NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622934675|ref|XP_028703530|]
View 

tenascin-X isoform X2 [Macaca mulatta]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
4174-4383 4.69e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


:

Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 370.31  E-value: 4.69e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4174 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNIS-GEFWLGN 4252
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4253 EALHSLTQAGDYSMRVDLRAG-DEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 4324
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934675 4325 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYYWKGFEFSVPFTEMKLRPR 4383
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
fn3 pfam00041
Fibronectin type III domain;
3906-3984 1.73e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 1.73e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3906 SPRDLQFSEIRETSAKVNWMPPPSRA---DSFKVSYQLADGGEP-QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3981
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934675 3982 SEP 3984
Cdd:pfam00041   82 GPP 84
fn3 pfam00041
Fibronectin type III domain;
3207-3280 5.74e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.74e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 3207 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 3280
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2991-3064 5.74e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.74e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 2991 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 3064
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2775-2848 5.74e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.74e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 2775 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2848
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2448-2521 7.40e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 7.40e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 2448 PRLGELTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGG 2521
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2135-2205 7.84e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 7.84e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 2135 GELTVTDATPDSLSLSWTVPE---GQFDHFLVQYR--NGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2205
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
3454-3818 1.36e-11

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.80  E-value: 1.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3454 VPVSGDLRAVTVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAPDTKLSPRLGeLTVTDATPDSVGLSWT-VPEGEFDS 3532
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG-LTATADTPGSVTLSWDpVTESDATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3533 FVVQYK-DKDGRLQVVpVAADQREVTVPGLEPSRKYKFLLYGLAGRKRMGPISaDGTTASLEKEPPPRLGELTVTEETSS 3611
Cdd:COG3401    264 YRVYRSnSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPS-NVVSVTTDLTPPAAPSGLTATAVGSS 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3612 SLHLSWT-VAQGPFESFVVqYRDT--DGQPRAVPVAADQHTVTIEDLEPGKKYKFLlyglvggkrlgpVSALGmTAPEED 3688
Cdd:COG3401    342 SITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTYYYK------------VTAVD-AAGNES 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3689 TPAPELASEAPEPPEEPRLGVLAVTDTAPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPY 3768
Cdd:COG3401    408 APSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTA 487

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3769 RFLLYGLHEGKRLGPLSAEGTTGPAPAGQTSGEPGPRLSQLSVTDVTTSS 3818
Cdd:COG3401    488 NLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVT 537
fn3 pfam00041
Fibronectin type III domain;
1308-1388 2.90e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1308 GPPRlgELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQ--PQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVG 1382
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 1622934675 1383 KKRHGP 1388
Cdd:pfam00041   79 GGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
2339-2412 4.81e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 4.81e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 2339 PRLGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2412
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1512-1589 6.20e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 6.20e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1512 GELTVTGVTPDSLRLSWT---VAQGPFDSFMVQYKDAQGQ--PQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGrQRVG 1586
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG-GGEG 82


                   ...
gi 1622934675 1587 PES 1589
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
750-831 7.32e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 7.32e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGaSPPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGT 826
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 1622934675  827 SWGPP 831
Cdd:pfam00041   80 GEGPP 84
fn3 pfam00041
Fibronectin type III domain;
843-919 1.48e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.12  E-value: 1.48e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  843 PQDLRVVAVTPTTLELGWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPPEADGTLLTDLMPGVEYVVTVTAERGRAVS 917
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 1622934675  918 YP 919
Cdd:pfam00041   83 PP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1406-1485 2.68e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 2.68e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1406 PPRLGNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDGRP--QVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1480
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NG 79


                   ....*
gi 1622934675 1481 KRYGP 1485
Cdd:cd00063     80 GGESP 84
fn3 pfam00041
Fibronectin type III domain;
3804-3886 9.81e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.81  E-value: 9.81e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3804 PRLSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFgvpSPSTLEPHPRpllqrELMVPGTRHSAVLRDLRPGTLYSLT 3880
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEY---RPKNSGEPWN-----EITVPGTTTSVTLTGLKPGTEYEVR 72


                   ....*.
gi 1622934675 3881 LYGLRG 3886
Cdd:pfam00041   73 VQAVNG 78
fn3 pfam00041
Fibronectin type III domain;
2889-2956 1.70e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.70e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 2889 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2956
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3105-3172 1.70e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.70e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 3105 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 3172
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2673-2740 1.70e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.70e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 2673 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2740
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3321-3388 1.80e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 1.80e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 3321 TVAGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDGQ--PQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3388
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1623-1693 2.25e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 2.25e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 1623 GELTVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEG 1693
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1722-1802 5.63e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.88  E-value: 5.63e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1722 PRLGELTVTDVTPNSVGLSWTVPE---GQFDSFMVQYKDKDGQ--PQAVPVAADQQEVTIYNLEPERKYKMNMYGLHdGQ 1796
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN-GG 79


                   ....*.
gi 1622934675 1797 RVGPLS 1802
Cdd:pfam00041   80 GEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
2559-2629 8.08e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 8.08e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 2559 GELTVTGSSPDSLSLSWTIP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEG 2629
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2246-2313 1.05e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 1.05e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 2246 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEG 2313
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3414-3476 1.23e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 1.23e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934675 3414 GELTVAAVTSDSVGLSWT---VAQGPFDSFLVQYR--DTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3476
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
1816-1883 5.43e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.80  E-value: 5.43e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934675 1816 GAPPRLGelwVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQV---VPVEGHERSVTIAPLDAGRKYRF 1883
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
4083-4160 1.28e-07

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 1.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4083 APRDLEAKEVTPRTALLTWTEPQVRP---TGYLLSFDTPGG--RTQEILLPGGVTSHQLLGLFPSTLYNARLQAMWGESL 4157
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934675 4158 LPP 4160
Cdd:pfam00041   82 GPP 84
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
3962-4152 1.50e-07

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.70  E-value: 1.50e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3962 GLIPGARYEVTVVSVRGFEESEPLTGFL----TTVPDGPTQLRALNLTEGFAVLHWKPPQNP-VDTYDVQVTAPGAPPLQ 4036
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4037 AEAPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPAS--ITFTTGLE---APRDLEAKEVTPRTALLTWTE-PQVRPTG 4110
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTppaAPSGLTATAVGSSSITLSWTAsSDADVTG 357

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622934675 4111 YLLSFDT-PGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQAM 4152
Cdd:COG3401    358 YNVYRSTsGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV 400
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1917-2006 2.49e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1917 PPKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQP--QVVPVEGSLREVSVPGLDPAHRYKLLLYGL 1991
Cdd:cd00063      1 PSPPT---NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*
gi 1622934675 1992 HSGKRVGPISAVVIT 2006
Cdd:cd00063     78 NGGGESPPSESVTVT 92
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 559-586 4.79e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 48.45  E-value: 4.79e-07
                           10        20
                   ....*....|....*....|....*...
gi 1622934675  559 CPGGCRGRGQCIDGRCVCEDGYSGEDCS 586
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
PTZ00214 super family cl31756
high cysteine membrane protein Group 4; Provisional
 254-669 6.81e-07

high cysteine membrane protein Group 4; Provisional


The actual alignment was detected with superfamily member PTZ00214:

Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 55.69  E-value: 6.81e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  254 SQRGRCEDGRCVCDPGYTGedcGMRSCPRGCSQRGRCENGRCvcNPGYTGEDCgvRSCPRGCSQrgrceDGRCVCDPGYT 333
Cdd:PTZ00214   341 SKNDDNNGDGYLCGDATNG---GVSGCATCGYNSGAVTCTRC--SAGYLGVDG--KSCSESCSG-----DTRGVCTKVAE 408

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  334 GEDCGTRSCRwdcgeggrcvdgrCVCWPGYTGEDCSTRTCPRDCrgrGRCEDGE---C-ICDTGYSGDDCGVRSCPGDCN 409
Cdd:PTZ00214   409 GSESTEVSCR-------------CVCKPTFYNSSGTCTPCTDSC---AVCKDGTptgCqQCSPGKILEFSIVSSESADCV 472

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  410 QRGRCEDGRCVCwpGYTgLDcGSRACPRDCRGRGRCENGVCVCNagySGEDCGVRSCPG----DCRGRGRCESGRCVCWP 485
Cdd:PTZ00214   473 DQCSVGSECAEC--GIT-ID-GSRYCTRCKDASTYPFNGVCIPN---TQRDAYCTSTANgactTCSGAAFLMNGGCYTTE 545

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  486 GYTGRDCGTRACPGDC----RGRGRCVDGRCV-CNP---GFTGEDCGS-RRCPGDC-------RGHGSCED-GVCVcDAG 548
Cdd:PTZ00214   546 HYPGSTICDKQSNGKCtttkKGYGISPDGKLLeCDPtclACTAPGPGRcTRCPSDKllkrasgAATGSCVDpGACV-DGY 624

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  549 YSGEDCSTRSCPGGCRGRG------QCIDGRCVCEDGYSgedcsvrrCPNDCSQHGVCQD---GVCICW------EAYVG 613
Cdd:PTZ00214   625 YADGDACLPCATPGCKTCGhasfctECAGELFVSLDGQS--------CLEECTGDKVVGEvsgGVRRCWcergflPALDR 696

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675  614 EDCSIRT-CPSNCHGRGRCEE-GRCL-CDPGYTGPTCATRMCPADCRGRGRCVQGVCMC 669
Cdd:PTZ00214   697 SGCVLPTeCPPDMPSCAACDEsGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755
fn3 pfam00041
Fibronectin type III domain;
2029-2099 7.89e-05

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 7.89e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 2029 GELTVEEATPHTLHLSWM---VTEGEFDSFEI--QHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLYGFHDG 2099
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVeyRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1083-1161 1.23e-04

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 1.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1083 APRHPKPEVLGSSAdgaLLVS---LDGLRGQFERVVLRWRPQPpAEGPGGELTVPGTTRTVSLPDLRPGTTYHVEVHGVR 1159
Cdd:pfam00041    2 APSNLTVTDVTSTS---LTVSwtpPPDGNGPITGYEVEYRPKN-SGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ..
gi 1622934675 1160 AG 1161
Cdd:pfam00041   78 GG 79
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 221-244 2.81e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 2.81e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934675  221 DCQGRGRCVQ--GVCVCRAGFSGPDC 244
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 719-745 4.58e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 40.36  E-value: 4.58e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934675  719 CPGDCRGRGECHDGSCICKDGYAGEDC 745
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 190-213 6.09e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.64  E-value: 6.09e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934675  190 DCNDQGRCVR--GRCVCFPGYTGPSC 213
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
4174-4383 4.69e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 370.31  E-value: 4.69e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4174 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNIS-GEFWLGN 4252
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4253 EALHSLTQAGDYSMRVDLRAG-DEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 4324
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934675 4325 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYYWKGFEFSVPFTEMKLRPR 4383
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 4174-4383 2.92e-112

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 356.20  E-value: 2.92e-112
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  4174 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNE 4253
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  4254 ALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-SMSYHSGSVFSARDRDPNNLLISCA 4331
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEdWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1622934675  4332 VSYRGAWWYRNCHYANLNGLYGS-TVDHQGVSWYYWKGFEFSVPFTEMKLRPR 4383
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYPnNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 4173-4383 3.09e-110

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 350.77  E-value: 3.09e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4173 PFPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGN 4252
Cdd:cd00087      1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4253 EALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNNLLISCA 4331
Cdd:cd00087     80 EKIHLLTSQGPYELRIDLEdWEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 4332 VSYRGAWWYRNCHYANLNGLYGSTVDHQ----GVSWYYWKGFEFSVPFTEMKLRPR 4383
Cdd:cd00087    160 ESYSGGWWYNSCHASNLNGRYYSGGHRNeydnGINWATWKGSTYSLKFTEMKIRPK 215
fn3 pfam00041
Fibronectin type III domain;
3906-3984 1.73e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 1.73e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3906 SPRDLQFSEIRETSAKVNWMPPPSRA---DSFKVSYQLADGGEP-QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3981
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934675 3982 SEP 3984
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3907-3986 5.33e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 5.33e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3907 PRDLQFSEIRETSAKVNWMPPP---SRADSFKVSYQLADGGEPQSVQVDGRARTQ-KLQGLIPGARYEVTVVSVRGFEES 3982
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGES 83


                   ....
gi 1622934675 3983 EPLT 3986
Cdd:cd00063     84 PPSE 87
fn3 pfam00041
Fibronectin type III domain;
3207-3280 5.74e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.74e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 3207 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 3280
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2991-3064 5.74e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.74e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 2991 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 3064
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2775-2848 5.74e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.74e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 2775 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2848
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2448-2521 7.40e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 7.40e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 2448 PRLGELTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGG 2521
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2135-2205 7.84e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 7.84e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 2135 GELTVTDATPDSLSLSWTVPE---GQFDHFLVQYR--NGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2205
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3454-3818 1.36e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.80  E-value: 1.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3454 VPVSGDLRAVTVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAPDTKLSPRLGeLTVTDATPDSVGLSWT-VPEGEFDS 3532
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG-LTATADTPGSVTLSWDpVTESDATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3533 FVVQYK-DKDGRLQVVpVAADQREVTVPGLEPSRKYKFLLYGLAGRKRMGPISaDGTTASLEKEPPPRLGELTVTEETSS 3611
Cdd:COG3401    264 YRVYRSnSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPS-NVVSVTTDLTPPAAPSGLTATAVGSS 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3612 SLHLSWT-VAQGPFESFVVqYRDT--DGQPRAVPVAADQHTVTIEDLEPGKKYKFLlyglvggkrlgpVSALGmTAPEED 3688
Cdd:COG3401    342 SITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTYYYK------------VTAVD-AAGNES 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3689 TPAPELASEAPEPPEEPRLGVLAVTDTAPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPY 3768
Cdd:COG3401    408 APSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTA 487

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3769 RFLLYGLHEGKRLGPLSAEGTTGPAPAGQTSGEPGPRLSQLSVTDVTTSS 3818
Cdd:COG3401    488 NLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVT 537
fn3 pfam00041
Fibronectin type III domain;
3596-3663 2.71e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.71e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 3596 PPPRlgELTVTEETSSSLHLSWT---VAQGPFESFVVQYRDTDGQ--PRAVPVAADQHTVTIEDLEPGKKYKF 3663
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
1308-1388 2.90e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1308 GPPRlgELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQ--PQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVG 1382
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 1622934675 1383 KKRHGP 1388
Cdd:pfam00041   79 GGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
2339-2412 4.81e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 4.81e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 2339 PRLGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2412
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1512-1589 6.20e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 6.20e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1512 GELTVTGVTPDSLRLSWT---VAQGPFDSFMVQYKDAQGQ--PQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGrQRVG 1586
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG-GGEG 82


                   ...
gi 1622934675 1587 PES 1589
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
750-831 7.32e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 7.32e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGaSPPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGT 826
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 1622934675  827 SWGPP 831
Cdd:pfam00041   80 GEGPP 84
fn3 pfam00041
Fibronectin type III domain;
843-919 1.48e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.12  E-value: 1.48e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  843 PQDLRVVAVTPTTLELGWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPPEADGTLLTDLMPGVEYVVTVTAERGRAVS 917
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 1622934675  918 YP 919
Cdd:pfam00041   83 PP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1406-1485 2.68e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 2.68e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1406 PPRLGNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDGRP--QVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1480
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NG 79


                   ....*
gi 1622934675 1481 KRYGP 1485
Cdd:cd00063     80 GGESP 84
fn3 pfam00041
Fibronectin type III domain;
3804-3886 9.81e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.81  E-value: 9.81e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3804 PRLSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFgvpSPSTLEPHPRpllqrELMVPGTRHSAVLRDLRPGTLYSLT 3880
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEY---RPKNSGEPWN-----EITVPGTTTSVTLTGLKPGTEYEVR 72


                   ....*.
gi 1622934675 3881 LYGLRG 3886
Cdd:pfam00041   73 VQAVNG 78
fn3 pfam00041
Fibronectin type III domain;
2889-2956 1.70e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.70e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 2889 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2956
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3105-3172 1.70e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.70e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 3105 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 3172
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2673-2740 1.70e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.70e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 2673 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2740
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3321-3388 1.80e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 1.80e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 3321 TVAGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDGQ--PQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3388
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1403-1474 2.19e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.85  E-value: 2.19e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934675  1403 PGTPPrlgNLWVTDPTPDSLHLSWTVPE-----GQFDTFMVQYRDKDGRPQVVPVEGPERSFVVSSLDPDHKYRFTL 1474
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
fn3 pfam00041
Fibronectin type III domain;
1623-1693 2.25e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 2.25e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 1623 GELTVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEG 1693
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1309-1378 2.38e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 2.38e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934675 1309 PPRLGELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQP--QVVPVEGPQRSAVITSLDPGRKYKFVLY 1378
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
1406-1487 3.81e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.27  E-value: 3.81e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1406 PPRlgNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDG--RPQVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1480
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV-NG 78


                   ....*..
gi 1622934675 1481 KRYGPLT 1487
Cdd:pfam00041   79 GGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1722-1802 5.63e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.88  E-value: 5.63e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1722 PRLGELTVTDVTPNSVGLSWTVPE---GQFDSFMVQYKDKDGQ--PQAVPVAADQQEVTIYNLEPERKYKMNMYGLHdGQ 1796
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN-GG 79


                   ....*.
gi 1622934675 1797 RVGPLS 1802
Cdd:pfam00041   80 GEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1308-1375 7.28e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 7.28e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675  1308 GPPRlgELTVTDRTSDSLLLRWTVPE-----GEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKF 1375
Cdd:smart00060    2 SPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3509-3569 7.45e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 7.45e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 3509 LTVTDATPDSVGLSWTVPE---GEFDSFVVQYKDKDGR--LQVVPVAADQREVTVPGLEPSRKYKF 3569
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
2559-2629 8.08e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 8.08e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 2559 GELTVTGSSPDSLSLSWTIP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEG 2629
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1470-1743 8.93e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 61.56  E-value: 8.93e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1470 YRFTLFGIANKKRYGP--LTADGTTAPErkeePPrpesleqpllGELTVTGVTPDSLRLSWT-VAQGPFDSFMVQYKDAQ 1546
Cdd:COG3401    207 YRVAATDTGGESAPSNevSVTTPTTPPS----AP----------TGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSG 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1547 GQPQAVPVAGDENEVTVPGLDPDRKYKmnlYGLRGRQRVGPESvvaktapqedvdeTPSPTELGTEAPEPSEEPLlgELT 1626
Cdd:COG3401    273 DGPFTKVATVTTTSYTDTGLTNGTTYY---YRVTAVDAAGNES-------------APSNVVSVTTDLTPPAAPS--GLT 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1627 VTGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGRPQAVRVGGEESEVTVGGLEPGHKYK-----MHLYGLhEGQRVGPV 1699
Cdd:COG3401    335 ATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYykvtaVDAAGN-ESAPSEEV 413

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1622934675 1700 SAVGVTAPQQEETPPATKPPLEPRLGELTVTDVTPNSVGLSWTV 1743
Cdd:COG3401    414 SATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAV 457
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 841-921 9.98e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 9.98e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  841 DGPQDLRVVAVTPTTLELGWLRPQ---AEVDRFVVSYVSAGNQRVRLEVPPEADGT--LLTDLMPGVEYVVTVTAERGRA 915
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*.
gi 1622934675  916 VSYPAS 921
Cdd:cd00063     82 ESPPSE 87
fn3 pfam00041
Fibronectin type III domain;
2246-2313 1.05e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 1.05e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 2246 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEG 2313
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3414-3476 1.23e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 1.23e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934675 3414 GELTVAAVTSDSVGLSWT---VAQGPFDSFLVQYR--DTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3476
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3596-3663 1.57e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 1.57e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675  3596 PPPRlgELTVTEETSSSLHLSWT-----VAQGPFESFVVQYRDTDGQPRAVPVAADQHTVTIEDLEPGKKYKF 3663
Cdd:smart00060    2 SPPS--NLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2996-3076 2.29e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 2.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2996 LTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPV 3070
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934675 3071 SVIRVT 3076
Cdd:cd00063     87 ESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3906-3982 3.06e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 3.06e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  3906 SPRDLQFSEIRETSAKVNWMPPPS-RADSFKVSYQLADGGEP---QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3981
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 1622934675  3982 S 3982
Cdd:smart00060   83 G 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 841-914 4.75e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 4.75e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675   841 DGPQDLRVVAVTPTTLELGWLRPQAE-----VDRFVVSYVSAGNQRVRLEVPPEADGTLLTDLMPGVEYVVTVTAERGR 914
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2769-2850 5.34e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 5.34e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2769 PEPPikprlGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLY 2843
Cdd:cd00063      1 PSPP-----TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75


                   ....*..
gi 1622934675 2844 GFHGGQR 2850
Cdd:cd00063     76 AVNGGGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3201-3282 5.34e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 5.34e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3201 PEPPikprlGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLY 3275
Cdd:cd00063      1 PSPP-----TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75


                   ....*..
gi 1622934675 3276 GFHGGQR 3282
Cdd:cd00063     76 AVNGGGE 82
fn3 pfam00041
Fibronectin type III domain;
1816-1883 5.43e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.80  E-value: 5.43e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934675 1816 GAPPRLGelwVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQV---VPVEGHERSVTIAPLDAGRKYRF 1883
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
4083-4160 1.28e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 1.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4083 APRDLEAKEVTPRTALLTWTEPQVRP---TGYLLSFDTPGG--RTQEILLPGGVTSHQLLGLFPSTLYNARLQAMWGESL 4157
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934675 4158 LPP 4160
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2137-2217 1.31e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 1.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2137 LTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGRP--KAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPV 2211
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934675 2212 SAIGVT 2217
Cdd:cd00063     87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1625-1705 1.43e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 1.43e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1625 LTVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEGQRVGPV 1699
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934675 1700 SAVGVT 1705
Cdd:cd00063     87 ESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3962-4152 1.50e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.70  E-value: 1.50e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3962 GLIPGARYEVTVVSVRGFEESEPLTGFL----TTVPDGPTQLRALNLTEGFAVLHWKPPQNP-VDTYDVQVTAPGAPPLQ 4036
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4037 AEAPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPAS--ITFTTGLE---APRDLEAKEVTPRTALLTWTE-PQVRPTG 4110
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTppaAPSGLTATAVGSSSITLSWTAsSDADVTG 357

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622934675 4111 YLLSFDT-PGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQAM 4152
Cdd:COG3401    358 YNVYRSTsGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV 400
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1514-1594 1.90e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 1.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1514 LTVTGVTPDSLRLSWTVAQ---GPFDSFMVQYKDAQGQP--QAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGRQRVGP- 1587
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPs 86


                   ....*..
gi 1622934675 1588 ESVVAKT 1594
Cdd:cd00063     87 ESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2889-2968 2.24e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2889 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGQRVGPVS 2963
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ....*
gi 1622934675 2964 AVGVT 2968
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1917-2006 2.49e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1917 PPKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQP--QVVPVEGSLREVSVPGLDPAHRYKLLLYGL 1991
Cdd:cd00063      1 PSPPT---NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*
gi 1622934675 1992 HSGKRVGPISAVVIT 2006
Cdd:cd00063     78 NGGGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3105-3184 2.52e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.52e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3105 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVS 3179
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ....*
gi 1622934675 3180 AVGVT 3184
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 4082-4167 2.75e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4082 EAPRDLEAKEVTPRTALLTWTEPQ---VRPTGYLLSF-DTPGGRTQEI-LLPGGVTSHQLLGLFPSTLYNARLQAM--WG 4154
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYrEKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVngGG 81

                           90
                   ....*....|...
gi 1622934675 4155 ESlLPPVSTSFTT 4167
Cdd:cd00063     82 ES-PPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 750-838 2.78e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.78e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGASPPFTARVPSSASaYDQRGLAPGQEYQVTVRALRGT 826
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1622934675  827 SWGPPA-SKTITT 838
Cdd:cd00063     81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3201-3275 3.07e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 3.07e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  3201 PEPPikprlGELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 3275
Cdd:smart00060    1 PSPP-----SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2769-2843 3.07e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 3.07e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  2769 PEPPikprlGELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2843
Cdd:smart00060    1 PSPP-----SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2246-2325 3.37e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2246 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEGRRVGPVS 2320
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ....*
gi 1622934675 2321 AVGVT 2325
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2453-2533 3.87e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2453 LTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQP--KTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGGQRVGPV 2527
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934675 2528 SAIGVT 2533
Cdd:cd00063     87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1719-1807 4.27e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 4.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1719 PLEPRlgELTVTDVTPNSVGLSWTVPE---GQFDSFMVQYKDKDGQP--QAVPVAADQQEVTIYNLEPERKYKMNMYGLH 1793
Cdd:cd00063      1 PSPPT--NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....
gi 1622934675 1794 DGQRVGPLSVVIMT 1807
Cdd:cd00063     79 GGGESPPSESVTVT 92
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 559-586 4.79e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 48.45  E-value: 4.79e-07
                           10        20
                   ....*....|....*....|....*...
gi 1622934675  559 CPGGCRGRGQCIDGRCVCEDGYSGEDCS 586
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
fn3 pfam00041
Fibronectin type III domain;
1918-2001 5.13e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.11  E-value: 5.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1918 PKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQ--PQVVPVEGSLREVSVPGLDPAHRYKLLLYGlH 1992
Cdd:pfam00041    1 SAPS---NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQA-V 76


                   ....*....
gi 1622934675 1993 SGKRVGPIS 2001
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 4083-4151 6.14e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 6.14e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934675  4083 APRDLEAKEVTPRTALLTWTEPQVRP-----TGYLLSFDTPGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQA 4151
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitgyiVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1815-1883 6.18e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 6.18e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934675 1815 PGAPprlGELWVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQVVPVE---GHERSVTIAPLDAGRKYRF 1883
Cdd:cd00063      1 PSPP---TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEF 72
PTZ00214 PTZ00214
high cysteine membrane protein Group 4; Provisional
 254-669 6.81e-07

high cysteine membrane protein Group 4; Provisional


Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 55.69  E-value: 6.81e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  254 SQRGRCEDGRCVCDPGYTGedcGMRSCPRGCSQRGRCENGRCvcNPGYTGEDCgvRSCPRGCSQrgrceDGRCVCDPGYT 333
Cdd:PTZ00214   341 SKNDDNNGDGYLCGDATNG---GVSGCATCGYNSGAVTCTRC--SAGYLGVDG--KSCSESCSG-----DTRGVCTKVAE 408

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  334 GEDCGTRSCRwdcgeggrcvdgrCVCWPGYTGEDCSTRTCPRDCrgrGRCEDGE---C-ICDTGYSGDDCGVRSCPGDCN 409
Cdd:PTZ00214   409 GSESTEVSCR-------------CVCKPTFYNSSGTCTPCTDSC---AVCKDGTptgCqQCSPGKILEFSIVSSESADCV 472

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  410 QRGRCEDGRCVCwpGYTgLDcGSRACPRDCRGRGRCENGVCVCNagySGEDCGVRSCPG----DCRGRGRCESGRCVCWP 485
Cdd:PTZ00214   473 DQCSVGSECAEC--GIT-ID-GSRYCTRCKDASTYPFNGVCIPN---TQRDAYCTSTANgactTCSGAAFLMNGGCYTTE 545

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  486 GYTGRDCGTRACPGDC----RGRGRCVDGRCV-CNP---GFTGEDCGS-RRCPGDC-------RGHGSCED-GVCVcDAG 548
Cdd:PTZ00214   546 HYPGSTICDKQSNGKCtttkKGYGISPDGKLLeCDPtclACTAPGPGRcTRCPSDKllkrasgAATGSCVDpGACV-DGY 624

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  549 YSGEDCSTRSCPGGCRGRG------QCIDGRCVCEDGYSgedcsvrrCPNDCSQHGVCQD---GVCICW------EAYVG 613
Cdd:PTZ00214   625 YADGDACLPCATPGCKTCGhasfctECAGELFVSLDGQS--------CLEECTGDKVVGEvsgGVRRCWcergflPALDR 696

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675  614 EDCSIRT-CPSNCHGRGRCEE-GRCL-CDPGYTGPTCATRMCPADCRGRGRCVQGVCMC 669
Cdd:PTZ00214   697 SGCVLPTeCPPDMPSCAACDEsGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2332-2421 7.44e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 7.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2332 PDAPlvkprlGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNL 2406
Cdd:cd00063      1 PSPP------TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRV 74

                           90
                   ....*....|....*
gi 1622934675 2407 YGFHGGQRMGPVSAV 2421
Cdd:cd00063     75 RAVNGGGESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2673-2735 7.51e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 7.51e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934675 2673 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLY 2735
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 311-337 8.21e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 48.06  E-value: 8.21e-07
                           10        20
                   ....*....|....*....|....*..
gi 1622934675  311 CPRGCSQRGRCEDGRCVCDPGYTGEDC 337
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2988-3059 9.00e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 9.00e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934675  2988 PIKPRlgELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 3059
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1625-1688 1.04e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 1.04e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675  1625 LTVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQAVRVGGEESEVTVGGLEPGHKYKMHLY 1688
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2137-2200 1.08e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 1.08e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675  2137 LTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2200
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2561-2641 1.22e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 1.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2561 LTVTGSSPDSLSLSWTIPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEGRRVGPV 2635
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934675 2636 SAVGVT 2641
Cdd:cd00063     87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3321-3397 1.55e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 1.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3321 TVAGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGQP--QAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEGRRVGPVS 3395
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ..
gi 1622934675 3396 AV 3397
Cdd:cd00063     88 SV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1514-1577 1.75e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 1.75e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675  1514 LTVTGVTPDSLRLSWT-----VAQGPFDSFMVQYKDAQGQPQAVPVAGDENEVTVPGLDPDRKYKMNLY 1577
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3105-3167 2.54e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.54e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934675  3105 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 3167
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2889-2951 2.54e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.54e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934675  2889 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 2951
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2673-2735 2.54e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.54e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934675  2673 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 2735
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
314-418 2.82e-06

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 49.76  E-value: 2.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  314 GCSQRG-RCEDGRCVC-----DPGYTGEDCGtrSCRWDCGEGGRCVDGRCVCWPGYT--GEDC-STRTCPRDCRGRGR-- 382
Cdd:NF041328    13 GCPEPGaVCPEGLSVCggacvDLRSDPSNCG--ACGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAac 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1622934675  383 -----CEDGEC--ICDTGYS--GDDC-GVRSCPGDCNQRG-RCEDGR 418
Cdd:NF041328    91 apgqvCEGGACreACSEGLTrcGGACvDLATDPLHCGACGvACDPGE 137
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2453-2516 3.54e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 3.54e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675  2453 LTMTDATPDSLSLSWTVPE-----GQFDHFLVQYKNGDGQPKTTRVPGHEDRVTISGLEPDHKYKMNLY 2516
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2246-2308 3.71e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 3.71e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934675  2246 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGNKYKMHLY 2308
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3807-3882 3.82e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 3.82e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934675  3807 SQLSVTDVTTSSLRLNWEAPPGA-FDSFLLRFgvpspsTLEPHPRPLLQRELMVPGTRHSAVLRDLRPGTLYSLTLY 3882
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDgITGYIVGY------RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2332-2407 4.60e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 4.60e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  2332 PDAPlvkprlGEMTVRDATPDSLSLSWTVPE-----GQFDHFLVQYKNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNL 2406
Cdd:smart00060    1 PSPP------SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                    .
gi 1622934675  2407 Y 2407
Cdd:smart00060   75 R 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1815-1883 5.28e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 5.28e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934675  1815 PGAPPRLgelWVTDPTPDSLHLSWTVPE-GQFDSFVVQFKDKDGP-----QVVPVEGHERSVTIAPLDAGRKYRF 1883
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1719-1786 5.60e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 5.60e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675  1719 PLEPRlgELTVTDVTPNSVGLSWTVPE-----GQFDSFMVQYKDKDGQPQAVPVAADQQEVTIYNLEPERKYK 1786
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYE 71
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2561-2624 6.42e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 6.42e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675  2561 LTVTGSSPDSLSLSWTIPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGSLEPGNKYKMHLY 2624
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
594-703 6.62e-06

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 48.99  E-value: 6.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  594 CSQHG-VCQDGVCICWEAYVgedcSIRTCPSNCHGRG-------RCEEGRCLCDPGYT--GPTC-ATRMCPADCRGRGR- 661
Cdd:NF041328    14 CPEPGaVCPEGLSVCGGACV----DLRSDPSNCGACGvacgagqTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAa 89

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622934675  662 ------CVQGVCMCHVGYGGEDCGQ-------EEPPASACPGGCGPRELCQAGQC 703
Cdd:NF041328    90 capgqvCEGGACREACSEGLTRCGGacvdlatDPLHCGACGVACDPGESCRGGAC 144
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1917-1986 7.01e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 7.01e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934675  1917 PPKPRlgeELQVTSVTQNSVGLSWTVPE-----GQFDSFVVQYKDRDGQPQVVPVEGSLREVSVPGLDPAHRYKL 1986
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3321-3388 8.61e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 8.61e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675  3321 TVAGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGQPQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3388
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3993-4079 1.58e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.34  E-value: 1.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3993 PDGPTQLRALNLTEGFAVLHWKPPQN---PVDTYDVQVTAPGAPPLQ--AEAPGSAVDYPLHDLVLHTNYTATVRGLRGP 4067
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDdggPITGYVVEYREKGSGDWKevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1622934675 4068 NLTSPA-SITFTT 4079
Cdd:cd00063     81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3416-3476 1.92e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.92e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675  3416 LTVAAVTSDSVGLSWT-----VAQGPFDSFLVQYRDTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3476
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
3996-4066 3.57e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 3.57e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 3996 PTQLRALNLTEGFAVLHWKPP---QNPVDTYDVQVTAPGAPPLQAE--APGSAVDYPLHDLVLHTNYTATVRGLRG 4066
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3807-3882 3.83e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 3.83e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 3807 SQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFGVPSPSTLEPHPRPllqrelmvPGTRHSAVLRDLRPGTLYSLTLY 3882
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT--------PGSETSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
2029-2099 7.89e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 7.89e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 2029 GELTVEEATPHTLHLSWM---VTEGEFDSFEI--QHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLYGFHDG 2099
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVeyRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1083-1161 1.23e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 1.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1083 APRHPKPEVLGSSAdgaLLVS---LDGLRGQFERVVLRWRPQPpAEGPGGELTVPGTTRTVSLPDLRPGTTYHVEVHGVR 1159
Cdd:pfam00041    2 APSNLTVTDVTSTS---LTVSwtpPPDGNGPITGYEVEYRPKN-SGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ..
gi 1622934675 1160 AG 1161
Cdd:pfam00041   78 GG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3993-4062 1.99e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 1.99e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934675  3993 PDGPTQLRALNLTEGFAVLHWKPPQNP-----VDTYDVQVTAPGAPPLQAEAPGSAVDYPLHDLVLHTNYTATVR 4062
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 221-244 2.81e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 2.81e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934675  221 DCQGRGRCVQ--GVCVCRAGFSGPDC 244
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 750-829 3.38e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 3.38e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675   750 PAIEGMRMHLLEETTVRTEWTPAPGP-VDAYEIQFIPTTEGASPPF-TARVPSSASAYDQRGLAPGQEYQVTVRALRGTS 827
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622934675   828 WG 829
Cdd:smart00060   82 EG 83
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
279-414 3.41e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 43.98  E-value: 3.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  279 SCPRGCSqrgRCeNGRCVCNPGyTGEDCGvrSCPRGCSQRGRCEDGRCVCDPGytGEDCG-----TRSCRWDCGE-GGRC 352
Cdd:NF041328    20 VCPEGLS---VC-GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHCGAcGAAC 90

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934675  353 VDGRcVCWPGYTGEDCSTrtcprdcrGRGRCeDGECI---CDTGYSGdDCGVRSCPGDCNQRGRC 414
Cdd:NF041328    91 APGQ-VCEGGACREACSE--------GLTRC-GGACVdlaTDPLHCG-ACGVACDPGESCRGGAC 144
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
191-295 4.09e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 43.59  E-value: 4.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  191 CNDQGRCVRGRCVCFPGYTgpSCGwpscpgdcqgrGRCVQ--------GVC--VCRAGFSgpdCSQRSCPRGCSQ-RGRC 259
Cdd:NF041328    49 CGAGQTCVAGACGCGPGTV--ACG-----------GACVDtasdpahcGACgaACAPGQV---CEGGACREACSEgLTRC 112

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1622934675  260 eDGRCV---CDPGYTGEdCGmRSCPRGCSqrgrCENGRC 295
Cdd:NF041328   113 -GGACVdlaTDPLHCGA-CG-VACDPGES----CRGGAC 144
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 719-745 4.58e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 40.36  E-value: 4.58e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934675  719 CPGDCRGRGECHDGSCICKDGYAGEDC 745
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
492-590 5.34e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 43.21  E-value: 5.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  492 CGtrACPGDCRGRGRCVDGRCVCNPGFT--GEDCGSRR--------CPGDCRGHGSCEDGVC--VCDAGYsgEDCStRSC 559
Cdd:NF041328    42 CG--ACGVACGAGQTCVAGACGCGPGTVacGGACVDTAsdpahcgaCGAACAPGQVCEGGACreACSEGL--TRCG-GAC 116

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1622934675  560 PGGCRGRGQCidGRC--VCEDgysGEDCSVRRC 590
Cdd:NF041328   117 VDLATDPLHC--GACgvACDP---GESCRGGAC 144
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 190-213 6.09e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.64  E-value: 6.09e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934675  190 DCNDQGRCVR--GRCVCFPGYTGPSC 213
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2031-2094 6.32e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 6.32e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675  2031 LTVEEATPHTLHLSWM-----VTEGEFDSFEIQHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLY 2094
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
416-543 7.98e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.82  E-value: 7.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  416 DGRCVCWPGyTGLDCGsrACPRDCRGRGRCENGVCVCNAGysGEDCG-----VRSCPGDCrgrGRCESgrcVCWPGYTgr 490
Cdd:NF041328    29 GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHC---GACGA---ACAPGQV-- 95

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622934675  491 dCGTRACPGDC-RGRGRCvDGRCVcNPGFTGEDCGSrrCPGDCRGHGSCEDGVC 543
Cdd:NF041328    96 -CEGGACREACsEGLTRC-GGACV-DLATDPLHCGA--CGVACDPGESCRGGAC 144
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 4203-4217 1.73e-03

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 39.08  E-value: 1.73e-03
                           10
                   ....*....|....*
gi 1622934675 4203 PLNVFCDMETDGGGW 4217
Cdd:NF040941    29 PFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2031-2099 2.23e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.17  E-value: 2.23e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934675 2031 LTVEEATPHTLHLSWMV---TEGEFDSFEIQHTDR-EGQLQTVRTG-GDRNDITLSGLESDHRYLVTLYGFHDG 2099
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKgSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAVNGG 80
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 498-523 9.73e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 9.73e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1622934675  498 PGDCRGRGRCVDG----RCVCNPGFTGEDC 523
Cdd:cd00054      8 GNPCQNGGTCVNTvgsyRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
4174-4383 4.69e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 370.31  E-value: 4.69e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4174 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNIS-GEFWLGN 4252
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4253 EALHSLTQAGDYSMRVDLRAG-DEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-------SMSYHSGSVFSARDRDPN 4324
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934675 4325 NLLISCAVSYRGAWWYRNCHYANLNG--LYGSTVDHQ-GVSWYYWKGFEFSVPFTEMKLRPR 4383
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGvyYYGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 4174-4383 2.92e-112

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 356.20  E-value: 2.92e-112
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  4174 FPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNE 4253
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  4254 ALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGD-SMSYHSGSVFSARDRDPNNLLISCA 4331
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEdWEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1622934675  4332 VSYRGAWWYRNCHYANLNGLYGS-TVDHQGVSWYYWKGFEFSVPFTEMKLRPR 4383
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYPnNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 4173-4383 3.09e-110

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 350.77  E-value: 3.09e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4173 PFPRDCGEEMQNGAGASRTTTIFLNGNReRPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGN 4252
Cdd:cd00087      1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4253 EALHSLTQAGDYSMRVDLR-AGDEAVFAQYDSFRVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNNLLISCA 4331
Cdd:cd00087     80 EKIHLLTSQGPYELRIDLEdWEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 4332 VSYRGAWWYRNCHYANLNGLYGSTVDHQ----GVSWYYWKGFEFSVPFTEMKLRPR 4383
Cdd:cd00087    160 ESYSGGWWYNSCHASNLNGRYYSGGHRNeydnGINWATWKGSTYSLKFTEMKIRPK 215
fn3 pfam00041
Fibronectin type III domain;
3906-3984 1.73e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 1.73e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3906 SPRDLQFSEIRETSAKVNWMPPPSRA---DSFKVSYQLADGGEP-QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3981
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934675 3982 SEP 3984
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3907-3986 5.33e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 5.33e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3907 PRDLQFSEIRETSAKVNWMPPP---SRADSFKVSYQLADGGEPQSVQVDGRARTQ-KLQGLIPGARYEVTVVSVRGFEES 3982
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGES 83


                   ....
gi 1622934675 3983 EPLT 3986
Cdd:cd00063     84 PPSE 87
fn3 pfam00041
Fibronectin type III domain;
3207-3280 5.74e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.74e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 3207 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 3280
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2991-3064 5.74e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.74e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 2991 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 3064
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2775-2848 5.74e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 5.74e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 2775 PRLGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2848
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2448-2521 7.40e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 7.40e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 2448 PRLGELTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGG 2521
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2135-2205 7.84e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 7.84e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 2135 GELTVTDATPDSLSLSWTVPE---GQFDHFLVQYR--NGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2205
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3454-3818 1.36e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 70.80  E-value: 1.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3454 VPVSGDLRAVTVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAPDTKLSPRLGeLTVTDATPDSVGLSWT-VPEGEFDS 3532
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG-LTATADTPGSVTLSWDpVTESDATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3533 FVVQYK-DKDGRLQVVpVAADQREVTVPGLEPSRKYKFLLYGLAGRKRMGPISaDGTTASLEKEPPPRLGELTVTEETSS 3611
Cdd:COG3401    264 YRVYRSnSGDGPFTKV-ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPS-NVVSVTTDLTPPAAPSGLTATAVGSS 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3612 SLHLSWT-VAQGPFESFVVqYRDT--DGQPRAVPVAADQHTVTIEDLEPGKKYKFLlyglvggkrlgpVSALGmTAPEED 3688
Cdd:COG3401    342 SITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTYYYK------------VTAVD-AAGNES 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3689 TPAPELASEAPEPPEEPRLGVLAVTDTAPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPY 3768
Cdd:COG3401    408 APSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTA 487

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3769 RFLLYGLHEGKRLGPLSAEGTTGPAPAGQTSGEPGPRLSQLSVTDVTTSS 3818
Cdd:COG3401    488 NLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVT 537
fn3 pfam00041
Fibronectin type III domain;
3596-3663 2.71e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.71e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 3596 PPPRlgELTVTEETSSSLHLSWT---VAQGPFESFVVQYRDTDGQ--PRAVPVAADQHTVTIEDLEPGKKYKF 3663
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
1308-1388 2.90e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 2.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1308 GPPRlgELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQ--PQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVG 1382
Cdd:pfam00041    1 SAPS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 1622934675 1383 KKRHGP 1388
Cdd:pfam00041   79 GGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
2339-2412 4.81e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 4.81e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 2339 PRLGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQ--PKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGG 2412
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1512-1589 6.20e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 6.20e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1512 GELTVTGVTPDSLRLSWT---VAQGPFDSFMVQYKDAQGQ--PQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGrQRVG 1586
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG-GGEG 82


                   ...
gi 1622934675 1587 PES 1589
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
750-831 7.32e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 7.32e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGaSPPFTARVPSSASAYDQRGLAPGQEYQVTVRALRGT 826
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSG-EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 1622934675  827 SWGPP 831
Cdd:pfam00041   80 GEGPP 84
fn3 pfam00041
Fibronectin type III domain;
843-919 1.48e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.12  E-value: 1.48e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  843 PQDLRVVAVTPTTLELGWLRP---QAEVDRFVVSYVSAGNQRVRLE--VPPEADGTLLTDLMPGVEYVVTVTAERGRAVS 917
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ..
gi 1622934675  918 YP 919
Cdd:pfam00041   83 PP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1406-1485 2.68e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 2.68e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1406 PPRLGNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDGRP--QVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1480
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV-NG 79


                   ....*
gi 1622934675 1481 KRYGP 1485
Cdd:cd00063     80 GGESP 84
fn3 pfam00041
Fibronectin type III domain;
3504-3569 4.16e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 4.16e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622934675 3504 PRLGELTVTDATPDSVGLSWTVPE---GEFDSFVVQYKDKDG--RLQVVPVAADQREVTVPGLEPSRKYKF 3569
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEV 71
fn3 pfam00041
Fibronectin type III domain;
3804-3886 9.81e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.81  E-value: 9.81e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3804 PRLSQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFgvpSPSTLEPHPRpllqrELMVPGTRHSAVLRDLRPGTLYSLT 3880
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEY---RPKNSGEPWN-----EITVPGTTTSVTLTGLKPGTEYEVR 72


                   ....*.
gi 1622934675 3881 LYGLRG 3886
Cdd:pfam00041   73 VQAVNG 78
fn3 pfam00041
Fibronectin type III domain;
2889-2956 1.70e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.70e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 2889 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2956
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3105-3172 1.70e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.70e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 3105 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 3172
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2673-2740 1.70e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 1.70e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 2673 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEG 2740
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
3321-3388 1.80e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 1.80e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 3321 TVAGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDGQ--PQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3388
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1403-1474 2.19e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.85  E-value: 2.19e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934675  1403 PGTPPrlgNLWVTDPTPDSLHLSWTVPE-----GQFDTFMVQYRDKDGRPQVVPVEGPERSFVVSSLDPDHKYRFTL 1474
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
fn3 pfam00041
Fibronectin type III domain;
1623-1693 2.25e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 2.25e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 1623 GELTVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEG 1693
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1309-1378 2.38e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 2.38e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934675 1309 PPRLGELTVTDRTSDSLLLRWTVPE---GEFDSFVIQYKDRDGQP--QVVPVEGPQRSAVITSLDPGRKYKFVLY 1378
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
1406-1487 3.81e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.27  E-value: 3.81e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1406 PPRlgNLWVTDPTPDSLHLSWTVPE---GQFDTFMVQYRDKDG--RPQVVPVEGPERSFVVSSLDPDHKYRFTLFGIaNK 1480
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV-NG 78


                   ....*..
gi 1622934675 1481 KRYGPLT 1487
Cdd:pfam00041   79 GGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1722-1802 5.63e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.88  E-value: 5.63e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1722 PRLGELTVTDVTPNSVGLSWTVPE---GQFDSFMVQYKDKDGQ--PQAVPVAADQQEVTIYNLEPERKYKMNMYGLHdGQ 1796
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN-GG 79


                   ....*.
gi 1622934675 1797 RVGPLS 1802
Cdd:pfam00041   80 GEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1308-1375 7.28e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 7.28e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675  1308 GPPRlgELTVTDRTSDSLLLRWTVPE-----GEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKF 1375
Cdd:smart00060    2 SPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3509-3569 7.45e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 7.45e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 3509 LTVTDATPDSVGLSWTVPE---GEFDSFVVQYKDKDGR--LQVVPVAADQREVTVPGLEPSRKYKF 3569
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
2559-2629 8.08e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 8.08e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 2559 GELTVTGSSPDSLSLSWTIP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEG 2629
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1470-1743 8.93e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 61.56  E-value: 8.93e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1470 YRFTLFGIANKKRYGP--LTADGTTAPErkeePPrpesleqpllGELTVTGVTPDSLRLSWT-VAQGPFDSFMVQYKDAQ 1546
Cdd:COG3401    207 YRVAATDTGGESAPSNevSVTTPTTPPS----AP----------TGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSG 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1547 GQPQAVPVAGDENEVTVPGLDPDRKYKmnlYGLRGRQRVGPESvvaktapqedvdeTPSPTELGTEAPEPSEEPLlgELT 1626
Cdd:COG3401    273 DGPFTKVATVTTTSYTDTGLTNGTTYY---YRVTAVDAAGNES-------------APSNVVSVTTDLTPPAAPS--GLT 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1627 VTGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGRPQAVRVGGEESEVTVGGLEPGHKYK-----MHLYGLhEGQRVGPV 1699
Cdd:COG3401    335 ATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDTGLTPGTTYYykvtaVDAAGN-ESAPSEEV 413

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1622934675 1700 SAVGVTAPQQEETPPATKPPLEPRLGELTVTDVTPNSVGLSWTV 1743
Cdd:COG3401    414 SATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAV 457
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 841-921 9.98e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 9.98e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  841 DGPQDLRVVAVTPTTLELGWLRPQ---AEVDRFVVSYVSAGNQRVRLEVPPEADGT--LLTDLMPGVEYVVTVTAERGRA 915
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*.
gi 1622934675  916 VSYPAS 921
Cdd:cd00063     82 ESPPSE 87
fn3 pfam00041
Fibronectin type III domain;
2246-2313 1.05e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 1.05e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675 2246 TVTGSSPDSLSLSWTVP---QGRFDSFTVQYKDRDG--RPQVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEG 2313
Cdd:pfam00041    7 TVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3597-3663 1.18e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 1.18e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934675 3597 PPRLGELTVTEETSSSLHLSWTVAQ---GPFESFVVQYRDTDGQP--RAVPVAADQHTVTIEDLEPGKKYKF 3663
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
3414-3476 1.23e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 1.23e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934675 3414 GELTVAAVTSDSVGLSWT---VAQGPFDSFLVQYR--DTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3476
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3596-3663 1.57e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 1.57e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675  3596 PPPRlgELTVTEETSSSLHLSWT-----VAQGPFESFVVQYRDTDGQPRAVPVAADQHTVTIEDLEPGKKYKF 3663
Cdd:smart00060    2 SPPS--NLRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2996-3076 2.29e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 2.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2996 LTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPV 3070
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934675 3071 SVIRVT 3076
Cdd:cd00063     87 ESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3509-3569 2.57e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 2.57e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675  3509 LTVTDATPDSVGLSWTVPE-----GEFDSFVVQYKDKDGRLQVVPVAADQREVTVPGLEPSRKYKF 3569
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3906-3982 3.06e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 3.06e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  3906 SPRDLQFSEIRETSAKVNWMPPPS-RADSFKVSYQLADGGEP---QSVQVDGRARTQKLQGLIPGARYEVTVVSVRGFEE 3981
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 1622934675  3982 S 3982
Cdd:smart00060   83 G 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3141-3378 3.49e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.63  E-value: 3.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3141 VVRVGGEESEVTVGGLEPGRKYKMhlyglhegrRVGPVSAVGVTAPEDEAEATQavPTTTPEPPikprlGELTVTDATPD 3220
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYY---------RVAATDTGGESAPSNEVSVTT--PTTPPSAP-----TGLTATADTPG 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3221 SLSLSWT-VPEGQFDHFLVqYRNGDGQPKAVRVpGHEDGVTI--SGLEPDHKYK-----MNLYGFHGgqrvGPMSVIGVT 3292
Cdd:COG3401    248 SVTLSWDpVTESDATGYRV-YRSNSGDGPFTKV-ATVTTTSYtdTGLTNGTTYYyrvtaVDAAGNES----APSNVVSVT 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3293 VAEEETPSPTepsteapeppeepllgELTVAGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGQPQAVRVGGEESEVTVR 3370
Cdd:COG3401    322 TDLTPPAAPS----------------GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDT 385


                   ....*...
gi 1622934675 3371 GLEPGRKY 3378
Cdd:COG3401    386 GLTPGTTY 393
fn3 pfam00041
Fibronectin type III domain;
3710-3785 3.71e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.57  E-value: 3.71e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3710 LAVTDTAPDSMRLSWS---VAQGPFDSFVVQYEDTNGQ--PQALLVDGDQSKILISGLEPSTPYRFLLYGLHeGKRLGPL 3784
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN-GGGEGPP 84


                   .
gi 1622934675 3785 S 3785
Cdd:pfam00041   85 S 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 841-914 4.75e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 4.75e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675   841 DGPQDLRVVAVTPTTLELGWLRPQAE-----VDRFVVSYVSAGNQRVRLEVPPEADGTLLTDLMPGVEYVVTVTAERGR 914
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2769-2850 5.34e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 5.34e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2769 PEPPikprlGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLY 2843
Cdd:cd00063      1 PSPP-----TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75


                   ....*..
gi 1622934675 2844 GFHGGQR 2850
Cdd:cd00063     76 AVNGGGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3201-3282 5.34e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 5.34e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3201 PEPPikprlGELTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNLY 3275
Cdd:cd00063      1 PSPP-----TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75


                   ....*..
gi 1622934675 3276 GFHGGQR 3282
Cdd:cd00063     76 AVNGGGE 82
fn3 pfam00041
Fibronectin type III domain;
1816-1883 5.43e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.80  E-value: 5.43e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934675 1816 GAPPRLGelwVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQV---VPVEGHERSVTIAPLDAGRKYRF 1883
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwneITVPGTTTSVTLTGLKPGTEYEV 71
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1352-1644 6.24e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.86  E-value: 6.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1352 VVPVEGPQRSAVITSLDPGRKYKFVLYGFVGKKRhGPLVTEAKILPQSDPrPGTPprlGNLWVTDPTPDSLHLSWT-VPE 1430
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGE-SAPSNEVSVTTPTTP-PSAP---TGLTATADTPGSVTLSWDpVTE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1431 GQFDTFMVqYRDKDGRPQVVPV-EGPERSFVVSSLDPDHKYRFTLFGIANKKRYGPL--TADGTTAPERkeePPRPESle 1507
Cdd:COG3401    259 SDATGYRV-YRSNSGDGPFTKVaTVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPsnVVSVTTDLTP---PAAPSG-- 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1508 qpllgeLTVTGVTPDSLRLSWT-VAQGPFDSFMVQYKDAQ-GQPQAVPVAGDENEVTVPGLDPDRKYKmnlYGLRGRQRV 1585
Cdd:COG3401    333 ------LTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGgGTYTKIAETVTTTSYTDTGLTPGTTYY---YKVTAVDAA 403

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 1586 GPESvvaktAPQEDVDETPSPTelgTEAPEPSEEPLLGELTVTGSSPDSLSLSWTVPQG 1644
Cdd:COG3401    404 GNES-----APSEEVSATTASA---ASGESLTASVDAVPLTDVAGATAAASAASNPGVS 454
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
763-928 6.51e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.86  E-value: 6.51e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  763 TTVRTEWTPAPGP-VDAYEIQFIPTTEGaspPFTARVPSSASAYDQRGLAPGQEYQVTVRAL--RGTSWGPPASKTITTM 839
Cdd:COG3401    247 GSVTLSWDPVTESdATGYRVYRSNSGDG---PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdaAGNESAPSNVVSVTTD 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  840 I---DGPQDLRVVAVTPTTLELGW-LRPQAEVDRFVVsYVSAGNQRVRLEVPPEADGTLLTD--LMPGVEYVVTVTA--E 911
Cdd:COG3401    324 LtppAAPSGLTATAVGSSSITLSWtASSDADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDtgLTPGTTYYYKVTAvdA 402

                          170
                   ....*....|....*..
gi 1622934675  912 RGRAVSYPASVRANTAP 928
Cdd:COG3401    403 AGNESAPSEEVSATTAS 419
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2925-3226 8.19e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.48  E-value: 8.19e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2925 VVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGQRVGPVSAVGVTAPedeaettqaaptttPEPPIKPrlGELTVTDATPD 3004
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTP--------------TTPPSAP--TGLTATADTPG 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3005 SLSLSWT-VPEGQFDHFLVqYRNGDGQPKAVRVpGHEDGVTI--SGLEPDHKYK-----MNLYGFHGGqrvgPVSVIRVT 3076
Cdd:COG3401    248 SVTLSWDpVTESDATGYRV-YRSNSGDGPFTKV-ATVTTTSYtdTGLTNGTTYYyrvtaVDAAGNESA----PSNVVSVT 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3077 AAEEETPAPTEPsteapeppeepllgelTVTGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGRPQVVRVGGEESEVTVG 3154
Cdd:COG3401    322 TDLTPPAAPSGL----------------TATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDT 385

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622934675 3155 GLEPGRKYKmhlYglhegrRVGPVSAVGvtapeDEAEATQAVPTTTPEPPIKPRLGELTVTDATPDSLSLSW 3226
Cdd:COG3401    386 GLTPGTTYY---Y------KVTAVDAAG-----NESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATA 443
fn3 pfam00041
Fibronectin type III domain;
4083-4160 1.28e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.03  E-value: 1.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4083 APRDLEAKEVTPRTALLTWTEPQVRP---TGYLLSFDTPGG--RTQEILLPGGVTSHQLLGLFPSTLYNARLQAMWGESL 4157
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSgePWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ...
gi 1622934675 4158 LPP 4160
Cdd:pfam00041   82 GPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2137-2217 1.31e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 1.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2137 LTVTDATPDSLSLSWTVPE---GQFDHFLVQYRNGDGRP--KAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPV 2211
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934675 2212 SAIGVT 2217
Cdd:cd00063     87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1625-1705 1.43e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 1.43e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1625 LTVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QAVRVGGEESEVTVGGLEPGHKYKMHLYGLHEGQRVGPV 1699
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934675 1700 SAVGVT 1705
Cdd:cd00063     87 ESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3962-4152 1.50e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.70  E-value: 1.50e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3962 GLIPGARYEVTVVSVRGFEESEPLTGFL----TTVPDGPTQLRALNLTEGFAVLHWKPPQNP-VDTYDVQVTAPGAPPLQ 4036
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4037 AEAPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPAS--ITFTTGLE---APRDLEAKEVTPRTALLTWTE-PQVRPTG 4110
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTppaAPSGLTATAVGSSSITLSWTAsSDADVTG 357

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622934675 4111 YLLSFDT-PGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQAM 4152
Cdd:COG3401    358 YNVYRSTsGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAV 400
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2709-2946 1.78e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.32  E-value: 1.78e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2709 VVRVGGEESEVTVGGLEPGRKYKMhlyglhegqRLGPVSAVGVTAPEDEAEATQavPTTTPEPPikprlGELTVTDATPD 2788
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYY---------RVAATDTGGESAPSNEVSVTT--PTTPPSAP-----TGLTATADTPG 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2789 SLSLSWT-VPEGQFDHFLVqYRNGDGQPKAVRVpGHEDGVTI--SGLEPDHKYK-----MNLYGFHGgqrvGPMSVIGVT 2860
Cdd:COG3401    248 SVTLSWDpVTESDATGYRV-YRSNSGDGPFTKV-ATVTTTSYtdTGLTNGTTYYyrvtaVDAAGNES----APSNVVSVT 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2861 AAEEETPSPTepsteapeppeepllgELTVTGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGRPQVVRVGGEESEVTVG 2938
Cdd:COG3401    322 TDLTPPAAPS----------------GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYTDT 385


                   ....*...
gi 1622934675 2939 GLEPGRKY 2946
Cdd:COG3401    386 GLTPGTTY 393
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1514-1594 1.90e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 1.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1514 LTVTGVTPDSLRLSWTVAQ---GPFDSFMVQYKDAQGQP--QAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGRQRVGP- 1587
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPs 86


                   ....*..
gi 1622934675 1588 ESVVAKT 1594
Cdd:cd00063     87 ESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2889-2968 2.24e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2889 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGQRVGPVS 2963
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ....*
gi 1622934675 2964 AVGVT 2968
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1917-2006 2.49e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1917 PPKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQP--QVVPVEGSLREVSVPGLDPAHRYKLLLYGL 1991
Cdd:cd00063      1 PSPPT---NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*
gi 1622934675 1992 HSGKRVGPISAVVIT 2006
Cdd:cd00063     78 NGGGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3105-3184 2.52e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.52e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3105 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVS 3179
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ....*
gi 1622934675 3180 AVGVT 3184
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 4082-4167 2.75e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 4082 EAPRDLEAKEVTPRTALLTWTEPQ---VRPTGYLLSF-DTPGGRTQEI-LLPGGVTSHQLLGLFPSTLYNARLQAM--WG 4154
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYrEKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVngGG 81

                           90
                   ....*....|...
gi 1622934675 4155 ESlLPPVSTSFTT 4167
Cdd:cd00063     82 ES-PPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 750-838 2.78e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 2.78e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  750 PAIEGMRMHLLEETTVRTEWTPAP---GPVDAYEIQFIPTTEGASPPFTARVPSSASaYDQRGLAPGQEYQVTVRALRGT 826
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1622934675  827 SWGPPA-SKTITT 838
Cdd:cd00063     81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3201-3275 3.07e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 3.07e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  3201 PEPPikprlGELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 3275
Cdd:smart00060    1 PSPP-----SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2769-2843 3.07e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 3.07e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  2769 PEPPikprlGELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2843
Cdd:smart00060    1 PSPP-----SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2246-2325 3.37e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2246 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGNKYKMHLYGLHEGRRVGPVS 2320
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ....*
gi 1622934675 2321 AVGVT 2325
Cdd:cd00063     88 SVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2453-2533 3.87e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 3.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2453 LTMTDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQP--KTTRVPGHEDRVTISGLEPDHKYKMNLYGFHGGQRVGPV 2527
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934675 2528 SAIGVT 2533
Cdd:cd00063     87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1719-1807 4.27e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 4.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1719 PLEPRlgELTVTDVTPNSVGLSWTVPE---GQFDSFMVQYKDKDGQP--QAVPVAADQQEVTIYNLEPERKYKMNMYGLH 1793
Cdd:cd00063      1 PSPPT--NLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....
gi 1622934675 1794 DGQRVGPLSVVIMT 1807
Cdd:cd00063     79 GGGESPPSESVTVT 92
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 559-586 4.79e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 48.45  E-value: 4.79e-07
                           10        20
                   ....*....|....*....|....*...
gi 1622934675  559 CPGGCRGRGQCIDGRCVCEDGYSGEDCS 586
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
fn3 pfam00041
Fibronectin type III domain;
1918-2001 5.13e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.11  E-value: 5.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1918 PKPRlgeELQVTSVTQNSVGLSWTVPE---GQFDSFVVQYKDRDGQ--PQVVPVEGSLREVSVPGLDPAHRYKLLLYGlH 1992
Cdd:pfam00041    1 SAPS---NLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQA-V 76


                   ....*....
gi 1622934675 1993 SGKRVGPIS 2001
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 4083-4151 6.14e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 6.14e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934675  4083 APRDLEAKEVTPRTALLTWTEPQVRP-----TGYLLSFDTPGGRTQEILLPGGVTSHQLLGLFPSTLYNARLQA 4151
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitgyiVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1815-1883 6.18e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 6.18e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934675 1815 PGAPprlGELWVTDPTPDSLHLSWTVPE---GQFDSFVVQFKDKDGPQVVPVE---GHERSVTIAPLDAGRKYRF 1883
Cdd:cd00063      1 PSPP---TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEF 72
PTZ00214 PTZ00214
high cysteine membrane protein Group 4; Provisional
 254-669 6.81e-07

high cysteine membrane protein Group 4; Provisional


Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 55.69  E-value: 6.81e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  254 SQRGRCEDGRCVCDPGYTGedcGMRSCPRGCSQRGRCENGRCvcNPGYTGEDCgvRSCPRGCSQrgrceDGRCVCDPGYT 333
Cdd:PTZ00214   341 SKNDDNNGDGYLCGDATNG---GVSGCATCGYNSGAVTCTRC--SAGYLGVDG--KSCSESCSG-----DTRGVCTKVAE 408

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  334 GEDCGTRSCRwdcgeggrcvdgrCVCWPGYTGEDCSTRTCPRDCrgrGRCEDGE---C-ICDTGYSGDDCGVRSCPGDCN 409
Cdd:PTZ00214   409 GSESTEVSCR-------------CVCKPTFYNSSGTCTPCTDSC---AVCKDGTptgCqQCSPGKILEFSIVSSESADCV 472

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  410 QRGRCEDGRCVCwpGYTgLDcGSRACPRDCRGRGRCENGVCVCNagySGEDCGVRSCPG----DCRGRGRCESGRCVCWP 485
Cdd:PTZ00214   473 DQCSVGSECAEC--GIT-ID-GSRYCTRCKDASTYPFNGVCIPN---TQRDAYCTSTANgactTCSGAAFLMNGGCYTTE 545

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  486 GYTGRDCGTRACPGDC----RGRGRCVDGRCV-CNP---GFTGEDCGS-RRCPGDC-------RGHGSCED-GVCVcDAG 548
Cdd:PTZ00214   546 HYPGSTICDKQSNGKCtttkKGYGISPDGKLLeCDPtclACTAPGPGRcTRCPSDKllkrasgAATGSCVDpGACV-DGY 624

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  549 YSGEDCSTRSCPGGCRGRG------QCIDGRCVCEDGYSgedcsvrrCPNDCSQHGVCQD---GVCICW------EAYVG 613
Cdd:PTZ00214   625 YADGDACLPCATPGCKTCGhasfctECAGELFVSLDGQS--------CLEECTGDKVVGEvsgGVRRCWcergflPALDR 696

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675  614 EDCSIRT-CPSNCHGRGRCEE-GRCL-CDPGYTGPTCATRMCPADCRGRGRCVQGVCMC 669
Cdd:PTZ00214   697 SGCVLPTeCPPDMPSCAACDEsGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMC 755
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2332-2421 7.44e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 7.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2332 PDAPlvkprlGEMTVRDATPDSLSLSWTVPE---GQFDHFLVQYKNGDGQP--KAVRVPGHEDGVTISGLEPDHKYKMNL 2406
Cdd:cd00063      1 PSPP------TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRV 74

                           90
                   ....*....|....*
gi 1622934675 2407 YGFHGGQRMGPVSAV 2421
Cdd:cd00063     75 RAVNGGGESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2673-2735 7.51e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 7.51e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934675 2673 TVTGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGGLEPGRKYKMHLY 2735
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 311-337 8.21e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 48.06  E-value: 8.21e-07
                           10        20
                   ....*....|....*....|....*..
gi 1622934675  311 CPRGCSQRGRCEDGRCVCDPGYTGEDC 337
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 249-275 8.21e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 48.06  E-value: 8.21e-07
                           10        20
                   ....*....|....*....|....*..
gi 1622934675  249 CPRGCSQRGRCEDGRCVCDPGYTGEDC 275
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2988-3059 9.00e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 9.00e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934675  2988 PIKPRlgELTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLY 3059
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 373-399 9.51e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 9.51e-07
                           10        20
                   ....*....|....*....|....*..
gi 1622934675  373 CPRDCRGRGRCEDGECICDTGYSGDDC 399
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1625-1688 1.04e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 1.04e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675  1625 LTVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQAVRVGGEESEVTVGGLEPGHKYKMHLY 1688
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2137-2200 1.08e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 1.08e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675  2137 LTVTDATPDSLSLSWTVPE-----GQFDHFLVQYRNGDGRPKAVRVPGHEDGVTISGLEPDHKYKMNLY 2200
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2561-2641 1.22e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 1.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2561 LTVTGSSPDSLSLSWTIPQ---GRFDSFTVQYKDRDGRP--QVVRVGGEESEVTVGSLEPGNKYKMHLYGLHEGRRVGPV 2635
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1622934675 2636 SAVGVT 2641
Cdd:cd00063     87 ESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3321-3397 1.55e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 1.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3321 TVAGSSPDSLSLSWTVPQ---GRFDSFTVQYKDRDGQP--QAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEGRRVGPVS 3395
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ..
gi 1622934675 3396 AV 3397
Cdd:cd00063     88 SV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1514-1577 1.75e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 1.75e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675  1514 LTVTGVTPDSLRLSWT-----VAQGPFDSFMVQYKDAQGQPQAVPVAGDENEVTVPGLDPDRKYKMNLY 1577
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1315-1473 2.10e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 53.85  E-value: 2.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1315 LTVTDRTSDSLLLRWT-VPEGEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVGKKRHGPLVTEA 1393
Cdd:COG3401    239 LTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVV 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1394 KILPQSDPrPGTPprlGNLWVTDPTPDSLHLSWT-VPEGQFDTFMVqYRDK--DGRPQVVPVEGPERSFVVSSLDPDHKY 1470
Cdd:COG3401    319 SVTTDLTP-PAAP---SGLTATAVGSSSITLSWTaSSDADVTGYNV-YRSTsgGGTYTKIAETVTTTSYTDTGLTPGTTY 393


                   ...
gi 1622934675 1471 RFT 1473
Cdd:COG3401    394 YYK 396
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3105-3167 2.54e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.54e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934675  3105 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 3167
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2889-2951 2.54e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.54e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934675  2889 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 2951
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2673-2735 2.54e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 2.54e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934675  2673 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLY 2735
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
314-418 2.82e-06

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 49.76  E-value: 2.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  314 GCSQRG-RCEDGRCVC-----DPGYTGEDCGtrSCRWDCGEGGRCVDGRCVCWPGYT--GEDC-STRTCPRDCRGRGR-- 382
Cdd:NF041328    13 GCPEPGaVCPEGLSVCggacvDLRSDPSNCG--ACGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAac 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1622934675  383 -----CEDGEC--ICDTGYS--GDDC-GVRSCPGDCNQRG-RCEDGR 418
Cdd:NF041328    91 apgqvCEGGACreACSEGLTrcGGACvDLATDPLHCGACGvACDPGE 137
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2453-2516 3.54e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 3.54e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675  2453 LTMTDATPDSLSLSWTVPE-----GQFDHFLVQYKNGDGQPKTTRVPGHEDRVTISGLEPDHKYKMNLY 2516
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2246-2308 3.71e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 3.71e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934675  2246 TVTGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGNKYKMHLY 2308
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3807-3882 3.82e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 3.82e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622934675  3807 SQLSVTDVTTSSLRLNWEAPPGA-FDSFLLRFgvpspsTLEPHPRPLLQRELMVPGTRHSAVLRDLRPGTLYSLTLY 3882
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDgITGYIVGY------RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2332-2407 4.60e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 4.60e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  2332 PDAPlvkprlGEMTVRDATPDSLSLSWTVPE-----GQFDHFLVQYKNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNL 2406
Cdd:smart00060    1 PSPP------SNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                    .
gi 1622934675  2407 Y 2407
Cdd:smart00060   75 R 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3710-3789 5.14e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 5.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3710 LAVTDTAPDSMRLSWSVAQ---GPFDSFVVQYEDTNGQP--QALLVDGDQSKILISGLEPSTPYRFLLYGLHEGKRlGPL 3784
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE-SPP 85


                   ....*
gi 1622934675 3785 SAEGT 3789
Cdd:cd00063     86 SESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1815-1883 5.28e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 5.28e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934675  1815 PGAPPRLgelWVTDPTPDSLHLSWTVPE-GQFDSFVVQFKDKDGP-----QVVPVEGHERSVTIAPLDAGRKYRF 1883
Cdd:smart00060    1 PSPPSNL---RVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1719-1786 5.60e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 5.60e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675  1719 PLEPRlgELTVTDVTPNSVGLSWTVPE-----GQFDSFMVQYKDKDGQPQAVPVAADQQEVTIYNLEPERKYK 1786
Cdd:smart00060    1 PSPPS--NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYE 71
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2561-2624 6.42e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 6.42e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675  2561 LTVTGSSPDSLSLSWTIPQ-----GRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGSLEPGNKYKMHLY 2624
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
594-703 6.62e-06

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 48.99  E-value: 6.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  594 CSQHG-VCQDGVCICWEAYVgedcSIRTCPSNCHGRG-------RCEEGRCLCDPGYT--GPTC-ATRMCPADCRGRGR- 661
Cdd:NF041328    14 CPEPGaVCPEGLSVCGGACV----DLRSDPSNCGACGvacgagqTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAa 89

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622934675  662 ------CVQGVCMCHVGYGGEDCGQ-------EEPPASACPGGCGPRELCQAGQC 703
Cdd:NF041328    90 capgqvCEGGACREACSEGLTRCGGacvdlatDPLHCGACGVACDPGESCRGGAC 144
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1917-1986 7.01e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 7.01e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934675  1917 PPKPRlgeELQVTSVTQNSVGLSWTVPE-----GQFDSFVVQYKDRDGQPQVVPVEGSLREVSVPGLDPAHRYKL 1986
Cdd:smart00060    1 PSPPS---NLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3321-3388 8.61e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 8.61e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622934675  3321 TVAGSSPDSLSLSWTVPQ-----GRFDSFTVQYKDRDGQPQAVRVGGEESEVTVRGLEPGRKYKMHLYGLYEG 3388
Cdd:smart00060    8 RVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3416-3496 1.34e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.34  E-value: 1.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3416 LTVAAVTSDSVGLSWTVAQ---GPFDSFLVQYRDTQGQP--QAVPVSGDLRAVTVSGLDPARKYKFLLFGlQNGKRHGP- 3489
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRA-VNGGGESPp 85


                   ....*...
gi 1622934675 3490 -VPVEART 3496
Cdd:cd00063     86 sESVTVTT 93
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 280-306 1.49e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 44.60  E-value: 1.49e-05
                           10        20
                   ....*....|....*....|....*..
gi 1622934675  280 CPRGCSQRGRCENGRCVCNPGYTGEDC 306
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2453-2654 1.51e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.16  E-value: 1.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2453 LTMTDATPDSLSLSWT-VPEGQFDHFLVQYKNGDGQPKTTRVPGHEDRVTISGLEPDHKYKmnlYGfhggqrvgpVSAIG 2531
Cdd:COG3401    239 LTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYY---YR---------VTAVD 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2532 vTAAEEETPSPTEPSTEAPEPSEEPLlgELTVTGSSPDSLSLSWT-IPQGRFDSFTVQYKDR-DGRPQVVRVGGEESEVT 2609
Cdd:COG3401    307 -AAGNESAPSNVVSVTTDLTPPAAPS--GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAETVTTTSYT 383

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2610 VGSLEPGNKYK-----MHLYGLhEGRRVGPVSAVGVTAPREDVDETPSPT 2654
Cdd:COG3401    384 DTGLTPGTTYYykvtaVDAAGN-ESAPSEEVSATTASAASGESLTASVDA 432
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3993-4079 1.58e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.34  E-value: 1.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3993 PDGPTQLRALNLTEGFAVLHWKPPQN---PVDTYDVQVTAPGAPPLQ--AEAPGSAVDYPLHDLVLHTNYTATVRGLRGP 4067
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDdggPITGYVVEYREKGSGDWKevEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1622934675 4068 NLTSPA-SITFTT 4079
Cdd:cd00063     81 GESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3710-3770 1.66e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 1.66e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675  3710 LAVTDTAPDSMRLSWS-----VAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPYRF 3770
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3416-3476 1.92e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.92e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675  3416 LTVAAVTSDSVGLSWT-----VAQGPFDSFLVQYRDTQGQPQAVPVSGDLRAVTVSGLDPARKYKF 3476
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
3996-4066 3.57e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 3.57e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 3996 PTQLRALNLTEGFAVLHWKPP---QNPVDTYDVQVTAPGAPPLQAE--APGSAVDYPLHDLVLHTNYTATVRGLRG 4066
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEitVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 3807-3882 3.83e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 3.83e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675 3807 SQLSVTDVTTSSLRLNWEAPP---GAFDSFLLRFGVPSPSTLEPHPRPllqrelmvPGTRHSAVLRDLRPGTLYSLTLY 3882
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT--------PGSETSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 528-555 5.18e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 43.06  E-value: 5.18e-05
                           10        20
                   ....*....|....*....|....*...
gi 1622934675  528 CPGDCRGHGSCEDGVCVCDAGYSGEDCS 555
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 625-647 6.26e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 42.72  E-value: 6.26e-05
                           10        20
                   ....*....|....*....|....*
gi 1622934675  625 CHGRGRCE--EGRCLCDPGYTGPTC 647
Cdd:pfam07974    2 CSGRGTCVnqCGKCVCDSGYQGATC 26
PTZ00214 PTZ00214
high cysteine membrane protein Group 4; Provisional
 266-577 6.56e-05

high cysteine membrane protein Group 4; Provisional


Pssm-ID: 173479 [Multi-domain]  Cd Length: 800  Bit Score: 49.14  E-value: 6.56e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  266 CDPGYTGEDCgmRSCPRGCS--QRGRCE-----------NGRCVCNPGYTGEDCGVRSCPRGCSQrgrCEDGR---C-VC 328
Cdd:PTZ00214   379 CSAGYLGVDG--KSCSESCSgdTRGVCTkvaegsestevSCRCVCKPTFYNSSGTCTPCTDSCAV---CKDGTptgCqQC 453

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  329 DPGYTGE---------DCGTR-SCRWDCGEGGRCVDG-----RC----------VCWPGyTGED--CSTR---TCPRdCR 378
Cdd:PTZ00214   454 SPGKILEfsivssesaDCVDQcSVGSECAECGITIDGsryctRCkdastypfngVCIPN-TQRDayCTSTangACTT-CS 531

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  379 GRGRCEDGECICDTGYSGDDCGVRSCPGDCNQR----GRCEDGRCV-CWPgyTGLDCGSRA------CPRDC---RGRGr 444
Cdd:PTZ00214   532 GAAFLMNGGCYTTEHYPGSTICDKQSNGKCTTTkkgyGISPDGKLLeCDP--TCLACTAPGpgrctrCPSDKllkRASG- 608

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  445 CENGVCV----CNAGY--SGEDCGVRSCPGdCRGRGrcESGRCVCWPGYTGRDCGTRACPGDCRGR---GRCVDG--RCV 513
Cdd:PTZ00214   609 AATGSCVdpgaCVDGYyaDGDACLPCATPG-CKTCG--HASFCTECAGELFVSLDGQSCLEECTGDkvvGEVSGGvrRCW 685

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622934675  514 CNPGF-----TGEDCGSRRCPGDCRGHGSC-EDGVCV-CDAGYSGEDCSTRSCPGGCRGRGQCIDGRCVCE 577
Cdd:PTZ00214   686 CERGFlpaldRSGCVLPTECPPDMPSCAACdESGRCLlCVTSGHNVQVDQRTCAEGCGARASSNQGVCMCE 756
fn3 pfam00041
Fibronectin type III domain;
2029-2099 7.89e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 7.89e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622934675 2029 GELTVEEATPHTLHLSWM---VTEGEFDSFEI--QHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLYGFHDG 2099
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTpppDGNGPITGYEVeyRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 497-523 1.08e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.90  E-value: 1.08e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934675  497 CPGDCRGRGRCVDGRCVCNPGFTGEDC 523
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
fn3 pfam00041
Fibronectin type III domain;
1083-1161 1.23e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 1.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1083 APRHPKPEVLGSSAdgaLLVS---LDGLRGQFERVVLRWRPQPpAEGPGGELTVPGTTRTVSLPDLRPGTTYHVEVHGVR 1159
Cdd:pfam00041    2 APSNLTVTDVTSTS---LTVSwtpPPDGNGPITGYEVEYRPKN-SGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ..
gi 1622934675 1160 AG 1161
Cdd:pfam00041   78 GG 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1663-1883 1.45e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.07  E-value: 1.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1663 VRVGGEESEVTVGGLEPGHKYKMHLYGLHEGQRVGPVSAVGVTAPQqeeTPPAtkPPleprlGELTVTDVTPNSVGLSWT 1742
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPT---TPPS--AP-----TGLTATADTPGSVTLSWD 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1743 -VPEGQFDSFMVqYKDKDGQPQAVPVAADQQ-EVTIYNLEPERKYK-----MNMYGLHdgqrvGPLSVVImTAARGDASP 1815
Cdd:COG3401    255 pVTESDATGYRV-YRSNSGDGPFTKVATVTTtSYTDTGLTNGTTYYyrvtaVDAAGNE-----SAPSNVV-SVTTDLTPP 327

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622934675 1816 GAPprlGELWVTDPTPDSLHLSWT-VPEGQFDSFVVQFKDKDGPQVVPV--EGHERSVTIAPLDAGRKYRF 1883
Cdd:COG3401    328 AAP---SGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGTYTKIaeTVTTTSYTDTGLTPGTTYYY 395
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 500-523 1.51e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 41.56  E-value: 1.51e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934675  500 DCRGRGRCVD--GRCVCNPGFTGEDC 523
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 590-617 1.53e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.52  E-value: 1.53e-04
                           10        20
                   ....*....|....*....|....*...
gi 1622934675  590 CPNDCSQHGVCQDGVCICWEAYVGEDCS 617
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1765-1961 1.66e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 47.69  E-value: 1.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1765 VPVAADQQEVTIYNLEPERKYKMNMYGLHDGQRVGPLSVVIMTAARgdASPGAPprlGELWVTDPTPDSLHLSWT-VPEG 1843
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPT--TPPSAP---TGLTATADTPGSVTLSWDpVTES 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 1844 QFDSFVV-QFKDKDGPQVVPVEGHERSVTIAPLDAGRKYRFLLYGLlgkkrhgplTADGTTEARSAMDD--TGTKRPPKP 1920
Cdd:COG3401    260 DATGYRVyRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAV---------DAAGNESAPSNVVSvtTDLTPPAAP 330

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1622934675 1921 rlgEELQVTSVTQNSVGLSWT-VPEGQFDSFVVQYKDRDGQP 1961
Cdd:COG3401    331 ---SGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 3993-4062 1.99e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 1.99e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934675  3993 PDGPTQLRALNLTEGFAVLHWKPPQNP-----VDTYDVQVTAPGAPPLQAEAPGSAVDYPLHDLVLHTNYTATVR 4062
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 469-492 2.03e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 41.18  E-value: 2.03e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934675  469 DCRGRGRCES--GRCVCWPGYTGRDC 492
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 531-554 2.11e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 41.18  E-value: 2.11e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934675  531 DCRGHGSCED--GVCVCDAGYSGEDC 554
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 221-244 2.81e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 2.81e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934675  221 DCQGRGRCVQ--GVCVCRAGFSGPDC 244
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 284-306 2.89e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 2.89e-04
                           10        20
                   ....*....|....*....|....*
gi 1622934675  284 CSQRGRCEN--GRCVCNPGYTGEDC 306
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 750-829 3.38e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 3.38e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675   750 PAIEGMRMHLLEETTVRTEWTPAPGP-VDAYEIQFIPTTEGASPPF-TARVPSSASAYDQRGLAPGQEYQVTVRALRGTS 827
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622934675   828 WG 829
Cdd:smart00060   82 EG 83
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
279-414 3.41e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 43.98  E-value: 3.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  279 SCPRGCSqrgRCeNGRCVCNPGyTGEDCGvrSCPRGCSQRGRCEDGRCVCDPGytGEDCG-----TRSCRWDCGE-GGRC 352
Cdd:NF041328    20 VCPEGLS---VC-GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHCGAcGAAC 90

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622934675  353 VDGRcVCWPGYTGEDCSTrtcprdcrGRGRCeDGECI---CDTGYSGdDCGVRSCPGDCNQRGRC 414
Cdd:NF041328    91 APGQ-VCEGGACREACSE--------GLTRC-GGACVdlaTDPLHCG-ACGVACDPGESCRGGAC 144
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 563-585 3.52e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.52e-04
                           10        20
                   ....*....|....*....|....*
gi 1622934675  563 CRGRGQCID--GRCVCEDGYSGEDC 585
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 438-461 3.52e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.52e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934675  438 DCRGRGRCEN--GVCVCNAGYSGEDC 461
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 315-337 3.62e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.62e-04
                           10        20
                   ....*....|....*....|....*
gi 1622934675  315 CSQRGRCED--GRCVCDPGYTGEDC 337
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 253-275 3.62e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.62e-04
                           10        20
                   ....*....|....*....|....*
gi 1622934675  253 CSQRGRCED--GRCVCDPGYTGEDC 275
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 376-399 3.84e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 3.84e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934675  376 DCRGRGRCED--GECICDTGYSGDDC 399
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
191-295 4.09e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 43.59  E-value: 4.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  191 CNDQGRCVRGRCVCFPGYTgpSCGwpscpgdcqgrGRCVQ--------GVC--VCRAGFSgpdCSQRSCPRGCSQ-RGRC 259
Cdd:NF041328    49 CGAGQTCVAGACGCGPGTV--ACG-----------GACVDtasdpahcGACgaACAPGQV---CEGGACREACSEgLTRC 112

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1622934675  260 eDGRCV---CDPGYTGEdCGmRSCPRGCSqrgrCENGRC 295
Cdd:NF041328   113 -GGACVdlaTDPLHCGA-CG-VACDPGES----CRGGAC 144
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 435-461 4.32e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 40.36  E-value: 4.32e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934675  435 CPRDCRGRGRCENGVCVCNAGYSGEDC 461
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 719-745 4.58e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 40.36  E-value: 4.58e-04
                           10        20
                   ....*....|....*....|....*..
gi 1622934675  719 CPGDCRGRGECHDGSCICKDGYAGEDC 745
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
492-590 5.34e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 43.21  E-value: 5.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  492 CGtrACPGDCRGRGRCVDGRCVCNPGFT--GEDCGSRR--------CPGDCRGHGSCEDGVC--VCDAGYsgEDCStRSC 559
Cdd:NF041328    42 CG--ACGVACGAGQTCVAGACGCGPGTVacGGACVDTAsdpahcgaCGAACAPGQVCEGGACreACSEGL--TRCG-GAC 116

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1622934675  560 PGGCRGRGQCidGRC--VCEDgysGEDCSVRRC 590
Cdd:NF041328   117 VDLATDPLHC--GACgvACDP---GESCRGGAC 144
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 190-213 6.09e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.64  E-value: 6.09e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934675  190 DCNDQGRCVR--GRCVCFPGYTGPSC 213
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2031-2094 6.32e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 6.32e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622934675  2031 LTVEEATPHTLHLSWM-----VTEGEFDSFEIQHTDREGQLQTVRTGGDRNDITLSGLESDHRYLVTLY 2094
Cdd:smart00060    7 LRVTDVTSTSVTLSWEpppddGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 218-245 7.78e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.59  E-value: 7.78e-04
                           10        20
                   ....*....|....*....|....*...
gi 1622934675  218 CPGDCQGRGRCVQGVCVCRAGFSGPDCS 245
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
416-543 7.98e-04

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 42.82  E-value: 7.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  416 DGRCVCWPGyTGLDCGsrACPRDCRGRGRCENGVCVCNAGysGEDCG-----VRSCPGDCrgrGRCESgrcVCWPGYTgr 490
Cdd:NF041328    29 GGACVDLRS-DPSNCG--ACGVACGAGQTCVAGACGCGPG--TVACGgacvdTASDPAHC---GACGA---ACAPGQV-- 95

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622934675  491 dCGTRACPGDC-RGRGRCvDGRCVcNPGFTGEDCGSrrCPGDCRGHGSCEDGVC 543
Cdd:NF041328    96 -CEGGACREACsEGLTRC-GGACV-DLATDPLHCGA--CGVACDPGESCRGGAC 144
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 407-430 8.10e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.25  E-value: 8.10e-04
                           10        20
                   ....*....|....*....|....*.
gi 1622934675  407 DCNQRGRCED--GRCVCWPGYTGLDC 430
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
2137-2335 1.41e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.61  E-value: 1.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2137 LTVTDATPDSLSLSWT-VPEGQFDHFLVQYRN-GDGRPKAV-RVPGHEdgVTISGLEPDHKYK-----MNLYGFHGgqrv 2208
Cdd:COG3401    239 LTATADTPGSVTLSWDpVTESDATGYRVYRSNsGDGPFTKVaTVTTTS--YTDTGLTNGTTYYyrvtaVDAAGNES---- 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 2209 GPVSAIGVTAAEEETPSPTepsteapeppeepllgELTVTGSSPDSLSLSWT-VPQGRFDSFTVQYKDR-DGRPQVVRVG 2286
Cdd:COG3401    313 APSNVVSVTTDLTPPAAPS----------------GLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSgGGTYTKIAET 376

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622934675 2287 GEESEVTVGGLEPGNKYK-----MHLYGLhEGRRVGPVSAVGVTAPKEESPDAP 2335
Cdd:COG3401    377 VTTTSYTDTGLTPGTTYYykvtaVDAAGN-ESAPSEEVSATTASAASGESLTAS 429
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
3641-3829 1.69e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.61  E-value: 1.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3641 VPVAADQHTVTIEDLEPGKKYKFLLYGLVGGKRLGPVSALGMTAPEEDTPAPElaseapeppeeprlgVLAVTDTAPDSM 3720
Cdd:COG3401    185 LTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT---------------GLTATADTPGSV 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675 3721 RLSWS-VAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPYRFLLYGLHEGKRLGPLS--AEGTTGPAPAGQ 3797
Cdd:COG3401    250 TLSWDpVTESDATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTPPAA 329

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1622934675 3798 TSGepgprlsqLSVTDVTTSSLRLNWEAPPGA 3829
Cdd:COG3401    330 PSG--------LTATAVGSSSITLSWTASSDA 353
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 4203-4217 1.73e-03

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 39.08  E-value: 1.73e-03
                           10
                   ....*....|....*
gi 1622934675 4203 PLNVFCDMETDGGGW 4217
Cdd:NF040941    29 PFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2031-2099 2.23e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.17  E-value: 2.23e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622934675 2031 LTVEEATPHTLHLSWMV---TEGEFDSFEIQHTDR-EGQLQTVRTG-GDRNDITLSGLESDHRYLVTLYGFHDG 2099
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPpedDGGPITGYVVEYREKgSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAVNGG 80
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 652-678 2.53e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.05  E-value: 2.53e-03
                           10        20
                   ....*....|....*....|....*..
gi 1622934675  652 CPADCRGRGRCVQGVCMCHVGYGGEDC 678
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 345-368 2.71e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.10  E-value: 2.71e-03
                           10        20
                   ....*....|....*....|....*.
gi 1622934675  345 DCGEGGRCVD--GRCVCWPGYTGEDC 368
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 621-648 2.85e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.05  E-value: 2.85e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622934675  621 CPSNCHGRGRCEEGRCLCDPGYTGPTCA 648
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 404-430 4.52e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.28  E-value: 4.52e-03
                           10        20
                   ....*....|....*....|....*..
gi 1622934675  404 CPGDCNQRGRCEDGRCVCWPGYTGLDC 430
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EB pfam01683
EB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 599-643 4.91e-03

EB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains pfam00014.


Pssm-ID: 460294  Cd Length: 52  Bit Score: 37.79  E-value: 4.91e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622934675  599 VCQDGVCIcWEAYVGEDCSIrtcPSNCHGRGRCEEGRCLCDPGYT 643
Cdd:pfam01683    6 VLVNGQCV-PKVAPGESCEA---DEQCPGGSVCVNGVCQCPPGFT 46
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 342-369 6.31e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.89  E-value: 6.31e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622934675  342 CRWDCGEGGRCVDGRCVCWPGYTGEDCS 369
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 191-348 6.85e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 40.54  E-value: 6.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622934675  191 CNDQGRCvrGRCVCFPGYTGPSCGWPSCPGDCQGRGRCVQGVCvCRAgFSGPDCSQRSCPRGCSQRGRCEDGRCVCDPGY 270
Cdd:pfam01500   14 CSTGGTC--GSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSC-CRP-TCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQ 89

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622934675  271 TGEDCGMRSCPRGCSQRGRCENgrcVCNPGYtgedCGVRSCPRGCSQRGRCEdGRCvCDPGYTGEDCGTRSCRWDCGE 348
Cdd:pfam01500   90 EGSSGAVSSRTRWCRPDCRVEG---TCLPPC----CVVSCTPPTCCQLHHAQ-ASC-CRPSYCGQSCCRPACCCQCSE 158
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 498-523 9.73e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 9.73e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1622934675  498 PGDCRGRGRCVDG----RCVCNPGFTGEDC 523
Cdd:cd00054      8 GNPCQNGGTCVNTvgsyRCSCPPGYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH