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Conserved domains on  [gi|1622922178|ref|XP_028701391|]
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zinc finger protein with KRAB and SCAN domains 5 isoform X5 [Macaca mulatta]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12142358)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
275-573 2.92e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 275 HKKSSTGERPHKCNECGKSFIQSAHLIQHQRIHTGEKPFRC--EECGKSYNQRVHLTQHQRVHTGEKPYTC--PLCGKAF 350
Cdd:COG5048    24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 351 RVRSHLVQHQSVHSgERPFKCNECGKGFGRRSHLAGHLRLHSREKAHQCRECGEIFFQY--VSLIEHQVLHMGQKNEKHG 428
Cdd:COG5048   104 KASSSSLSSSSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 429 VCEEAYSWNLTVIEDKKIELQEQ--------------------PYQCDICGKAFGYSSDLIQHYRTHTAEKPYQCDTCRE 488
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLsssysipssssdqnlensssSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 489 NVGQCSHTKQHQKIYSS-------TKSHQCHECGRGFTLKPHLNQHQR--IHTGE--KPFQCKE--CGMNFSWSCSLFKH 555
Cdd:COG5048   263 SSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330
                  ....*....|....*...
gi 1622922178 556 LRSHERTDPINTLSVEGS 573
Cdd:COG5048   343 ILLHTSISPAKEKLLNSS 360
zf-H2C2_2 pfam13465
Zinc-finger double domain;
124-147 5.69e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.69e-04
                          10        20
                  ....*....|....*....|....
gi 1622922178 124 HLTQHQRVHTGEKPYKCQVCGKAF 147
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
96-121 3.75e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622922178  96 NFIQHRRIHTGEKPFKCGECGKSYNQ 121
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
275-573 2.92e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 275 HKKSSTGERPHKCNECGKSFIQSAHLIQHQRIHTGEKPFRC--EECGKSYNQRVHLTQHQRVHTGEKPYTC--PLCGKAF 350
Cdd:COG5048    24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 351 RVRSHLVQHQSVHSgERPFKCNECGKGFGRRSHLAGHLRLHSREKAHQCRECGEIFFQY--VSLIEHQVLHMGQKNEKHG 428
Cdd:COG5048   104 KASSSSLSSSSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 429 VCEEAYSWNLTVIEDKKIELQEQ--------------------PYQCDICGKAFGYSSDLIQHYRTHTAEKPYQCDTCRE 488
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLsssysipssssdqnlensssSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 489 NVGQCSHTKQHQKIYSS-------TKSHQCHECGRGFTLKPHLNQHQR--IHTGE--KPFQCKE--CGMNFSWSCSLFKH 555
Cdd:COG5048   263 SSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330
                  ....*....|....*...
gi 1622922178 556 LRSHERTDPINTLSVEGS 573
Cdd:COG5048   343 ILLHTSISPAKEKLLNSS 360
zf-H2C2_2 pfam13465
Zinc-finger double domain;
299-324 5.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.26e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622922178 299 HLIQHQRIHTGEKPFRCEECGKSYNQ 324
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
124-147 5.69e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.69e-04
                          10        20
                  ....*....|....*....|....
gi 1622922178 124 HLTQHQRVHTGEKPYKCQVCGKAF 147
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
96-121 3.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622922178  96 NFIQHRRIHTGEKPFKCGECGKSYNQ 121
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 285-335 6.71e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 6.71e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622922178 285 HKCNECGKSFIQSAHLIQHQRIHTgekpFRCEECGKSYNQRVHLTQH-QRVH 335
Cdd:cd20908     2 PWCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
275-573 2.92e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 275 HKKSSTGERPHKCNECGKSFIQSAHLIQHQRIHTGEKPFRC--EECGKSYNQRVHLTQHQRVHTGEKPYTC--PLCGKAF 350
Cdd:COG5048    24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 351 RVRSHLVQHQSVHSgERPFKCNECGKGFGRRSHLAGHLRLHSREKAHQCRECGEIFFQY--VSLIEHQVLHMGQKNEKHG 428
Cdd:COG5048   104 KASSSSLSSSSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 429 VCEEAYSWNLTVIEDKKIELQEQ--------------------PYQCDICGKAFGYSSDLIQHYRTHTAEKPYQCDTCRE 488
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLsssysipssssdqnlensssSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 489 NVGQCSHTKQHQKIYSS-------TKSHQCHECGRGFTLKPHLNQHQR--IHTGE--KPFQCKE--CGMNFSWSCSLFKH 555
Cdd:COG5048   263 SSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330
                  ....*....|....*...
gi 1622922178 556 LRSHERTDPINTLSVEGS 573
Cdd:COG5048   343 ILLHTSISPAKEKLLNSS 360
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
494-559 1.51e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.51e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622922178 494 SHTKQHQKIYSSTKSHQCHECGRGFTLKPHLNQHQRIHTGEKPFQC--KECGMNFSWSCSLFKHLRSH 559
Cdd:COG5048    19 TPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTH 86
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
54-498 3.07e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 3.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178  54 SRQNPSQKRNPDVITDLSPKQSTHgERGHRCSDCGKFFLQASNFIQHRRIHTGEKPFKCG--ECGKSYNQRVHLTQHQRV 131
Cdd:COG5048     7 QSSSSNNSVLSSTPKSTLKSLSNA-PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 132 HTGEKPYKC--QVCGKAFRVSSHLVQHHSVHSgerPYGCNECGKNFGRHSHLIEHLKRHFREKSQRCSDKRSKNTKLSVK 209
Cdd:COG5048    86 HHNNPSDLNskSLPLSNSKASSSSLSSSSSNS---NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 210 KKISEYSEADMELSGKTQRNVSQVqdfgegyelQSKLDRKQGIPMKEIVGQPSSKRMNYSEVPYVHKKSSTGERPhkCNE 289
Cdd:COG5048   163 QSNSLHPPLPANSLSKDPSSNLSL---------LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLP--LTT 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 290 CgkSFIQSAHLIQHQRIHTGEK--PFRCEECGKSYNQRVHLTQHQRVHTGE-------KPYTCPLCGKAFRVRSHLVQHQ 360
Cdd:COG5048   232 N--SQLSPKSLLSQSPSSLSSSdsSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHL 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 361 --SVHSGE--RPFKCNE--CGKGFGRRSHLAGHLRLHSREKAHQCRECGEIFFQYVSLIE--------HQVLHMGQKNEK 426
Cdd:COG5048   310 rsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqqYKDLKNDKKSET 389

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622922178 427 HGVCEEAYSW-NLTVIEDKKIELQEQPYQCD--ICGKAFGYSSDLIQHYRTHTAEKPYQCDTCRENVGQ---CSHTKQ 498
Cdd:COG5048   390 LSNSCIRNFKrDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDldlSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
299-324 5.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.26e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622922178 299 HLIQHQRIHTGEKPFRCEECGKSYNQ 324
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
124-147 5.69e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.69e-04
                          10        20
                  ....*....|....*....|....
gi 1622922178 124 HLTQHQRVHTGEKPYKCQVCGKAF 147
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
327-350 7.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.35e-04
                          10        20
                  ....*....|....*....|....
gi 1622922178 327 HLTQHQRVHTGEKPYTCPLCGKAF 350
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
136-547 1.15e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 136 KPYKCQVCGKAFRVSSHLVQHHSVHSGERPYGCN--ECGKNFGRHSHLIEHLKRHFREKSQRCSDKRSKNTKLSVKKKIS 213
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 214 EYSEADMELSGktqrnvsqvqdfgegyelqskldrkqgipmkeIVGQPSSKRMNYSEVPYVHKKSSTGERPHK-CNECGK 292
Cdd:COG5048   112 SSSSNSNDNNL--------------------------------LSSHSLPPSSRDPQLPDLLSISNLRNNPLPgNNSSSV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 293 SFIQSAHLIQhqrihtgEKPFRCEECGKSYNQRVHLtqHQRVHTGEKPYTCPLCGKAFRVRSHLVQHQSVHSGERPFKCN 372
Cdd:COG5048   160 NTPQSNSLHP-------PLPANSLSKDPSSNLSLLI--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLT 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 373 ECGKGFGRRSHLAGHLRLHSREKAHQCRECGEIFFQYVSLIEHQVLHMGQKNEKhgvceeayswnltviedkkieLQEQP 452
Cdd:COG5048   231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEK---------------------GFSLP 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922178 453 YQCDICGKAFGYSSDLIQHYRthtaekpyqcdtcrenvgQCSHTKQHQKIYSSTKShqchECGRGFTLKPHLNQHQRIHT 532
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLR------------------SVNHSGESLKPFSCPYS----LCGKLFSRNDALKRHILLHT 347

                         410
                  ....*....|....*
gi 1622922178 533 GEKPFQCKECGMNFS 547
Cdd:COG5048   348 SISPAKEKLLNSSSK 362
zf-H2C2_2 pfam13465
Zinc-finger double domain;
523-547 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....*
gi 1622922178 523 HLNQHQRIHTGEKPFQCKECGMNFS 547
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
96-121 3.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622922178  96 NFIQHRRIHTGEKPFKCGECGKSYNQ 121
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 285-307 6.60e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.60e-03
                          10        20
                  ....*....|....*....|...
gi 1622922178 285 HKCNECGKSFIQSAHLIQHQRIH 307
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 285-335 6.71e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 6.71e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622922178 285 HKCNECGKSFIQSAHLIQHQRIHTgekpFRCEECGKSYNQRVHLTQH-QRVH 335
Cdd:cd20908     2 PWCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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