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Conserved domains on  [gi|1622920354|ref|XP_028701098|]
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keratin-associated protein 12-1 isoform X3 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
10-53 9.12e-06

Keratin, high sulfur B2 protein;


:

Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 39.29  E-value: 9.12e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 1622920354 10 CQPACCVSSPCQASCCVPVGCQSSVCVPVSCKPVVYAAPSCQSS 53
Cdd:pfam13885  2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-96 8.01e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 33.61  E-value: 8.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920354   7 SSGCQPACCVSSPCQASCCVPVGCQSSVCVPVSCKPVvyAAPSCQSSVCVPVSCRPVVYVAPSCQSSGCCQPSCASVLCR 86
Cdd:pfam01500  22 SGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPT--CQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSR 99

                          90
                  ....*....|
gi 1622920354  87 PISCGIPSCC 96
Cdd:pfam01500 100 TRWCRPDCRV 109
 
Name Accession Description Interval E-value
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
10-53 9.12e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 39.29  E-value: 9.12e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 1622920354 10 CQPACCVSSPCQASCCVPVGCQSSVCVPVSCKPVVYAAPSCQSS 53
Cdd:pfam13885  2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-96 8.01e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 33.61  E-value: 8.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920354   7 SSGCQPACCVSSPCQASCCVPVGCQSSVCVPVSCKPVvyAAPSCQSSVCVPVSCRPVVYVAPSCQSSGCCQPSCASVLCR 86
Cdd:pfam01500  22 SGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPT--CQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSR 99

                          90
                  ....*....|
gi 1622920354  87 PISCGIPSCC 96
Cdd:pfam01500 100 TRWCRPDCRV 109
 
Name Accession Description Interval E-value
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
10-53 9.12e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 39.29  E-value: 9.12e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 1622920354 10 CQPACCVSSPCQASCCVPVGCQSSVCVPVSCKPVVYAAPSCQSS 53
Cdd:pfam13885  2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
7-46 3.09e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 37.75  E-value: 3.09e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 1622920354  7 SSGCQPACCVSSPCQASCCVPVGCQSSVCVPVSCKPVVYA 46
Cdd:pfam13885  4 PSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQ 43
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
19-63 2.96e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 35.44  E-value: 2.96e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 1622920354 19 PCQASCCVPVGCQSSVCVPVSCKPVVYAAPSCQSSVCVPVSCRPV 63
Cdd:pfam13885  1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 7-90 9.25e-04

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 36.33  E-value: 9.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920354   7 SSGCQPACCVSSPCQASCCVP-VGCQSSVCVPVSCKPVVYAAPSCQSSVCVPVSCRPVVYVAPSCQSSGCCQPSCASVLC 85
Cdd:pfam05287  73 PCTSSTSYCVPSPCQRSCYSPrTSCVCSPCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGSSGFRPLGCLSKGFQSLGY 152


                  ....*
gi 1622920354  86 RPISC 90
Cdd:pfam05287 153 GSSFC 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
7-38 3.03e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 32.74  E-value: 3.03e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 1622920354  7 SSGCQPACCVSSPCQASCCVPVGCQSSVCVPV 38
Cdd:pfam13885 14 PSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 7-82 5.18e-03

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 34.02  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920354   7 SSGCQPACCVSSPCQASCCVPVGCQSSVCVPVSCK-----PVVYAAPSCQSSVCVPVSCRPVVYVAPSCQSSgCCQPSCA 81
Cdd:pfam05287  99 CSPCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGssgfrPLGCLSKGFQSLGYGSSFCRPSYVSSRSYQPS-CFRPSCG 177


                  .
gi 1622920354  82 S 82
Cdd:pfam05287 178 S 178
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-96 8.01e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 33.61  E-value: 8.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622920354   7 SSGCQPACCVSSPCQASCCVPVGCQSSVCVPVSCKPVvyAAPSCQSSVCVPVSCRPVVYVAPSCQSSGCCQPSCASVLCR 86
Cdd:pfam01500  22 SGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPT--CQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSR 99

                          90
                  ....*....|
gi 1622920354  87 PISCGIPSCC 96
Cdd:pfam01500 100 TRWCRPDCRV 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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