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Conserved domains on  [gi|1622934685|ref|XP_028703534|]
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tenascin-X isoform X6 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
4061-4270 4.56e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


:

Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 370.31  E-value: 4.56e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 4061 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNIS-GEFWLGN 4139
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 4140 EALHSLTQAGDYSMRVDLRAG-DEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 4211
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934685 4212 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYYWKGFEFSVPFTEMKLRPR 4270
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
fn3 pfam00041
Fibronectin type III domain;
3793-3871 1.50e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 1.50e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3793 SPRDLQFSEIRETSAKVNWMPPPSRA---DSFKVSYQLADGGEP-QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3868
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81

                   ...
gi 1622934685 3869 SEP 3871
Cdd:pfam00041   82 GPP 84
fn3 pfam00041
Fibronectin type III domain;
3094-3167 5.32e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.32e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685 3094 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 3167
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2878-2951 5.32e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.32e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685 2878 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2951
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2551-2624 6.73e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 6.73e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685 2551 PRLGELTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGG 2624
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2238-2308 7.13e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 7.13e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 2238 GELTVTDATPDSLSLSWTVPE---GQFDHFLVQYR--NGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2308
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
3341-3705 1.04e-11

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.19  E-value: 1.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3341 VPVSGDLRAVTVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAPDTKLSPRLGeLTVTDATPDSVGLSWT-VPEGEFDS 3419
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG-LTATADTPGSVTLSWDpVTESDATG 263
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3420 FVVQYK-DKDGRLQVVpVAADQREVTVPGLEPSRKYKFLLYGLAGRKRMGPISaDGTTASLEKEPPPRLGELTVTEETSS 3498
Cdd:COG3401    264 YRVYRSnSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPS-NVVSVTTDLTPPAAPSGLTATAVGSS 341
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3499 SLHLSWT-VAQGPFESFVVqYRDT--DGQPRAVPVAADQHTVTIEDLEPGKKYKFLlyglvggkrlgpVSALGmTAPEED 3575
Cdd:COG3401    342 SITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTYYYK------------VTAVD-AAGNES 407
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3576 TPAPELASEAPEPPEEPRLGVLAVTDTAPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPY 3655
Cdd:COG3401    408 APSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTA 487
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3656 RFLLYGLHEGKRLGPLSAEGTTGPAPAGQTSGEPGPRLSQLSVTDVTTSS 3705
Cdd:COG3401    488 NLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVT 537
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
1663-1942 2.34e-11

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.03  E-value: 2.34e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1663 VRVGGEESEVTVGGLEPGHKYKMHLYGLHEGQRVGPVSAVGVTAPQqeeTPPAtkPPleprlGELTVTDVTPNSVGLSWT 1742
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPT---TPPS--AP-----TGLTATADTPGSVTLSWD 254
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1743 -VPEGQFDSFMVqYKDKDGQPQAVPVAADQQ-EVTIYNLEPERKYkmnMYglhdgqRVgplSVV----IMTAPLPPAPAT 1816
Cdd:COG3401    255 pVTESDATGYRV-YRSNSGDGPFTKVATVTTtSYTDTGLTNGTTY---YY------RV---TAVdaagNESAPSNVVSVT 321
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1817 EASEPPLEPRlgELTVTDVTPDSVGLSWT-VPEGEFDSFVVQYKDR-DGQPQVVPVAADQREVTIPGLEPSRKYKFLLFG 1894
Cdd:COG3401    322 TDLTPPAAPS--GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622934685 1895 IQDGKRRSPVSVEA---KTAARGDASPGAPPRLGELWVTDPTPDSLHLSWT 1942
Cdd:COG3401    400 VDAAGNESAPSEEVsatTASAASGESLTASVDAVPLTDVAGATAAASAASN 450
fn3 pfam00041
Fibronectin type III domain;
1308-1388 2.69e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.69e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1308 GPPRlgELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQ--PQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVG 1382
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78

                   ....*.
gi 1622934685 1383 KKRHGP 1388
Cdd:pfam00041   79 GGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
2442-2515 4.46e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 4.46e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685 2442 PRLGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2515
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1512-1589 5.70e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 5.70e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1512 GELTVTGVTPDSLRLSWT---VAQGPFDSFMVQYKDAQGQ--PQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGrQRVG 1586
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG-GGEG 82

                   ...
gi 1622934685 1587 PES 1589
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
750-831 6.60e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 6.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGaSPPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGT 826
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79

                   ....*
gi 1622934685  827 SWGPP 831
Cdd:pfam00041   80 GEGPP 84
fn3 pfam00041
Fibronectin type III domain;
843-919 1.29e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.51  E-value: 1.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  843 PQDLRVVAVTPTTLELGWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPPEADGTLLTDLMPGVEYVVTVTAERGRAVS 917
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82

                   ..
gi 1622934685  918 YP 919
Cdd:pfam00041   83 PP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1406-1485 2.34e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 2.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1406 PPRLGNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDGRP--QVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1480
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NG 79

                   ....*
gi 1622934685 1481 KRYGP 1485
Cdd:cd00063     80 GGESP 84
fn3 pfam00041
Fibronectin type III domain;
3691-3773 8.93e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 8.93e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3691 PRLSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFgvpSPSTLEPHPRpllqrELMVPGTRHSAVLRDLRPGTLYSLT 3767
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEY---RPKNSGEPWN-----EITVPGTTTSVTLTGLKPGTEYEVR 72

                   ....*.
gi 1622934685 3768 LYGLRG 3773
Cdd:pfam00041   73 VQAVNG 78
fn3 pfam00041
Fibronectin type III domain;
2992-3059 1.57e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.57e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685 2992 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 3059
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2776-2843 1.57e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.57e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685 2776 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2843
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3208-3275 1.67e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.67e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685 3208 TVAGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDGQ--PQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3275
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1623-1693 2.11e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 2.11e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 1623 GELTVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEG 1693
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2662-2732 7.57e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 7.57e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 2662 GELTVTGSSPDSLSLSWTIP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEG 2732
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2349-2416 9.86e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 9.86e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685 2349 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEG 2416
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3301-3363 1.13e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 1.13e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934685 3301 GELTVAAVTSDSVGLSWT---VAQGPFDSFLVQYR--DTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3363
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
1919-1986 5.04e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 5.04e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934685 1919 GAPPRLGelwVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQV---VPVEGHERSVTIAPLDAGRKYRF 1986
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
3970-4047 1.10e-07

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3970 APRDLEAKEVTPRTALLTWTEPQVRP---TGYLLSFDTPGG--RTQEILLPGGVTSHQLLGLFPSTLYNARLQAMWGESL 4044
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81

                   ...
gi 1622934685 4045 LPP 4047
Cdd:pfam00041   82 GPP 84
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
3849-4039 1.23e-07

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.09  E-value: 1.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3849 GLIPGARYEVTVVSVRGFEESEPLTGFL----TTVPDGPTQLRALNLTEGFAVLHWKPPQNP-VDTYDVQVTAPGAPPLQ 3923
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFT 277
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3924 AEAPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPAS--ITFTTGLE---APRDLEAKEVTPRTALLTWTE-PQVRPTG 3997
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTppaAPSGLTATAVGSSSITLSWTAsSDADVTG 357
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622934685 3998 YLLSFDT-PGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQAM 4039
Cdd:COG3401    358 YNVYRSTsGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV 400
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2020-2109 2.31e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2020 PPKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQP--QVVPVEGSLREVSVPGLDPAHRYKLLLYGL 2094
Cdd:cd00063      1 PSPPT---NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77
                           90
                   ....*....|....*
gi 1622934685 2095 HSGKRVGPISAVVIT 2109
Cdd:cd00063     78 NGGGESPPSESVTVT 92
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
559-586 5.74e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 48.45  E-value: 5.74e-07
                           10        20
                   ....*....|....*....|....*...
gi 1622934685  559 CPGGCRGRGQCIDGRCVCEDGYSGEDCS 586
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
249-275 9.64e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 47.68  E-value: 9.64e-07
                           10        20
                   ....*....|....*....|....*..
gi 1622934685  249 CPRGCSQRGRCEDGRCVCDPGYTGEDC 275
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
311-337 9.64e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 47.68  E-value: 9.64e-07
                           10        20
                   ....*....|....*....|....*..
gi 1622934685  311 CPRGCSQRGRCEDGRCVCDPGYTGEDC 337
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
PTZ00214 super family cl31756
high cysteine membrane protein Group 4; Provisional
254-669 9.69e-07

high cysteine membrane protein Group 4; Provisional


The actual alignment was detected with superfamily member PTZ00214:

Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 55.31  E-value: 9.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  254 SQRGRCEDGRCVCDPGYTGedcGMRSCPRGCSQRGRCENGRCvcNPGYTGEDCgvRSCPRGCSQrgrceDGRCVCDPGYT 333
Cdd:PTZ00214   341 SKNDDNNGDGYLCGDATNG---GVSGCATCGYNSGAVTCTRC--SAGYLGVDG--KSCSESCSG-----DTRGVCTKVAE 408
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  334 GEDCGTRSCRwdcgeggrcvdgrCVCWPGYTGEDCSTRTCPRDCrgrGRCEDGE---C-ICDTGYSGDDCGVRSCPGDCN 409
Cdd:PTZ00214   409 GSESTEVSCR-------------CVCKPTFYNSSGTCTPCTDSC---AVCKDGTptgCqQCSPGKILEFSIVSSESADCV 472
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  410 QRGRCEDGRCVCwpGYTgLDcGSRACPRDCRGRGRCENGVCVCNagySGEDCGVRSCPG----DCRGRGRCESGRCVCWP 485
Cdd:PTZ00214   473 DQCSVGSECAEC--GIT-ID-GSRYCTRCKDASTYPFNGVCIPN---TQRDAYCTSTANgactTCSGAAFLMNGGCYTTE 545
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  486 GYTGRDCGTRACPGDC----RGRGRCVDGRCV-CNP---GFTGEDCGS-RRCPGDC-------RGHGSCED-GVCVcDAG 548
Cdd:PTZ00214   546 HYPGSTICDKQSNGKCtttkKGYGISPDGKLLeCDPtclACTAPGPGRcTRCPSDKllkrasgAATGSCVDpGACV-DGY 624
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  549 YSGEDCSTRSCPGGCRGRG------QCIDGRCVCEDGYSgedcsvrrCPNDCSQHGVCQD---GVCICW------EAYVG 613
Cdd:PTZ00214   625 YADGDACLPCATPGCKTCGhasfctECAGELFVSLDGQS--------CLEECTGDKVVGEvsgGVRRCWcergflPALDR 696
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685  614 EDCSIRT-CPSNCHGRGRCEE-GRCL-CDPGYTGPTCATRMCPADCRGRGRCVQGVCMC 669
Cdd:PTZ00214   697 SGCVLPTeCPPDMPSCAACDEsGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755
fn3 pfam00041
Fibronectin type III domain;
2132-2202 7.04e-05

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 7.04e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 2132 GELTVEEATPHTLHLSWM---VTEGEFDSFEI--QHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLYGFHDG 2202
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVeyRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1083-1161 1.09e-04

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 1.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1083 APRHPKPEVLGSSAdgaLLVS---LDGLRGQFERVVLRWRPQPpAEGPGGELTVPGTTRTVSLPDLRPGTTYHVEVHGVR 1159
Cdd:pfam00041    2 APSNLTVTDVTSTS---LTVSwtpPPDGNGPITGYEVEYRPKN-SGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77

                   ..
gi 1622934685 1160 AG 1161
Cdd:pfam00041   78 GG 79
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
221-244 2.93e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 2.93e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934685  221 DCQGRGRCVQ--GVCVCRAGFSGPDC 244
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
719-745 5.17e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 39.97  E-value: 5.17e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934685  719 CPGDCRGRGECHDGSCICKDGYAGEDC 745
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
190-213 6.23e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.64  E-value: 6.23e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934685  190 DCNDQGRCVR--GRCVCFPGYTGPSC 213
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
4061-4270 4.56e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 370.31  E-value: 4.56e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 4061 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNIS-GEFWLGN 4139
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 4140 EALHSLTQAGDYSMRVDLRAG-DEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 4211
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934685 4212 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYYWKGFEFSVPFTEMKLRPR 4270
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
4061-4270 2.28e-112

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 356.59  E-value: 2.28e-112
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  4061 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNE 4140
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  4141 ALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-SMSYHSGSVFSARDRDPNNLLISCA 4218
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEdWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159
                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1622934685  4219 VSYRGAWWYRNCHYANLNGLYGS-TVDHQGVSWYYWKGFEFSVPFTEMKLRPR 4270
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYPnNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
4060-4270 3.00e-110

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 350.77  E-value: 3.00e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 4060 PFPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGN 4139
Cdd:cd00087      1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 4140 EALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNNLLISCA 4218
Cdd:cd00087     80 EKIHLLTSQGPYELRIDLEdWEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 4219 VSYRGAWWYRNCHYANLNGLYGSTVDHQ----GVSWYYWKGFEFSVPFTEMKLRPR 4270
Cdd:cd00087    160 ESYSGGWWYNSCHASNLNGRYYSGGHRNeydnGINWATWKGSTYSLKFTEMKIRPK 215
fn3 pfam00041
Fibronectin type III domain;
3793-3871 1.50e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 1.50e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3793 SPRDLQFSEIRETSAKVNWMPPPSRA---DSFKVSYQLADGGEP-QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3868
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81

                   ...
gi 1622934685 3869 SEP 3871
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3794-3873 4.80e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 4.80e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3794 PRDLQFSEIRETSAKVNWMPPP---SRADSFKVSYQLADGGEPQSVQVDGRARTQ-KLQGLIPGARYEVTVVSVRGFEES 3869
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGES 83

                   ....
gi 1622934685 3870 EPLT 3873
Cdd:cd00063     84 PPSE 87
fn3 pfam00041
Fibronectin type III domain;
3094-3167 5.32e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.32e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685 3094 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 3167
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2878-2951 5.32e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.32e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685 2878 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2951
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2551-2624 6.73e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 6.73e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685 2551 PRLGELTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGG 2624
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2238-2308 7.13e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 7.13e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 2238 GELTVTDATPDSLSLSWTVPE---GQFDHFLVQYR--NGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2308
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3341-3705 1.04e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.19  E-value: 1.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3341 VPVSGDLRAVTVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAPDTKLSPRLGeLTVTDATPDSVGLSWT-VPEGEFDS 3419
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG-LTATADTPGSVTLSWDpVTESDATG 263
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3420 FVVQYK-DKDGRLQVVpVAADQREVTVPGLEPSRKYKFLLYGLAGRKRMGPISaDGTTASLEKEPPPRLGELTVTEETSS 3498
Cdd:COG3401    264 YRVYRSnSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPS-NVVSVTTDLTPPAAPSGLTATAVGSS 341
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3499 SLHLSWT-VAQGPFESFVVqYRDT--DGQPRAVPVAADQHTVTIEDLEPGKKYKFLlyglvggkrlgpVSALGmTAPEED 3575
Cdd:COG3401    342 SITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTYYYK------------VTAVD-AAGNES 407
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3576 TPAPELASEAPEPPEEPRLGVLAVTDTAPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPY 3655
Cdd:COG3401    408 APSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTA 487
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3656 RFLLYGLHEGKRLGPLSAEGTTGPAPAGQTSGEPGPRLSQLSVTDVTTSS 3705
Cdd:COG3401    488 NLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVT 537
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1663-1942 2.34e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.03  E-value: 2.34e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1663 VRVGGEESEVTVGGLEPGHKYKMHLYGLHEGQRVGPVSAVGVTAPQqeeTPPAtkPPleprlGELTVTDVTPNSVGLSWT 1742
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPT---TPPS--AP-----TGLTATADTPGSVTLSWD 254
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1743 -VPEGQFDSFMVqYKDKDGQPQAVPVAADQQ-EVTIYNLEPERKYkmnMYglhdgqRVgplSVV----IMTAPLPPAPAT 1816
Cdd:COG3401    255 pVTESDATGYRV-YRSNSGDGPFTKVATVTTtSYTDTGLTNGTTY---YY------RV---TAVdaagNESAPSNVVSVT 321
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1817 EASEPPLEPRlgELTVTDVTPDSVGLSWT-VPEGEFDSFVVQYKDR-DGQPQVVPVAADQREVTIPGLEPSRKYKFLLFG 1894
Cdd:COG3401    322 TDLTPPAAPS--GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622934685 1895 IQDGKRRSPVSVEA---KTAARGDASPGAPPRLGELWVTDPTPDSLHLSWT 1942
Cdd:COG3401    400 VDAAGNESAPSEEVsatTASAASGESLTASVDAVPLTDVAGATAAASAASN 450
fn3 pfam00041
Fibronectin type III domain;
3483-3550 2.44e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.44e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685 3483 PPPRlgELTVTEETSSSLHLSWT---VAQGPFESFVVQYRDTDGQ--PRAVPVAADQHTVTIEDLEPGKKYKF 3550
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
1308-1388 2.69e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.69e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1308 GPPRlgELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQ--PQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVG 1382
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78

                   ....*.
gi 1622934685 1383 KKRHGP 1388
Cdd:pfam00041   79 GGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
2442-2515 4.46e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 4.46e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685 2442 PRLGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2515
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1512-1589 5.70e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 5.70e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1512 GELTVTGVTPDSLRLSWT---VAQGPFDSFMVQYKDAQGQ--PQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGrQRVG 1586
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG-GGEG 82

                   ...
gi 1622934685 1587 PES 1589
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
750-831 6.60e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 6.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGaSPPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGT 826
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79

                   ....*
gi 1622934685  827 SWGPP 831
Cdd:pfam00041   80 GEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1825-1890 1.02e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.51  E-value: 1.02e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622934685 1825 PRLGELTVTDVTPDSVGLSWTVPE---GEFDSFVVQYKDRDGQ--PQVVPVAADQREVTIPGLEPSRKYKF 1890
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
843-919 1.29e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.51  E-value: 1.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  843 PQDLRVVAVTPTTLELGWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPPEADGTLLTDLMPGVEYVVTVTAERGRAVS 917
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82

                   ..
gi 1622934685  918 YP 919
Cdd:pfam00041   83 PP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1406-1485 2.34e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 2.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1406 PPRLGNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDGRP--QVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1480
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NG 79

                   ....*
gi 1622934685 1481 KRYGP 1485
Cdd:cd00063     80 GGESP 84
fn3 pfam00041
Fibronectin type III domain;
3691-3773 8.93e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 8.93e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3691 PRLSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFgvpSPSTLEPHPRpllqrELMVPGTRHSAVLRDLRPGTLYSLT 3767
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEY---RPKNSGEPWN-----EITVPGTTTSVTLTGLKPGTEYEVR 72

                   ....*.
gi 1622934685 3768 LYGLRG 3773
Cdd:pfam00041   73 VQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1822-1910 1.41e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.89  E-value: 1.41e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1822 PLEPRlgELTVTDVTPDSVGLSWTVPE---GEFDSFVVQYKDRDGQP--QVVPVAADQREVTIPGLEPSRKYKFLLFGIq 1896
Cdd:cd00063      1 PSPPT--NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV- 77
                           90
                   ....*....|....*.
gi 1622934685 1897 DGKRRSPVS--VEAKT 1910
Cdd:cd00063     78 NGGGESPPSesVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
2992-3059 1.57e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.57e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685 2992 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 3059
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2776-2843 1.57e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.57e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685 2776 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2843
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3208-3275 1.67e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.67e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685 3208 TVAGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDGQ--PQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3275
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1403-1474 1.99e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.85  E-value: 1.99e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934685  1403 PGTPPrlgNLWVTDPTPDSLHLSWTVPE-----GQFDTFMVQYRDKDGRPQVVPVEGPERSFVVSSLDPDHKYRFTL 1474
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
fn3 pfam00041
Fibronectin type III domain;
1623-1693 2.11e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 2.11e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 1623 GELTVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEG 1693
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1309-1378 2.16e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 2.16e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934685 1309 PPRLGELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQP--QVVPVEGPQRSAVITSLDPGRKYKFVLY 1378
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
1406-1487 3.47e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.27  E-value: 3.47e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1406 PPRlgNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDG--RPQVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1480
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV-NG 78

                   ....*..
gi 1622934685 1481 KRYGPLT 1487
Cdd:pfam00041   79 GGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1470-1743 6.44e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 62.33  E-value: 6.44e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1470 YRFTLFGIANKKRYGP--LTADGTTAPErkeePPrpesleqpllGELTVTGVTPDSLRLSWT-VAQGPFDSFMVQYKDAQ 1546
Cdd:COG3401    207 YRVAATDTGGESAPSNevSVTTPTTPPS----AP----------TGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSG 272
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1547 GQPQAVPVAGDENEVTVPGLDPDRKYKmnlYGLRGRQRVGPESvvaktapqedvdeTPSPTELGTEAPEPSEEPLlgELT 1626
Cdd:COG3401    273 DGPFTKVATVTTTSYTDTGLTNGTTYY---YRVTAVDAAGNES-------------APSNVVSVTTDLTPPAAPS--GLT 334
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1627 VTGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGRPQAVRVGGEESEVTVGGLEPGHKYK-----MHLYGLhEGQRVGPV 1699
Cdd:COG3401    335 ATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYykvtaVDAAGN-ESAPSEEV 413
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1622934685 1700 SAVGVTAPQQEETPPATKPPLEPRLGELTVTDVTPNSVGLSWTV 1743
Cdd:COG3401    414 SATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAV 457
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1308-1375 6.68e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 6.68e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685  1308 GPPRlgELTVTDRTSDSLLLRWTVPE-----GEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKF 1375
Cdd:smart00060    2 SPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3396-3456 6.71e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 6.71e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 3396 LTVTDATPDSVGLSWTVPE---GEFDSFVVQYKDKDGR--LQVVPVAADQREVTVPGLEPSRKYKF 3456
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
2662-2732 7.57e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 7.57e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 2662 GELTVTGSSPDSLSLSWTIP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEG 2732
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
841-921 8.99e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 8.99e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  841 DGPQDLRVVAVTPTTLELGWLRPQ---AEVDRFVVSYVSAGNQRVRLEVPPEADGT--LLTDLMPGVEYVVTVTAERGRA 915
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81

                   ....*.
gi 1622934685  916 VSYPAS 921
Cdd:cd00063     82 ESPPSE 87
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1822-1890 9.14e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 9.14e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934685  1822 PLEPRlgELTVTDVTPDSVGLSWTVPE-----GEFDSFVVQYKDRDGQPQVVPVAADQREVTIPGLEPSRKYKF 1890
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
2349-2416 9.86e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 9.86e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685 2349 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEG 2416
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3301-3363 1.13e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 1.13e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934685 3301 GELTVAAVTSDSVGLSWT---VAQGPFDSFLVQYR--DTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3363
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3483-3550 1.39e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 1.39e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685  3483 PPPRlgELTVTEETSSSLHLSWT-----VAQGPFESFVVQYRDTDGQPRAVPVAADQHTVTIEDLEPGKKYKF 3550
Cdd:smart00060    2 SPPS--NLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2883-2963 2.04e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 2.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2883 LTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPV 2957
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86

                   ....*.
gi 1622934685 2958 SVIRVT 2963
Cdd:cd00063     87 ESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3793-3869 2.78e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 2.78e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  3793 SPRDLQFSEIRETSAKVNWMPPPS-RADSFKVSYQLADGGEP---QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3868
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82

                    .
gi 1622934685  3869 S 3869
Cdd:smart00060   83 G 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
841-914 4.40e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 4.40e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685   841 DGPQDLRVVAVTPTTLELGWLRPQAE-----VDRFVVSYVSAGNQRVRLEVPPEADGTLLTDLMPGVEYVVTVTAERGR 914
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3088-3169 4.72e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 4.72e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3088 PEPPikprlGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLY 3162
Cdd:cd00063      1 PSPP-----TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                   ....*..
gi 1622934685 3163 GFHGGQR 3169
Cdd:cd00063     76 AVNGGGE 82
fn3 pfam00041
Fibronectin type III domain;
1919-1986 5.04e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 5.04e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934685 1919 GAPPRLGelwVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQV---VPVEGHERSVTIAPLDAGRKYRF 1986
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
3970-4047 1.10e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3970 APRDLEAKEVTPRTALLTWTEPQVRP---TGYLLSFDTPGG--RTQEILLPGGVTSHQLLGLFPSTLYNARLQAMWGESL 4044
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81

                   ...
gi 1622934685 4045 LPP 4047
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2240-2320 1.17e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 1.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2240 LTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGRP--KAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPV 2314
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86

                   ....*.
gi 1622934685 2315 SAIGVT 2320
Cdd:cd00063     87 ESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3849-4039 1.23e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.09  E-value: 1.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3849 GLIPGARYEVTVVSVRGFEESEPLTGFL----TTVPDGPTQLRALNLTEGFAVLHWKPPQNP-VDTYDVQVTAPGAPPLQ 3923
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFT 277
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3924 AEAPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPAS--ITFTTGLE---APRDLEAKEVTPRTALLTWTE-PQVRPTG 3997
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTppaAPSGLTATAVGSSSITLSWTAsSDADVTG 357
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622934685 3998 YLLSFDT-PGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQAM 4039
Cdd:COG3401    358 YNVYRSTsGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV 400
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1514-1594 1.69e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 1.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1514 LTVTGVTPDSLRLSWTVAQ---GPFDSFMVQYKDAQGQP--QAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGRQRVGP- 1587
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPs 86

                   ....*..
gi 1622934685 1588 ESVVAKT 1594
Cdd:cd00063     87 ESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2992-3071 2.31e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2992 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVS 3066
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87

                   ....*
gi 1622934685 3067 AVGVT 3071
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2020-2109 2.31e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2020 PPKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQP--QVVPVEGSLREVSVPGLDPAHRYKLLLYGL 2094
Cdd:cd00063      1 PSPPT---NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77
                           90
                   ....*....|....*
gi 1622934685 2095 HSGKRVGPISAVVIT 2109
Cdd:cd00063     78 NGGGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3969-4054 2.55e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3969 EAPRDLEAKEVTPRTALLTWTEPQ---VRPTGYLLSF-DTPGGRTQEI-LLPGGVTSHQLLGLFPSTLYNARLQAM--WG 4041
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYrEKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVngGG 81
                           90
                   ....*....|...
gi 1622934685 4042 ESlLPPVSTSFTT 4054
Cdd:cd00063     82 ES-PPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
750-838 2.55e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGASPPFTARVPSSASaYDQRGLAPGQEYQVTVRALRGT 826
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGG 80
                           90
                   ....*....|...
gi 1622934685  827 SWGPPA-SKTITT 838
Cdd:cd00063     81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3088-3162 2.76e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 2.76e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  3088 PEPPikprlGELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 3162
Cdd:smart00060    1 PSPP-----SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2349-2428 3.10e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2349 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEGRRVGPVS 2423
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87

                   ....*
gi 1622934685 2424 AVGVT 2428
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2556-2636 3.45e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2556 LTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQP--KTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGGQRVGPV 2630
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86

                   ....*.
gi 1622934685 2631 SAIGVT 2636
Cdd:cd00063     87 ESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
2021-2104 4.67e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.49  E-value: 4.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2021 PKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQ--PQVVPVEGSLREVSVPGLDPAHRYKLLLYGlH 2095
Cdd:pfam00041    1 SAPS---NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQA-V 76

                   ....*....
gi 1622934685 2096 SGKRVGPIS 2104
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1918-1986 5.62e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 5.62e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934685 1918 PGAPprlGELWVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQVVPVE---GHERSVTIAPLDAGRKYRF 1986
Cdd:cd00063      1 PSPP---TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEF 72
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
559-586 5.74e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 48.45  E-value: 5.74e-07
                           10        20
                   ....*....|....*....|....*...
gi 1622934685  559 CPGGCRGRGQCIDGRCVCEDGYSGEDCS 586
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3970-4038 5.81e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 5.81e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934685  3970 APRDLEAKEVTPRTALLTWTEPQVRP-----TGYLLSFDTPGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQA 4038
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitgyiVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2435-2524 6.57e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 6.57e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2435 PDAPlvkprlGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNL 2509
Cdd:cd00063      1 PSPP------TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRV 74
                           90
                   ....*....|....*
gi 1622934685 2510 YGFHGGQRMGPVSAV 2524
Cdd:cd00063     75 RAVNGGGESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2776-2838 6.90e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 6.90e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934685 2776 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLY 2838
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2875-2946 8.10e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 8.10e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934685  2875 PIKPRlgELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2946
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1625-1688 9.57e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 9.57e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685  1625 LTVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQAVRVGGEESEVTVGGLEPGHKYKMHLY 1688
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
249-275 9.64e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 9.64e-07
                           10        20
                   ....*....|....*....|....*..
gi 1622934685  249 CPRGCSQRGRCEDGRCVCDPGYTGEDC 275
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
311-337 9.64e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 9.64e-07
                           10        20
                   ....*....|....*....|....*..
gi 1622934685  311 CPRGCSQRGRCEDGRCVCDPGYTGEDC 337
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
PTZ00214 PTZ00214
high cysteine membrane protein Group 4; Provisional
254-669 9.69e-07

high cysteine membrane protein Group 4; Provisional


Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 55.31  E-value: 9.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  254 SQRGRCEDGRCVCDPGYTGedcGMRSCPRGCSQRGRCENGRCvcNPGYTGEDCgvRSCPRGCSQrgrceDGRCVCDPGYT 333
Cdd:PTZ00214   341 SKNDDNNGDGYLCGDATNG---GVSGCATCGYNSGAVTCTRC--SAGYLGVDG--KSCSESCSG-----DTRGVCTKVAE 408
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  334 GEDCGTRSCRwdcgeggrcvdgrCVCWPGYTGEDCSTRTCPRDCrgrGRCEDGE---C-ICDTGYSGDDCGVRSCPGDCN 409
Cdd:PTZ00214   409 GSESTEVSCR-------------CVCKPTFYNSSGTCTPCTDSC---AVCKDGTptgCqQCSPGKILEFSIVSSESADCV 472
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  410 QRGRCEDGRCVCwpGYTgLDcGSRACPRDCRGRGRCENGVCVCNagySGEDCGVRSCPG----DCRGRGRCESGRCVCWP 485
Cdd:PTZ00214   473 DQCSVGSECAEC--GIT-ID-GSRYCTRCKDASTYPFNGVCIPN---TQRDAYCTSTANgactTCSGAAFLMNGGCYTTE 545
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  486 GYTGRDCGTRACPGDC----RGRGRCVDGRCV-CNP---GFTGEDCGS-RRCPGDC-------RGHGSCED-GVCVcDAG 548
Cdd:PTZ00214   546 HYPGSTICDKQSNGKCtttkKGYGISPDGKLLeCDPtclACTAPGPGRcTRCPSDKllkrasgAATGSCVDpGACV-DGY 624
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  549 YSGEDCSTRSCPGGCRGRG------QCIDGRCVCEDGYSgedcsvrrCPNDCSQHGVCQD---GVCICW------EAYVG 613
Cdd:PTZ00214   625 YADGDACLPCATPGCKTCGhasfctECAGELFVSLDGQS--------CLEECTGDKVVGEvsgGVRRCWcergflPALDR 696
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685  614 EDCSIRT-CPSNCHGRGRCEE-GRCL-CDPGYTGPTCATRMCPADCRGRGRCVQGVCMC 669
Cdd:PTZ00214   697 SGCVLPTeCPPDMPSCAACDEsGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2240-2303 9.85e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 9.85e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685  2240 LTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2303
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
373-399 1.09e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 1.09e-06
                           10        20
                   ....*....|....*....|....*..
gi 1622934685  373 CPRDCRGRGRCEDGECICDTGYSGDDC 399
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2664-2744 1.13e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 1.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2664 LTVTGSSPDSLSLSWTIPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEGRRVGPV 2738
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86

                   ....*.
gi 1622934685 2739 SAVGVT 2744
Cdd:cd00063     87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3208-3284 1.42e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 1.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3208 TVAGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGQP--QAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEGRRVGPVS 3282
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87

                   ..
gi 1622934685 3283 AV 3284
Cdd:cd00063     88 SV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1514-1577 1.61e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 1.61e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685  1514 LTVTGVTPDSLRLSWT-----VAQGPFDSFMVQYKDAQGQPQAVPVAGDENEVTVPGLDPDRKYKMNLY 1577
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2992-3054 2.33e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.33e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934685  2992 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 3054
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2776-2838 2.33e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.33e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934685  2776 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 2838
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2556-2619 3.25e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 3.25e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685  2556 LTMTDATPDSLSLSWTVPE-----GQFDHFLVQYKNGDGQPKTTRVPGHEDRVTISGLEPDHKYKMNLY 2619
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2349-2411 3.41e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 3.41e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934685  2349 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGNKYKMHLY 2411
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3694-3769 3.41e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 3.41e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934685  3694 SQLSVTDVTTSSLRLNWEAPPGA-FDSFLLRFgvpspsTLEPHPRPLLQRELMVPGTRHSAVLRDLRPGTLYSLTLY 3769
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDgITGYIVGY------RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
314-418 3.45e-06

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 49.76  E-value: 3.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  314 GCSQRG-RCEDGRCVC-----DPGYTGEDCGtrSCRWDCGEGGRCVDGRCVCWPGYT--GEDC-STRTCPRDCRGRGR-- 382
Cdd:NF041328    13 GCPEPGaVCPEGLSVCggacvDLRSDPSNCG--ACGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAac 90
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1622934685  383 -----CEDGEC--ICDTGYS--GDDC-GVRSCPGDCNQRG-RCEDGR 418
Cdd:NF041328    91 apgqvCEGGACreACSEGLTrcGGACvDLATDPLHCGACGvACDPGE 137
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2435-2510 4.19e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 4.19e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  2435 PDAPlvkprlGEMTVRDATPDSLSLSWTVPE-----GQFDHFLVQYKNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNL 2509
Cdd:smart00060    1 PSPP------SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74

                    .
gi 1622934685  2510 Y 2510
Cdd:smart00060   75 R 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1918-1986 4.76e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 4.76e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934685  1918 PGAPPRLgelWVTDPTPDSLHLSWTVPE-GQFDSFVVQFKDKDGP-----QVVPVEGHERSVTIAPLDAGRKYRF 1986
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2664-2727 5.96e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 5.96e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685  2664 LTVTGSSPDSLSLSWTIPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGSLEPGNKYKMHLY 2727
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2020-2089 6.44e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 6.44e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934685  2020 PPKPRlgeELQVTSVTQNSVGLSWTVPE-----GQFDSFVVQYKDRDGQPQVVPVEGSLREVSVPGLDPAHRYKL 2089
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
594-703 7.88e-06

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 48.60  E-value: 7.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  594 CSQHG-VCQDGVCICWEAYVgedcSIRTCPSNCHGRG-------RCEEGRCLCDPGYT--GPTC-ATRMCPADCRGRGR- 661
Cdd:NF041328    14 CPEPGaVCPEGLSVCGGACV----DLRSDPSNCGACGvacgagqTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAa 89
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622934685  662 ------CVQGVCMCHVGYGGEDCGQ-------EEPPASACPGGCGPRELCQAGQC 703
Cdd:NF041328    90 capgqvCEGGACREACSEGLTRCGGacvdlatDPLHCGACGVACDPGESCRGGAC 144
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3208-3275 7.91e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 7.91e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685  3208 TVAGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGQPQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3275
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3880-3966 1.45e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.34  E-value: 1.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3880 PDGPTQLRALNLTEGFAVLHWKPPQN---PVDTYDVQVTAPGAPPLQ--AEAPGSAVDYPLHDLVLHTNYTATVRGLRGP 3954
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDdggPITGYVVEYREKGSGDWKevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
                           90
                   ....*....|...
gi 1622934685 3955 NLTSPA-SITFTT 3966
Cdd:cd00063     81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3303-3363 1.73e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.73e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685  3303 LTVAAVTSDSVGLSWT-----VAQGPFDSFLVQYRDTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3363
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
3883-3953 3.16e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 3.16e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 3883 PTQLRALNLTEGFAVLHWKPP---QNPVDTYDVQVTAPGAPPLQAE--APGSAVDYPLHDLVLHTNYTATVRGLRG 3953
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3694-3769 3.52e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 3.52e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685 3694 SQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFGVPSPSTLEPHPRPllqrelmvPGTRHSAVLRDLRPGTLYSLTLY 3769
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT--------PGSETSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
2132-2202 7.04e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 7.04e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 2132 GELTVEEATPHTLHLSWM---VTEGEFDSFEI--QHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLYGFHDG 2202
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVeyRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1083-1161 1.09e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 1.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1083 APRHPKPEVLGSSAdgaLLVS---LDGLRGQFERVVLRWRPQPpAEGPGGELTVPGTTRTVSLPDLRPGTTYHVEVHGVR 1159
Cdd:pfam00041    2 APSNLTVTDVTSTS---LTVSwtpPPDGNGPITGYEVEYRPKN-SGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77

                   ..
gi 1622934685 1160 AG 1161
Cdd:pfam00041   78 GG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3880-3949 1.90e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 1.90e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934685  3880 PDGPTQLRALNLTEGFAVLHWKPPQNP-----VDTYDVQVTAPGAPPLQAEAPGSAVDYPLHDLVLHTNYTATVR 3949
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
221-244 2.93e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 2.93e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934685  221 DCQGRGRCVQ--GVCVCRAGFSGPDC 244
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
750-829 3.13e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 3.13e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685   750 PAIEGMRMHLLEETTVRTEWTPAPGP-VDAYEIQFIPTTEGASPPF-TARVPSSASAYDQRGLAPGQEYQVTVRALRGTS 827
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 1622934685   828 WG 829
Cdd:smart00060   82 EG 83
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
279-414 4.38e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 43.59  E-value: 4.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  279 SCPRGCSqrgRCeNGRCVCNPGyTGEDCGvrSCPRGCSQRGRCEDGRCVCDPGytGEDCG-----TRSCRWDCGE-GGRC 352
Cdd:NF041328    20 VCPEGLS---VC-GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHCGAcGAAC 90
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934685  353 VDGRcVCWPGYTGEDCSTrtcprdcrGRGRCeDGECI---CDTGYSGdDCGVRSCPGDCNQRGRC 414
Cdd:NF041328    91 APGQ-VCEGGACREACSE--------GLTRC-GGACVdlaTDPLHCG-ACGVACDPGESCRGGAC 144
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
191-295 5.10e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 43.21  E-value: 5.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  191 CNDQGRCVRGRCVCFPGYTgpSCGwpscpgdcqgrGRCVQ--------GVC--VCRAGFSgpdCSQRSCPRGCSQ-RGRC 259
Cdd:NF041328    49 CGAGQTCVAGACGCGPGTV--ACG-----------GACVDtasdpahcGACgaACAPGQV---CEGGACREACSEgLTRC 112
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1622934685  260 eDGRCV---CDPGYTGEdCGmRSCPRGCSqrgrCENGRC 295
Cdd:NF041328   113 -GGACVdlaTDPLHCGA-CG-VACDPGES----CRGGAC 144
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
719-745 5.17e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.97  E-value: 5.17e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934685  719 CPGDCRGRGECHDGSCICKDGYAGEDC 745
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2134-2197 5.86e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 5.86e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685  2134 LTVEEATPHTLHLSWM-----VTEGEFDSFEIQHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLY 2197
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
190-213 6.23e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.64  E-value: 6.23e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934685  190 DCNDQGRCVR--GRCVCFPGYTGPSC 213
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
492-590 6.73e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.82  E-value: 6.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  492 CGtrACPGDCRGRGRCVDGRCVCNPGFT--GEDCGSRR--------CPGDCRGHGSCEDGVC--VCDAGYsgEDCStRSC 559
Cdd:NF041328    42 CG--ACGVACGAGQTCVAGACGCGPGTVacGGACVDTAsdpahcgaCGAACAPGQVCEGGACreACSEGL--TRCG-GAC 116
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1622934685  560 PGGCRGRGQCidGRC--VCEDgysGEDCSVRRC 590
Cdd:NF041328   117 VDLATDPLHC--GACgvACDP---GESCRGGAC 144
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
416-543 1.00e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.44  E-value: 1.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  416 DGRCVCWPGyTGLDCGsrACPRDCRGRGRCENGVCVCNAGysGEDCG-----VRSCPGDCrgrGRCESgrcVCWPGYTgr 490
Cdd:NF041328    29 GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHC---GACGA---ACAPGQV-- 95
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622934685  491 dCGTRACPGDC-RGRGRCvDGRCVcNPGFTGEDCGSrrCPGDCRGHGSCEDGVC 543
Cdd:NF041328    96 -CEGGACREACsEGLTRC-GGACV-DLATDPLHCGA--CGVACDPGESCRGGAC 144
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
4090-4104 1.67e-03

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 39.08  E-value: 1.67e-03
                           10
                   ....*....|....*
gi 1622934685 4090 PLNVFCDMETDGGGW 4104
Cdd:NF040941    29 PFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2134-2202 2.10e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.17  E-value: 2.10e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934685 2134 LTVEEATPHTLHLSWMV---TEGEFDSFEIQHTDR-EGQLQTVRTG-GDRNDITLSGLESDHRYLVTLYGFHDG 2202
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKgSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAVNGG 80
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
4061-4270 4.56e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 370.31  E-value: 4.56e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 4061 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNIS-GEFWLGN 4139
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 4140 EALHSLTQAGDYSMRVDLRAG-DEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 4211
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934685 4212 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYYWKGFEFSVPFTEMKLRPR 4270
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
4061-4270 2.28e-112

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 356.59  E-value: 2.28e-112
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  4061 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNE 4140
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  4141 ALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-SMSYHSGSVFSARDRDPNNLLISCA 4218
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEdWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159
                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1622934685  4219 VSYRGAWWYRNCHYANLNGLYGS-TVDHQGVSWYYWKGFEFSVPFTEMKLRPR 4270
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYPnNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
4060-4270 3.00e-110

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 350.77  E-value: 3.00e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 4060 PFPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGN 4139
Cdd:cd00087      1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 4140 EALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNNLLISCA 4218
Cdd:cd00087     80 EKIHLLTSQGPYELRIDLEdWEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 4219 VSYRGAWWYRNCHYANLNGLYGSTVDHQ----GVSWYYWKGFEFSVPFTEMKLRPR 4270
Cdd:cd00087    160 ESYSGGWWYNSCHASNLNGRYYSGGHRNeydnGINWATWKGSTYSLKFTEMKIRPK 215
fn3 pfam00041
Fibronectin type III domain;
3793-3871 1.50e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 1.50e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3793 SPRDLQFSEIRETSAKVNWMPPPSRA---DSFKVSYQLADGGEP-QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3868
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81

                   ...
gi 1622934685 3869 SEP 3871
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3794-3873 4.80e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 4.80e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3794 PRDLQFSEIRETSAKVNWMPPP---SRADSFKVSYQLADGGEPQSVQVDGRARTQ-KLQGLIPGARYEVTVVSVRGFEES 3869
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGES 83

                   ....
gi 1622934685 3870 EPLT 3873
Cdd:cd00063     84 PPSE 87
fn3 pfam00041
Fibronectin type III domain;
3094-3167 5.32e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.32e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685 3094 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 3167
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2878-2951 5.32e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.32e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685 2878 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2951
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2551-2624 6.73e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 6.73e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685 2551 PRLGELTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGG 2624
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2238-2308 7.13e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 7.13e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 2238 GELTVTDATPDSLSLSWTVPE---GQFDHFLVQYR--NGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2308
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3341-3705 1.04e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.19  E-value: 1.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3341 VPVSGDLRAVTVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAPDTKLSPRLGeLTVTDATPDSVGLSWT-VPEGEFDS 3419
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG-LTATADTPGSVTLSWDpVTESDATG 263
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3420 FVVQYK-DKDGRLQVVpVAADQREVTVPGLEPSRKYKFLLYGLAGRKRMGPISaDGTTASLEKEPPPRLGELTVTEETSS 3498
Cdd:COG3401    264 YRVYRSnSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPS-NVVSVTTDLTPPAAPSGLTATAVGSS 341
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3499 SLHLSWT-VAQGPFESFVVqYRDT--DGQPRAVPVAADQHTVTIEDLEPGKKYKFLlyglvggkrlgpVSALGmTAPEED 3575
Cdd:COG3401    342 SITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTYYYK------------VTAVD-AAGNES 407
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3576 TPAPELASEAPEPPEEPRLGVLAVTDTAPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPY 3655
Cdd:COG3401    408 APSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTA 487
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3656 RFLLYGLHEGKRLGPLSAEGTTGPAPAGQTSGEPGPRLSQLSVTDVTTSS 3705
Cdd:COG3401    488 NLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVT 537
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1663-1942 2.34e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.03  E-value: 2.34e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1663 VRVGGEESEVTVGGLEPGHKYKMHLYGLHEGQRVGPVSAVGVTAPQqeeTPPAtkPPleprlGELTVTDVTPNSVGLSWT 1742
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPT---TPPS--AP-----TGLTATADTPGSVTLSWD 254
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1743 -VPEGQFDSFMVqYKDKDGQPQAVPVAADQQ-EVTIYNLEPERKYkmnMYglhdgqRVgplSVV----IMTAPLPPAPAT 1816
Cdd:COG3401    255 pVTESDATGYRV-YRSNSGDGPFTKVATVTTtSYTDTGLTNGTTY---YY------RV---TAVdaagNESAPSNVVSVT 321
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1817 EASEPPLEPRlgELTVTDVTPDSVGLSWT-VPEGEFDSFVVQYKDR-DGQPQVVPVAADQREVTIPGLEPSRKYKFLLFG 1894
Cdd:COG3401    322 TDLTPPAAPS--GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622934685 1895 IQDGKRRSPVSVEA---KTAARGDASPGAPPRLGELWVTDPTPDSLHLSWT 1942
Cdd:COG3401    400 VDAAGNESAPSEEVsatTASAASGESLTASVDAVPLTDVAGATAAASAASN 450
fn3 pfam00041
Fibronectin type III domain;
3483-3550 2.44e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.44e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685 3483 PPPRlgELTVTEETSSSLHLSWT---VAQGPFESFVVQYRDTDGQ--PRAVPVAADQHTVTIEDLEPGKKYKF 3550
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
1308-1388 2.69e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.69e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1308 GPPRlgELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQ--PQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVG 1382
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78

                   ....*.
gi 1622934685 1383 KKRHGP 1388
Cdd:pfam00041   79 GGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
2442-2515 4.46e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 4.46e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685 2442 PRLGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2515
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1512-1589 5.70e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 5.70e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1512 GELTVTGVTPDSLRLSWT---VAQGPFDSFMVQYKDAQGQ--PQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGrQRVG 1586
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG-GGEG 82

                   ...
gi 1622934685 1587 PES 1589
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
750-831 6.60e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 6.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGaSPPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGT 826
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79

                   ....*
gi 1622934685  827 SWGPP 831
Cdd:pfam00041   80 GEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1825-1890 1.02e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.51  E-value: 1.02e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622934685 1825 PRLGELTVTDVTPDSVGLSWTVPE---GEFDSFVVQYKDRDGQ--PQVVPVAADQREVTIPGLEPSRKYKF 1890
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
843-919 1.29e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.51  E-value: 1.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  843 PQDLRVVAVTPTTLELGWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPPEADGTLLTDLMPGVEYVVTVTAERGRAVS 917
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82

                   ..
gi 1622934685  918 YP 919
Cdd:pfam00041   83 PP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1406-1485 2.34e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 2.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1406 PPRLGNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDGRP--QVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1480
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NG 79

                   ....*
gi 1622934685 1481 KRYGP 1485
Cdd:cd00063     80 GGESP 84
fn3 pfam00041
Fibronectin type III domain;
3391-3456 3.86e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 3.86e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622934685 3391 PRLGELTVTDATPDSVGLSWTVPE---GEFDSFVVQYKDKDG--RLQVVPVAADQREVTVPGLEPSRKYKF 3456
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
3691-3773 8.93e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 8.93e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3691 PRLSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFgvpSPSTLEPHPRpllqrELMVPGTRHSAVLRDLRPGTLYSLT 3767
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEY---RPKNSGEPWN-----EITVPGTTTSVTLTGLKPGTEYEVR 72

                   ....*.
gi 1622934685 3768 LYGLRG 3773
Cdd:pfam00041   73 VQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1822-1910 1.41e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.89  E-value: 1.41e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1822 PLEPRlgELTVTDVTPDSVGLSWTVPE---GEFDSFVVQYKDRDGQP--QVVPVAADQREVTIPGLEPSRKYKFLLFGIq 1896
Cdd:cd00063      1 PSPPT--NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV- 77
                           90
                   ....*....|....*.
gi 1622934685 1897 DGKRRSPVS--VEAKT 1910
Cdd:cd00063     78 NGGGESPPSesVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
2992-3059 1.57e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.57e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685 2992 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 3059
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2776-2843 1.57e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.57e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685 2776 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2843
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3208-3275 1.67e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.67e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685 3208 TVAGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDGQ--PQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3275
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1403-1474 1.99e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.85  E-value: 1.99e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934685  1403 PGTPPrlgNLWVTDPTPDSLHLSWTVPE-----GQFDTFMVQYRDKDGRPQVVPVEGPERSFVVSSLDPDHKYRFTL 1474
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
fn3 pfam00041
Fibronectin type III domain;
1623-1693 2.11e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 2.11e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 1623 GELTVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEG 1693
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1309-1378 2.16e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 2.16e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934685 1309 PPRLGELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQP--QVVPVEGPQRSAVITSLDPGRKYKFVLY 1378
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
1406-1487 3.47e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.27  E-value: 3.47e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1406 PPRlgNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDG--RPQVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1480
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV-NG 78

                   ....*..
gi 1622934685 1481 KRYGPLT 1487
Cdd:pfam00041   79 GGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1722-1802 5.28e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.88  E-value: 5.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1722 PRLGELTVTDVTPNSVGLSWTVPE---GQFDSFMVQYKDKDGQ--PQAVPVAADQQEVTIYNLEPERKYKMNMYGLHdGQ 1796
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN-GG 79

                   ....*.
gi 1622934685 1797 RVGPLS 1802
Cdd:pfam00041   80 GEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1470-1743 6.44e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 62.33  E-value: 6.44e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1470 YRFTLFGIANKKRYGP--LTADGTTAPErkeePPrpesleqpllGELTVTGVTPDSLRLSWT-VAQGPFDSFMVQYKDAQ 1546
Cdd:COG3401    207 YRVAATDTGGESAPSNevSVTTPTTPPS----AP----------TGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSG 272
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1547 GQPQAVPVAGDENEVTVPGLDPDRKYKmnlYGLRGRQRVGPESvvaktapqedvdeTPSPTELGTEAPEPSEEPLlgELT 1626
Cdd:COG3401    273 DGPFTKVATVTTTSYTDTGLTNGTTYY---YRVTAVDAAGNES-------------APSNVVSVTTDLTPPAAPS--GLT 334
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1627 VTGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGRPQAVRVGGEESEVTVGGLEPGHKYK-----MHLYGLhEGQRVGPV 1699
Cdd:COG3401    335 ATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYykvtaVDAAGN-ESAPSEEV 413
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1622934685 1700 SAVGVTAPQQEETPPATKPPLEPRLGELTVTDVTPNSVGLSWTV 1743
Cdd:COG3401    414 SATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAV 457
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1308-1375 6.68e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 6.68e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685  1308 GPPRlgELTVTDRTSDSLLLRWTVPE-----GEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKF 1375
Cdd:smart00060    2 SPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3396-3456 6.71e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 6.71e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 3396 LTVTDATPDSVGLSWTVPE---GEFDSFVVQYKDKDGR--LQVVPVAADQREVTVPGLEPSRKYKF 3456
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
2662-2732 7.57e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 7.57e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 2662 GELTVTGSSPDSLSLSWTIP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEG 2732
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
841-921 8.99e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 8.99e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  841 DGPQDLRVVAVTPTTLELGWLRPQ---AEVDRFVVSYVSAGNQRVRLEVPPEADGT--LLTDLMPGVEYVVTVTAERGRA 915
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81

                   ....*.
gi 1622934685  916 VSYPAS 921
Cdd:cd00063     82 ESPPSE 87
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1822-1890 9.14e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.93  E-value: 9.14e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934685  1822 PLEPRlgELTVTDVTPDSVGLSWTVPE-----GEFDSFVVQYKDRDGQPQVVPVAADQREVTIPGLEPSRKYKF 1890
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
2349-2416 9.86e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 9.86e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685 2349 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEG 2416
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3484-3550 1.10e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 1.10e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934685 3484 PPRLGELTVTEETSSSLHLSWTVAQ---GPFESFVVQYRDTDGQP--RAVPVAADQHTVTIEDLEPGKKYKF 3550
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
3301-3363 1.13e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 1.13e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934685 3301 GELTVAAVTSDSVGLSWT---VAQGPFDSFLVQYR--DTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3363
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3483-3550 1.39e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 1.39e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685  3483 PPPRlgELTVTEETSSSLHLSWT-----VAQGPFESFVVQYRDTDGQPRAVPVAADQHTVTIEDLEPGKKYKF 3550
Cdd:smart00060    2 SPPS--NLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2883-2963 2.04e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 2.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2883 LTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPV 2957
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86

                   ....*.
gi 1622934685 2958 SVIRVT 2963
Cdd:cd00063     87 ESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3396-3456 2.33e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 2.33e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685  3396 LTVTDATPDSVGLSWTVPE-----GEFDSFVVQYKDKDGRLQVVPVAADQREVTVPGLEPSRKYKF 3456
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3028-3265 2.54e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.02  E-value: 2.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3028 VVRVGGEESEVTVGGLEPGRKYKMhlyglhegrRVGPVSAVGVTAPEDEAEATQavPTTTPEPPikprlGELTVTDATPD 3107
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYY---------RVAATDTGGESAPSNEVSVTT--PTTPPSAP-----TGLTATADTPG 247
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3108 SLSLSWT-VPEGQFDHFLVqYRNGDGQPKAVRVpGHEDGVTI--SGLEPDHKYK-----MNLYGFHGgqrvGPMSVIGVT 3179
Cdd:COG3401    248 SVTLSWDpVTESDATGYRV-YRSNSGDGPFTKV-ATVTTTSYtdTGLTNGTTYYyrvtaVDAAGNES----APSNVVSVT 321
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3180 VAEEETPSPTepsteapeppeepllgELTVAGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGQPQAVRVGGEESEVTVR 3257
Cdd:COG3401    322 TDLTPPAAPS----------------GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDT 385

                   ....*...
gi 1622934685 3258 GLEPGRKY 3265
Cdd:COG3401    386 GLTPGTTY 393
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3793-3869 2.78e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 2.78e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  3793 SPRDLQFSEIRETSAKVNWMPPPS-RADSFKVSYQLADGGEP---QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3868
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82

                    .
gi 1622934685  3869 S 3869
Cdd:smart00060   83 G 83
fn3 pfam00041
Fibronectin type III domain;
3597-3672 3.51e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.57  E-value: 3.51e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3597 LAVTDTAPDSMRLSWS---VAQGPFDSFVVQYEDTNGQ--PQALLVDGDQSKILISGLEPSTPYRFLLYGLHeGKRLGPL 3671
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN-GGGEGPP 84

                   .
gi 1622934685 3672 S 3672
Cdd:pfam00041   85 S 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
841-914 4.40e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 4.40e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685   841 DGPQDLRVVAVTPTTLELGWLRPQAE-----VDRFVVSYVSAGNQRVRLEVPPEADGTLLTDLMPGVEYVVTVTAERGR 914
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3088-3169 4.72e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 4.72e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3088 PEPPikprlGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLY 3162
Cdd:cd00063      1 PSPP-----TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                   ....*..
gi 1622934685 3163 GFHGGQR 3169
Cdd:cd00063     76 AVNGGGE 82
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1352-1644 4.78e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.25  E-value: 4.78e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1352 VVPVEGPQRSAVITSLDPGRKYKFVLYGFVGKKRhGPLVTEAKILPQSDPrPGTPprlGNLWVTDPTPDSLHLSWT-VPE 1430
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGE-SAPSNEVSVTTPTTP-PSAP---TGLTATADTPGSVTLSWDpVTE 258
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1431 GQFDTFMVqYRDKDGRPQVVPV-EGPERSFVVSSLDPDHKYRFTLFGIANKKRYGPL--TADGTTAPERkeePPRPESle 1507
Cdd:COG3401    259 SDATGYRV-YRSNSGDGPFTKVaTVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPsnVVSVTTDLTP---PAAPSG-- 332
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1508 qpllgeLTVTGVTPDSLRLSWT-VAQGPFDSFMVQYKDAQ-GQPQAVPVAGDENEVTVPGLDPDRKYKmnlYGLRGRQRV 1585
Cdd:COG3401    333 ------LTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGgGTYTKIAETVTTTSYTDTGLTPGTTYY---YKVTAVDAA 403
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685 1586 GPESvvaktAPQEDVDETPSPTelgTEAPEPSEEPLLGELTVTGSSPDSLSLSWTVPQG 1644
Cdd:COG3401    404 GNES-----APSEEVSATTASA---ASGESLTASVDAVPLTDVAGATAAASAASNPGVS 454
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
763-928 4.99e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.25  E-value: 4.99e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  763 TTVRTEWTPAPGP-VDAYEIQFIPTTEGaspPFTARVPSSASAYDQRGLAPGQEYQVTVRAL--RGTSWGPPASKTITTM 839
Cdd:COG3401    247 GSVTLSWDPVTESdATGYRVYRSNSGDG---PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdaAGNESAPSNVVSVTTD 323
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  840 I---DGPQDLRVVAVTPTTLELGW-LRPQAEVDRFVVsYVSAGNQRVRLEVPPEADGTLLTD--LMPGVEYVVTVTA--E 911
Cdd:COG3401    324 LtppAAPSGLTATAVGSSSITLSWtASSDADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDtgLTPGTTYYYKVTAvdA 402
                          170
                   ....*....|....*..
gi 1622934685  912 RGRAVSYPASVRANTAP 928
Cdd:COG3401    403 AGNESAPSEEVSATTAS 419
fn3 pfam00041
Fibronectin type III domain;
1919-1986 5.04e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 5.04e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934685 1919 GAPPRLGelwVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQV---VPVEGHERSVTIAPLDAGRKYRF 1986
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEV 71
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2812-3113 5.62e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.25  E-value: 5.62e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2812 VVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGQRLGPVSAVGVTAPedeaettqaaptttPEPPIKPrlGELTVTDATPD 2891
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTP--------------TTPPSAP--TGLTATADTPG 247
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2892 SLSLSWT-VPEGQFDHFLVqYRNGDGQPKAVRVpGHEDGVTI--SGLEPDHKYK-----MNLYGFHGgqrvGPVSVIRVT 2963
Cdd:COG3401    248 SVTLSWDpVTESDATGYRV-YRSNSGDGPFTKV-ATVTTTSYtdTGLTNGTTYYyrvtaVDAAGNES----APSNVVSVT 321
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2964 AAEEETPAPTepsteapeppeepllgELTVTGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGRPQVVRVGGEESEVTVG 3041
Cdd:COG3401    322 TDLTPPAAPS----------------GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDT 385
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934685 3042 GLEPGRKYKmhlYglhegrRVGPVSAVGvtapeDEAEATQAVPTTTPEPPIKPRLGELTVTDATPDSLSLSW 3113
Cdd:COG3401    386 GLTPGTTYY---Y------KVTAVDAAG-----NESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATA 443
fn3 pfam00041
Fibronectin type III domain;
3970-4047 1.10e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3970 APRDLEAKEVTPRTALLTWTEPQVRP---TGYLLSFDTPGG--RTQEILLPGGVTSHQLLGLFPSTLYNARLQAMWGESL 4044
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81

                   ...
gi 1622934685 4045 LPP 4047
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2240-2320 1.17e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 1.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2240 LTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGRP--KAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPV 2314
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86

                   ....*.
gi 1622934685 2315 SAIGVT 2320
Cdd:cd00063     87 ESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3849-4039 1.23e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.09  E-value: 1.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3849 GLIPGARYEVTVVSVRGFEESEPLTGFL----TTVPDGPTQLRALNLTEGFAVLHWKPPQNP-VDTYDVQVTAPGAPPLQ 3923
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFT 277
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3924 AEAPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPAS--ITFTTGLE---APRDLEAKEVTPRTALLTWTE-PQVRPTG 3997
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTppaAPSGLTATAVGSSSITLSWTAsSDADVTG 357
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622934685 3998 YLLSFDT-PGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQAM 4039
Cdd:COG3401    358 YNVYRSTsGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV 400
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1625-1705 1.31e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 1.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1625 LTVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEGQRVGPV 1699
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86

                   ....*.
gi 1622934685 1700 SAVGVT 1705
Cdd:cd00063     87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1514-1594 1.69e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 1.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1514 LTVTGVTPDSLRLSWTVAQ---GPFDSFMVQYKDAQGQP--QAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGRQRVGP- 1587
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPs 86

                   ....*..
gi 1622934685 1588 ESVVAKT 1594
Cdd:cd00063     87 ESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2992-3071 2.31e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2992 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVS 3066
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87

                   ....*
gi 1622934685 3067 AVGVT 3071
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2020-2109 2.31e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2020 PPKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQP--QVVPVEGSLREVSVPGLDPAHRYKLLLYGL 2094
Cdd:cd00063      1 PSPPT---NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77
                           90
                   ....*....|....*
gi 1622934685 2095 HSGKRVGPISAVVIT 2109
Cdd:cd00063     78 NGGGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3969-4054 2.55e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3969 EAPRDLEAKEVTPRTALLTWTEPQ---VRPTGYLLSF-DTPGGRTQEI-LLPGGVTSHQLLGLFPSTLYNARLQAM--WG 4041
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYrEKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVngGG 81
                           90
                   ....*....|...
gi 1622934685 4042 ESlLPPVSTSFTT 4054
Cdd:cd00063     82 ES-PPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
750-838 2.55e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGASPPFTARVPSSASaYDQRGLAPGQEYQVTVRALRGT 826
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGG 80
                           90
                   ....*....|...
gi 1622934685  827 SWGPPA-SKTITT 838
Cdd:cd00063     81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3088-3162 2.76e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 2.76e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  3088 PEPPikprlGELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 3162
Cdd:smart00060    1 PSPP-----SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2349-2428 3.10e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2349 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEGRRVGPVS 2423
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87

                   ....*
gi 1622934685 2424 AVGVT 2428
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2556-2636 3.45e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2556 LTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQP--KTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGGQRVGPV 2630
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86

                   ....*.
gi 1622934685 2631 SAIGVT 2636
Cdd:cd00063     87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1719-1807 3.84e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.84e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1719 PLEPRlgELTVTDVTPNSVGLSWTVPE---GQFDSFMVQYKDKDGQP--QAVPVAADQQEVTIYNLEPERKYKMNMYGLH 1793
Cdd:cd00063      1 PSPPT--NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78
                           90
                   ....*....|....
gi 1622934685 1794 DGQRVGPLSVVIMT 1807
Cdd:cd00063     79 GGGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
2021-2104 4.67e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.49  E-value: 4.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2021 PKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQ--PQVVPVEGSLREVSVPGLDPAHRYKLLLYGlH 2095
Cdd:pfam00041    1 SAPS---NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQA-V 76

                   ....*....
gi 1622934685 2096 SGKRVGPIS 2104
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
1918-1986 5.62e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 5.62e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934685 1918 PGAPprlGELWVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQVVPVE---GHERSVTIAPLDAGRKYRF 1986
Cdd:cd00063      1 PSPP---TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEF 72
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
559-586 5.74e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 48.45  E-value: 5.74e-07
                           10        20
                   ....*....|....*....|....*...
gi 1622934685  559 CPGGCRGRGQCIDGRCVCEDGYSGEDCS 586
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3970-4038 5.81e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 5.81e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934685  3970 APRDLEAKEVTPRTALLTWTEPQVRP-----TGYLLSFDTPGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQA 4038
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitgyiVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2435-2524 6.57e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 6.57e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2435 PDAPlvkprlGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNL 2509
Cdd:cd00063      1 PSPP------TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRV 74
                           90
                   ....*....|....*
gi 1622934685 2510 YGFHGGQRMGPVSAV 2524
Cdd:cd00063     75 RAVNGGGESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2776-2838 6.90e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 6.90e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934685 2776 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLY 2838
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2875-2946 8.10e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 8.10e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934685  2875 PIKPRlgELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2946
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1625-1688 9.57e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 9.57e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685  1625 LTVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQAVRVGGEESEVTVGGLEPGHKYKMHLY 1688
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
249-275 9.64e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 9.64e-07
                           10        20
                   ....*....|....*....|....*..
gi 1622934685  249 CPRGCSQRGRCEDGRCVCDPGYTGEDC 275
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
311-337 9.64e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 9.64e-07
                           10        20
                   ....*....|....*....|....*..
gi 1622934685  311 CPRGCSQRGRCEDGRCVCDPGYTGEDC 337
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
PTZ00214 PTZ00214
high cysteine membrane protein Group 4; Provisional
254-669 9.69e-07

high cysteine membrane protein Group 4; Provisional


Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 55.31  E-value: 9.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  254 SQRGRCEDGRCVCDPGYTGedcGMRSCPRGCSQRGRCENGRCvcNPGYTGEDCgvRSCPRGCSQrgrceDGRCVCDPGYT 333
Cdd:PTZ00214   341 SKNDDNNGDGYLCGDATNG---GVSGCATCGYNSGAVTCTRC--SAGYLGVDG--KSCSESCSG-----DTRGVCTKVAE 408
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  334 GEDCGTRSCRwdcgeggrcvdgrCVCWPGYTGEDCSTRTCPRDCrgrGRCEDGE---C-ICDTGYSGDDCGVRSCPGDCN 409
Cdd:PTZ00214   409 GSESTEVSCR-------------CVCKPTFYNSSGTCTPCTDSC---AVCKDGTptgCqQCSPGKILEFSIVSSESADCV 472
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  410 QRGRCEDGRCVCwpGYTgLDcGSRACPRDCRGRGRCENGVCVCNagySGEDCGVRSCPG----DCRGRGRCESGRCVCWP 485
Cdd:PTZ00214   473 DQCSVGSECAEC--GIT-ID-GSRYCTRCKDASTYPFNGVCIPN---TQRDAYCTSTANgactTCSGAAFLMNGGCYTTE 545
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  486 GYTGRDCGTRACPGDC----RGRGRCVDGRCV-CNP---GFTGEDCGS-RRCPGDC-------RGHGSCED-GVCVcDAG 548
Cdd:PTZ00214   546 HYPGSTICDKQSNGKCtttkKGYGISPDGKLLeCDPtclACTAPGPGRcTRCPSDKllkrasgAATGSCVDpGACV-DGY 624
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  549 YSGEDCSTRSCPGGCRGRG------QCIDGRCVCEDGYSgedcsvrrCPNDCSQHGVCQD---GVCICW------EAYVG 613
Cdd:PTZ00214   625 YADGDACLPCATPGCKTCGhasfctECAGELFVSLDGQS--------CLEECTGDKVVGEvsgGVRRCWcergflPALDR 696
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685  614 EDCSIRT-CPSNCHGRGRCEE-GRCL-CDPGYTGPTCATRMCPADCRGRGRCVQGVCMC 669
Cdd:PTZ00214   697 SGCVLPTeCPPDMPSCAACDEsGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2240-2303 9.85e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 9.85e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685  2240 LTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2303
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
373-399 1.09e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 1.09e-06
                           10        20
                   ....*....|....*....|....*..
gi 1622934685  373 CPRDCRGRGRCEDGECICDTGYSGDDC 399
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2664-2744 1.13e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 1.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2664 LTVTGSSPDSLSLSWTIPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEGRRVGPV 2738
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86

                   ....*.
gi 1622934685 2739 SAVGVT 2744
Cdd:cd00063     87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3208-3284 1.42e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 1.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3208 TVAGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGQP--QAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEGRRVGPVS 3282
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87

                   ..
gi 1622934685 3283 AV 3284
Cdd:cd00063     88 SV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1514-1577 1.61e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 1.61e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685  1514 LTVTGVTPDSLRLSWT-----VAQGPFDSFMVQYKDAQGQPQAVPVAGDENEVTVPGLDPDRKYKMNLY 1577
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1315-1473 1.78e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 54.24  E-value: 1.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1315 LTVTDRTSDSLLLRWT-VPEGEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVGKKRHGPLVTEA 1393
Cdd:COG3401    239 LTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVV 318
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1394 KILPQSDPrPGTPprlGNLWVTDPTPDSLHLSWT-VPEGQFDTFMVqYRDK--DGRPQVVPVEGPERSFVVSSLDPDHKY 1470
Cdd:COG3401    319 SVTTDLTP-PAAP---SGLTATAVGSSSITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTY 393

                   ...
gi 1622934685 1471 RFT 1473
Cdd:COG3401    394 YYK 396
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2992-3054 2.33e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.33e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934685  2992 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 3054
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2776-2838 2.33e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.33e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934685  2776 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 2838
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2556-2619 3.25e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 3.25e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685  2556 LTMTDATPDSLSLSWTVPE-----GQFDHFLVQYKNGDGQPKTTRVPGHEDRVTISGLEPDHKYKMNLY 2619
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2349-2411 3.41e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 3.41e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934685  2349 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGNKYKMHLY 2411
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3694-3769 3.41e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 3.41e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934685  3694 SQLSVTDVTTSSLRLNWEAPPGA-FDSFLLRFgvpspsTLEPHPRPLLQRELMVPGTRHSAVLRDLRPGTLYSLTLY 3769
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDgITGYIVGY------RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
314-418 3.45e-06

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 49.76  E-value: 3.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  314 GCSQRG-RCEDGRCVC-----DPGYTGEDCGtrSCRWDCGEGGRCVDGRCVCWPGYT--GEDC-STRTCPRDCRGRGR-- 382
Cdd:NF041328    13 GCPEPGaVCPEGLSVCggacvDLRSDPSNCG--ACGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAac 90
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1622934685  383 -----CEDGEC--ICDTGYS--GDDC-GVRSCPGDCNQRG-RCEDGR 418
Cdd:NF041328    91 apgqvCEGGACreACSEGLTrcGGACvDLATDPLHCGACGvACDPGE 137
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2435-2510 4.19e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 4.19e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  2435 PDAPlvkprlGEMTVRDATPDSLSLSWTVPE-----GQFDHFLVQYKNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNL 2509
Cdd:smart00060    1 PSPP------SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74

                    .
gi 1622934685  2510 Y 2510
Cdd:smart00060   75 R 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1918-1986 4.76e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 4.76e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934685  1918 PGAPPRLgelWVTDPTPDSLHLSWTVPE-GQFDSFVVQFKDKDGP-----QVVPVEGHERSVTIAPLDAGRKYRF 1986
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3597-3676 4.90e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 4.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3597 LAVTDTAPDSMRLSWSVAQ---GPFDSFVVQYEDTNGQP--QALLVDGDQSKILISGLEPSTPYRFLLYGLHEGKRlGPL 3671
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE-SPP 85

                   ....*
gi 1622934685 3672 SAEGT 3676
Cdd:cd00063     86 SESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
1719-1786 5.19e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 5.19e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685  1719 PLEPRlgELTVTDVTPNSVGLSWTVPE-----GQFDSFMVQYKDKDGQPQAVPVAADQQEVTIYNLEPERKYK 1786
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYE 71
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2664-2727 5.96e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 5.96e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685  2664 LTVTGSSPDSLSLSWTIPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGSLEPGNKYKMHLY 2727
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2020-2089 6.44e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 6.44e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934685  2020 PPKPRlgeELQVTSVTQNSVGLSWTVPE-----GQFDSFVVQYKDRDGQPQVVPVEGSLREVSVPGLDPAHRYKL 2089
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
594-703 7.88e-06

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 48.60  E-value: 7.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  594 CSQHG-VCQDGVCICWEAYVgedcSIRTCPSNCHGRG-------RCEEGRCLCDPGYT--GPTC-ATRMCPADCRGRGR- 661
Cdd:NF041328    14 CPEPGaVCPEGLSVCGGACV----DLRSDPSNCGACGvacgagqTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAa 89
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622934685  662 ------CVQGVCMCHVGYGGEDCGQ-------EEPPASACPGGCGPRELCQAGQC 703
Cdd:NF041328    90 capgqvCEGGACREACSEGLTRCGGacvdlatDPLHCGACGVACDPGESCRGGAC 144
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3208-3275 7.91e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 7.91e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934685  3208 TVAGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGQPQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3275
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2556-2757 1.16e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.54  E-value: 1.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2556 LTMTDATPDSLSLSWT-VPEGQFDHFLVQYKNGDGQPKTTRVPGHEDRVTISGLEPDHKYKmnlYGfhggqrvgpVSAIG 2634
Cdd:COG3401    239 LTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYY---YR---------VTAVD 306
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2635 vTAAEEETPSPTEPSTEAPEPSEEPLlgELTVTGSSPDSLSLSWT-IPQGRFDSFTVQYKDR-DGRPQVVRVGGEESEVT 2712
Cdd:COG3401    307 -AAGNESAPSNVVSVTTDLTPPAAPS--GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYT 383
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2713 VGSLEPGNKYK-----MHLYGLhEGRRVGPVSAVGVTAPREDVDETPSPT 2757
Cdd:COG3401    384 DTGLTPGTTYYykvtaVDAAGN-ESAPSEEVSATTASAASGESLTASVDA 432
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3303-3383 1.22e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 1.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3303 LTVAAVTSDSVGLSWTVAQ---GPFDSFLVQYRDTQGQP--QAVPVSGDLRAVTVSGLDPARKYKFLLFGlQNGKRHGP- 3376
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRA-VNGGGESPp 85

                   ....*...
gi 1622934685 3377 -VPVEART 3383
Cdd:cd00063     86 sESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3880-3966 1.45e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.34  E-value: 1.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3880 PDGPTQLRALNLTEGFAVLHWKPPQN---PVDTYDVQVTAPGAPPLQ--AEAPGSAVDYPLHDLVLHTNYTATVRGLRGP 3954
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDdggPITGYVVEYREKGSGDWKevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80
                           90
                   ....*....|...
gi 1622934685 3955 NLTSPA-SITFTT 3966
Cdd:cd00063     81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3597-3657 1.52e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 1.52e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685  3597 LAVTDTAPDSMRLSWS-----VAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPYRF 3657
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
280-306 1.72e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 44.21  E-value: 1.72e-05
                           10        20
                   ....*....|....*....|....*..
gi 1622934685  280 CPRGCSQRGRCENGRCVCNPGYTGEDC 306
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3303-3363 1.73e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.73e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685  3303 LTVAAVTSDSVGLSWT-----VAQGPFDSFLVQYRDTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3363
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
3883-3953 3.16e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 3.16e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 3883 PTQLRALNLTEGFAVLHWKPP---QNPVDTYDVQVTAPGAPPLQAE--APGSAVDYPLHDLVLHTNYTATVRGLRG 3953
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
3694-3769 3.52e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 3.52e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685 3694 SQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFGVPSPSTLEPHPRPllqrelmvPGTRHSAVLRDLRPGTLYSLTLY 3769
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT--------PGSETSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
528-555 6.03e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 42.67  E-value: 6.03e-05
                           10        20
                   ....*....|....*....|....*...
gi 1622934685  528 CPGDCRGHGSCEDGVCVCDAGYSGEDCS 555
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
625-647 6.47e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 42.33  E-value: 6.47e-05
                           10        20
                   ....*....|....*....|....*
gi 1622934685  625 CHGRGRCE--EGRCLCDPGYTGPTC 647
Cdd:pfam07974    2 CSGRGTCVnqCGKCVCDSGYQGATC 26
fn3 pfam00041
Fibronectin type III domain;
2132-2202 7.04e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 7.04e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934685 2132 GELTVEEATPHTLHLSWM---VTEGEFDSFEI--QHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLYGFHDG 2202
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVeyRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
PTZ00214 PTZ00214
high cysteine membrane protein Group 4; Provisional
266-577 9.49e-05

high cysteine membrane protein Group 4; Provisional


Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 48.76  E-value: 9.49e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  266 CDPGYTGEDCgmRSCPRGCS--QRGRCE-----------NGRCVCNPGYTGEDCGVRSCPRGCSQrgrCEDGR---C-VC 328
Cdd:PTZ00214   379 CSAGYLGVDG--KSCSESCSgdTRGVCTkvaegsestevSCRCVCKPTFYNSSGTCTPCTDSCAV---CKDGTptgCqQC 453
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  329 DPGYTGE---------DCGTR-SCRWDCGEGGRCVDG-----RC----------VCWPGyTGED--CSTR---TCPRdCR 378
Cdd:PTZ00214   454 SPGKILEfsivssesaDCVDQcSVGSECAECGITIDGsryctRCkdastypfngVCIPN-TQRDayCTSTangACTT-CS 531
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  379 GRGRCEDGECICDTGYSGDDCGVRSCPGDCNQR----GRCEDGRCV-CWPgyTGLDCGSRA------CPRDC---RGRGr 444
Cdd:PTZ00214   532 GAAFLMNGGCYTTEHYPGSTICDKQSNGKCTTTkkgyGISPDGKLLeCDP--TCLACTAPGpgrctrCPSDKllkRASG- 608
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  445 CENGVCV----CNAGY--SGEDCGVRSCPGdCRGRGrcESGRCVCWPGYTGRDCGTRACPGDCRGR---GRCVDG--RCV 513
Cdd:PTZ00214   609 AATGSCVdpgaCVDGYyaDGDACLPCATPG-CKTCG--HASFCTECAGELFVSLDGQSCLEECTGDkvvGEVSGGvrRCW 685
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622934685  514 CNPGF-----TGEDCGSRRCPGDCRGHGSC-EDGVCV-CDAGYSGEDCSTRSCPGGCRGRGQCIDGRCVCE 577
Cdd:PTZ00214   686 CERGFlpaldRSGCVLPTECPPDMPSCAACdESGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMCE 756
fn3 pfam00041
Fibronectin type III domain;
1083-1161 1.09e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 1.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1083 APRHPKPEVLGSSAdgaLLVS---LDGLRGQFERVVLRWRPQPpAEGPGGELTVPGTTRTVSLPDLRPGTTYHVEVHGVR 1159
Cdd:pfam00041    2 APSNLTVTDVTSTS---LTVSwtpPPDGNGPITGYEVEYRPKN-SGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77

                   ..
gi 1622934685 1160 AG 1161
Cdd:pfam00041   78 GG 79
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
497-523 1.23e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.90  E-value: 1.23e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934685  497 CPGDCRGRGRCVDGRCVCNPGFTGEDC 523
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
500-523 1.59e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 41.18  E-value: 1.59e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934685  500 DCRGRGRCVD--GRCVCNPGFTGEDC 523
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
590-617 1.74e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.52  E-value: 1.74e-04
                           10        20
                   ....*....|....*....|....*...
gi 1622934685  590 CPNDCSQHGVCQDGVCICWEAYVGEDCS 617
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
3880-3949 1.90e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 1.90e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934685  3880 PDGPTQLRALNLTEGFAVLHWKPPQNP-----VDTYDVQVTAPGAPPLQAEAPGSAVDYPLHDLVLHTNYTATVR 3949
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
469-492 2.10e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 41.18  E-value: 2.10e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934685  469 DCRGRGRCES--GRCVCWPGYTGRDC 492
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
531-554 2.20e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 2.20e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934685  531 DCRGHGSCED--GVCVCDAGYSGEDC 554
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1696-2064 2.33e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 47.30  E-value: 2.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1696 VGPVSAVGVTAPQQEETPPATKPPLEPRLGELTVTDVTPNSVGLSWTVPEGQFDSFMVQYKDKDGQPQAVPVAADQQEVT 1775
Cdd:COG3401     43 VLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAV 122
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1776 IYNLEPERKYKMNMYGLHDGQRVGPLSVVIMTAPLPPAPATEASEPPLEPRLGELTVTDVTPDSVGLSWTVPEGefdsfv 1855
Cdd:COG3401    123 GTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGG------ 196
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1856 vqykdrdgqpqvvpvaadqrevtiPGLEPSRKYKFLLFGIQDGKRRSP---VSVEAKTAArgdasPGAPprlGELWVTDP 1932
Cdd:COG3401    197 ------------------------GDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTP-----PSAP---TGLTATAD 244
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 1933 TPDSLHLSWT-VPEGQFDSFVV-QFKDKDGPQVVPVEGHERSVTIAPLDAGRKYRFLLYGLlgkkrhgplTADGTTEARS 2010
Cdd:COG3401    245 TPGSVTLSWDpVTESDATGYRVyRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAV---------DAAGNESAPS 315
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934685 2011 AMDD--TGTKRPPKPrlgEELQVTSVTQNSVGLSWT-VPEGQFDSFVVQYKDRDGQP 2064
Cdd:COG3401    316 NVVSvtTDLTPPAAP---SGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
221-244 2.93e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 2.93e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934685  221 DCQGRGRCVQ--GVCVCRAGFSGPDC 244
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
284-306 3.02e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.02e-04
                           10        20
                   ....*....|....*....|....*
gi 1622934685  284 CSQRGRCEN--GRCVCNPGYTGEDC 306
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
750-829 3.13e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 3.13e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685   750 PAIEGMRMHLLEETTVRTEWTPAPGP-VDAYEIQFIPTTEGASPPF-TARVPSSASAYDQRGLAPGQEYQVTVRALRGTS 827
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81

                    ..
gi 1622934685   828 WG 829
Cdd:smart00060   82 EG 83
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
563-585 3.63e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.63e-04
                           10        20
                   ....*....|....*....|....*
gi 1622934685  563 CRGRGQCID--GRCVCEDGYSGEDC 585
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
438-461 3.67e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.67e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934685  438 DCRGRGRCEN--GVCVCNAGYSGEDC 461
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
315-337 3.78e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.78e-04
                           10        20
                   ....*....|....*....|....*
gi 1622934685  315 CSQRGRCED--GRCVCDPGYTGEDC 337
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
253-275 3.78e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.78e-04
                           10        20
                   ....*....|....*....|....*
gi 1622934685  253 CSQRGRCED--GRCVCDPGYTGEDC 275
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
376-399 3.97e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.97e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934685  376 DCRGRGRCED--GECICDTGYSGDDC 399
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
279-414 4.38e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 43.59  E-value: 4.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  279 SCPRGCSqrgRCeNGRCVCNPGyTGEDCGvrSCPRGCSQRGRCEDGRCVCDPGytGEDCG-----TRSCRWDCGE-GGRC 352
Cdd:NF041328    20 VCPEGLS---VC-GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHCGAcGAAC 90
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934685  353 VDGRcVCWPGYTGEDCSTrtcprdcrGRGRCeDGECI---CDTGYSGdDCGVRSCPGDCNQRGRC 414
Cdd:NF041328    91 APGQ-VCEGGACREACSE--------GLTRC-GGACVdlaTDPLHCG-ACGVACDPGESCRGGAC 144
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
435-461 4.92e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.97  E-value: 4.92e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934685  435 CPRDCRGRGRCENGVCVCNAGYSGEDC 461
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
191-295 5.10e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 43.21  E-value: 5.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  191 CNDQGRCVRGRCVCFPGYTgpSCGwpscpgdcqgrGRCVQ--------GVC--VCRAGFSgpdCSQRSCPRGCSQ-RGRC 259
Cdd:NF041328    49 CGAGQTCVAGACGCGPGTV--ACG-----------GACVDtasdpahcGACgaACAPGQV---CEGGACREACSEgLTRC 112
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1622934685  260 eDGRCV---CDPGYTGEdCGmRSCPRGCSqrgrCENGRC 295
Cdd:NF041328   113 -GGACVdlaTDPLHCGA-CG-VACDPGES----CRGGAC 144
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
719-745 5.17e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.97  E-value: 5.17e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934685  719 CPGDCRGRGECHDGSCICKDGYAGEDC 745
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
2134-2197 5.86e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 5.86e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934685  2134 LTVEEATPHTLHLSWM-----VTEGEFDSFEIQHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLY 2197
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
190-213 6.23e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.64  E-value: 6.23e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934685  190 DCNDQGRCVR--GRCVCFPGYTGPSC 213
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
492-590 6.73e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.82  E-value: 6.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  492 CGtrACPGDCRGRGRCVDGRCVCNPGFT--GEDCGSRR--------CPGDCRGHGSCEDGVC--VCDAGYsgEDCStRSC 559
Cdd:NF041328    42 CG--ACGVACGAGQTCVAGACGCGPGTVacGGACVDTAsdpahcgaCGAACAPGQVCEGGACreACSEGL--TRCG-GAC 116
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1622934685  560 PGGCRGRGQCidGRC--VCEDgysGEDCSVRRC 590
Cdd:NF041328   117 VDLATDPLHC--GACgvACDP---GESCRGGAC 144
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
407-430 8.37e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.25  E-value: 8.37e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934685  407 DCNQRGRCED--GRCVCWPGYTGLDC 430
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
218-245 8.87e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.20  E-value: 8.87e-04
                           10        20
                   ....*....|....*....|....*...
gi 1622934685  218 CPGDCQGRGRCVQGVCVCRAGFSGPDCS 245
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
416-543 1.00e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.44  E-value: 1.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  416 DGRCVCWPGyTGLDCGsrACPRDCRGRGRCENGVCVCNAGysGEDCG-----VRSCPGDCrgrGRCESgrcVCWPGYTgr 490
Cdd:NF041328    29 GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHC---GACGA---ACAPGQV-- 95
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622934685  491 dCGTRACPGDC-RGRGRCvDGRCVcNPGFTGEDCGSrrCPGDCRGHGSCEDGVC 543
Cdd:NF041328    96 -CEGGACREACsEGLTRC-GGACV-DLATDPLHCGA--CGVACDPGESCRGGAC 144
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2240-2438 1.09e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.99  E-value: 1.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2240 LTVTDATPDSLSLSWT-VPEGQFDHFLVQYRN-GDGRPKAV-RVPGHEdgVTISGLEPDHKYK-----MNLYGFHGgqrv 2311
Cdd:COG3401    239 LTATADTPGSVTLSWDpVTESDATGYRVYRSNsGDGPFTKVaTVTTTS--YTDTGLTNGTTYYyrvtaVDAAGNES---- 312
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2312 GPVSAIGVTAAEEETPSPTepsteapeppeepllgELTVTGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGRPQVVRVG 2389
Cdd:COG3401    313 APSNVVSVTTDLTPPAAPS----------------GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAET 376
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622934685 2390 GEESEVTVGGLEPGNKYK-----MHLYGLhEGRRVGPVSAVGVTAPKEESPDAP 2438
Cdd:COG3401    377 VTTTSYTDTGLTPGTTYYykvtaVDAAGN-ESAPSEEVSATTASAASGESLTAS 429
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3528-3716 1.50e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.61  E-value: 1.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3528 VPVAADQHTVTIEDLEPGKKYKFLLYGLVGGKRLGPVSALGMTAPEEDTPAPElaseapeppeeprlgVLAVTDTAPDSM 3607
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT---------------GLTATADTPGSV 249
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3608 RLSWS-VAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPYRFLLYGLHEGKRLGPLS--AEGTTGPAPAGQ 3684
Cdd:COG3401    250 TLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTPPAA 329
                          170       180       190
                   ....*....|....*....|....*....|..
gi 1622934685 3685 TSGepgprlsqLSVTDVTTSSLRLNWEAPPGA 3716
Cdd:COG3401    330 PSG--------LTATAVGSSSITLSWTASSDA 353
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
4090-4104 1.67e-03

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 39.08  E-value: 1.67e-03
                           10
                   ....*....|....*
gi 1622934685 4090 PLNVFCDMETDGGGW 4104
Cdd:NF040941    29 PFQVYCDMTTDGGGW 43
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
2885-3157 1.77e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 44.55  E-value: 1.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2885 VTDATPDSLSLSWTVPEGQFDHFLVQYRNGDgqpkAVRVPGHEDGV----TISGLEPDHKYKMnLYGFHGGQRVGPVSVi 2960
Cdd:COG4733    431 PVTMEAGDRYLRVRLPDGTSVARTVQSVAGR----TLTVSTAYSETpeagAVWAFGPDELETQ-LFRVVSIEENEDGTY- 504
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 2961 RVTAAE--------EETPAPTEPSTEAPEPPEEPLLGELTVT-GSSPDSLSLSWTVPQGRFdSFTVQYkdRDGRPQVVRV 3031
Cdd:COG4733    505 TITAVQhapekyaaIDAGAFDDVPPQWPPVNVTTSESLSVVAqGTAVTTLTVSWDAPAGAV-AYEVEW--RRDDGNWVSV 581
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685 3032 GG-EESEVTVGGLEPGRkYKMhlyglhegrRVGPVSAVGV-TAPEDEAEATQAVPTTTPEPPikprlGELTVTdATPDSL 3109
Cdd:COG4733    582 PRtSGTSFEVPGIYAGD-YEV---------RVRAINALGVsSAWAASSETTVTGKTAPPPAP-----TGLTAT-GGLGGI 645
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622934685 3110 SLSWTVPEG-QFDHFLVQYRNGDGQPKAV----RVPGHEdgVTISGLEPDHKY 3157
Cdd:COG4733    646 TLSWSFPVDaDTLRTEIRYSTTGDWASATvaqaLYPGNT--YTLAGLKAGQTY 696
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
2134-2202 2.10e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.17  E-value: 2.10e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934685 2134 LTVEEATPHTLHLSWMV---TEGEFDSFEIQHTDR-EGQLQTVRTG-GDRNDITLSGLESDHRYLVTLYGFHDG 2202
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKgSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAVNGG 80
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
345-368 2.83e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 2.83e-03
                           10        20
                   ....*....|....*....|....*.
gi 1622934685  345 DCGEGGRCVD--GRCVCWPGYTGEDC 368
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
652-678 2.83e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.05  E-value: 2.83e-03
                           10        20
                   ....*....|....*....|....*..
gi 1622934685  652 CPADCRGRGRCVQGVCMCHVGYGGEDC 678
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
621-648 3.15e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.66  E-value: 3.15e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622934685  621 CPSNCHGRGRCEEGRCLCDPGYTGPTCA 648
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
404-430 5.10e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.28  E-value: 5.10e-03
                           10        20
                   ....*....|....*....|....*..
gi 1622934685  404 CPGDCNQRGRCEDGRCVCWPGYTGLDC 430
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EB pfam01683
EB module; This domain has no known function. It is found in several C. elegans proteins. The ...
599-643 5.54e-03

EB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains pfam00014.


Pssm-ID: 460294  Cd Length: 52  Bit Score: 37.79  E-value: 5.54e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622934685  599 VCQDGVCIcWEAYVGEDCSIrtcPSNCHGRGRCEEGRCLCDPGYT 643
Cdd:pfam01683    6 VLVNGQCV-PKVAPGESCEA---DEQCPGGSVCVNGVCQCPPGFT 46
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
342-369 7.05e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.89  E-value: 7.05e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622934685  342 CRWDCGEGGRCVDGRCVCWPGYTGEDCS 369
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
191-348 8.44e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 40.16  E-value: 8.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934685  191 CNDQGRCvrGRCVCFPGYTGPSCGWPSCPGDCQGRGRCVQGVCvCRAgFSGPDCSQRSCPRGCSQRGRCEDGRCVCDPGY 270
Cdd:pfam01500   14 CSTGGTC--GSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSC-CRP-TCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQ 89
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934685  271 TGEDCGMRSCPRGCSQRGRCENgrcVCNPGYtgedCGVRSCPRGCSQRGRCEdGRCvCDPGYTGEDCGTRSCRWDCGE 348
Cdd:pfam01500   90 EGSSGAVSSRTRWCRPDCRVEG---TCLPPC----CVVSCTPPTCCQLHHAQ-ASC-CRPSYCGQSCCRPACCCQCSE 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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