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Conserved domains on  [gi|1622928910|ref|XP_028702606|]
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kelch-like protein 32 isoform X5 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
121-392 4.55e-40

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 144.14  E-value: 4.55e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 121 ANWSELAPMPVGRSHHCVAVMGDFLFVAGGeveHASGRtcAVRTACRYDPRSNSWAEIAPMKNC-REHFVLGAMEEYLYA 199
Cdd:COG3055     1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGS--ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 200 VGGRNEL---RQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAqYQNRLMVYEPNQNKWISRSP 276
Cdd:COG3055    76 FGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 277 MLQRRVYHSMAAV-ERKLYVLGGndldynndrilvrhiDSYNIDTDQWTRCSfNLLTGQNESGVAVHNGRIYLVGGYSIW 355
Cdd:COG3055   155 LPTPRDHLAAAVLpDGKILVIGG---------------RNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVFGGESGF 218

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1622928910 356 TNEplacIQVLDVSREGKEEVfygPTLPFASNGIAAC 392
Cdd:COG3055   219 SDE----VEAYDPATNTWTAL---GELPTPRHGHAAV 248
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 6-33 1.71e-14

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18471:

Pssm-ID: 475122 [Multi-domain]  Cd Length: 98  Bit Score: 68.78  E-value: 1.71e-14
                          10        20
                  ....*....|....*....|....*...
gi 1622928910   6 QLAVRWLEHNCHYQHMDELLQYIRFGLM 33
Cdd:cd18471    71 QLAVRWLEHNCRYQYMDELLQYVRFGLM 98
Kelch smart00612
Kelch domain;
88-143 2.38e-05

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 2.38e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622928910   88 LYIIGGKKREVCkVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGD 143
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNK---------WTPLPSMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
121-392 4.55e-40

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 144.14  E-value: 4.55e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 121 ANWSELAPMPVGRSHHCVAVMGDFLFVAGGeveHASGRtcAVRTACRYDPRSNSWAEIAPMKNC-REHFVLGAMEEYLYA 199
Cdd:COG3055     1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGS--ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 200 VGGRNEL---RQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAqYQNRLMVYEPNQNKWISRSP 276
Cdd:COG3055    76 FGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 277 MLQRRVYHSMAAV-ERKLYVLGGndldynndrilvrhiDSYNIDTDQWTRCSfNLLTGQNESGVAVHNGRIYLVGGYSIW 355
Cdd:COG3055   155 LPTPRDHLAAAVLpDGKILVIGG---------------RNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVFGGESGF 218

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1622928910 356 TNEplacIQVLDVSREGKEEVfygPTLPFASNGIAAC 392
Cdd:COG3055   219 SDE----VEAYDPATNTWTAL---GELPTPRHGHAAV 248
PHA03098 PHA03098
kelch-like protein; Provisional
 86-324 5.41e-24

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 104.08  E-value: 5.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910  86 DTLYIIGGKKREVCKVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGDFLFVAGGEvehasGRTCAVRTA 165
Cdd:PHA03098  295 NVIYFIGGMNKNNLSVNSVVSYDTKTKS---------WNKVPELIYPRKNPGVTVFNNRIYVIGGI-----YNSISLNTV 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 166 CRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLL 245
Cdd:PHA03098  361 ESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKI 440

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 246 WISGGVTNTAQYQ--NRLMVYEPNQNKWISRSPMLQRRVYHSMAAVERKLYVLGGNDLDYNNDrilvrHIDSYNIDTDQW 323
Cdd:PHA03098  441 YVIGGISYIDNIKvyNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYIN-----EIEVYDDKTNTW 515


                  .
gi 1622928910 324 T 324
Cdd:PHA03098  516 T 516
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 6-33 1.71e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 68.78  E-value: 1.71e-14
                          10        20
                  ....*....|....*....|....*...
gi 1622928910   6 QLAVRWLEHNCHYQHMDELLQYIRFGLM 33
Cdd:cd18471    71 QLAVRWLEHNCRYQYMDELLQYVRFGLM 98
Kelch_6 pfam13964
Kelch motif;
133-185 1.23e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 45.02  E-value: 1.23e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622928910 133 RSHHCVAVMGDFLFVAGGevehASGRTCAVRTACRYDPRSNSWAEIAPMKNCR 185
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 6-41 6.00e-06

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 44.64  E-value: 6.00e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1622928910    6 QLAVRWLEHNC--HYQHMDELLQYIRFGLMDVDTLHTV 41
Cdd:smart00875  64 EAVLRWVKHDPekRREHLPELLEHVRLPLLSPDYLLEV 101
Kelch smart00612
Kelch domain;
88-143 2.38e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 2.38e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622928910   88 LYIIGGKKREVCkVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGD 143
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNK---------WTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
197-228 3.60e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.92  E-value: 3.60e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622928910  197 LYAVGGRNElRQVLPTVERYCPKKNKWTFVQS 228
Cdd:smart00612   2 IYVVGGFDG-GQRLKSVEVYDPETNKWTPLPS 32
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 6-41 2.96e-03

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 37.14  E-value: 2.96e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1622928910   6 QLAVRWLEHN--CHYQHMDELLQYIRFGLMDVDTLHTV 41
Cdd:pfam07707  64 EAVIRWVKHDveRRKKHLPELLSAVRLPLLSPQYLLNL 101
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
121-392 4.55e-40

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 144.14  E-value: 4.55e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 121 ANWSELAPMPVGRSHHCVAVMGDFLFVAGGeveHASGRtcAVRTACRYDPRSNSWAEIAPMKNC-REHFVLGAMEEYLYA 199
Cdd:COG3055     1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGS--ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 200 VGGRNEL---RQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAqYQNRLMVYEPNQNKWISRSP 276
Cdd:COG3055    76 FGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 277 MLQRRVYHSMAAV-ERKLYVLGGndldynndrilvrhiDSYNIDTDQWTRCSfNLLTGQNESGVAVHNGRIYLVGGYSIW 355
Cdd:COG3055   155 LPTPRDHLAAAVLpDGKILVIGG---------------RNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVFGGESGF 218

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1622928910 356 TNEplacIQVLDVSREGKEEVfygPTLPFASNGIAAC 392
Cdd:COG3055   219 SDE----VEAYDPATNTWTAL---GELPTPRHGHAAV 248
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
86-298 6.88e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 108.70  E-value: 6.88e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910  86 DTLYIIGGkkrevckvkeLRYFNPVDQENALIAAIANWSELAPMP-VGRSHHCVAVMGDFLFVAGGEVEHASGRTcAVRT 164
Cdd:COG3055    23 GKVYVAGG----------LSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGFTGANPSST-PLND 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 165 ACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVlPTVERYCPKKNKWTFVQSFDRSLSCHAGYVA-DG 243
Cdd:COG3055    92 VYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNV-AWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 244 LLWISGGVTNTAQYQ---------------------NRLMV-------------YEPNQNKWISRSPMLQRRVYHSMAAV 289
Cdd:COG3055   171 KILVIGGRNGSGFSNtwttlaplptaraghaaavlgGKILVfggesgfsdeveaYDPATNTWTALGELPTPRHGHAAVLT 250


                  ....*....
gi 1622928910 290 ERKLYVLGG 298
Cdd:COG3055   251 DGKVYVIGG 259
PHA03098 PHA03098
kelch-like protein; Provisional
 86-324 5.41e-24

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 104.08  E-value: 5.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910  86 DTLYIIGGKKREVCKVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGDFLFVAGGEvehasGRTCAVRTA 165
Cdd:PHA03098  295 NVIYFIGGMNKNNLSVNSVVSYDTKTKS---------WNKVPELIYPRKNPGVTVFNNRIYVIGGI-----YNSISLNTV 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 166 CRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLL 245
Cdd:PHA03098  361 ESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKI 440

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 246 WISGGVTNTAQYQ--NRLMVYEPNQNKWISRSPMLQRRVYHSMAAVERKLYVLGGNDLDYNNDrilvrHIDSYNIDTDQW 323
Cdd:PHA03098  441 YVIGGISYIDNIKvyNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYIN-----EIEVYDDKTNTW 515


                  .
gi 1622928910 324 T 324
Cdd:PHA03098  516 T 516
PHA03098 PHA03098
kelch-like protein; Provisional
 137-387 2.89e-22

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 98.69  E-value: 2.89e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 137 CVAVMGDFLFVAGGEVEhasgRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRnELRQVLPTVERY 216
Cdd:PHA03098  289 GSVVLNNVIYFIGGMNK----NNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGI-YNSISLNTVESW 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 217 CPKKNKWTFVQS--FDRSLSCHAGYvaDGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVERKLY 294
Cdd:PHA03098  364 KPGESKWREEPPliFPRYNPCVVNV--NNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIY 441

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 295 VLGGndLDYNNDRILVRHIDSYNIDTDQWTRCSFNLLTGQNESGVAVHNgRIYLVGGYSI--WTNEplacIQVLDVsrEG 372
Cdd:PHA03098  442 VIGG--ISYIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNN-KIYVVGGDKYeyYINE----IEVYDD--KT 512

                         250
                  ....*....|....*
gi 1622928910 373 KEEVFYGPTLPFASN 387
Cdd:PHA03098  513 NTWTLFCKFPKVIGS 527
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
84-265 1.26e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 79.43  E-value: 1.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910  84 QSDTLYIIGGKKREVCKVKELR---YFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHAsgrtc 160
Cdd:COG3055    69 QDGKLYVFGGFTGANPSSTPLNdvyVYDPATNT---------WTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG----- 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 161 AVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEE-YLYAVGGRNE---------------------------------- 205
Cdd:COG3055   135 NVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDgKILVIGGRNGsgfsntwttlaplptaraghaaavlggkilvfgg 214

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 206 LRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYE 265
Cdd:COG3055   215 ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGVRTPLVTSAE 274
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 6-33 1.71e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 68.78  E-value: 1.71e-14
                          10        20
                  ....*....|....*....|....*...
gi 1622928910   6 QLAVRWLEHNCHYQHMDELLQYIRFGLM 33
Cdd:cd18471    71 QLAVRWLEHNCRYQYMDELLQYVRFGLM 98
PLN02193 PLN02193
nitrile-specifier protein
 245-353 3.03e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 55.35  E-value: 3.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 245 LWISGGVTNTAQYqNRLMVYEPNQNKWISRSPMLQ---RRVYHSMAAVERKLYVLGGndldyNNDRILVRHIDSYNIDTD 321
Cdd:PLN02193  231 LYVFGGRDASRQY-NGFYSFDTTTNEWKLLTPVEEgptPRSFHSMAADEENVYVFGG-----VSATARLKTLDSYNIVDK 304

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622928910 322 QWTRCS--FNLLTGQNESGVAVHNGRIYLVGGYS 353
Cdd:PLN02193  305 KWFHCStpGDSFSIRGGAGLEVVQGKVWVVYGFN 338
Kelch_6 pfam13964
Kelch motif;
133-185 1.23e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 45.02  E-value: 1.23e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622928910 133 RSHHCVAVMGDFLFVAGGevehASGRTCAVRTACRYDPRSNSWAEIAPMKNCR 185
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
PLN02153 PLN02153
epithiospecifier protein
 130-353 1.42e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 49.98  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 130 PVGRSHHCVAVMGDFLFVAGGEV---EHASgrtcavRTACRYDPRSNSWAEIAPMKNCREHFVLG----AMEEYLYAVGG 202
Cdd:PLN02153   20 PGPRCSHGIAVVGDKLYSFGGELkpnEHID------KDLYVFDFNTHTWSIAPANGDVPRISCLGvrmvAVGTKLYIFGG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 203 RNELRQvLPTVERYCPKKNKWTFVQSFDrslschagyvadgllwISGGvtntaqyqnrlmvyepnqnkwisrsPmlQRRV 282
Cdd:PLN02153   94 RDEKRE-FSDFYSYDTVKNEWTFLTKLD----------------EEGG-------------------------P--EART 129

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622928910 283 YHSMAAVERKLYVLGG---NDLDYNNDRIlvRHIDSYNIDTDQWTRC-----SFNLLTGqneSGVAVHNGRIYLVGGYS 353
Cdd:PLN02153  130 FHSMASDENHVYVFGGvskGGLMKTPERF--RTIEAYNIADGKWVQLpdpgeNFEKRGG---AGFAVVQGKIWVVYGFA 203
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 6-41 6.00e-06

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 44.64  E-value: 6.00e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1622928910    6 QLAVRWLEHNC--HYQHMDELLQYIRFGLMDVDTLHTV 41
Cdd:smart00875  64 EAVLRWVKHDPekRREHLPELLEHVRLPLLSPDYLLEV 101
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 280-327 6.91e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.98  E-value: 6.91e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622928910 280 RRVYHSMAAVERKLYVLGGndldYNNDRILvRHIDSYNIDTDQWTRCS 327
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGG----FDGNQSL-NSVEVYDPETNTWSKLP 43
Kelch smart00612
Kelch domain;
88-143 2.38e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 2.38e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622928910   88 LYIIGGKKREVCkVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGD 143
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNK---------WTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 185-228 2.90e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.06  E-value: 2.90e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622928910 185 REHFVLGAMEEYLYAVGGRNElRQVLPTVERYCPKKNKWTFVQS 228
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDG-NQSLNSVEVYDPETNTWSKLPS 44
PHA02713 PHA02713
hypothetical protein; Provisional
 177-320 3.96e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 45.77  E-value: 3.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 177 EIAPMKNCREHFVLGAMEEYLYAVGGRNElRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQ 256
Cdd:PHA02713  334 ELPPMIKNRCRFSLAVIDDTIYAIGGQNG-TNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHID 412

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 257 Y-----------------QNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVERKLYVLggndLDYNNDRILVRHIDSYNID 319
Cdd:PHA02713  413 YtsvhhmnsidmeedthsSNKVIRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV----CDIKDEKNVKTCIFRYNTN 488


                  .
gi 1622928910 320 T 320
Cdd:PHA02713  489 T 489
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 133-182 5.88e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 40.29  E-value: 5.88e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622928910 133 RSHHCVAVMGDFLFVAGGevehaSGRTCAVRTACRYDPRSNSWAEIAPMK 182
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGG-----FDGNQSLNSVEVYDPETNTWSKLPSMP 46
PRK14131 PRK14131
N-acetylneuraminate epimerase;
286-353 1.11e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 44.24  E-value: 1.11e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622928910 286 MAAVERKLYVLGGNDlDYNNDR--ILVRHIDSYNIDTDQW----TRCSFNLLTGqneSGVAVHNGRIYLVGGYS 353
Cdd:PRK14131   80 AAFIDGKLYVFGGIG-KTNSEGspQVFDDVYKYDPKTNSWqkldTRSPVGLAGH---VAVSLHNGKAYITGGVN 149
Kelch smart00612
Kelch domain;
197-228 3.60e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.92  E-value: 3.60e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622928910  197 LYAVGGRNElRQVLPTVERYCPKKNKWTFVQS 228
Cdd:smart00612   2 IYVVGGFDG-GQRLKSVEVYDPETNKWTPLPS 32
Kelch smart00612
Kelch domain;
292-344 4.56e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.54  E-value: 4.56e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622928910  292 KLYVLGGndldYNNDRILvRHIDSYNIDTDQWTRCSfNLLTGQNESGVAVHNG 344
Cdd:smart00612   1 KIYVVGG----FDGGQRL-KSVEVYDPETNKWTPLP-SMPTPRSGHGVAVING 47
PRK14131 PRK14131
N-acetylneuraminate epimerase;
172-298 7.44e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.54  E-value: 7.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 172 SNSWAEIAPMKNC-REHFVLGAMEEYLYAVGG---RNE--LRQVLPTVERYCPKKNKWTFVQSFD-RSLSCHAGYVADG- 243
Cdd:PRK14131   61 SKGWTKIAAFPGGpREQAVAAFIDGKLYVFGGigkTNSegSPQVFDDVYKYDPKTNSWQKLDTRSpVGLAGHVAVSLHNg 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 244 LLWISGGV-----------TNTA----------------------QYQNRLMVYEPNQNKWIS--RSPMLQrRVYHSMAA 288
Cdd:PRK14131  141 KAYITGGVnknifdgyfedLAAAgkdktpkdkindayfdkkpedyFFNKEVLSYDPSTNQWKNagESPFLG-TAGSAVVI 219

                         170
                  ....*....|
gi 1622928910 289 VERKLYVLGG 298
Cdd:PRK14131  220 KGNKLWLING 229
PHA03098 PHA03098
kelch-like protein; Provisional
 219-354 7.96e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 41.68  E-value: 7.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928910 219 KKNKWTFVQSfDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVERKLYVLGG 298
Cdd:PHA03098  272 PLSEINTIID-IHYVYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGG 350

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622928910 299 NDLDynndrILVRHIDSYNIDTDQWTRCSfNLLTGQNESGVAVHNGRIYLVGGYSI 354
Cdd:PHA03098  351 IYNS-----ISLNTVESWKPGESKWREEP-PLIFPRYNPCVVNVNNLIYVIGGISK 400
Kelch smart00612
Kelch domain;
244-290 2.06e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.00  E-value: 2.06e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622928910  244 LLWISGGvTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVE 290
Cdd:smart00612   1 KIYVVGG-FDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 6-41 2.96e-03

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 37.14  E-value: 2.96e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1622928910   6 QLAVRWLEHN--CHYQHMDELLQYIRFGLMDVDTLHTV 41
Cdd:pfam07707  64 EAVIRWVKHDveRRKKHLPELLSAVRLPLLSPQYLLNL 101
Kelch_3 pfam13415
Galactose oxidase, central domain;
242-289 4.08e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.96  E-value: 4.08e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622928910 242 DGLLWISGG-VTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAV 289
Cdd:pfam13415   1 GDKLYIFGGlGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
Kelch_4 pfam13418
Galactose oxidase, central domain;
280-327 4.14e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 4.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622928910 280 RRVYHSMAAVER-KLYVLGGndldYNNDRILVRHIDSYNIDTDQWTRCS 327
Cdd:pfam13418   1 PRAYHTSTSIPDdTIYLFGG----EGEDGTLLSDLWVFDLSTNEWTRLG 45
Kelch smart00612
Kelch domain;
145-188 4.90e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 34.84  E-value: 4.90e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1622928910  145 LFVAGGeveHASGRTCavRTACRYDPRSNSWAEIAPMKNCREHF 188
Cdd:smart00612   2 IYVVGG---FDGGQRL--KSVEVYDPETNKWTPLPSMPTPRSGH 40
Kelch_6 pfam13964
Kelch motif;
281-327 7.39e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.62  E-value: 7.39e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1622928910 281 RVYHSMAAVERKLYVLGGndldYNNDRILVRHIDSYNIDTDQWTRCS 327
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEELP 44
Kelch_4 pfam13418
Galactose oxidase, central domain;
132-181 9.03e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.12  E-value: 9.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622928910 132 GRSHH-CVAVMGDFLFVAGGEVEhaSGRTCAvrTACRYDPRSNSWAEIAPM 181
Cdd:pfam13418   1 PRAYHtSTSIPDDTIYLFGGEGE--DGTLLS--DLWVFDLSTNEWTRLGSL 47
Kelch_6 pfam13964
Kelch motif;
240-281 9.37e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.23  E-value: 9.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622928910 240 VADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRR 281
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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