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Conserved domains on  [gi|1622930263|ref|XP_028702892|]
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discoidin, CUB and LCCL domain-containing protein 1 isoform X3 [Macaca mulatta]

Protein Classification

CUB domain-containing protein( domain architecture ID 10036023)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
307-458 1.14e-40

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 144.03  E-value: 1.14e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263 307 SLDPDGQIRASSSWQSvnesgdqvHWSPGQARLqDQGPSWasgdSSSNHKPREWLEIDLGEKKKITGIRTTGSTQSNFNF 386
Cdd:cd00057     7 SGLADDQITASSSYSS--------GWEASRARL-NSDNAW----TPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGSSE 73
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622930263 387 YVKSFVMNFKNNNSKWKTYKGivNNEEKVFQGNSNFRDPVQNNFIPPIVARYVRVVPQTWHQRIALKVELIG 458
Cdd:cd00057    74 WVTSYKVQYSLDGETWTTYKD--KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
88-196 7.34e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 104.80  E-value: 7.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263  88 CGHLVTYQDSGTMTSKNYPGTYPNHTVCEKTITVPKGKRLILRLGDLDIE-SQTCASDYLLF----TSSSDQYGPYCGSM 162
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLEsSPNCSYDYLEIydgpSTSSPLLGRFCGST 80
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622930263 163 TvPRELLLNTSEVTVRFESGSHISGRGFLLTYAS 196
Cdd:cd00041    81 L-PPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
LCCL super family cl02694
LCCL domain;
203-285 8.95e-18

LCCL domain;


The actual alignment was detected with superfamily member smart00603:

Pssm-ID: 445888  Cd Length: 85  Bit Score: 78.20  E-value: 8.95e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263  203 ITCLERASHYLK--TEYSKFCPAGCRDVAGDISGNmvDGYRDTSLLCKAAIHAGIIaDELGGQISVLQRKGISRYEGILA 280
Cdd:smart00603   3 VTCDTRGLDLCKpvTDNRVLCPAGCLLEKAKVFGT--IVYASLSSICRAAVHAGVI-SNSGGAVDVVRVGGRENYISSDA 79

                   ....*
gi 1622930263  281 NGVLS 285
Cdd:smart00603  80 NGIQS 84
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
307-458 1.14e-40

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 144.03  E-value: 1.14e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263 307 SLDPDGQIRASSSWQSvnesgdqvHWSPGQARLqDQGPSWasgdSSSNHKPREWLEIDLGEKKKITGIRTTGSTQSNFNF 386
Cdd:cd00057     7 SGLADDQITASSSYSS--------GWEASRARL-NSDNAW----TPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGSSE 73
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622930263 387 YVKSFVMNFKNNNSKWKTYKGivNNEEKVFQGNSNFRDPVQNNFIPPIVARYVRVVPQTWHQRIALKVELIG 458
Cdd:cd00057    74 WVTSYKVQYSLDGETWTTYKD--KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
301-459 4.99e-28

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 109.14  E-value: 4.99e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263  301 GCSRSLSLDPDGQIRASSSwqsvnesgdqvHWSPGQARL-QDQGPSWASGDSSSNHkpreWLEIDLGEKKKITGIRTTGS 379
Cdd:smart00231   1 PCNEPLGLESDSQITASSS-----------YWAAKIARLnGGSDGGWCPAKNDLPP----WIQVDLGRLRTVTGVITGRR 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263  380 TQSNFnfYVKSFVMnFKNNNSKWKTYKGivnNEEKVFQGNSNFRDPVQNNFIPPIVARYVRVVPQTWHQRIALKVELIGC 459
Cdd:smart00231  66 HGNGD--WVTYKLE-YSDDGVNWTTYKD---GNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
313-456 1.12e-27

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 107.92  E-value: 1.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263 313 QIRASSSWQSvnesgdqvHWsPGQARL-QDQGPSWASGDSSSNHkpreWLEIDLGEKKKITGIRTTGStQSNFNFYVKSF 391
Cdd:pfam00754   1 QITASSSYSG--------EG-PAAAALdGDPNTAWSAWSGDDPQ----WIQVDLGKPKKITGVVTQGR-QDGSNGYVTSY 66
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622930263 392 VMNFKNNNSKWKTYKgivnneEKVFQGNSNFRDPVQNNFIPPIVARYVRVVPQTWH--QRIALKVEL 456
Cdd:pfam00754  67 KIEYSLDGENWTTVK------DEKIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNggNGIALRAEL 127
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
88-196 7.34e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 104.80  E-value: 7.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263  88 CGHLVTYQDSGTMTSKNYPGTYPNHTVCEKTITVPKGKRLILRLGDLDIE-SQTCASDYLLF----TSSSDQYGPYCGSM 162
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLEsSPNCSYDYLEIydgpSTSSPLLGRFCGST 80
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622930263 163 TvPRELLLNTSEVTVRFESGSHISGRGFLLTYAS 196
Cdd:cd00041    81 L-PPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
98-194 1.73e-23

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 95.15  E-value: 1.73e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263   98 GTMTSKNYPGTYPNHTVCEKTITVPKGKRLILRLGDLDIE-SQTCASDYLLF----TSSSDQYGPYCGSMTVPRELLLNT 172
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLEsSDNCEYDYVEIydgpSASSPLLGRFCGSEAPPPVISSSS 80
                           90       100
                   ....*....|....*....|..
gi 1622930263  173 SEVTVRFESGSHISGRGFLLTY 194
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
88-194 1.02e-20

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 87.35  E-value: 1.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263  88 CGHLVTyQDSGTMTSKNYPGTYPNHTVCEKTITVPKGKRLILRLGDLDIE-SQTCASDYLLFT----SSSDQYGPYCGSm 162
Cdd:pfam00431   1 CGGVLT-DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEdHDECGYDYVEIRdgpsASSPLLGRFCGS- 78
                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622930263 163 TVPRELLLNTSEVTVRFESGSHISGRGFLLTY 194
Cdd:pfam00431  79 GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
LCCL smart00603
LCCL domain;
203-285 8.95e-18

LCCL domain;


Pssm-ID: 128866  Cd Length: 85  Bit Score: 78.20  E-value: 8.95e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263  203 ITCLERASHYLK--TEYSKFCPAGCRDVAGDISGNmvDGYRDTSLLCKAAIHAGIIaDELGGQISVLQRKGISRYEGILA 280
Cdd:smart00603   3 VTCDTRGLDLCKpvTDNRVLCPAGCLLEKAKVFGT--IVYASLSSICRAAVHAGVI-SNSGGAVDVVRVGGRENYISSDA 79

                   ....*
gi 1622930263  281 NGVLS 285
Cdd:smart00603  80 NGIQS 84
LCCL pfam03815
LCCL domain;
221-285 6.72e-13

LCCL domain;


Pssm-ID: 427521  Cd Length: 96  Bit Score: 64.61  E-value: 6.72e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622930263 221 CPAGCRDVAGDISGNMVdgYRDTSLLCKAAIHAGIIADElGGQISVLQRKGISRYEGILANGVLS 285
Cdd:pfam03815  25 CPANCADEKASVYGTDV--YSSDSSICKAAIHAGVIDNS-GGLVVVRIVGGQNEYTGSTQNGIES 86
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
307-458 1.14e-40

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 144.03  E-value: 1.14e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263 307 SLDPDGQIRASSSWQSvnesgdqvHWSPGQARLqDQGPSWasgdSSSNHKPREWLEIDLGEKKKITGIRTTGSTQSNFNF 386
Cdd:cd00057     7 SGLADDQITASSSYSS--------GWEASRARL-NSDNAW----TPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGGGSSE 73
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622930263 387 YVKSFVMNFKNNNSKWKTYKGivNNEEKVFQGNSNFRDPVQNNFIPPIVARYVRVVPQTWHQRIALKVELIG 458
Cdd:cd00057    74 WVTSYKVQYSLDGETWTTYKD--KGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
301-459 4.99e-28

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 109.14  E-value: 4.99e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263  301 GCSRSLSLDPDGQIRASSSwqsvnesgdqvHWSPGQARL-QDQGPSWASGDSSSNHkpreWLEIDLGEKKKITGIRTTGS 379
Cdd:smart00231   1 PCNEPLGLESDSQITASSS-----------YWAAKIARLnGGSDGGWCPAKNDLPP----WIQVDLGRLRTVTGVITGRR 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263  380 TQSNFnfYVKSFVMnFKNNNSKWKTYKGivnNEEKVFQGNSNFRDPVQNNFIPPIVARYVRVVPQTWHQRIALKVELIGC 459
Cdd:smart00231  66 HGNGD--WVTYKLE-YSDDGVNWTTYKD---GNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
313-456 1.12e-27

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 107.92  E-value: 1.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263 313 QIRASSSWQSvnesgdqvHWsPGQARL-QDQGPSWASGDSSSNHkpreWLEIDLGEKKKITGIRTTGStQSNFNFYVKSF 391
Cdd:pfam00754   1 QITASSSYSG--------EG-PAAAALdGDPNTAWSAWSGDDPQ----WIQVDLGKPKKITGVVTQGR-QDGSNGYVTSY 66
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622930263 392 VMNFKNNNSKWKTYKgivnneEKVFQGNSNFRDPVQNNFIPPIVARYVRVVPQTWH--QRIALKVEL 456
Cdd:pfam00754  67 KIEYSLDGENWTTVK------DEKIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNggNGIALRAEL 127
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
88-196 7.34e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 104.80  E-value: 7.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263  88 CGHLVTYQDSGTMTSKNYPGTYPNHTVCEKTITVPKGKRLILRLGDLDIE-SQTCASDYLLF----TSSSDQYGPYCGSM 162
Cdd:cd00041     1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLEsSPNCSYDYLEIydgpSTSSPLLGRFCGST 80
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622930263 163 TvPRELLLNTSEVTVRFESGSHISGRGFLLTYAS 196
Cdd:cd00041    81 L-PPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
98-194 1.73e-23

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 95.15  E-value: 1.73e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263   98 GTMTSKNYPGTYPNHTVCEKTITVPKGKRLILRLGDLDIE-SQTCASDYLLF----TSSSDQYGPYCGSMTVPRELLLNT 172
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLEsSDNCEYDYVEIydgpSASSPLLGRFCGSEAPPPVISSSS 80
                           90       100
                   ....*....|....*....|..
gi 1622930263  173 SEVTVRFESGSHISGRGFLLTY 194
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
88-194 1.02e-20

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 87.35  E-value: 1.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263  88 CGHLVTyQDSGTMTSKNYPGTYPNHTVCEKTITVPKGKRLILRLGDLDIE-SQTCASDYLLFT----SSSDQYGPYCGSm 162
Cdd:pfam00431   1 CGGVLT-DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEdHDECGYDYVEIRdgpsASSPLLGRFCGS- 78
                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622930263 163 TVPRELLLNTSEVTVRFESGSHISGRGFLLTY 194
Cdd:pfam00431  79 GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
LCCL smart00603
LCCL domain;
203-285 8.95e-18

LCCL domain;


Pssm-ID: 128866  Cd Length: 85  Bit Score: 78.20  E-value: 8.95e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622930263  203 ITCLERASHYLK--TEYSKFCPAGCRDVAGDISGNmvDGYRDTSLLCKAAIHAGIIaDELGGQISVLQRKGISRYEGILA 280
Cdd:smart00603   3 VTCDTRGLDLCKpvTDNRVLCPAGCLLEKAKVFGT--IVYASLSSICRAAVHAGVI-SNSGGAVDVVRVGGRENYISSDA 79

                   ....*
gi 1622930263  281 NGVLS 285
Cdd:smart00603  80 NGIQS 84
LCCL pfam03815
LCCL domain;
221-285 6.72e-13

LCCL domain;


Pssm-ID: 427521  Cd Length: 96  Bit Score: 64.61  E-value: 6.72e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622930263 221 CPAGCRDVAGDISGNMVdgYRDTSLLCKAAIHAGIIADElGGQISVLQRKGISRYEGILANGVLS 285
Cdd:pfam03815  25 CPANCADEKASVYGTDV--YSSDSSICKAAIHAGVIDNS-GGLVVVRIVGGQNEYTGSTQNGIES 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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