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Conserved domains on  [gi|1622920414|ref|XP_028701117|]
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cilia- and flagella-associated protein 410 isoform X2 [Macaca mulatta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1908540)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 108-198 1.82e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 1.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920414 108 PSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELF-YLKGLPRLRVLWLAENPCCgtSPHRYRMTVLRTLPRL 186
Cdd:cd21340   120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSL 197

                          90
                  ....*....|..
gi 1622920414 187 QKLDNQAVTEEE 198
Cdd:cd21340   198 EVLDGKEITDTE 209
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
95-299 2.27e-07

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 2.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920414  95 GSRLTDISIC-REMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAElfyLKGLPRLRVLWLAENPCcgTSPH 173
Cdd:COG4886   214 GNQLTDLPEPlANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPP---LANLTNLKTLDLSNNQL--TDLK 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920414 174 RYRMTVLRTLPRLQKLDNQAVTEEELSRALSEGEEITAAPEREGTGHGGPKPCFTLSSLSSAAETGQDPLDSEEEAIAQG 253
Cdd:COG4886   289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1622920414 254 ELGLKPPSRDQFPSFSPRDASSSHRSRNVLTAILLLLRELDAEGLE 299
Cdd:COG4886   369 LGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 108-198 1.82e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 1.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920414 108 PSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELF-YLKGLPRLRVLWLAENPCCgtSPHRYRMTVLRTLPRL 186
Cdd:cd21340   120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSL 197

                          90
                  ....*....|..
gi 1622920414 187 QKLDNQAVTEEE 198
Cdd:cd21340   198 EVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-201 3.15e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 3.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920414  95 GSRLTDI-SICREMPSLEVITLSVNSISTL-EPVSRCQRLSELYLRRNRIPSLAElfYLKGLPRLRVLWLAENpccgtsp 172
Cdd:COG4886   145 NNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEELDLSGN------- 215

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1622920414 173 hryRMT----VLRTLPRLQKLD---NQAVTEEELSR 201
Cdd:COG4886   216 ---QLTdlpePLANLTNLETLDlsnNQLTDLPELGN 248
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-299 2.27e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 2.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920414  95 GSRLTDISIC-REMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAElfyLKGLPRLRVLWLAENPCcgTSPH 173
Cdd:COG4886   214 GNQLTDLPEPlANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPP---LANLTNLKTLDLSNNQL--TDLK 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920414 174 RYRMTVLRTLPRLQKLDNQAVTEEELSRALSEGEEITAAPEREGTGHGGPKPCFTLSSLSSAAETGQDPLDSEEEAIAQG 253
Cdd:COG4886   289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1622920414 254 ELGLKPPSRDQFPSFSPRDASSSHRSRNVLTAILLLLRELDAEGLE 299
Cdd:COG4886   369 LGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 108-148 1.19e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 1.19e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622920414 108 PSLEVITLSVNSISTLEPVSRCQRLSELYLRRN-RIPSLAEL 148
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDL 42
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 172-190 1.62e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 35.36  E-value: 1.62e-03
                           10
                   ....*....|....*....
gi 1622920414  172 PHRYRMTVLRTLPRLQKLD 190
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 106-172 9.78e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.91  E-value: 9.78e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622920414 106 EMPSLEVITLSVNSIS-TLEPVSRCQRLSELYLRRNRIpSLAELFYLKGLPRLRVLWLAENPCCGTSP 172
Cdd:PLN00113  450 DMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQF-SGAVPRKLGSLSELMQLKLSENKLSGEIP 516
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 108-198 1.82e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 1.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920414 108 PSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELF-YLKGLPRLRVLWLAENPCCgtSPHRYRMTVLRTLPRL 186
Cdd:cd21340   120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSL 197

                          90
                  ....*....|..
gi 1622920414 187 QKLDNQAVTEEE 198
Cdd:cd21340   198 EVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-201 3.15e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 3.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920414  95 GSRLTDI-SICREMPSLEVITLSVNSISTL-EPVSRCQRLSELYLRRNRIPSLAElfYLKGLPRLRVLWLAENpccgtsp 172
Cdd:COG4886   145 NNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEELDLSGN------- 215

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1622920414 173 hryRMT----VLRTLPRLQKLD---NQAVTEEELSR 201
Cdd:COG4886   216 ---QLTdlpePLANLTNLETLDlsnNQLTDLPELGN 248
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-299 2.27e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 2.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920414  95 GSRLTDISIC-REMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAElfyLKGLPRLRVLWLAENPCcgTSPH 173
Cdd:COG4886   214 GNQLTDLPEPlANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPP---LANLTNLKTLDLSNNQL--TDLK 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920414 174 RYRMTVLRTLPRLQKLDNQAVTEEELSRALSEGEEITAAPEREGTGHGGPKPCFTLSSLSSAAETGQDPLDSEEEAIAQG 253
Cdd:COG4886   289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1622920414 254 ELGLKPPSRDQFPSFSPRDASSSHRSRNVLTAILLLLRELDAEGLE 299
Cdd:COG4886   369 LGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 98-198 5.49e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 5.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920414  98 LTDISICRempSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAelfYLKGLPRLRVLWLAENpccgtsphryRM 177
Cdd:cd21340    17 IDNLSLCK---NLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGN----------RI 80

                          90       100
                  ....*....|....*....|....*.
gi 1622920414 178 TV---LRTLPRLQ--KLDNQAVTEEE 198
Cdd:cd21340    81 SVvegLENLTNLEelHIENQRLPPGE 106
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 108-148 1.19e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 1.19e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622920414 108 PSLEVITLSVNSISTLEPVSRCQRLSELYLRRN-RIPSLAEL 148
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDL 42
LRR_9 pfam14580
Leucine-rich repeat;
132-202 3.34e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.90  E-value: 3.34e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622920414 132 LSELYLRRNRIPSLAELFYLKGLPRLRVLWLAENPCCgTSPHrYRMTVLRTLPRLQKLDNQAVTEEELSRA 202
Cdd:pfam14580  90 LTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT-NKPH-YRLYVIYKVPQLRLLDFRKVKQKERQAA 158
LRR_8 pfam13855
Leucine rich repeat;
108-166 4.51e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 4.51e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622920414 108 PSLEVITLSVNSISTLEPVS--RCQRLSELYLRRNRIPSL-AELFYlkGLPRLRVLWLAENP 166
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLsPGAFS--GLPSLRYLDLSGNR 60
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 130-166 1.18e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.18e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1622920414 130 QRLSELYLRRNRIPSLAELfylKGLPRLRVLWLAENP 166
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPL---AKLPNLETLDLSGNN 34
LRR_8 pfam13855
Leucine rich repeat;
107-142 1.48e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 1.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1622920414 107 MPSLEVITLSVNSISTLEPVS--RCQRLSELYLRRNRI 142
Cdd:pfam13855  24 LSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNRL 61
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 172-190 1.62e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 35.36  E-value: 1.62e-03
                           10
                   ....*....|....*....
gi 1622920414  172 PHRYRMTVLRTLPRLQKLD 190
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 106-172 9.78e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.91  E-value: 9.78e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622920414 106 EMPSLEVITLSVNSIS-TLEPVSRCQRLSELYLRRNRIpSLAELFYLKGLPRLRVLWLAENPCCGTSP 172
Cdd:PLN00113  450 DMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQF-SGAVPRKLGSLSELMQLKLSENKLSGEIP 516
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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