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Conserved domains on  [gi|1622933510|ref|XP_028703341|]
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dynein regulatory complex subunit 5 [Macaca mulatta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 10061432)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 179-489 5.39e-69

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 223.39  E-value: 5.39e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 179 DLLPLCRNYVRRVHVDQFLPPVQIPAQLRPGDQSDSGSEGEMEEPTVDHYQ-LGDLVAGLSHLEELDLVydVKDCGMNFE 257
Cdd:cd00116     1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPsLKELCLSLNETGRIPRG--LQSLLQGLT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 258 --WNLFLFTYRDCHS---LAAAIKACH---TLKIFKLTRSKVDDDKARIIIRSLLDHPV-LEELDLSHNLIGDRGARGAA 328
Cdd:cd00116    79 kgCGLQELDLSDNALgpdGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 329 KLL-NHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSE-PT 406
Cdd:cd00116   159 KALrANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDaGA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 407 ATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANREaaRQRALNPSH 486
Cdd:cd00116   239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGN--ELESLWVKD 316


                  ...
gi 1622933510 487 FMS 489
Cdd:cd00116   317 DSF 319
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 179-489 5.39e-69

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 223.39  E-value: 5.39e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 179 DLLPLCRNYVRRVHVDQFLPPVQIPAQLRPGDQSDSGSEGEMEEPTVDHYQ-LGDLVAGLSHLEELDLVydVKDCGMNFE 257
Cdd:cd00116     1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPsLKELCLSLNETGRIPRG--LQSLLQGLT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 258 --WNLFLFTYRDCHS---LAAAIKACH---TLKIFKLTRSKVDDDKARIIIRSLLDHPV-LEELDLSHNLIGDRGARGAA 328
Cdd:cd00116    79 kgCGLQELDLSDNALgpdGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 329 KLL-NHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSE-PT 406
Cdd:cd00116   159 KALrANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDaGA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 407 ATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANREaaRQRALNPSH 486
Cdd:cd00116   239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGN--ELESLWVKD 316


                  ...
gi 1622933510 487 FMS 489
Cdd:cd00116   317 DSF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 268-474 1.82e-35

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 137.23  E-value: 1.82e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 268 CHSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSHNLIGDRGARGAAKLL-NHSRLRVLNLANNQV 346
Cdd:COG5238   197 IEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALkNNTTVETLYLSGNQI 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 347 RAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLS 426
Cdd:COG5238   277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLS 356

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1622933510 427 CNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDV-AQESEYLIgQALYANR 474
Cdd:COG5238   357 DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIgKQGAEALI-DALQTNR 404
LRR_6 pfam13516
Leucine Rich repeat;
360-383 2.80e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 37.99  E-value: 2.80e-04
                          10        20
                  ....*....|....*....|....
gi 1622933510 360 HNTNLISLNLRLNCIEDEGGQALA 383
Cdd:pfam13516   1 SNTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
333-360 4.13e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.69  E-value: 4.13e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622933510  333 HSRLRVLNLANNQVRAPGAQSLAHALAH 360
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 179-489 5.39e-69

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 223.39  E-value: 5.39e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 179 DLLPLCRNYVRRVHVDQFLPPVQIPAQLRPGDQSDSGSEGEMEEPTVDHYQ-LGDLVAGLSHLEELDLVydVKDCGMNFE 257
Cdd:cd00116     1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPsLKELCLSLNETGRIPRG--LQSLLQGLT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 258 --WNLFLFTYRDCHS---LAAAIKACH---TLKIFKLTRSKVDDDKARIIIRSLLDHPV-LEELDLSHNLIGDRGARGAA 328
Cdd:cd00116    79 kgCGLQELDLSDNALgpdGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 329 KLL-NHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSE-PT 406
Cdd:cd00116   159 KALrANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDaGA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 407 ATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANREaaRQRALNPSH 486
Cdd:cd00116   239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGN--ELESLWVKD 316


                  ...
gi 1622933510 487 FMS 489
Cdd:cd00116   317 DSF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 268-474 1.82e-35

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 137.23  E-value: 1.82e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 268 CHSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSHNLIGDRGARGAAKLL-NHSRLRVLNLANNQV 346
Cdd:COG5238   197 IEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALkNNTTVETLYLSGNQI 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 347 RAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLS 426
Cdd:COG5238   277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLS 356

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1622933510 427 CNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDV-AQESEYLIgQALYANR 474
Cdd:COG5238   357 DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIgKQGAEALI-DALQTNR 404
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 268-473 1.06e-30

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 123.75  E-value: 1.06e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 268 CHSLAAAIKAcHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSHNLIGDRGARGAAKLLNHS-RLRVLNLANNQV 346
Cdd:COG5238   170 AISMAKALQN-NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNkSLTTLDLSNNQI 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 347 RAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLS 426
Cdd:COG5238   249 GDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLA 328

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1622933510 427 CNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYAN 473
Cdd:COG5238   329 YNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGN 375
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 309-474 2.89e-29

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 119.51  E-value: 2.89e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 309 LEELDLSHNLIGDRGARGAAKLLNHSR-LRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQ 387
Cdd:COG5238   182 VETVYLGCNQIGDEGIEELAEALTQNTtVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALK 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 388 TNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIG 467
Cdd:COG5238   262 NNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALA 341


                  ....*..
gi 1622933510 468 QALYANR 474
Cdd:COG5238   342 KALQENT 348
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 294-473 8.29e-23

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 100.63  E-value: 8.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 294 DKARIIIRSLLDHPVLEELDLS---HNLIGDRGARGAAKLLNHSrLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLR 370
Cdd:COG5238   138 PRRINLIQVLKDPLGGNAVHLLglaARLGLLAAISMAKALQNNS-VETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLK 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 371 LNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLE 450
Cdd:COG5238   217 RNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTS 296

                         170       180
                  ....*....|....*....|...
gi 1622933510 451 FDLRLSDVAQESEYLIGQALYAN 473
Cdd:COG5238   297 LDLSVNRIGDEGAIALAEGLQGN 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 313-474 6.17e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 67.51  E-value: 6.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 313 DLSHNLIGDRGARGAAKLLNHSRLRVLNLANNQVRAPGAQsLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQ----- 387
Cdd:COG5238    93 DWEGAEEVSPVALAETATAVATPPPDLRRIMAKTLEDSLI-LYLALPRRINLIQVLKDPLGGNAVHLLGLAARLGllaai 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 388 ------TNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQE 461
Cdd:COG5238   172 smakalQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDE 251

                         170
                  ....*....|...
gi 1622933510 462 SEYLIGQALYANR 474
Cdd:COG5238   252 GVIALAEALKNNT 264
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 230-360 4.43e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 58.65  E-value: 4.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 230 LGDLVAGLSHLEELDLVYD-VKDCGMNFewnlflftyrdchsLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPV 308
Cdd:COG5238   312 LAEGLQGNKTLHTLNLAYNgIGAQGAIA--------------LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTT 377

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622933510 309 LEELDLSHNLIGDRGARGAAKLLNHSRLRVLNLANNQVRAPGAQSLAHALAH 360
Cdd:COG5238   378 LRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAEAQQRLEQLLER 429
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
230-475 6.80e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 6.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 230 LGDLVAGLSHLEELDLvydvkdcgmnfewnlflfTYRDCHSLAAAIKACHTLKIFKLTRSKVDDdkariIIRSLLDHPVL 309
Cdd:COG4886   128 LPEELANLTNLKELDL------------------SNNQLTDLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNL 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 310 EELDLSHNLIGDrgarGAAKLLNHSRLRVLNLANNQVRapgaqSLAHALAHNTNLISLNLRLNCIEDeggqalAHALQTN 389
Cdd:COG4886   185 KELDLSNNQITD----LPEPLGNLTNLEELDLSGNQLT-----DLPEPLANLTNLETLDLSNNQLTD------LPELGNL 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 390 KCLTTLHLGGNELSEPTAtllsqvLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQA 469
Cdd:COG4886   250 TNLEELDLSNNQLTDLPP------LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323


                  ....*.
gi 1622933510 470 LYANRE 475
Cdd:COG4886   324 LLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
255-430 7.67e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 7.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 255 NFEWNLFLFTYRDCHSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSHNligdrgargaAKLLNHS 334
Cdd:COG4886    44 SLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN----------EELSNLT 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 335 RLRVLNLANNQVrapgaQSLAHALAHNTNLISLNLRLNCIEDeggqaLAHALQTNKCLTTLHLGGNELSEptatlLSQVL 414
Cdd:COG4886   114 NLESLDLSGNQL-----TDLPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTD-----LPEEL 178

                         170
                  ....*....|....*.
gi 1622933510 415 AINTTLTSINLSCNHI 430
Cdd:COG4886   179 GNLTNLKELDLSNNQI 194
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
229-473 4.06e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 4.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 229 QLGDLVAGLSHLEELDLvydvKDCGMNfewnlflftyrdchSLAAAIKACHTLKIFKLTRSKVDDdkariIIRSLLDHPV 308
Cdd:COG4886   150 DLPEPLGNLTNLKSLDL----SNNQLT--------------DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTN 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 309 LEELDLSHNLIGDRGargaAKLLNHSRLRVLNLANNQVRapgaqSLAhALAHNTNLISLNLRLNCIEDEGgqalahALQT 388
Cdd:COG4886   207 LEELDLSGNQLTDLP----EPLANLTNLETLDLSNNQLT-----DLP-ELGNLTNLEELDLSNNQLTDLP------PLAN 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 389 NKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQ 468
Cdd:COG4886   271 LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350


                  ....*
gi 1622933510 469 ALYAN 473
Cdd:COG4886   351 TLLLL 355
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
230-473 8.32e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.01  E-value: 8.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 230 LGDLVAGLSHLEELDLvydvkdcgmnfewnlflfTYRDCHSLAAAIKACHTLKIFKLTRSKVDDdkariIIRSLLDHPVL 309
Cdd:COG4886   174 LPEELGNLTNLKELDL------------------SNNQITDLPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 310 EELDLSHNLIGDrgargAAKLLNHSRLRVLNLANNQVRAPGAqslahaLAHNTNLISLNLRLNCIEDEGGQALAHALQTN 389
Cdd:COG4886   231 ETLDLSNNQLTD-----LPELGNLTNLEELDLSNNQLTDLPP------LANLTNLKTLDLSNNQLTDLKLKELELLLGLN 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 390 KCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQA 469
Cdd:COG4886   300 SLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATL 379


                  ....
gi 1622933510 470 LYAN 473
Cdd:COG4886   380 LTLA 383
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
229-456 1.94e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 1.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 229 QLGDL---VAGLSHLEELDLVYdvkdcgmnfewNLFlftyrdcHSLAAAIKACHTLKIFKLTRSKVDDdkariiIRSLLD 305
Cdd:COG4886   193 QITDLpepLGNLTNLEELDLSG-----------NQL-------TDLPEPLANLTNLETLDLSNNQLTD------LPELGN 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622933510 306 HPVLEELDLSHNLIGDrgargAAKLLNHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHA 385
Cdd:COG4886   249 LTNLEELDLSNNQLTD-----LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622933510 386 LQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLS 456
Cdd:COG4886   324 LLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394
LRR_6 pfam13516
Leucine Rich repeat;
360-383 2.80e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 37.99  E-value: 2.80e-04
                          10        20
                  ....*....|....*....|....
gi 1622933510 360 HNTNLISLNLRLNCIEDEGGQALA 383
Cdd:pfam13516   1 SNTHLTTLDLSDNDIGDEGAEALA 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 336-400 1.85e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 1.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622933510 336 LRVLNLANNQVRapgaqSLAhALAHNTNLISLNLRLNCIEDegGQALAHALQTNKCLTTLHLGGN 400
Cdd:cd21340   122 LRVLNISGNNID-----SLE-PLAPLRNLEQLDASNNQISD--LEELLDLLSSWPSLRELDLTGN 178
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
333-360 4.13e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.69  E-value: 4.13e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622933510  333 HSRLRVLNLANNQVRAPGAQSLAHALAH 360
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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