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Conserved domains on  [gi|1622934690|ref|XP_028703535|]
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tenascin-X isoform X8 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
3845-4054 4.33e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


:

Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 370.31  E-value: 4.33e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3845 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNIS-GEFWLGN 3923
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3924 EALHSLTQAGDYSMRVDLRAG-DEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 3995
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934690 3996 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYYWKGFEFSVPFTEMKLRPR 4054
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
fn3 pfam00041
Fibronectin type III domain;
3577-3655 1.22e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 66.28  E-value: 1.22e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3577 SPRDLQFSEIRETSAKVNWMPPPSRA---DSFKVSYQLADGGEP-QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3652
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934690 3653 SEP 3655
Cdd:pfam00041   82 GPP 84
fn3 pfam00041
Fibronectin type III domain;
2878-2951 4.37e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 4.37e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690 2878 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2951
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2551-2624 5.57e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.57e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690 2551 PRLGELTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGG 2624
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2238-2308 5.79e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.79e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 2238 GELTVTDATPDSLSLSWTVPE---GQFDHFLVQYR--NGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2308
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
3125-3489 8.28e-12

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.57  E-value: 8.28e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3125 VPVSGDLRAVTVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAPDTKLSPRLGeLTVTDATPDSVGLSWT-VPEGEFDS 3203
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG-LTATADTPGSVTLSWDpVTESDATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3204 FVVQYK-DKDGRLQVVpVAADQREVTVPGLEPSRKYKFLLYGLAGRKRMGPISaDGTTASLEKEPPPRLGELTVTEETSS 3282
Cdd:COG3401    264 YRVYRSnSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPS-NVVSVTTDLTPPAAPSGLTATAVGSS 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3283 SLHLSWT-VAQGPFESFVVqYRDT--DGQPRAVPVAADQHTVTIEDLEPGKKYKFLlyglvggkrlgpVSALGmTAPEED 3359
Cdd:COG3401    342 SITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTYYYK------------VTAVD-AAGNES 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3360 TPAPELASEAPEPPEEPRLGVLAVTDTAPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPY 3439
Cdd:COG3401    408 APSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTA 487

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3440 RFLLYGLHEGKRLGPLSAEGTTGPAPAGQTSGEPGPRLSQLSVTDVTTSS 3489
Cdd:COG3401    488 NLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVT 537
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
1663-1942 1.51e-11

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.42  E-value: 1.51e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1663 VRVGGEESEVTVGGLEPGHKYKMHLYGLHEGQRVGPVSAVGVTAPQqeeTPPAtkPPleprlGELTVTDVTPNSVGLSWT 1742
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPT---TPPS--AP-----TGLTATADTPGSVTLSWD 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1743 -VPEGQFDSFMVqYKDKDGQPQAVPVAADQQ-EVTIYNLEPERKYkmnMYglhdgqRVgplSVV----IMTAPLPPAPAT 1816
Cdd:COG3401    255 pVTESDATGYRV-YRSNSGDGPFTKVATVTTtSYTDTGLTNGTTY---YY------RV---TAVdaagNESAPSNVVSVT 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1817 EASEPPLEPRlgELTVTDVTPDSVGLSWT-VPEGEFDSFVVQYKDR-DGQPQVVPVAADQREVTIPGLEPSRKYKFLLFG 1894
Cdd:COG3401    322 TDLTPPAAPS--GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622934690 1895 IQDGKRRSPVSVEA---KTAARGDASPGAPPRLGELWVTDPTPDSLHLSWT 1942
Cdd:COG3401    400 VDAAGNESAPSEEVsatTASAASGESLTASVDAVPLTDVAGATAAASAASN 450
fn3 pfam00041
Fibronectin type III domain;
1308-1388 2.14e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.14e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1308 GPPRlgELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQ--PQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVG 1382
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 1622934690 1383 KKRHGP 1388
Cdd:pfam00041   79 GGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
2442-2515 3.70e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 3.70e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690 2442 PRLGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2515
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1512-1589 4.72e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 4.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1512 GELTVTGVTPDSLRLSWT---VAQGPFDSFMVQYKDAQGQ--PQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGrQRVG 1586
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG-GGEG 82


                   ...
gi 1622934690 1587 PES 1589
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
750-831 5.73e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 5.73e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGaSPPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGT 826
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 1622934690  827 SWGPP 831
Cdd:pfam00041   80 GEGPP 84
fn3 pfam00041
Fibronectin type III domain;
843-919 1.07e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.51  E-value: 1.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  843 PQDLRVVAVTPTTLELGWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPPEADGTLLTDLMPGVEYVVTVTAERGRAVS 917
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 1622934690  918 YP 919
Cdd:pfam00041   83 PP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1406-1485 2.02e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 2.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1406 PPRLGNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDGRP--QVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1480
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NG 79


                   ....*
gi 1622934690 1481 KRYGP 1485
Cdd:cd00063     80 GGESP 84
fn3 pfam00041
Fibronectin type III domain;
3475-3557 7.54e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 7.54e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3475 PRLSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFgvpSPSTLEPHPRpllqrELMVPGTRHSAVLRDLRPGTLYSLT 3551
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEY---RPKNSGEPWN-----EITVPGTTTSVTLTGLKPGTEYEVR 72


                   ....*.
gi 1622934690 3552 LYGLRG 3557
Cdd:pfam00041   73 VQAVNG 78
fn3 pfam00041
Fibronectin type III domain;
2776-2843 1.34e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.34e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690 2776 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2843
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2992-3059 1.41e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.41e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690 2992 TVAGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDGQ--PQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3059
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1623-1693 1.76e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 1.76e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 1623 GELTVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEG 1693
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2662-2732 6.39e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 6.39e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 2662 GELTVTGSSPDSLSLSWTIP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEG 2732
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2349-2416 8.40e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 8.40e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690 2349 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEG 2416
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3085-3147 9.63e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 9.63e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934690 3085 GELTVAAVTSDSVGLSWT---VAQGPFDSFLVQYR--DTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3147
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
1919-1986 4.29e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 4.29e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934690 1919 GAPPRLGelwVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQV---VPVEGHERSVTIAPLDAGRKYRF 1986
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEV 71
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
3633-3823 9.02e-08

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.48  E-value: 9.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3633 GLIPGARYEVTVVSVRGFEESEPLTGFL----TTVPDGPTQLRALNLTEGFAVLHWKPPQNP-VDTYDVQVTAPGAPPLQ 3707
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3708 AEAPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPAS--ITFTTGLE---APRDLEAKEVTPRTALLTWTE-PQVRPTG 3781
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTppaAPSGLTATAVGSSSITLSWTAsSDADVTG 357

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622934690 3782 YLLSFDT-PGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQAM 3823
Cdd:COG3401    358 YNVYRSTsGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV 400
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2020-2109 2.03e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 2.03e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2020 PPKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQP--QVVPVEGSLREVSVPGLDPAHRYKLLLYGL 2094
Cdd:cd00063      1 PSPPT---NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*
gi 1622934690 2095 HSGKRVGPISAVVIT 2109
Cdd:cd00063     78 NGGGESPPSESVTVT 92
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 559-586 6.69e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 48.06  E-value: 6.69e-07
                           10        20
                   ....*....|....*....|....*...
gi 1622934690  559 CPGGCRGRGQCIDGRCVCEDGYSGEDCS 586
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 249-275 1.10e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 47.68  E-value: 1.10e-06
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  249 CPRGCSQRGRCEDGRCVCDPGYTGEDC 275
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 311-337 1.10e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 47.68  E-value: 1.10e-06
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  311 CPRGCSQRGRCEDGRCVCDPGYTGEDC 337
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 373-399 1.29e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 47.29  E-value: 1.29e-06
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  373 CPRDCRGRGRCEDGECICDTGYSGDDC 399
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
PTZ00214 super family cl31756
high cysteine membrane protein Group 4; Provisional
 254-669 1.60e-06

high cysteine membrane protein Group 4; Provisional


The actual alignment was detected with superfamily member PTZ00214:

Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 54.54  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  254 SQRGRCEDGRCVCDPGYTGedcGMRSCPRGCSQRGRCENGRCvcNPGYTGEDCgvRSCPRGCSQrgrceDGRCVCDPGYT 333
Cdd:PTZ00214   341 SKNDDNNGDGYLCGDATNG---GVSGCATCGYNSGAVTCTRC--SAGYLGVDG--KSCSESCSG-----DTRGVCTKVAE 408

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  334 GEDCGTRSCRwdcgeggrcvdgrCVCWPGYTGEDCSTRTCPRDCrgrGRCEDGE---C-ICDTGYSGDDCGVRSCPGDCN 409
Cdd:PTZ00214   409 GSESTEVSCR-------------CVCKPTFYNSSGTCTPCTDSC---AVCKDGTptgCqQCSPGKILEFSIVSSESADCV 472

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  410 QRGRCEDGRCVCwpGYTgLDcGSRACPRDCRGRGRCENGVCVCNagySGEDCGVRSCPG----DCRGRGRCESGRCVCWP 485
Cdd:PTZ00214   473 DQCSVGSECAEC--GIT-ID-GSRYCTRCKDASTYPFNGVCIPN---TQRDAYCTSTANgactTCSGAAFLMNGGCYTTE 545

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  486 GYTGRDCGTRACPGDC----RGRGRCVDGRCV-CNP---GFTGEDCGS-RRCPGDC-------RGHGSCED-GVCVcDAG 548
Cdd:PTZ00214   546 HYPGSTICDKQSNGKCtttkKGYGISPDGKLLeCDPtclACTAPGPGRcTRCPSDKllkrasgAATGSCVDpGACV-DGY 624

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  549 YSGEDCSTRSCPGGCRGRG------QCIDGRCVCEDGYSgedcsvrrCPNDCSQHGVCQD---GVCICW------EAYVG 613
Cdd:PTZ00214   625 YADGDACLPCATPGCKTCGhasfctECAGELFVSLDGQS--------CLEECTGDKVVGEvsgGVRRCWcergflPALDR 696

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690  614 EDCSIRT-CPSNCHGRGRCEE-GRCL-CDPGYTGPTCATRMCPADCRGRGRCVQGVCMC 669
Cdd:PTZ00214   697 SGCVLPTeCPPDMPSCAACDEsGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755
fn3 pfam00041
Fibronectin type III domain;
2132-2202 6.06e-05

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 6.06e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 2132 GELTVEEATPHTLHLSWM---VTEGEFDSFEI--QHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLYGFHDG 2202
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVeyRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1083-1161 9.50e-05

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 9.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1083 APRHPKPEVLGSSAdgaLLVS---LDGLRGQFERVVLRWRPQPpAEGPGGELTVPGTTRTVSLPDLRPGTTYHVEVHGVR 1159
Cdd:pfam00041    2 APSNLTVTDVTSTS---LTVSwtpPPDGNGPITGYEVEYRPKN-SGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ..
gi 1622934690 1160 AG 1161
Cdd:pfam00041   78 GG 79
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 221-244 3.66e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.66e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934690  221 DCQGRGRCVQ--GVCVCRAGFSGPDC 244
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 719-745 5.86e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 39.97  E-value: 5.86e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  719 CPGDCRGRGECHDGSCICKDGYAGEDC 745
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 190-213 7.72e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.25  E-value: 7.72e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934690  190 DCNDQGRCVR--GRCVCFPGYTGPSC 213
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
3845-4054 4.33e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 370.31  E-value: 4.33e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3845 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNIS-GEFWLGN 3923
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3924 EALHSLTQAGDYSMRVDLRAG-DEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 3995
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934690 3996 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYYWKGFEFSVPFTEMKLRPR 4054
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 3845-4054 2.16e-112

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 356.59  E-value: 2.16e-112
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  3845 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNE 3924
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  3925 ALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-SMSYHSGSVFSARDRDPNNLLISCA 4002
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEdWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1622934690  4003 VSYRGAWWYRNCHYANLNGLYGS-TVDHQGVSWYYWKGFEFSVPFTEMKLRPR 4054
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYPnNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 3844-4054 2.85e-110

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 350.77  E-value: 2.85e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3844 PFPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGN 3923
Cdd:cd00087      1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3924 EALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNNLLISCA 4002
Cdd:cd00087     80 EKIHLLTSQGPYELRIDLEdWEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 4003 VSYRGAWWYRNCHYANLNGLYGSTVDHQ----GVSWYYWKGFEFSVPFTEMKLRPR 4054
Cdd:cd00087    160 ESYSGGWWYNSCHASNLNGRYYSGGHRNeydnGINWATWKGSTYSLKFTEMKIRPK 215
fn3 pfam00041
Fibronectin type III domain;
3577-3655 1.22e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 66.28  E-value: 1.22e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3577 SPRDLQFSEIRETSAKVNWMPPPSRA---DSFKVSYQLADGGEP-QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3652
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934690 3653 SEP 3655
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3578-3657 4.01e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 4.01e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3578 PRDLQFSEIRETSAKVNWMPPP---SRADSFKVSYQLADGGEPQSVQVDGRARTQ-KLQGLIPGARYEVTVVSVRGFEES 3653
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGES 83


                   ....
gi 1622934690 3654 EPLT 3657
Cdd:cd00063     84 PPSE 87
fn3 pfam00041
Fibronectin type III domain;
2878-2951 4.37e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 4.37e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690 2878 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2951
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2551-2624 5.57e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.57e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690 2551 PRLGELTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGG 2624
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2238-2308 5.79e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.79e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 2238 GELTVTDATPDSLSLSWTVPE---GQFDHFLVQYR--NGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2308
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3125-3489 8.28e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.57  E-value: 8.28e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3125 VPVSGDLRAVTVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAPDTKLSPRLGeLTVTDATPDSVGLSWT-VPEGEFDS 3203
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG-LTATADTPGSVTLSWDpVTESDATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3204 FVVQYK-DKDGRLQVVpVAADQREVTVPGLEPSRKYKFLLYGLAGRKRMGPISaDGTTASLEKEPPPRLGELTVTEETSS 3282
Cdd:COG3401    264 YRVYRSnSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPS-NVVSVTTDLTPPAAPSGLTATAVGSS 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3283 SLHLSWT-VAQGPFESFVVqYRDT--DGQPRAVPVAADQHTVTIEDLEPGKKYKFLlyglvggkrlgpVSALGmTAPEED 3359
Cdd:COG3401    342 SITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTYYYK------------VTAVD-AAGNES 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3360 TPAPELASEAPEPPEEPRLGVLAVTDTAPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPY 3439
Cdd:COG3401    408 APSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTA 487

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3440 RFLLYGLHEGKRLGPLSAEGTTGPAPAGQTSGEPGPRLSQLSVTDVTTSS 3489
Cdd:COG3401    488 NLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVT 537
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1663-1942 1.51e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.42  E-value: 1.51e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1663 VRVGGEESEVTVGGLEPGHKYKMHLYGLHEGQRVGPVSAVGVTAPQqeeTPPAtkPPleprlGELTVTDVTPNSVGLSWT 1742
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPT---TPPS--AP-----TGLTATADTPGSVTLSWD 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1743 -VPEGQFDSFMVqYKDKDGQPQAVPVAADQQ-EVTIYNLEPERKYkmnMYglhdgqRVgplSVV----IMTAPLPPAPAT 1816
Cdd:COG3401    255 pVTESDATGYRV-YRSNSGDGPFTKVATVTTtSYTDTGLTNGTTY---YY------RV---TAVdaagNESAPSNVVSVT 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1817 EASEPPLEPRlgELTVTDVTPDSVGLSWT-VPEGEFDSFVVQYKDR-DGQPQVVPVAADQREVTIPGLEPSRKYKFLLFG 1894
Cdd:COG3401    322 TDLTPPAAPS--GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622934690 1895 IQDGKRRSPVSVEA---KTAARGDASPGAPPRLGELWVTDPTPDSLHLSWT 1942
Cdd:COG3401    400 VDAAGNESAPSEEVsatTASAASGESLTASVDAVPLTDVAGATAAASAASN 450
fn3 pfam00041
Fibronectin type III domain;
3267-3334 2.00e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 2.00e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690 3267 PPPRlgELTVTEETSSSLHLSWT---VAQGPFESFVVQYRDTDGQ--PRAVPVAADQHTVTIEDLEPGKKYKF 3334
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
1308-1388 2.14e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.14e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1308 GPPRlgELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQ--PQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVG 1382
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 1622934690 1383 KKRHGP 1388
Cdd:pfam00041   79 GGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
2442-2515 3.70e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 3.70e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690 2442 PRLGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2515
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1512-1589 4.72e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 4.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1512 GELTVTGVTPDSLRLSWT---VAQGPFDSFMVQYKDAQGQ--PQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGrQRVG 1586
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG-GGEG 82


                   ...
gi 1622934690 1587 PES 1589
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
750-831 5.73e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 5.73e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGaSPPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGT 826
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 1622934690  827 SWGPP 831
Cdd:pfam00041   80 GEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1825-1890 8.39e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 8.39e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622934690 1825 PRLGELTVTDVTPDSVGLSWTVPE---GEFDSFVVQYKDRDGQ--PQVVPVAADQREVTIPGLEPSRKYKF 1890
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
843-919 1.07e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.51  E-value: 1.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  843 PQDLRVVAVTPTTLELGWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPPEADGTLLTDLMPGVEYVVTVTAERGRAVS 917
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 1622934690  918 YP 919
Cdd:pfam00041   83 PP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1406-1485 2.02e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 2.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1406 PPRLGNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDGRP--QVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1480
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NG 79


                   ....*
gi 1622934690 1481 KRYGP 1485
Cdd:cd00063     80 GGESP 84
fn3 pfam00041
Fibronectin type III domain;
3475-3557 7.54e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 7.54e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3475 PRLSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFgvpSPSTLEPHPRpllqrELMVPGTRHSAVLRDLRPGTLYSLT 3551
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEY---RPKNSGEPWN-----EITVPGTTTSVTLTGLKPGTEYEVR 72


                   ....*.
gi 1622934690 3552 LYGLRG 3557
Cdd:pfam00041   73 VQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1822-1910 1.19e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.89  E-value: 1.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1822 PLEPRlgELTVTDVTPDSVGLSWTVPE---GEFDSFVVQYKDRDGQP--QVVPVAADQREVTIPGLEPSRKYKFLLFGIq 1896
Cdd:cd00063      1 PSPPT--NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV- 77

                           90
                   ....*....|....*.
gi 1622934690 1897 DGKRRSPVS--VEAKT 1910
Cdd:cd00063     78 NGGGESPPSesVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
2776-2843 1.34e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.34e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690 2776 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2843
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2992-3059 1.41e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.41e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690 2992 TVAGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDGQ--PQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3059
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1403-1474 1.66e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 1.66e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934690  1403 PGTPPrlgNLWVTDPTPDSLHLSWTVPE-----GQFDTFMVQYRDKDGRPQVVPVEGPERSFVVSSLDPDHKYRFTL 1474
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
fn3 pfam00041
Fibronectin type III domain;
1623-1693 1.76e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 1.76e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 1623 GELTVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEG 1693
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1309-1378 1.90e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.90e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934690 1309 PPRLGELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQP--QVVPVEGPQRSAVITSLDPGRKYKFVLY 1378
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
1406-1487 2.76e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.65  E-value: 2.76e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1406 PPRlgNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDG--RPQVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1480
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV-NG 78


                   ....*..
gi 1622934690 1481 KRYGPLT 1487
Cdd:pfam00041   79 GGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1470-1743 4.30e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 62.71  E-value: 4.30e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1470 YRFTLFGIANKKRYGP--LTADGTTAPErkeePPrpesleqpllGELTVTGVTPDSLRLSWT-VAQGPFDSFMVQYKDAQ 1546
Cdd:COG3401    207 YRVAATDTGGESAPSNevSVTTPTTPPS----AP----------TGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSG 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1547 GQPQAVPVAGDENEVTVPGLDPDRKYKmnlYGLRGRQRVGPESvvaktapqedvdeTPSPTELGTEAPEPSEEPLlgELT 1626
Cdd:COG3401    273 DGPFTKVATVTTTSYTDTGLTNGTTYY---YRVTAVDAAGNES-------------APSNVVSVTTDLTPPAAPS--GLT 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1627 VTGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGRPQAVRVGGEESEVTVGGLEPGHKYK-----MHLYGLhEGQRVGPV 1699
Cdd:COG3401    335 ATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYykvtaVDAAGN-ESAPSEEV 413

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1622934690 1700 SAVGVTAPQQEETPPATKPPLEPRLGELTVTDVTPNSVGLSWTV 1743
Cdd:COG3401    414 SATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAV 457
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1308-1375 5.37e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 5.37e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690  1308 GPPRlgELTVTDRTSDSLLLRWTVPE-----GEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKF 1375
Cdd:smart00060    2 SPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3180-3240 5.89e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 5.89e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 3180 LTVTDATPDSVGLSWTVPE---GEFDSFVVQYKDKDGR--LQVVPVAADQREVTVPGLEPSRKYKF 3240
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
2662-2732 6.39e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 6.39e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 2662 GELTVTGSSPDSLSLSWTIP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEG 2732
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 841-921 7.30e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 7.30e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  841 DGPQDLRVVAVTPTTLELGWLRPQ---AEVDRFVVSYVSAGNQRVRLEVPPEADGT--LLTDLMPGVEYVVTVTAERGRA 915
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*.
gi 1622934690  916 VSYPAS 921
Cdd:cd00063     82 ESPPSE 87
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1822-1890 7.71e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 7.71e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934690  1822 PLEPRlgELTVTDVTPDSVGLSWTVPE-----GEFDSFVVQYKDRDGQPQVVPVAADQREVTIPGLEPSRKYKF 1890
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
2349-2416 8.40e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 8.40e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690 2349 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEG 2416
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3085-3147 9.63e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 9.63e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934690 3085 GELTVAAVTSDSVGLSWT---VAQGPFDSFLVQYR--DTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3147
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3267-3334 1.15e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 1.15e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690  3267 PPPRlgELTVTEETSSSLHLSWT-----VAQGPFESFVVQYRDTDGQPRAVPVAADQHTVTIEDLEPGKKYKF 3334
Cdd:smart00060    2 SPPS--NLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3577-3653 2.30e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 2.30e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  3577 SPRDLQFSEIRETSAKVNWMPPPS-RADSFKVSYQLADGGEP---QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3652
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 1622934690  3653 S 3653
Cdd:smart00060   83 G 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 841-914 3.65e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.39  E-value: 3.65e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690   841 DGPQDLRVVAVTPTTLELGWLRPQAE-----VDRFVVSYVSAGNQRVRLEVPPEADGTLLTDLMPGVEYVVTVTAERGR 914
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2872-2953 4.02e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.65  E-value: 4.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2872 PEPPikprlGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLY 2946
Cdd:cd00063      1 PSPP-----TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75


                   ....*..
gi 1622934690 2947 GFHGGQR 2953
Cdd:cd00063     76 AVNGGGE 82
fn3 pfam00041
Fibronectin type III domain;
1919-1986 4.29e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 4.29e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934690 1919 GAPPRLGelwVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQV---VPVEGHERSVTIAPLDAGRKYRF 1986
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEV 71
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3633-3823 9.02e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.48  E-value: 9.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3633 GLIPGARYEVTVVSVRGFEESEPLTGFL----TTVPDGPTQLRALNLTEGFAVLHWKPPQNP-VDTYDVQVTAPGAPPLQ 3707
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3708 AEAPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPAS--ITFTTGLE---APRDLEAKEVTPRTALLTWTE-PQVRPTG 3781
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTppaAPSGLTATAVGSSSITLSWTAsSDADVTG 357

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622934690 3782 YLLSFDT-PGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQAM 3823
Cdd:COG3401    358 YNVYRSTsGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV 400
fn3 pfam00041
Fibronectin type III domain;
3754-3831 9.85e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 9.85e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3754 APRDLEAKEVTPRTALLTWTEPQVRP---TGYLLSFDTPGG--RTQEILLPGGVTSHQLLGLFPSTLYNARLQAMWGESL 3828
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934690 3829 LPP 3831
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2240-2320 1.02e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 1.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2240 LTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGRP--KAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPV 2314
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934690 2315 SAIGVT 2320
Cdd:cd00063     87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1514-1594 1.46e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1514 LTVTGVTPDSLRLSWTVAQ---GPFDSFMVQYKDAQGQP--QAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGRQRVGP- 1587
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPs 86


                   ....*..
gi 1622934690 1588 ESVVAKT 1594
Cdd:cd00063     87 ESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2020-2109 2.03e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 2.03e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2020 PPKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQP--QVVPVEGSLREVSVPGLDPAHRYKLLLYGL 2094
Cdd:cd00063      1 PSPPT---NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*
gi 1622934690 2095 HSGKRVGPISAVVIT 2109
Cdd:cd00063     78 NGGGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3753-3838 2.13e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3753 EAPRDLEAKEVTPRTALLTWTEPQ---VRPTGYLLSF-DTPGGRTQEI-LLPGGVTSHQLLGLFPSTLYNARLQA--MWG 3825
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYrEKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAvnGGG 81

                           90
                   ....*....|...
gi 1622934690 3826 ESlLPPVSTSFTT 3838
Cdd:cd00063     82 ES-PPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 750-838 2.20e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGASPPFTARVPSSASaYDQRGLAPGQEYQVTVRALRGT 826
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1622934690  827 SWGPPA-SKTITT 838
Cdd:cd00063     81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2872-2946 2.33e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 2.33e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  2872 PEPPikprlGELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2946
Cdd:smart00060    1 PSPP-----SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2349-2428 2.75e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2349 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEGRRVGPVS 2423
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ....*
gi 1622934690 2424 AVGVT 2428
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2556-2636 3.06e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2556 LTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQP--KTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGGQRVGPV 2630
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934690 2631 SAIGVT 2636
Cdd:cd00063     87 ESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
2021-2104 3.87e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.49  E-value: 3.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2021 PKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQ--PQVVPVEGSLREVSVPGLDPAHRYKLLLYGlH 2095
Cdd:pfam00041    1 SAPS---NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQA-V 76


                   ....*....
gi 1622934690 2096 SGKRVGPIS 2104
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1918-1986 4.61e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 4.61e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934690 1918 PGAPprlGELWVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQVVPVE---GHERSVTIAPLDAGRKYRF 1986
Cdd:cd00063      1 PSPP---TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3754-3822 4.63e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 4.63e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934690  3754 APRDLEAKEVTPRTALLTWTEPQVRP-----TGYLLSFDTPGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQA 3822
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitgyiVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2435-2524 5.66e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 5.66e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2435 PDAPlvkprlGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNL 2509
Cdd:cd00063      1 PSPP------TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRV 74

                           90
                   ....*....|....*
gi 1622934690 2510 YGFHGGQRMGPVSAV 2524
Cdd:cd00063     75 RAVNGGGESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2776-2838 6.12e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 6.12e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934690 2776 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLY 2838
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 559-586 6.69e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 48.06  E-value: 6.69e-07
                           10        20
                   ....*....|....*....|....*...
gi 1622934690  559 CPGGCRGRGQCIDGRCVCEDGYSGEDCS 586
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1625-1688 8.08e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 8.08e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690  1625 LTVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQAVRVGGEESEVTVGGLEPGHKYKMHLY 1688
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2240-2303 8.40e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 8.40e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690  2240 LTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2303
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2664-2744 9.87e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 9.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2664 LTVTGSSPDSLSLSWTIPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEGRRVGPV 2738
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934690 2739 SAVGVT 2744
Cdd:cd00063     87 ESVTVT 92
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 249-275 1.10e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 1.10e-06
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  249 CPRGCSQRGRCEDGRCVCDPGYTGEDC 275
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 311-337 1.10e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 1.10e-06
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  311 CPRGCSQRGRCEDGRCVCDPGYTGEDC 337
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2992-3068 1.26e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 1.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2992 TVAGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGQP--QAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEGRRVGPVS 3066
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ..
gi 1622934690 3067 AV 3068
Cdd:cd00063     88 SV 89
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 373-399 1.29e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.29  E-value: 1.29e-06
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  373 CPRDCRGRGRCEDGECICDTGYSGDDC 399
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1514-1577 1.41e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 1.41e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690  1514 LTVTGVTPDSLRLSWT-----VAQGPFDSFMVQYKDAQGQPQAVPVAGDENEVTVPGLDPDRKYKMNLY 1577
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
PTZ00214 PTZ00214
high cysteine membrane protein Group 4; Provisional
 254-669 1.60e-06

high cysteine membrane protein Group 4; Provisional


Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 54.54  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  254 SQRGRCEDGRCVCDPGYTGedcGMRSCPRGCSQRGRCENGRCvcNPGYTGEDCgvRSCPRGCSQrgrceDGRCVCDPGYT 333
Cdd:PTZ00214   341 SKNDDNNGDGYLCGDATNG---GVSGCATCGYNSGAVTCTRC--SAGYLGVDG--KSCSESCSG-----DTRGVCTKVAE 408

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  334 GEDCGTRSCRwdcgeggrcvdgrCVCWPGYTGEDCSTRTCPRDCrgrGRCEDGE---C-ICDTGYSGDDCGVRSCPGDCN 409
Cdd:PTZ00214   409 GSESTEVSCR-------------CVCKPTFYNSSGTCTPCTDSC---AVCKDGTptgCqQCSPGKILEFSIVSSESADCV 472

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  410 QRGRCEDGRCVCwpGYTgLDcGSRACPRDCRGRGRCENGVCVCNagySGEDCGVRSCPG----DCRGRGRCESGRCVCWP 485
Cdd:PTZ00214   473 DQCSVGSECAEC--GIT-ID-GSRYCTRCKDASTYPFNGVCIPN---TQRDAYCTSTANgactTCSGAAFLMNGGCYTTE 545

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  486 GYTGRDCGTRACPGDC----RGRGRCVDGRCV-CNP---GFTGEDCGS-RRCPGDC-------RGHGSCED-GVCVcDAG 548
Cdd:PTZ00214   546 HYPGSTICDKQSNGKCtttkKGYGISPDGKLLeCDPtclACTAPGPGRcTRCPSDKllkrasgAATGSCVDpGACV-DGY 624

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  549 YSGEDCSTRSCPGGCRGRG------QCIDGRCVCEDGYSgedcsvrrCPNDCSQHGVCQD---GVCICW------EAYVG 613
Cdd:PTZ00214   625 YADGDACLPCATPGCKTCGhasfctECAGELFVSLDGQS--------CLEECTGDKVVGEvsgGVRRCWcergflPALDR 696

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690  614 EDCSIRT-CPSNCHGRGRCEE-GRCL-CDPGYTGPTCATRMCPADCRGRGRCVQGVCMC 669
Cdd:PTZ00214   697 SGCVLPTeCPPDMPSCAACDEsGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2776-2838 1.99e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 1.99e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934690  2776 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 2838
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2556-2619 2.77e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 2.77e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690  2556 LTMTDATPDSLSLSWTVPE-----GQFDHFLVQYKNGDGQPKTTRVPGHEDRVTISGLEPDHKYKMNLY 2619
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3478-3553 2.88e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 2.88e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934690  3478 SQLSVTDVTTSSLRLNWEAPPGA-FDSFLLRFgvpspsTLEPHPRPLLQRELMVPGTRHSAVLRDLRPGTLYSLTLY 3553
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDgITGYIVGY------RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2349-2411 2.91e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 2.91e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934690  2349 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGNKYKMHLY 2411
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2435-2510 3.50e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 3.50e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  2435 PDAPlvkprlGEMTVRDATPDSLSLSWTVPE-----GQFDHFLVQYKNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNL 2509
Cdd:smart00060    1 PSPP------SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                    .
gi 1622934690  2510 Y 2510
Cdd:smart00060   75 R 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1918-1986 4.01e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 4.01e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934690  1918 PGAPPRLgelWVTDPTPDSLHLSWTVPE-GQFDSFVVQFKDKDGP-----QVVPVEGHERSVTIAPLDAGRKYRF 1986
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2664-2727 5.03e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 5.03e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690  2664 LTVTGSSPDSLSLSWTIPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGSLEPGNKYKMHLY 2727
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2020-2089 5.49e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 5.49e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934690  2020 PPKPRlgeELQVTSVTQNSVGLSWTVPE-----GQFDSFVVQYKDRDGQPQVVPVEGSLREVSVPGLDPAHRYKL 2089
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
314-418 5.72e-06

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 48.99  E-value: 5.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  314 GCSQRG-RCEDGRCVC-----DPGYTGEDCGtrSCRWDCGEGGRCVDGRCVCWPGYT--GEDC-STRTCPRDCRGRGR-- 382
Cdd:NF041328    13 GCPEPGaVCPEGLSVCggacvDLRSDPSNCG--ACGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAac 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1622934690  383 -----CEDGEC--ICDTGYS--GDDC-GVRSCPGDCNQRG-RCEDGR 418
Cdd:NF041328    91 apgqvCEGGACreACSEGLTrcGGACvDLATDPLHCGACGvACDPGE 137
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2992-3059 6.81e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 6.81e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690  2992 TVAGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGQPQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3059
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
594-703 1.20e-05

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 47.83  E-value: 1.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  594 CSQHG-VCQDGVCICWEAYVgedcSIRTCPSNCHGRG-------RCEEGRCLCDPGYT--GPTC-ATRMCPADCRGRGR- 661
Cdd:NF041328    14 CPEPGaVCPEGLSVCGGACV----DLRSDPSNCGACGvacgagqTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAa 89

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622934690  662 ------CVQGVCMCHVGYGGEDCGQ-------EEPPASACPGGCGPRELCQAGQC 703
Cdd:NF041328    90 capgqvCEGGACREACSEGLTRCGGacvdlatDPLHCGACGVACDPGESCRGGAC 144
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3087-3147 1.49e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 1.49e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690  3087 LTVAAVTSDSVGLSWT-----VAQGPFDSFLVQYRDTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3147
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 280-306 1.97e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 43.83  E-value: 1.97e-05
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  280 CPRGCSQRGRCENGRCVCNPGYTGEDC 306
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3478-3553 2.92e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 2.92e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690 3478 SQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFGVPSPSTLEPHPRPllqrelmvPGTRHSAVLRDLRPGTLYSLTLY 3553
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT--------PGSETSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
2132-2202 6.06e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 6.06e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 2132 GELTVEEATPHTLHLSWM---VTEGEFDSFEI--QHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLYGFHDG 2202
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVeyRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1083-1161 9.50e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 9.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1083 APRHPKPEVLGSSAdgaLLVS---LDGLRGQFERVVLRWRPQPpAEGPGGELTVPGTTRTVSLPDLRPGTTYHVEVHGVR 1159
Cdd:pfam00041    2 APSNLTVTDVTSTS---LTVSwtpPPDGNGPITGYEVEYRPKN-SGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ..
gi 1622934690 1160 AG 1161
Cdd:pfam00041   78 GG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 750-829 2.64e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 2.64e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690   750 PAIEGMRMHLLEETTVRTEWTPAPGP-VDAYEIQFIPTTEGASPPF-TARVPSSASAYDQRGLAPGQEYQVTVRALRGTS 827
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622934690   828 WG 829
Cdd:smart00060   82 EG 83
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 221-244 3.66e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.66e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934690  221 DCQGRGRCVQ--GVCVCRAGFSGPDC 244
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2134-2197 5.00e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 5.00e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690  2134 LTVEEATPHTLHLSWM-----VTEGEFDSFEIQHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLY 2197
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 719-745 5.86e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.97  E-value: 5.86e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  719 CPGDCRGRGECHDGSCICKDGYAGEDC 745
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
279-414 6.96e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.82  E-value: 6.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  279 SCPRGCSqrgRCeNGRCVCNPGyTGEDCGvrSCPRGCSQRGRCEDGRCVCDPGytGEDCG-----TRSCRWDCGE-GGRC 352
Cdd:NF041328    20 VCPEGLS---VC-GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHCGAcGAAC 90

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934690  353 VDGRcVCWPGYTGEDCSTrtcprdcrGRGRCeDGECI---CDTGYSGdDCGVRSCPGDCNQRGRC 414
Cdd:NF041328    91 APGQ-VCEGGACREACSE--------GLTRC-GGACVdlaTDPLHCG-ACGVACDPGESCRGGAC 144
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 190-213 7.72e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.25  E-value: 7.72e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934690  190 DCNDQGRCVR--GRCVCFPGYTGPSC 213
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
191-295 8.18e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.82  E-value: 8.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  191 CNDQGRCVRGRCVCFPGYTgpSCGwpscpgdcqgrGRCVQ--------GVC--VCRAGFSgpdCSQRSCPRGCSQ-RGRC 259
Cdd:NF041328    49 CGAGQTCVAGACGCGPGTV--ACG-----------GACVDtasdpahcGACgaACAPGQV---CEGGACREACSEgLTRC 112

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1622934690  260 eDGRCV---CDPGYTGEdCGmRSCPRGCSqrgrCENGRC 295
Cdd:NF041328   113 -GGACVdlaTDPLHCGA-CG-VACDPGES----CRGGAC 144
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
492-590 9.71e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.44  E-value: 9.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  492 CGtrACPGDCRGRGRCVDGRCVCNPGFT--GEDCGSRR--------CPGDCRGHGSCEDGVC--VCDAGYsgEDCStRSC 559
Cdd:NF041328    42 CG--ACGVACGAGQTCVAGACGCGPGTVacGGACVDTAsdpahcgaCGAACAPGQVCEGGACreACSEGL--TRCG-GAC 116

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1622934690  560 PGGCRGRGQCidGRC--VCEDgysGEDCSVRRC 590
Cdd:NF041328   117 VDLATDPLHC--GACgvACDP---GESCRGGAC 144
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
416-543 1.49e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.05  E-value: 1.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  416 DGRCVCWPGyTGLDCGsrACPRDCRGRGRCENGVCVCNAGysGEDCG-----VRSCPGDCrgrGRCESgrcVCWPGYTgr 490
Cdd:NF041328    29 GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHC---GACGA---ACAPGQV-- 95

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622934690  491 dCGTRACPGDC-RGRGRCvDGRCVcNPGFTGEDCGSrrCPGDCRGHGSCEDGVC 543
Cdd:NF041328    96 -CEGGACREACsEGLTRC-GGACV-DLATDPLHCGA--CGVACDPGESCRGGAC 144
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 3874-3888 1.70e-03

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 38.70  E-value: 1.70e-03
                           10
                   ....*....|....*
gi 1622934690 3874 PLNVFCDMETDGGGW 3888
Cdd:NF040941    29 PFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2134-2202 1.81e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.17  E-value: 1.81e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934690 2134 LTVEEATPHTLHLSWMV---TEGEFDSFEIQHTDR-EGQLQTVRTG-GDRNDITLSGLESDHRYLVTLYGFHDG 2202
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKgSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAVNGG 80
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
3845-4054 4.33e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 370.31  E-value: 4.33e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3845 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNIS-GEFWLGN 3923
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3924 EALHSLTQAGDYSMRVDLRAG-DEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 3995
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934690 3996 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYYWKGFEFSVPFTEMKLRPR 4054
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 3845-4054 2.16e-112

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 356.59  E-value: 2.16e-112
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  3845 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNE 3924
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  3925 ALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-SMSYHSGSVFSARDRDPNNLLISCA 4002
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEdWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1622934690  4003 VSYRGAWWYRNCHYANLNGLYGS-TVDHQGVSWYYWKGFEFSVPFTEMKLRPR 4054
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYPnNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 3844-4054 2.85e-110

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 350.77  E-value: 2.85e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3844 PFPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGN 3923
Cdd:cd00087      1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3924 EALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNNLLISCA 4002
Cdd:cd00087     80 EKIHLLTSQGPYELRIDLEdWEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 4003 VSYRGAWWYRNCHYANLNGLYGSTVDHQ----GVSWYYWKGFEFSVPFTEMKLRPR 4054
Cdd:cd00087    160 ESYSGGWWYNSCHASNLNGRYYSGGHRNeydnGINWATWKGSTYSLKFTEMKIRPK 215
fn3 pfam00041
Fibronectin type III domain;
3577-3655 1.22e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 66.28  E-value: 1.22e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3577 SPRDLQFSEIRETSAKVNWMPPPSRA---DSFKVSYQLADGGEP-QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3652
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934690 3653 SEP 3655
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3578-3657 4.01e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 4.01e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3578 PRDLQFSEIRETSAKVNWMPPP---SRADSFKVSYQLADGGEPQSVQVDGRARTQ-KLQGLIPGARYEVTVVSVRGFEES 3653
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGES 83


                   ....
gi 1622934690 3654 EPLT 3657
Cdd:cd00063     84 PPSE 87
fn3 pfam00041
Fibronectin type III domain;
2878-2951 4.37e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 4.37e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690 2878 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2951
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2551-2624 5.57e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.57e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690 2551 PRLGELTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGG 2624
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2238-2308 5.79e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.79e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 2238 GELTVTDATPDSLSLSWTVPE---GQFDHFLVQYR--NGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2308
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3125-3489 8.28e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.57  E-value: 8.28e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3125 VPVSGDLRAVTVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAPDTKLSPRLGeLTVTDATPDSVGLSWT-VPEGEFDS 3203
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG-LTATADTPGSVTLSWDpVTESDATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3204 FVVQYK-DKDGRLQVVpVAADQREVTVPGLEPSRKYKFLLYGLAGRKRMGPISaDGTTASLEKEPPPRLGELTVTEETSS 3282
Cdd:COG3401    264 YRVYRSnSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPS-NVVSVTTDLTPPAAPSGLTATAVGSS 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3283 SLHLSWT-VAQGPFESFVVqYRDT--DGQPRAVPVAADQHTVTIEDLEPGKKYKFLlyglvggkrlgpVSALGmTAPEED 3359
Cdd:COG3401    342 SITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTYYYK------------VTAVD-AAGNES 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3360 TPAPELASEAPEPPEEPRLGVLAVTDTAPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPY 3439
Cdd:COG3401    408 APSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTA 487

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3440 RFLLYGLHEGKRLGPLSAEGTTGPAPAGQTSGEPGPRLSQLSVTDVTTSS 3489
Cdd:COG3401    488 NLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVT 537
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1663-1942 1.51e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.42  E-value: 1.51e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1663 VRVGGEESEVTVGGLEPGHKYKMHLYGLHEGQRVGPVSAVGVTAPQqeeTPPAtkPPleprlGELTVTDVTPNSVGLSWT 1742
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPT---TPPS--AP-----TGLTATADTPGSVTLSWD 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1743 -VPEGQFDSFMVqYKDKDGQPQAVPVAADQQ-EVTIYNLEPERKYkmnMYglhdgqRVgplSVV----IMTAPLPPAPAT 1816
Cdd:COG3401    255 pVTESDATGYRV-YRSNSGDGPFTKVATVTTtSYTDTGLTNGTTY---YY------RV---TAVdaagNESAPSNVVSVT 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1817 EASEPPLEPRlgELTVTDVTPDSVGLSWT-VPEGEFDSFVVQYKDR-DGQPQVVPVAADQREVTIPGLEPSRKYKFLLFG 1894
Cdd:COG3401    322 TDLTPPAAPS--GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622934690 1895 IQDGKRRSPVSVEA---KTAARGDASPGAPPRLGELWVTDPTPDSLHLSWT 1942
Cdd:COG3401    400 VDAAGNESAPSEEVsatTASAASGESLTASVDAVPLTDVAGATAAASAASN 450
fn3 pfam00041
Fibronectin type III domain;
3267-3334 2.00e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 2.00e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690 3267 PPPRlgELTVTEETSSSLHLSWT---VAQGPFESFVVQYRDTDGQ--PRAVPVAADQHTVTIEDLEPGKKYKF 3334
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
1308-1388 2.14e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.14e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1308 GPPRlgELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQ--PQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVG 1382
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 1622934690 1383 KKRHGP 1388
Cdd:pfam00041   79 GGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
2442-2515 3.70e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 3.70e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690 2442 PRLGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2515
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1512-1589 4.72e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 4.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1512 GELTVTGVTPDSLRLSWT---VAQGPFDSFMVQYKDAQGQ--PQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGrQRVG 1586
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG-GGEG 82


                   ...
gi 1622934690 1587 PES 1589
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
750-831 5.73e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 5.73e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGaSPPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGT 826
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 1622934690  827 SWGPP 831
Cdd:pfam00041   80 GEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1825-1890 8.39e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 8.39e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622934690 1825 PRLGELTVTDVTPDSVGLSWTVPE---GEFDSFVVQYKDRDGQ--PQVVPVAADQREVTIPGLEPSRKYKF 1890
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
843-919 1.07e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.51  E-value: 1.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  843 PQDLRVVAVTPTTLELGWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPPEADGTLLTDLMPGVEYVVTVTAERGRAVS 917
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 1622934690  918 YP 919
Cdd:pfam00041   83 PP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1406-1485 2.02e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 2.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1406 PPRLGNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDGRP--QVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1480
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NG 79


                   ....*
gi 1622934690 1481 KRYGP 1485
Cdd:cd00063     80 GGESP 84
fn3 pfam00041
Fibronectin type III domain;
3175-3240 3.16e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 3.16e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622934690 3175 PRLGELTVTDATPDSVGLSWTVPE---GEFDSFVVQYKDKDG--RLQVVPVAADQREVTVPGLEPSRKYKF 3240
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
3475-3557 7.54e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 7.54e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3475 PRLSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFgvpSPSTLEPHPRpllqrELMVPGTRHSAVLRDLRPGTLYSLT 3551
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEY---RPKNSGEPWN-----EITVPGTTTSVTLTGLKPGTEYEVR 72


                   ....*.
gi 1622934690 3552 LYGLRG 3557
Cdd:pfam00041   73 VQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1822-1910 1.19e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.89  E-value: 1.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1822 PLEPRlgELTVTDVTPDSVGLSWTVPE---GEFDSFVVQYKDRDGQP--QVVPVAADQREVTIPGLEPSRKYKFLLFGIq 1896
Cdd:cd00063      1 PSPPT--NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV- 77

                           90
                   ....*....|....*.
gi 1622934690 1897 DGKRRSPVS--VEAKT 1910
Cdd:cd00063     78 NGGGESPPSesVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
2776-2843 1.34e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.34e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690 2776 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2843
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2992-3059 1.41e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.41e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690 2992 TVAGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDGQ--PQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3059
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1403-1474 1.66e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 1.66e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934690  1403 PGTPPrlgNLWVTDPTPDSLHLSWTVPE-----GQFDTFMVQYRDKDGRPQVVPVEGPERSFVVSSLDPDHKYRFTL 1474
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
fn3 pfam00041
Fibronectin type III domain;
1623-1693 1.76e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 1.76e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 1623 GELTVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEG 1693
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1309-1378 1.90e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.90e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934690 1309 PPRLGELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQP--QVVPVEGPQRSAVITSLDPGRKYKFVLY 1378
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
1406-1487 2.76e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.65  E-value: 2.76e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1406 PPRlgNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDG--RPQVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1480
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV-NG 78


                   ....*..
gi 1622934690 1481 KRYGPLT 1487
Cdd:pfam00041   79 GGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1722-1802 4.28e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.88  E-value: 4.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1722 PRLGELTVTDVTPNSVGLSWTVPE---GQFDSFMVQYKDKDGQ--PQAVPVAADQQEVTIYNLEPERKYKMNMYGLHdGQ 1796
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN-GG 79


                   ....*.
gi 1622934690 1797 RVGPLS 1802
Cdd:pfam00041   80 GEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1470-1743 4.30e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 62.71  E-value: 4.30e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1470 YRFTLFGIANKKRYGP--LTADGTTAPErkeePPrpesleqpllGELTVTGVTPDSLRLSWT-VAQGPFDSFMVQYKDAQ 1546
Cdd:COG3401    207 YRVAATDTGGESAPSNevSVTTPTTPPS----AP----------TGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSG 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1547 GQPQAVPVAGDENEVTVPGLDPDRKYKmnlYGLRGRQRVGPESvvaktapqedvdeTPSPTELGTEAPEPSEEPLlgELT 1626
Cdd:COG3401    273 DGPFTKVATVTTTSYTDTGLTNGTTYY---YRVTAVDAAGNES-------------APSNVVSVTTDLTPPAAPS--GLT 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1627 VTGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGRPQAVRVGGEESEVTVGGLEPGHKYK-----MHLYGLhEGQRVGPV 1699
Cdd:COG3401    335 ATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYykvtaVDAAGN-ESAPSEEV 413

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1622934690 1700 SAVGVTAPQQEETPPATKPPLEPRLGELTVTDVTPNSVGLSWTV 1743
Cdd:COG3401    414 SATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAV 457
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1308-1375 5.37e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.70  E-value: 5.37e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690  1308 GPPRlgELTVTDRTSDSLLLRWTVPE-----GEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKF 1375
Cdd:smart00060    2 SPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3180-3240 5.89e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 5.89e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 3180 LTVTDATPDSVGLSWTVPE---GEFDSFVVQYKDKDGR--LQVVPVAADQREVTVPGLEPSRKYKF 3240
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
2662-2732 6.39e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 6.39e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 2662 GELTVTGSSPDSLSLSWTIP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEG 2732
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 841-921 7.30e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 7.30e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  841 DGPQDLRVVAVTPTTLELGWLRPQ---AEVDRFVVSYVSAGNQRVRLEVPPEADGT--LLTDLMPGVEYVVTVTAERGRA 915
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*.
gi 1622934690  916 VSYPAS 921
Cdd:cd00063     82 ESPPSE 87
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1822-1890 7.71e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 7.71e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934690  1822 PLEPRlgELTVTDVTPDSVGLSWTVPE-----GEFDSFVVQYKDRDGQPQVVPVAADQREVTIPGLEPSRKYKF 1890
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
2349-2416 8.40e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 8.40e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690 2349 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEG 2416
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3268-3334 9.31e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 9.31e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934690 3268 PPRLGELTVTEETSSSLHLSWTVAQ---GPFESFVVQYRDTDGQP--RAVPVAADQHTVTIEDLEPGKKYKF 3334
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
3085-3147 9.63e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 9.63e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934690 3085 GELTVAAVTSDSVGLSWT---VAQGPFDSFLVQYR--DTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3147
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3267-3334 1.15e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 1.15e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690  3267 PPPRlgELTVTEETSSSLHLSWT-----VAQGPFESFVVQYRDTDGQPRAVPVAADQHTVTIEDLEPGKKYKF 3334
Cdd:smart00060    2 SPPS--NLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3180-3240 1.99e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 1.99e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690  3180 LTVTDATPDSVGLSWTVPE-----GEFDSFVVQYKDKDGRLQVVPVAADQREVTVPGLEPSRKYKF 3240
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3577-3653 2.30e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 2.30e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  3577 SPRDLQFSEIRETSAKVNWMPPPS-RADSFKVSYQLADGGEP---QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3652
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 1622934690  3653 S 3653
Cdd:smart00060   83 G 83
fn3 pfam00041
Fibronectin type III domain;
3381-3456 2.82e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.57  E-value: 2.82e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3381 LAVTDTAPDSMRLSWS---VAQGPFDSFVVQYEDTNGQ--PQALLVDGDQSKILISGLEPSTPYRFLLYGLHeGKRLGPL 3455
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN-GGGEGPP 84


                   .
gi 1622934690 3456 S 3456
Cdd:pfam00041   85 S 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1352-1644 3.24e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.63  E-value: 3.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1352 VVPVEGPQRSAVITSLDPGRKYKFVLYGFVGKKRhGPLVTEAKILPQSDPrPGTPprlGNLWVTDPTPDSLHLSWT-VPE 1430
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGE-SAPSNEVSVTTPTTP-PSAP---TGLTATADTPGSVTLSWDpVTE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1431 GQFDTFMVqYRDKDGRPQVVPV-EGPERSFVVSSLDPDHKYRFTLFGIANKKRYGPL--TADGTTAPERkeePPRPESle 1507
Cdd:COG3401    259 SDATGYRV-YRSNSGDGPFTKVaTVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPsnVVSVTTDLTP---PAAPSG-- 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1508 qpllgeLTVTGVTPDSLRLSWT-VAQGPFDSFMVQYKDAQ-GQPQAVPVAGDENEVTVPGLDPDRKYKmnlYGLRGRQRV 1585
Cdd:COG3401    333 ------LTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGgGTYTKIAETVTTTSYTDTGLTPGTTYY---YKVTAVDAA 403

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690 1586 GPESvvaktAPQEDVDETPSPTelgTEAPEPSEEPLLGELTVTGSSPDSLSLSWTVPQG 1644
Cdd:COG3401    404 GNES-----APSEEVSATTASA---ASGESLTASVDAVPLTDVAGATAAASAASNPGVS 454
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 841-914 3.65e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.39  E-value: 3.65e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690   841 DGPQDLRVVAVTPTTLELGWLRPQAE-----VDRFVVSYVSAGNQRVRLEVPPEADGTLLTDLMPGVEYVVTVTAERGR 914
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
763-928 3.72e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.63  E-value: 3.72e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  763 TTVRTEWTPAPGP-VDAYEIQFIPTTEGaspPFTARVPSSASAYDQRGLAPGQEYQVTVRAL--RGTSWGPPASKTITTM 839
Cdd:COG3401    247 GSVTLSWDPVTESdATGYRVYRSNSGDG---PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdaAGNESAPSNVVSVTTD 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  840 I---DGPQDLRVVAVTPTTLELGW-LRPQAEVDRFVVsYVSAGNQRVRLEVPPEADGTLLTD--LMPGVEYVVTVTA--E 911
Cdd:COG3401    324 LtppAAPSGLTATAVGSSSITLSWtASSDADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDtgLTPGTTYYYKVTAvdA 402

                          170
                   ....*....|....*..
gi 1622934690  912 RGRAVSYPASVRANTAP 928
Cdd:COG3401    403 AGNESAPSEEVSATTAS 419
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2872-2953 4.02e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.65  E-value: 4.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2872 PEPPikprlGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLY 2946
Cdd:cd00063      1 PSPP-----TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75


                   ....*..
gi 1622934690 2947 GFHGGQR 2953
Cdd:cd00063     76 AVNGGGE 82
fn3 pfam00041
Fibronectin type III domain;
1919-1986 4.29e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 4.29e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934690 1919 GAPPRLGelwVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQV---VPVEGHERSVTIAPLDAGRKYRF 1986
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEV 71
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2812-3049 4.72e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.25  E-value: 4.72e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2812 VVRVGGEESEVTVGGLEPGRKYKMhlyglhegqRLGPVSAVGVTAPEDEAEATQavPTTTPEPPikprlGELTVTDATPD 2891
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYY---------RVAATDTGGESAPSNEVSVTT--PTTPPSAP-----TGLTATADTPG 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2892 SLSLSWT-VPEGQFDHFLVqYRNGDGQPKAVRVpGHEDGVTI--SGLEPDHKYK-----MNLYGFHGgqrvGPMSVIGVT 2963
Cdd:COG3401    248 SVTLSWDpVTESDATGYRV-YRSNSGDGPFTKV-ATVTTTSYtdTGLTNGTTYYyrvtaVDAAGNES----APSNVVSVT 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2964 VAEEETPSPTepsteapeppeepllgELTVAGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGQPQAVRVGGEESEVTVR 3041
Cdd:COG3401    322 TDLTPPAAPS----------------GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDT 385


                   ....*...
gi 1622934690 3042 GLEPGRKY 3049
Cdd:COG3401    386 GLTPGTTY 393
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3633-3823 9.02e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.48  E-value: 9.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3633 GLIPGARYEVTVVSVRGFEESEPLTGFL----TTVPDGPTQLRALNLTEGFAVLHWKPPQNP-VDTYDVQVTAPGAPPLQ 3707
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3708 AEAPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPAS--ITFTTGLE---APRDLEAKEVTPRTALLTWTE-PQVRPTG 3781
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTppaAPSGLTATAVGSSSITLSWTAsSDADVTG 357

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622934690 3782 YLLSFDT-PGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQAM 3823
Cdd:COG3401    358 YNVYRSTsGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV 400
fn3 pfam00041
Fibronectin type III domain;
3754-3831 9.85e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 9.85e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3754 APRDLEAKEVTPRTALLTWTEPQVRP---TGYLLSFDTPGG--RTQEILLPGGVTSHQLLGLFPSTLYNARLQAMWGESL 3828
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934690 3829 LPP 3831
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2240-2320 1.02e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 1.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2240 LTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGRP--KAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPV 2314
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934690 2315 SAIGVT 2320
Cdd:cd00063     87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1625-1705 1.15e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 1.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1625 LTVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEGQRVGPV 1699
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934690 1700 SAVGVT 1705
Cdd:cd00063     87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1514-1594 1.46e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1514 LTVTGVTPDSLRLSWTVAQ---GPFDSFMVQYKDAQGQP--QAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGRQRVGP- 1587
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPs 86


                   ....*..
gi 1622934690 1588 ESVVAKT 1594
Cdd:cd00063     87 ESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2020-2109 2.03e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 2.03e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2020 PPKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQP--QVVPVEGSLREVSVPGLDPAHRYKLLLYGL 2094
Cdd:cd00063      1 PSPPT---NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*
gi 1622934690 2095 HSGKRVGPISAVVIT 2109
Cdd:cd00063     78 NGGGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3753-3838 2.13e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3753 EAPRDLEAKEVTPRTALLTWTEPQ---VRPTGYLLSF-DTPGGRTQEI-LLPGGVTSHQLLGLFPSTLYNARLQA--MWG 3825
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYrEKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAvnGGG 81

                           90
                   ....*....|...
gi 1622934690 3826 ESlLPPVSTSFTT 3838
Cdd:cd00063     82 ES-PPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 750-838 2.20e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGASPPFTARVPSSASaYDQRGLAPGQEYQVTVRALRGT 826
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1622934690  827 SWGPPA-SKTITT 838
Cdd:cd00063     81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2872-2946 2.33e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 2.33e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  2872 PEPPikprlGELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2946
Cdd:smart00060    1 PSPP-----SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2349-2428 2.75e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2349 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEGRRVGPVS 2423
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ....*
gi 1622934690 2424 AVGVT 2428
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2556-2636 3.06e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2556 LTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQP--KTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGGQRVGPV 2630
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934690 2631 SAIGVT 2636
Cdd:cd00063     87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1719-1807 3.24e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1719 PLEPRlgELTVTDVTPNSVGLSWTVPE---GQFDSFMVQYKDKDGQP--QAVPVAADQQEVTIYNLEPERKYKMNMYGLH 1793
Cdd:cd00063      1 PSPPT--NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....
gi 1622934690 1794 DGQRVGPLSVVIMT 1807
Cdd:cd00063     79 GGGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
2021-2104 3.87e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.49  E-value: 3.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2021 PKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQ--PQVVPVEGSLREVSVPGLDPAHRYKLLLYGlH 2095
Cdd:pfam00041    1 SAPS---NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQA-V 76


                   ....*....
gi 1622934690 2096 SGKRVGPIS 2104
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1918-1986 4.61e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 4.61e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934690 1918 PGAPprlGELWVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQVVPVE---GHERSVTIAPLDAGRKYRF 1986
Cdd:cd00063      1 PSPP---TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3754-3822 4.63e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 4.63e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934690  3754 APRDLEAKEVTPRTALLTWTEPQVRP-----TGYLLSFDTPGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQA 3822
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitgyiVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2435-2524 5.66e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 5.66e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2435 PDAPlvkprlGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNL 2509
Cdd:cd00063      1 PSPP------TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRV 74

                           90
                   ....*....|....*
gi 1622934690 2510 YGFHGGQRMGPVSAV 2524
Cdd:cd00063     75 RAVNGGGESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2776-2838 6.12e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 6.12e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934690 2776 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLY 2838
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 559-586 6.69e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 48.06  E-value: 6.69e-07
                           10        20
                   ....*....|....*....|....*...
gi 1622934690  559 CPGGCRGRGQCIDGRCVCEDGYSGEDCS 586
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1625-1688 8.08e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 8.08e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690  1625 LTVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQAVRVGGEESEVTVGGLEPGHKYKMHLY 1688
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2240-2303 8.40e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 8.40e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690  2240 LTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2303
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2664-2744 9.87e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 9.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2664 LTVTGSSPDSLSLSWTIPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEGRRVGPV 2738
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934690 2739 SAVGVT 2744
Cdd:cd00063     87 ESVTVT 92
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 249-275 1.10e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 1.10e-06
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  249 CPRGCSQRGRCEDGRCVCDPGYTGEDC 275
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 311-337 1.10e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 1.10e-06
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  311 CPRGCSQRGRCEDGRCVCDPGYTGEDC 337
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2992-3068 1.26e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 1.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2992 TVAGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGQP--QAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEGRRVGPVS 3066
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ..
gi 1622934690 3067 AV 3068
Cdd:cd00063     88 SV 89
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 373-399 1.29e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.29  E-value: 1.29e-06
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  373 CPRDCRGRGRCEDGECICDTGYSGDDC 399
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1315-1473 1.40e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 54.62  E-value: 1.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1315 LTVTDRTSDSLLLRWT-VPEGEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVGKKRHGPLVTEA 1393
Cdd:COG3401    239 LTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVV 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1394 KILPQSDPrPGTPprlGNLWVTDPTPDSLHLSWT-VPEGQFDTFMVqYRDK--DGRPQVVPVEGPERSFVVSSLDPDHKY 1470
Cdd:COG3401    319 SVTTDLTP-PAAP---SGLTATAVGSSSITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTY 393


                   ...
gi 1622934690 1471 RFT 1473
Cdd:COG3401    394 YYK 396
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1514-1577 1.41e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 1.41e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690  1514 LTVTGVTPDSLRLSWT-----VAQGPFDSFMVQYKDAQGQPQAVPVAGDENEVTVPGLDPDRKYKMNLY 1577
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
PTZ00214 PTZ00214
high cysteine membrane protein Group 4; Provisional
 254-669 1.60e-06

high cysteine membrane protein Group 4; Provisional


Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 54.54  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  254 SQRGRCEDGRCVCDPGYTGedcGMRSCPRGCSQRGRCENGRCvcNPGYTGEDCgvRSCPRGCSQrgrceDGRCVCDPGYT 333
Cdd:PTZ00214   341 SKNDDNNGDGYLCGDATNG---GVSGCATCGYNSGAVTCTRC--SAGYLGVDG--KSCSESCSG-----DTRGVCTKVAE 408

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  334 GEDCGTRSCRwdcgeggrcvdgrCVCWPGYTGEDCSTRTCPRDCrgrGRCEDGE---C-ICDTGYSGDDCGVRSCPGDCN 409
Cdd:PTZ00214   409 GSESTEVSCR-------------CVCKPTFYNSSGTCTPCTDSC---AVCKDGTptgCqQCSPGKILEFSIVSSESADCV 472

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  410 QRGRCEDGRCVCwpGYTgLDcGSRACPRDCRGRGRCENGVCVCNagySGEDCGVRSCPG----DCRGRGRCESGRCVCWP 485
Cdd:PTZ00214   473 DQCSVGSECAEC--GIT-ID-GSRYCTRCKDASTYPFNGVCIPN---TQRDAYCTSTANgactTCSGAAFLMNGGCYTTE 545

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  486 GYTGRDCGTRACPGDC----RGRGRCVDGRCV-CNP---GFTGEDCGS-RRCPGDC-------RGHGSCED-GVCVcDAG 548
Cdd:PTZ00214   546 HYPGSTICDKQSNGKCtttkKGYGISPDGKLLeCDPtclACTAPGPGRcTRCPSDKllkrasgAATGSCVDpGACV-DGY 624

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  549 YSGEDCSTRSCPGGCRGRG------QCIDGRCVCEDGYSgedcsvrrCPNDCSQHGVCQD---GVCICW------EAYVG 613
Cdd:PTZ00214   625 YADGDACLPCATPGCKTCGhasfctECAGELFVSLDGQS--------CLEECTGDKVVGEvsgGVRRCWcergflPALDR 696

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690  614 EDCSIRT-CPSNCHGRGRCEE-GRCL-CDPGYTGPTCATRMCPADCRGRGRCVQGVCMC 669
Cdd:PTZ00214   697 SGCVLPTeCPPDMPSCAACDEsGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2776-2838 1.99e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 1.99e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934690  2776 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 2838
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2556-2619 2.77e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 2.77e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690  2556 LTMTDATPDSLSLSWTVPE-----GQFDHFLVQYKNGDGQPKTTRVPGHEDRVTISGLEPDHKYKMNLY 2619
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3478-3553 2.88e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 2.88e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934690  3478 SQLSVTDVTTSSLRLNWEAPPGA-FDSFLLRFgvpspsTLEPHPRPLLQRELMVPGTRHSAVLRDLRPGTLYSLTLY 3553
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDgITGYIVGY------RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2349-2411 2.91e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 2.91e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934690  2349 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGNKYKMHLY 2411
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2435-2510 3.50e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 3.50e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  2435 PDAPlvkprlGEMTVRDATPDSLSLSWTVPE-----GQFDHFLVQYKNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNL 2509
Cdd:smart00060    1 PSPP------SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                    .
gi 1622934690  2510 Y 2510
Cdd:smart00060   75 R 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3381-3460 3.98e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.88  E-value: 3.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3381 LAVTDTAPDSMRLSWSVAQ---GPFDSFVVQYEDTNGQP--QALLVDGDQSKILISGLEPSTPYRFLLYGLHEGKRlGPL 3455
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE-SPP 85


                   ....*
gi 1622934690 3456 SAEGT 3460
Cdd:cd00063     86 SESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1918-1986 4.01e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 4.01e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934690  1918 PGAPPRLgelWVTDPTPDSLHLSWTVPE-GQFDSFVVQFKDKDGP-----QVVPVEGHERSVTIAPLDAGRKYRF 1986
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1719-1786 4.38e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 4.38e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690  1719 PLEPRlgELTVTDVTPNSVGLSWTVPE-----GQFDSFMVQYKDKDGQPQAVPVAADQQEVTIYNLEPERKYK 1786
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYE 71
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2664-2727 5.03e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 5.03e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690  2664 LTVTGSSPDSLSLSWTIPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGSLEPGNKYKMHLY 2727
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2020-2089 5.49e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 5.49e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934690  2020 PPKPRlgeELQVTSVTQNSVGLSWTVPE-----GQFDSFVVQYKDRDGQPQVVPVEGSLREVSVPGLDPAHRYKL 2089
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
314-418 5.72e-06

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 48.99  E-value: 5.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  314 GCSQRG-RCEDGRCVC-----DPGYTGEDCGtrSCRWDCGEGGRCVDGRCVCWPGYT--GEDC-STRTCPRDCRGRGR-- 382
Cdd:NF041328    13 GCPEPGaVCPEGLSVCggacvDLRSDPSNCG--ACGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAac 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1622934690  383 -----CEDGEC--ICDTGYS--GDDC-GVRSCPGDCNQRG-RCEDGR 418
Cdd:NF041328    91 apgqvCEGGACreACSEGLTrcGGACvDLATDPLHCGACGvACDPGE 137
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2992-3059 6.81e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 6.81e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934690  2992 TVAGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGQPQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3059
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2556-2757 8.65e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.93  E-value: 8.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2556 LTMTDATPDSLSLSWT-VPEGQFDHFLVQYKNGDGQPKTTRVPGHEDRVTISGLEPDHKYKmnlYGfhggqrvgpVSAIG 2634
Cdd:COG3401    239 LTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYY---YR---------VTAVD 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2635 vTAAEEETPSPTEPSTEAPEPSEEPLlgELTVTGSSPDSLSLSWT-IPQGRFDSFTVQYKDR-DGRPQVVRVGGEESEVT 2712
Cdd:COG3401    307 -AAGNESAPSNVVSVTTDLTPPAAPS--GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYT 383

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2713 VGSLEPGNKYK-----MHLYGLhEGRRVGPVSAVGVTAPREDVDETPSPT 2757
Cdd:COG3401    384 DTGLTPGTTYYykvtaVDAAGN-ESAPSEEVSATTASAASGESLTASVDA 432
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3087-3167 1.03e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 1.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3087 LTVAAVTSDSVGLSWTVAQ---GPFDSFLVQYRDTQGQP--QAVPVSGDLRAVTVSGLDPARKYKFLLFGlQNGKRHGP- 3160
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRA-VNGGGESPp 85


                   ....*...
gi 1622934690 3161 -VPVEART 3167
Cdd:cd00063     86 sESVTVTT 93
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
594-703 1.20e-05

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 47.83  E-value: 1.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  594 CSQHG-VCQDGVCICWEAYVgedcSIRTCPSNCHGRG-------RCEEGRCLCDPGYT--GPTC-ATRMCPADCRGRGR- 661
Cdd:NF041328    14 CPEPGaVCPEGLSVCGGACV----DLRSDPSNCGACGvacgagqTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAa 89

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622934690  662 ------CVQGVCMCHVGYGGEDCGQ-------EEPPASACPGGCGPRELCQAGQC 703
Cdd:NF041328    90 capgqvCEGGACREACSEGLTRCGGacvdlatDPLHCGACGVACDPGESCRGGAC 144
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3664-3750 1.26e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.34  E-value: 1.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3664 PDGPTQLRALNLTEGFAVLHWKPPQN---PVDTYDVQVTAPGAPPLQ--AEAPGSAVDYPLHDLVLHTNYTATVRGLRGP 3738
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDdggPITGYVVEYREKGSGDWKevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1622934690 3739 NLTSPA-SITFTT 3750
Cdd:cd00063     81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3381-3441 1.34e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 1.34e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690  3381 LAVTDTAPDSMRLSWS-----VAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPYRF 3441
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3087-3147 1.49e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 1.49e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690  3087 LTVAAVTSDSVGLSWT-----VAQGPFDSFLVQYRDTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3147
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 280-306 1.97e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 43.83  E-value: 1.97e-05
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  280 CPRGCSQRGRCENGRCVCNPGYTGEDC 306
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
fn3 pfam00041
Fibronectin type III domain;
3667-3737 2.69e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 2.69e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 3667 PTQLRALNLTEGFAVLHWKPP---QNPVDTYDVQVTAPGAPPLQAE--APGSAVDYPLHDLVLHTNYTATVRGLRG 3737
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3478-3553 2.92e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 2.92e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690 3478 SQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFGVPSPSTLEPHPRPllqrelmvPGTRHSAVLRDLRPGTLYSLTLY 3553
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT--------PGSETSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
2132-2202 6.06e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 6.06e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934690 2132 GELTVEEATPHTLHLSWM---VTEGEFDSFEI--QHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLYGFHDG 2202
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVeyRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 528-555 7.03e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 42.29  E-value: 7.03e-05
                           10        20
                   ....*....|....*....|....*...
gi 1622934690  528 CPGDCRGHGSCEDGVCVCDAGYSGEDCS 555
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 625-647 8.09e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 41.95  E-value: 8.09e-05
                           10        20
                   ....*....|....*....|....*
gi 1622934690  625 CHGRGRCE--EGRCLCDPGYTGPTC 647
Cdd:pfam07974    2 CSGRGTCVnqCGKCVCDSGYQGATC 26
fn3 pfam00041
Fibronectin type III domain;
1083-1161 9.50e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 9.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1083 APRHPKPEVLGSSAdgaLLVS---LDGLRGQFERVVLRWRPQPpAEGPGGELTVPGTTRTVSLPDLRPGTTYHVEVHGVR 1159
Cdd:pfam00041    2 APSNLTVTDVTSTS---LTVSwtpPPDGNGPITGYEVEYRPKN-SGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ..
gi 1622934690 1160 AG 1161
Cdd:pfam00041   78 GG 79
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 497-523 1.40e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.52  E-value: 1.40e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  497 CPGDCRGRGRCVDGRCVCNPGFTGEDC 523
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3664-3733 1.61e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 1.61e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934690  3664 PDGPTQLRALNLTEGFAVLHWKPPQNP-----VDTYDVQVTAPGAPPLQAEAPGSAVDYPLHDLVLHTNYTATVR 3733
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
PTZ00214 PTZ00214
high cysteine membrane protein Group 4; Provisional
 266-577 1.61e-04

high cysteine membrane protein Group 4; Provisional


Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 47.99  E-value: 1.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  266 CDPGYTGEDCgmRSCPRGCS--QRGRCE-----------NGRCVCNPGYTGEDCGVRSCPRGCSQrgrCEDGR---C-VC 328
Cdd:PTZ00214   379 CSAGYLGVDG--KSCSESCSgdTRGVCTkvaegsestevSCRCVCKPTFYNSSGTCTPCTDSCAV---CKDGTptgCqQC 453

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  329 DPGYTGE---------DCGTR-SCRWDCGEGGRCVDG-----RC----------VCWPGyTGED--CSTR---TCPRdCR 378
Cdd:PTZ00214   454 SPGKILEfsivssesaDCVDQcSVGSECAECGITIDGsryctRCkdastypfngVCIPN-TQRDayCTSTangACTT-CS 531

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  379 GRGRCEDGECICDTGYSGDDCGVRSCPGDCNQR----GRCEDGRCV-CWPgyTGLDCGSRA------CPRDC---RGRGr 444
Cdd:PTZ00214   532 GAAFLMNGGCYTTEHYPGSTICDKQSNGKCTTTkkgyGISPDGKLLeCDP--TCLACTAPGpgrctrCPSDKllkRASG- 608

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  445 CENGVCV----CNAGY--SGEDCGVRSCPGdCRGRGrcESGRCVCWPGYTGRDCGTRACPGDCRGR---GRCVDG--RCV 513
Cdd:PTZ00214   609 AATGSCVdpgaCVDGYyaDGDACLPCATPG-CKTCG--HASFCTECAGELFVSLDGQSCLEECTGDkvvGEVSGGvrRCW 685

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622934690  514 CNPGF-----TGEDCGSRRCPGDCRGHGSC-EDGVCV-CDAGYSGEDCSTRSCPGGCRGRGQCIDGRCVCE 577
Cdd:PTZ00214   686 CERGFlpaldRSGCVLPTECPPDMPSCAACdESGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMCE 756
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1696-2064 1.63e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 47.69  E-value: 1.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1696 VGPVSAVGVTAPQQEETPPATKPPLEPRLGELTVTDVTPNSVGLSWTVPEGQFDSFMVQYKDKDGQPQAVPVAADQQEVT 1775
Cdd:COG3401     43 VLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAV 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1776 IYNLEPERKYKMNMYGLHDGQRVGPLSVVIMTAPLPPAPATEASEPPLEPRLGELTVTDVTPDSVGLSWTVPEGefdsfv 1855
Cdd:COG3401    123 GTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGG------ 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1856 vqykdrdgqpqvvpvaadqrevtiPGLEPSRKYKFLLFGIQDGKRRSP---VSVEAKTAArgdasPGAPprlGELWVTDP 1932
Cdd:COG3401    197 ------------------------GDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTP-----PSAP---TGLTATAD 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1933 TPDSLHLSWT-VPEGQFDSFVV-QFKDKDGPQVVPVEGHERSVTIAPLDAGRKYRFLLYGLlgkkrhgplTADGTTEARS 2010
Cdd:COG3401    245 TPGSVTLSWDpVTESDATGYRVyRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAV---------DAAGNESAPS 315

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934690 2011 AMDD--TGTKRPPKPrlgEELQVTSVTQNSVGLSWT-VPEGQFDSFVVQYKDRDGQP 2064
Cdd:COG3401    316 NVVSvtTDLTPPAAP---SGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 500-523 1.97e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 41.18  E-value: 1.97e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934690  500 DCRGRGRCVD--GRCVCNPGFTGEDC 523
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 590-617 2.03e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.13  E-value: 2.03e-04
                           10        20
                   ....*....|....*....|....*...
gi 1622934690  590 CPNDCSQHGVCQDGVCICWEAYVGEDCS 617
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 469-492 2.62e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 2.62e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934690  469 DCRGRGRCES--GRCVCWPGYTGRDC 492
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 750-829 2.64e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 2.64e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690   750 PAIEGMRMHLLEETTVRTEWTPAPGP-VDAYEIQFIPTTEGASPPF-TARVPSSASAYDQRGLAPGQEYQVTVRALRGTS 827
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622934690   828 WG 829
Cdd:smart00060   82 EG 83
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 531-554 2.78e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 2.78e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934690  531 DCRGHGSCED--GVCVCDAGYSGEDC 554
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 221-244 3.66e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.66e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934690  221 DCQGRGRCVQ--GVCVCRAGFSGPDC 244
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 284-306 3.73e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.73e-04
                           10        20
                   ....*....|....*....|....*
gi 1622934690  284 CSQRGRCEN--GRCVCNPGYTGEDC 306
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 563-585 4.59e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.02  E-value: 4.59e-04
                           10        20
                   ....*....|....*....|....*
gi 1622934690  563 CRGRGQCID--GRCVCEDGYSGEDC 585
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 438-461 4.63e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.02  E-value: 4.63e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934690  438 DCRGRGRCEN--GVCVCNAGYSGEDC 461
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 253-275 4.68e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.02  E-value: 4.68e-04
                           10        20
                   ....*....|....*....|....*
gi 1622934690  253 CSQRGRCED--GRCVCDPGYTGEDC 275
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 315-337 4.68e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.02  E-value: 4.68e-04
                           10        20
                   ....*....|....*....|....*
gi 1622934690  315 CSQRGRCED--GRCVCDPGYTGEDC 337
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 376-399 4.96e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.02  E-value: 4.96e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934690  376 DCRGRGRCED--GECICDTGYSGDDC 399
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2134-2197 5.00e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 5.00e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934690  2134 LTVEEATPHTLHLSWM-----VTEGEFDSFEIQHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLY 2197
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 435-461 5.69e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.97  E-value: 5.69e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  435 CPRDCRGRGRCENGVCVCNAGYSGEDC 461
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 719-745 5.86e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.97  E-value: 5.86e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  719 CPGDCRGRGECHDGSCICKDGYAGEDC 745
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
279-414 6.96e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.82  E-value: 6.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  279 SCPRGCSqrgRCeNGRCVCNPGyTGEDCGvrSCPRGCSQRGRCEDGRCVCDPGytGEDCG-----TRSCRWDCGE-GGRC 352
Cdd:NF041328    20 VCPEGLS---VC-GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHCGAcGAAC 90

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934690  353 VDGRcVCWPGYTGEDCSTrtcprdcrGRGRCeDGECI---CDTGYSGdDCGVRSCPGDCNQRGRC 414
Cdd:NF041328    91 APGQ-VCEGGACREACSE--------GLTRC-GGACVdlaTDPLHCG-ACGVACDPGESCRGGAC 144
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 190-213 7.72e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.25  E-value: 7.72e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934690  190 DCNDQGRCVR--GRCVCFPGYTGPSC 213
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2240-2438 7.90e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 45.38  E-value: 7.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2240 LTVTDATPDSLSLSWT-VPEGQFDHFLVQYRN-GDGRPKAV-RVPGHEdgVTISGLEPDHKYK-----MNLYGFHGgqrv 2311
Cdd:COG3401    239 LTATADTPGSVTLSWDpVTESDATGYRVYRSNsGDGPFTKVaTVTTTS--YTDTGLTNGTTYYyrvtaVDAAGNES---- 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 2312 GPVSAIGVTAAEEETPSPTepsteapeppeepllgELTVTGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGRPQVVRVG 2389
Cdd:COG3401    313 APSNVVSVTTDLTPPAAPS----------------GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAET 376

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622934690 2390 GEESEVTVGGLEPGNKYK-----MHLYGLhEGRRVGPVSAVGVTAPKEESPDAP 2438
Cdd:COG3401    377 VTTTSYTDTGLTPGTTYYykvtaVDAAGN-ESAPSEEVSATTASAASGESLTAS 429
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
191-295 8.18e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.82  E-value: 8.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  191 CNDQGRCVRGRCVCFPGYTgpSCGwpscpgdcqgrGRCVQ--------GVC--VCRAGFSgpdCSQRSCPRGCSQ-RGRC 259
Cdd:NF041328    49 CGAGQTCVAGACGCGPGTV--ACG-----------GACVDtasdpahcGACgaACAPGQV---CEGGACREACSEgLTRC 112

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1622934690  260 eDGRCV---CDPGYTGEdCGmRSCPRGCSqrgrCENGRC 295
Cdd:NF041328   113 -GGACVdlaTDPLHCGA-CG-VACDPGES----CRGGAC 144
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
492-590 9.71e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.44  E-value: 9.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  492 CGtrACPGDCRGRGRCVDGRCVCNPGFT--GEDCGSRR--------CPGDCRGHGSCEDGVC--VCDAGYsgEDCStRSC 559
Cdd:NF041328    42 CG--ACGVACGAGQTCVAGACGCGPGTVacGGACVDTAsdpahcgaCGAACAPGQVCEGGACreACSEGL--TRCG-GAC 116

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1622934690  560 PGGCRGRGQCidGRC--VCEDgysGEDCSVRRC 590
Cdd:NF041328   117 VDLATDPLHC--GACgvACDP---GESCRGGAC 144
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 218-245 1.01e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.20  E-value: 1.01e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622934690  218 CPGDCQGRGRCVQGVCVCRAGFSGPDCS 245
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 407-430 1.03e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.87  E-value: 1.03e-03
                           10        20
                   ....*....|....*....|....*.
gi 1622934690  407 DCNQRGRCED--GRCVCWPGYTGLDC 430
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3312-3500 1.15e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.99  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3312 VPVAADQHTVTIEDLEPGKKYKFLLYGLVGGKRLGPVSALGMTAPEEDTPAPElaseapeppeeprlgVLAVTDTAPDSM 3391
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT---------------GLTATADTPGSV 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 3392 RLSWS-VAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPYRFLLYGLHEGKRLGPLS--AEGTTGPAPAGQ 3468
Cdd:COG3401    250 TLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTPPAA 329

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1622934690 3469 TSGepgprlsqLSVTDVTTSSLRLNWEAPPGA 3500
Cdd:COG3401    330 PSG--------LTATAVGSSSITLSWTASSDA 353
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
416-543 1.49e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.05  E-value: 1.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690  416 DGRCVCWPGyTGLDCGsrACPRDCRGRGRCENGVCVCNAGysGEDCG-----VRSCPGDCrgrGRCESgrcVCWPGYTgr 490
Cdd:NF041328    29 GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHC---GACGA---ACAPGQV-- 95

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622934690  491 dCGTRACPGDC-RGRGRCvDGRCVcNPGFTGEDCGSrrCPGDCRGHGSCEDGVC 543
Cdd:NF041328    96 -CEGGACREACsEGLTRC-GGACV-DLATDPLHCGA--CGVACDPGESCRGGAC 144
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 3874-3888 1.70e-03

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 38.70  E-value: 1.70e-03
                           10
                   ....*....|....*
gi 1622934690 3874 PLNVFCDMETDGGGW 3888
Cdd:NF040941    29 PFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2134-2202 1.81e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.17  E-value: 1.81e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934690 2134 LTVEEATPHTLHLSWMV---TEGEFDSFEIQHTDR-EGQLQTVRTG-GDRNDITLSGLESDHRYLVTLYGFHDG 2202
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKgSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAVNGG 80
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 652-678 3.20e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.66  E-value: 3.20e-03
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  652 CPADCRGRGRCVQGVCMCHVGYGGEDC 678
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 345-368 3.47e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 3.47e-03
                           10        20
                   ....*....|....*....|....*.
gi 1622934690  345 DCGEGGRCVD--GRCVCWPGYTGEDC 368
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 621-648 3.50e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.66  E-value: 3.50e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622934690  621 CPSNCHGRGRCEEGRCLCDPGYTGPTCA 648
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 404-430 5.56e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.89  E-value: 5.56e-03
                           10        20
                   ....*....|....*....|....*..
gi 1622934690  404 CPGDCNQRGRCEDGRCVCWPGYTGLDC 430
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EB pfam01683
EB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 599-643 6.28e-03

EB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains pfam00014.


Pssm-ID: 460294  Cd Length: 52  Bit Score: 37.41  E-value: 6.28e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622934690  599 VCQDGVCIcWEAYVGEDCSIrtcPSNCHGRGRCEEGRCLCDPGYT 643
Cdd:pfam01683    6 VLVNGQCV-PKVAPGESCEA---DEQCPGGSVCVNGVCQCPPGFT 46
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 342-369 7.84e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.51  E-value: 7.84e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622934690  342 CRWDCGEGGRCVDGRCVCWPGYTGEDCS 369
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1515-1840 9.16e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 42.24  E-value: 9.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1515 TVTGVTPDSLRLSWTVAQGPFDSFMVQYKDAQGQPQAVPV----AGDENEVTVPGL--DPDrKYkmnlyglrgrqrvgpe 1588
Cdd:COG4733    454 TVQSVAGRTLTVSTAYSETPEAGAVWAFGPDELETQLFRVvsieENEDGTYTITAVqhAPE-KY---------------- 516

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1589 svvakTAPQEDVDETPSPtelgteAPEPSEEPLLGELTVT--GSSPDSLSLSWTVPQGRFdSFTVQYKDRDGRPQAV-RV 1665
Cdd:COG4733    517 -----AAIDAGAFDDVPP------QWPPVNVTTSESLSVVaqGTAVTTLTVSWDAPAGAV-AYEVEWRRDDGNWVSVpRT 584

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1666 GGEESEVTvgGLEPGHkYKMHLYGLHEGQRVGPVSAVGVTAPQQEETPPatkpplePRLGELTVTDVtPNSVGLSWTVPE 1745
Cdd:COG4733    585 SGTSFEVP--GIYAGD-YEVRVRAINALGVSSAWAASSETTVTGKTAPP-------PAPTGLTATGG-LGGITLSWSFPV 653

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934690 1746 G-QFDSFMVQYKDKDGQPQAV--PVAADQQEVTIYNLEPERKYKMNMYGLHDGQRVGPLSVVIMTAPLPPAPATEASEPP 1822
Cdd:COG4733    654 DaDTLRTEIRYSTTGDWASATvaQALYPGNTYTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQASADAAGILDAITGQI 733

                          330
                   ....*....|....*...
gi 1622934690 1823 LEPRLGELTVTDVTPDSV 1840
Cdd:COG4733    734 LETELGQELDAIIQNATV 751
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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