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Conserved domains on  [gi|1622922142|ref|XP_028701387|]
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actin-related protein 2/3 complex subunit 1A isoform X1 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-266 4.58e-18

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 4.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  15 AWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILR 94
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLW--DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTG 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  95 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRV 168
Cdd:COG2319   203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLAT--GKLLRtltghsGSVRSVAFSPDGRLLASGSADGTVRL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142 169 FSAyikevdekpaSTpwgskmpfGQLMSEFGGSGtgGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLP 248
Cdd:COG2319   273 WDL----------AT--------GELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                         250
                  ....*....|....*...
gi 1622922142 249 LLSVSFVSENSVVAAGHD 266
Cdd:COG2319   333 VRSVAFSPDGKTLASGSD 350
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-266 4.58e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 4.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  15 AWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILR 94
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLW--DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTG 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  95 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRV 168
Cdd:COG2319   203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLAT--GKLLRtltghsGSVRSVAFSPDGRLLASGSADGTVRL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142 169 FSAyikevdekpaSTpwgskmpfGQLMSEFGGSGtgGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLP 248
Cdd:COG2319   273 WDL----------AT--------GELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                         250
                  ....*....|....*...
gi 1622922142 249 LLSVSFVSENSVVAAGHD 266
Cdd:COG2319   333 VRSVAFSPDGKTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-288 8.55e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 8.55e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  46 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRInrAATFVKWSPLENKFAVGSGARLISVcyf 125
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142 126 esendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRVFSayikevdekpastpwgskMPFGQLMSEFg 199
Cdd:cd00200    78 -----WDLET--GECVRtltghtSYVSSVAFSPDGRILSSSSRDKTIKVWD------------------VETGKCLTTL- 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142 200 gSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFV-SENSVVAAGHDCCPMLFNYDDRG 278
Cdd:cd00200   132 -RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGK 210

                         250
                  ....*....|.
gi 1622922142 279 CL-TFVSKLDI 288
Cdd:cd00200   211 CLgTLRGHENG 221
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 46-80 9.74e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 9.74e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622922142   46 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
42-80 5.87e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 5.87e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622922142  42 WVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-266 4.58e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 4.58e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  15 AWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILR 94
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLW--DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTG 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  95 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRV 168
Cdd:COG2319   203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLAT--GKLLRtltghsGSVRSVAFSPDGRLLASGSADGTVRL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142 169 FSAyikevdekpaSTpwgskmpfGQLMSEFGGSGtgGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLP 248
Cdd:COG2319   273 WDL----------AT--------GELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                         250
                  ....*....|....*...
gi 1622922142 249 LLSVSFVSENSVVAAGHD 266
Cdd:COG2319   333 VRSVAFSPDGKTLASGSD 350
WD40 COG2319
WD40 repeat [General function prediction only];
9-264 2.31e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.57  E-value: 2.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142   9 EPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVkaHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKP 88
Cdd:COG2319   163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG--KL 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  89 TLVILRINRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVS----KHIKKPIRSTVLSLDWHPNNVLLAAGSCDF 164
Cdd:COG2319   239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL--------WDLAtgelLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142 165 KCRVFSAyikevdekpaSTpwgskmpfGQLMSEFggSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKT 244
Cdd:COG2319   311 TVRLWDL----------AT--------GKLLRTL--TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG 370

                         250       260
                  ....*....|....*....|
gi 1622922142 245 EFLPLLSVSFVSENSVVAAG 264
Cdd:COG2319   371 HTGAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-288 8.55e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 8.55e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  46 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRInrAATFVKWSPLENKFAVGSGARLISVcyf 125
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142 126 esendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRVFSayikevdekpastpwgskMPFGQLMSEFg 199
Cdd:cd00200    78 -----WDLET--GECVRtltghtSYVSSVAFSPDGRILSSSSRDKTIKVWD------------------VETGKCLTTL- 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142 200 gSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFV-SENSVVAAGHDCCPMLFNYDDRG 278
Cdd:cd00200   132 -RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGK 210

                         250
                  ....*....|.
gi 1622922142 279 CL-TFVSKLDI 288
Cdd:cd00200   211 CLgTLRGHENG 221
WD40 COG2319
WD40 repeat [General function prediction only];
15-266 2.21e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 2.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  15 AWNRDRTQIALSPNNHEVHIYKKNGSQWVkaHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILR 94
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLL--RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG--KLLRTLTG 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  95 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIRS------TVLSLDWHPNNVLLAAGSCDFKCRV 168
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRL--------WDLAT--GKLLRTltghtgAVRSVAFSPDGKLLASGSADGTVRL 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142 169 FSayikevdekpASTpwgskmpfGQLMSEFGGSgtGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLP 248
Cdd:COG2319   231 WD----------LAT--------GKLLRTLTGH--SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG 290

                         250
                  ....*....|....*...
gi 1622922142 249 LLSVSFVSENSVVAAGHD 266
Cdd:COG2319   291 VNSVAFSPDGKLLASGSD 308
WD40 COG2319
WD40 repeat [General function prediction only];
15-234 6.40e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 6.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  15 AWNRDRTQIALSPNNHEVHIYKKNGSQWVkaHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVilR 94
Cdd:COG2319   211 AFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--G 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  95 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIRS------TVLSLDWHPNNVLLAAGSCDFKCRV 168
Cdd:COG2319   287 HSGGVNSVAFSPDGKLLASGSDDGTVRL--------WDLAT--GKLLRTltghtgAVRSVAFSPDGKTLASGSDDGTVRL 356

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622922142 169 FSAyikevdekpastpwgskmPFGQLMSEFggSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADAS 234
Cdd:COG2319   357 WDL------------------ATGELLRTL--TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-268 4.80e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 4.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  10 PITCHAWNRDRTQIALSPNNHEVHIYKKNGSQwvKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPT 89
Cdd:cd00200    53 PVRDVAASADGTYLASGSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  90 LVILRINRAATFVKWSPlENKFAVGSGA-RLISVCYFESEndwwvskhikKPIR------STVLSLDWHPNNVLLAAGSC 162
Cdd:cd00200   129 TTLRGHTDWVNSVAFSP-DGTFVASSSQdGTIKLWDLRTG----------KCVAtltghtGEVNSVAFSPDGEKLLSSSS 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142 163 DFKCRVFSayikevdekpastpwgskMPFGQLMSEFGGSgtGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTL 242
Cdd:cd00200   198 DGTIKLWD------------------LSTGKCLGTLRGH--ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257

                         250       260
                  ....*....|....*....|....*..
gi 1622922142 243 KTEFLPLLSVSFVSENSVVAAG-HDCC 268
Cdd:cd00200   258 SGHTNSVTSLAWSPDGKRLASGsADGT 284
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-170 4.33e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.04  E-value: 4.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  10 PITCHAWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPT 89
Cdd:cd00200   137 WVNSVAFSPDGTFVASSSQDGTIKLW--DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  90 LVilRINRAATFVKWSPLENKFAVGSGARLISVcyfesendW-WVSKHIKKPIR---STVLSLDWHPNNVLLAAGSCDFK 165
Cdd:cd00200   215 LR--GHENGVNSVAFSPDGYLLASGSEDGTIRV--------WdLRTGECVQTLSghtNSVTSLAWSPDGKRLASGSADGT 284


                  ....*
gi 1622922142 166 CRVFS 170
Cdd:cd00200   285 IRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-230 8.65e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 8.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142   9 EPITCHAWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKP 88
Cdd:cd00200    94 SYVSSVAFSPDGRILSSSSRDKTIKVW--DVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG--KC 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  89 TLVILRINRAATFVKWSPLENKFAVGSGARLI---------SVCYFESENDWwvskhikkpirstVLSLDWHPNNVLLAA 159
Cdd:cd00200   170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIklwdlstgkCLGTLRGHENG-------------VNSVAFSPDGYLLAS 236

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622922142 160 GSCDFKCRVFSAYIkevdekpastpwgskmpfGQLMSEFggSGTGGWVHGVSFSASGSRLAWVSHDSTVSV 230
Cdd:cd00200   237 GSEDGTIRVWDLRT------------------GECVQTL--SGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
59-266 5.62e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 5.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142  59 DWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRinRAATFVKWSPLENKFAVGSGARLISVcyfeSENDWWVSKHIK 138
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLA--AAVASLAASPDGARLAAGAGDLTLLL----LDAAAGALLATL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622922142 139 KPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAyikeVDEKPASTPWGskmpfgqlmsefggsgTGGWVHGVSFSASGSR 218
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDL----ATGLLLRTLTG----------------HTGAVRSVAFSPDGKT 134

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1622922142 219 LAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHD 266
Cdd:COG2319   135 LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD 182
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 46-80 9.74e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 9.74e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622922142   46 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
42-80 5.87e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 5.87e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622922142  42 WVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-80 8.98e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 37.70  E-value: 8.98e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622922142   9 EPITCHAWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:cd00200   220 NGVNSVAFSPDGYLLASGSEDGTIRVW--DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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