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  954 FQKAARVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQALASWQQWV 1033
Cdd:COG1196    667 RRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEE 746
                          570       580
                   ....*....|....*....|....*.
gi 1622938759 1034 ADGPGILNEPGEVDSERQVSTVLQQA 1059
Cdd:COG1196    747 LLEEEALEELPEPPDLEELERELERL 772
PTZ00121 PTZ00121
MAEBL; Provisional
656-949 7.92e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 7.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  656 KRRRELLQKHREQRREQlsiSEAFQAVEDAGQYLRQRRSLMEEQGAAlEELQERLDQAALDDLRALTLSlfeKATDELRR 735
Cdd:PTZ00121  1469 AKKADEAKKKAEEAKKA---DEAKKKAEEAKKKADEAKKAAEAKKKA-DEAKKAEEAKKADEAKKAEEA---KKADEAKK 1541
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  736 LQNSAMTQELLK----------RSVPwlflQQILEEHGKEMAVR-AEQLEGEERDRDQEGVQSVRQRLKDDAPEAATEEQ 804
Cdd:PTZ00121  1542 AEEKKKADELKKaeelkkaeekKKAE----EAKKAEEDKNMALRkAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEE 1617
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  805 A-----ELRRWEHlvfMKLCSSVFSLSEEELLRMRQEVHgcfaqmdRSLALPKIRARVLLQQFQTAWREAEFL------- 872
Cdd:PTZ00121  1618 AkikaeELKKAEE---EKKKVEQLKKKEAEEKKKAEELK-------KAEEENKIKAAEEAKKAEEDKKKAEEAkkaeede 1687
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  873 -KLDQALA--APELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLR------ERVQRLEAQEG 943
Cdd:PTZ00121  1688 kKAAEALKkeAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKkdeeekKKIAHLKKEEE 1767

                   ....*.
gi 1622938759  944 GFAQSL 949
Cdd:PTZ00121  1768 KKAEEI 1773
DUF4175 pfam13779
Domain of unknown function (DUF4175);
657-791 8.42e-03

Domain of unknown function (DUF4175);


Pssm-ID: 463981 [Multi-domain]  Cd Length: 833  Bit Score: 40.36  E-value: 8.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  657 RRRELLQkhREQRREQLSISEAFQA-----VEDAGQYLR----QRRSLMEEQGAALEELQERLDQAAL---DDLRALTLS 724
Cdd:pfam13779  412 RRRLALD--RENRPRVARALDALTLapeefGPDAGVYLGlrsaLARLELARSDEALDEVADLLWELALrieDGDLSDAER 489
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622938759  725 LFEKATDELRR-LQNSAMTQELLKRSVPwlfLQQILEEHGKEMAVRAEQLEGEERDRDQEGVQSVRQR 791
Cdd:pfam13779  490 RLRAAQERLSEaLERGASDEEIAKLMQE---LREALDDYMQALAEQAQQNPQDLQQPDDPNAQEMTQQ 554
 
Name Accession Description Interval E-value
EVC2_like pfam12297
Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. ...
237-641 0e+00

Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. Proteins in this family are typically between 571 and 1310 amino acids in length. There are two conserved sequence motifs: LPA and ELH. EVC2 is implicated in Ellis van Creveld chondrodysplastic dwarfism in humans. Mutations in this protein can give rise to this congenital condition. LIMBIN is a protein which shares around 80% sequence homology with EVC2 and it is implicated in a similar condition in bovine chondrodysplastic dwarfism.


Pssm-ID: 463525 [Multi-domain]  Cd Length: 428  Bit Score: 627.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  237 GDAFAVSYAATLQAGDLGNGESLKLPAQLTFQSSSQ----------------------VLPHHGLHAAGFFIAFLLSLVL 294
Cdd:pfam12297    1 GEEYAVSYTAELDAKERGKGESLTLPAQLTFQNSSQnnrtqlgpltanltltveektkVLPNHGLHAAGFFIGFLVSLVL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  295 TWAALFLMVHYQCLKGSMLTRHQVWQYDSKLEPLPFTSADGVNEDLSLNDQMIDILSSEDPGSMLQALEELEIATLNRAD 374
Cdd:pfam12297   81 TLLAFFLLGRTRCLQGSLLSRNRRLSQESKLEYSQFTSAEGVKEDLAFEDQMIDILTFEDPGSMLQALENLEIATLLRAD 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  375 ADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSDVFKKQFMLLENEIQEEYDRKMVALTAECDLETRKKMENQYQR 454
Cdd:pfam12297  161 ADLEACRTQISKDIIAILLKNLRSSGHLSPQAEKRMSSVFNKQFLAMEGRLQEEYERKMAALAAECNLETREKMEAQHQR 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  455 EMMAMEEAEELLKRASERSAVECNSLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHRIFFTQIKSAILKG 534
Cdd:pfam12297  241 EMAEKEEAEELLKHADEQEALECSSLLDKLHKLEQEHLQRSLLLRQEEDFAKAQRQLAVFQRVELHKIFFTQLKEATRKG 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  535 ELKPEAAKTLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGY 614
Cdd:pfam12297  321 ELKPEAAKRLLQDYSKIQEQIEELMDFFQANQRYHLSERFAQREYLVQSLQSLETRVSGLLNTAATQLTSLIQKMERAGY 400
                          410       420
                   ....*....|....*....|....*..
gi 1622938759  615 LDEDQMEMLLERAQTEVFSIKQKLDND 641
Cdd:pfam12297  401 LDEEQMEMLLERAQKELLSVKQKLDND 427
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
493-1059 1.94e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.63  E-value: 1.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  493 RKSLALQQEEDFAKAhrQLAVFQRNELHRifftQIKSAILKGELKPEAAKTLLQNYSKIQENVEELmdffqASKRYHLSK 572
Cdd:COG1196    213 ERYRELKEELKELEA--ELLLLKLRELEA----ELEELEAELEELEAELEELEAELAELEAELEEL-----RLELEELEL 281
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  573 RFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLQQK 652
Cdd:COG1196    282 ELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA 361
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  653 LITKRRRELLQKHREQRREQLSISEAFQAVEDAGQYLRQRRSLMEEQGAALEELQERLDQAALDDLRALTLSLFEKATDE 732
Cdd:COG1196    362 EAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE 441
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  733 LRRLQNSAMTQELLKRSvpwLFLQQILEEHGKEMAVRAEQLEGEERDRDQEgvQSVRQRLKDDAPEAATEEQAELRRWEH 812
Cdd:COG1196    442 EALEEAAEEEAELEEEE---EALLELLAELLEEAALLEAALAELLEELAEA--AARLLLLLEAEADYEGFLEGVKAALLL 516
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  813 lvfmklcsSVFSLSEEELLRMRQEVHGCFAQMDRSLALpkIRARVLLQQFQTAWREAEFLKLDQALAAPEL------QQQ 886
Cdd:COG1196    517 --------AGLRGLAGAVAVLIGVEAAYEAALEAALAA--ALQNIVVEDDEVAAAAIEYLKAAKAGRATFLpldkirARA 586
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  887 SKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKV-------------RGELLRERVQRLEAQEGGFAQSLVALQ 953
Cdd:COG1196    587 ALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTlvaarleaalrraVTLAGRLREVTLEGEGGSAGGSLTGGS 666
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  954 FQKAARVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQALASWQQWV 1033
Cdd:COG1196    667 RRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEE 746
                          570       580
                   ....*....|....*....|....*.
gi 1622938759 1034 ADGPGILNEPGEVDSERQVSTVLQQA 1059
Cdd:COG1196    747 LLEEEALEELPEPPDLEELERELERL 772
PTZ00121 PTZ00121
MAEBL; Provisional
656-949 7.92e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 7.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  656 KRRRELLQKHREQRREQlsiSEAFQAVEDAGQYLRQRRSLMEEQGAAlEELQERLDQAALDDLRALTLSlfeKATDELRR 735
Cdd:PTZ00121  1469 AKKADEAKKKAEEAKKA---DEAKKKAEEAKKKADEAKKAAEAKKKA-DEAKKAEEAKKADEAKKAEEA---KKADEAKK 1541
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  736 LQNSAMTQELLK----------RSVPwlflQQILEEHGKEMAVR-AEQLEGEERDRDQEGVQSVRQRLKDDAPEAATEEQ 804
Cdd:PTZ00121  1542 AEEKKKADELKKaeelkkaeekKKAE----EAKKAEEDKNMALRkAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEE 1617
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  805 A-----ELRRWEHlvfMKLCSSVFSLSEEELLRMRQEVHgcfaqmdRSLALPKIRARVLLQQFQTAWREAEFL------- 872
Cdd:PTZ00121  1618 AkikaeELKKAEE---EKKKVEQLKKKEAEEKKKAEELK-------KAEEENKIKAAEEAKKAEEDKKKAEEAkkaeede 1687
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  873 -KLDQALA--APELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLR------ERVQRLEAQEG 943
Cdd:PTZ00121  1688 kKAAEALKkeAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKkdeeekKKIAHLKKEEE 1767

                   ....*.
gi 1622938759  944 GFAQSL 949
Cdd:PTZ00121  1768 KKAEEI 1773
PLN03094 PLN03094
Substrate binding subunit of ER-derived-lipid transporter; Provisional
671-750 1.98e-03

Substrate binding subunit of ER-derived-lipid transporter; Provisional


Pssm-ID: 178642 [Multi-domain]  Cd Length: 370  Bit Score: 42.07  E-value: 1.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  671 EQLSISEAFQAVEDAGQYLRQRRSLMEEQGAALEELQERL----DQAALDDLRALTLSLFEKATDeLRRLQNSAMT---Q 743
Cdd:PLN03094   244 EAIGVAKMYALAERAADLMEEARPLLLKIQAMAEDLQPLLsevrDSGLLKEVEKLTRVAAEASED-LRRLNSSILTpenT 322

                   ....*..
gi 1622938759  744 ELLKRSV 750
Cdd:PLN03094   323 ELLRQSI 329
DUF4175 pfam13779
Domain of unknown function (DUF4175);
657-791 8.42e-03

Domain of unknown function (DUF4175);


Pssm-ID: 463981 [Multi-domain]  Cd Length: 833  Bit Score: 40.36  E-value: 8.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622938759  657 RRRELLQkhREQRREQLSISEAFQA-----VEDAGQYLR----QRRSLMEEQGAALEELQERLDQAAL---DDLRALTLS 724
Cdd:pfam13779  412 RRRLALD--RENRPRVARALDALTLapeefGPDAGVYLGlrsaLARLELARSDEALDEVADLLWELALrieDGDLSDAER 489
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622938759  725 LFEKATDELRR-LQNSAMTQELLKRSVPwlfLQQILEEHGKEMAVRAEQLEGEERDRDQEGVQSVRQR 791
Cdd:pfam13779  490 RLRAAQERLSEaLERGASDEEIAKLMQE---LREALDDYMQALAEQAQQNPQDLQQPDDPNAQEMTQQ 554
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure