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Conserved domains on  [gi|1622923224|ref|XP_028701561|]
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zinc finger protein 92 isoform X2 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB super family cl42959
krueppel associated box;
1-32 7.37e-14

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 66.08  E-value: 7.37e-14
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622923224    1 MLENYRNLVFLGIAVSKPDLITWLEQGKEPWN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-547 1.68e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.72  E-value: 1.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 195 KPYKCEECGKAFNRSSNLTKHKIIHTGEKPYKC--EECGKAFNRSSTLTKHKRIHTEEKPYKCE---------------- 256
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 257 ECGKAFNQFSILNKHKRIHMEDKP-------------YKCEECGKAFRVF-SILKKHKII-------------------- 302
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPqlpdllsisnlrnNPLPGNNSSSVNTpQSNSLHPPLpanslskdpssnlsllissn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 303 -HTGEKPFKCEECGKAFNQFSNLTKHKIIHTGEKPYKCDECGKAFNQSSTLTKHKRIHTGEKPYKCEECGKAFKQSSTLT 381
Cdd:COG5048   192 vSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 382 EHKIIHTGE-------KPYKCEECGKAFSWSSAFTKHKR--NH--MEDKPYKCEE--CGKAFSVFSTLTKHKIIHTREKP 448
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 449 YKC--EECGKAFNQSSI------FTKHKINHTEGKSYKCEKCGN-AFNQSSNLTAHKIVYTGEKPYKYE--ECDKAFNNF 517
Cdd:COG5048   352 AKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSNSCIrNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|
gi 1622923224 518 STLITHQIIYTGEKPYKHECGRAFNKSSNY 547
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-32 7.37e-14

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 66.08  E-value: 7.37e-14
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622923224    1 MLENYRNLVFLGIAVSKPDLITWLEQGKEPWN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-547 1.68e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.72  E-value: 1.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 195 KPYKCEECGKAFNRSSNLTKHKIIHTGEKPYKC--EECGKAFNRSSTLTKHKRIHTEEKPYKCE---------------- 256
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 257 ECGKAFNQFSILNKHKRIHMEDKP-------------YKCEECGKAFRVF-SILKKHKII-------------------- 302
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPqlpdllsisnlrnNPLPGNNSSSVNTpQSNSLHPPLpanslskdpssnlsllissn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 303 -HTGEKPFKCEECGKAFNQFSNLTKHKIIHTGEKPYKCDECGKAFNQSSTLTKHKRIHTGEKPYKCEECGKAFKQSSTLT 381
Cdd:COG5048   192 vSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 382 EHKIIHTGE-------KPYKCEECGKAFSWSSAFTKHKR--NH--MEDKPYKCEE--CGKAFSVFSTLTKHKIIHTREKP 448
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 449 YKC--EECGKAFNQSSI------FTKHKINHTEGKSYKCEKCGN-AFNQSSNLTAHKIVYTGEKPYKYE--ECDKAFNNF 517
Cdd:COG5048   352 AKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSNSCIrNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|
gi 1622923224 518 STLITHQIIYTGEKPYKHECGRAFNKSSNY 547
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-376 1.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.46e-04
                          10        20
                  ....*....|....*....|....*
gi 1622923224 352 LTKHKRIHTGEKPYKCEECGKAFKQ 376
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-32 7.37e-14

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 66.08  E-value: 7.37e-14
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622923224    1 MLENYRNLVFLGIAVSKPDLITWLEQGKEPWN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-547 1.68e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.72  E-value: 1.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 195 KPYKCEECGKAFNRSSNLTKHKIIHTGEKPYKC--EECGKAFNRSSTLTKHKRIHTEEKPYKCE---------------- 256
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 257 ECGKAFNQFSILNKHKRIHMEDKP-------------YKCEECGKAFRVF-SILKKHKII-------------------- 302
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPqlpdllsisnlrnNPLPGNNSSSVNTpQSNSLHPPLpanslskdpssnlsllissn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 303 -HTGEKPFKCEECGKAFNQFSNLTKHKIIHTGEKPYKCDECGKAFNQSSTLTKHKRIHTGEKPYKCEECGKAFKQSSTLT 381
Cdd:COG5048   192 vSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 382 EHKIIHTGE-------KPYKCEECGKAFSWSSAFTKHKR--NH--MEDKPYKCEE--CGKAFSVFSTLTKHKIIHTREKP 448
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 449 YKC--EECGKAFNQSSI------FTKHKINHTEGKSYKCEKCGN-AFNQSSNLTAHKIVYTGEKPYKYE--ECDKAFNNF 517
Cdd:COG5048   352 AKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSNSCIrNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|
gi 1622923224 518 STLITHQIIYTGEKPYKHECGRAFNKSSNY 547
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
307-468 1.59e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 307 KPFKCEECGKAFNQFSNLTKHK--IIHTGE--KPYKCDE--CGKAFNQSSTLTKHKRIHTGEKPYKC--EECGKAFKQSS 378
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 379 T------LTEHKIIHTGEKPYKCEECGKAFSWSSAF-TKHKRNHMEDKP--YKCEECGKAFSVFSTLTKHKIIHTREKPY 449
Cdd:COG5048   368 NneppqsLQQYKDLKNDKKSETLSNSCIRNFKRDSNlSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 1622923224 450 KCEECGKAFNQSSIFTKHK 468
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 221-300 1.94e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 1.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 221 GEKPYKCE--ECGKAFNRSSTLtKHKRIHTEEKPYKCEECGKafnqfsilNKHKRIHMEDKPYKCEECGKAFRVFSILKK 298
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1622923224 299 HK 300
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 361-440 6.46e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 6.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 361 GEKPYKCE--ECGKAFKQSSTLTEHKiihtgekpyKCEECGKAFSWSSAFTKHKRNHMEDKPYKCEECGKAFSVFSTLTK 438
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1622923224 439 HK 440
Cdd:COG5189   417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
139-272 7.93e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 7.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 139 KPFKCKNRGKSFCMLSQLTQHK--KIHTREYSYKCEE----CGKAFNWSSTLTKHKIIHTGEKPYKC------------- 199
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEkllnssskfspll 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 200 ------------------------EECGKAFNRSSNLTKHKIIHTGEKP--YKCEECGKAFNRSSTLTKHKRIHTEEKPY 253
Cdd:COG5048   368 nneppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 1622923224 254 KCEECGKAFNQFSILNKHK 272
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-376 1.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.46e-04
                          10        20
                  ....*....|....*....|....*
gi 1622923224 352 LTKHKRIHTGEKPYKCEECGKAFKQ 376
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
323-348 2.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.48e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622923224 323 NLTKHKIIHTGEKPYKCDECGKAFNQ 348
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-320 2.93e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.93e-04
                          10        20
                  ....*....|....*....|....*
gi 1622923224 296 LKKHKIIHTGEKPFKCEECGKAFNQ 320
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
211-236 3.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.49e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622923224 211 NLTKHKIIHTGEKPYKCEECGKAFNR 236
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 305-384 6.83e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 6.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 305 GEKPFKCE--ECGKAFNQFSNLTKHKiihtgekpyKCDECGKAFNQSSTLTKHKRIHTGEKPYKCEECGKAFKQSSTLTE 382
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1622923224 383 HK 384
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-264 7.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.66e-04
                          10        20
                  ....*....|....*....|....*
gi 1622923224 240 LTKHKRIHTEEKPYKCEECGKAFNQ 264
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
184-208 9.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.79e-04
                          10        20
                  ....*....|....*....|....*
gi 1622923224 184 LTKHKIIHTGEKPYKCEECGKAFNR 208
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
418-491 2.16e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.16e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622923224 418 DKPYKCEECGKAFSVFSTLTKHKIIHTREKPYKC--EECGKAFNQSSIFTKHKINHTEGKSYKCEKCGNAFNQSSN 491
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
zf-H2C2_2 pfam13465
Zinc-finger double domain;
380-403 2.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.28e-03
                          10        20
                  ....*....|....*....|....
gi 1622923224 380 LTEHKIIHTGEKPYKCEECGKAFS 403
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 249-328 2.61e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 249 EEKPYKCE--ECGKAF-NQFSIlnKHKRIHMEDKPYKCEECGKafrvfsilKKHKIIHTGEKPFKCEECGKAFNQFSNLT 325
Cdd:COG5189   346 DGKPYKCPveGCNKKYkNQNGL--KYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ...
gi 1622923224 326 KHK 328
Cdd:COG5189   416 YHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 276-356 3.69e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622923224 276 MEDKPYKCE--ECGKAFRVFSILKKHKiihtgekpfKCEECGKAFNQFSNLTKHKIIHTGEKPYKCDECGKAFNQSSTLT 353
Cdd:COG5189   345 KDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ...
gi 1622923224 354 KHK 356
Cdd:COG5189   416 YHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-350 3.85e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.85e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622923224 278 DKPYKCEECGKAFRVFSILKKHKIIHTGEKPFKC--EECGKAFNQFSNLTKHKIIHTGEKPYKCDECGKAFNQSS 350
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
zf-H2C2_2 pfam13465
Zinc-finger double domain;
436-460 3.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.95e-03
                          10        20
                  ....*....|....*....|....*
gi 1622923224 436 LTKHKIIHTREKPYKCEECGKAFNQ 460
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-290 3.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.99e-03
                          10        20
                  ....*....|....*....|...
gi 1622923224 268 LNKHKRIHMEDKPYKCEECGKAF 290
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 225-247 5.88e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.88e-03
                          10        20
                  ....*....|....*....|...
gi 1622923224 225 YKCEECGKAFNRSSTLTKHKRIH 247
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 197-219 8.05e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.05e-03
                          10        20
                  ....*....|....*....|...
gi 1622923224 197 YKCEECGKAFNRSSNLTKHKIIH 219
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 337-359 9.33e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.33e-03
                          10        20
                  ....*....|....*....|...
gi 1622923224 337 YKCDECGKAFNQSSTLTKHKRIH 359
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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