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Conserved domains on  [gi|1622825792|ref|XP_028701043|]
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metal regulatory transcription factor 1 isoform X2 [Macaca mulatta]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
5-203 8.13e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 8.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825792   5 YVQHIISPDQIHLTINPGSTPMPRNIEGATlTLQSECPETKRKEVKRYQCTfeGCPRTYSTAGNLRTHQKT--HRGEY-- 80
Cdd:COG5048   244 SPSSLSSSDSSSSASESPRSSLPTASSQSS-SPNESDSSSEKGFSLPIKSK--QCNISFSRSSPLTRHLRSvnHSGESlk 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825792  81 TFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTL------YRLKAHQRLHTGKTFNCESEGCSKYFTT 154
Cdd:COG5048   321 PFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKR 400

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1622825792 155 LSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFC 203
Cdd:COG5048   401 DSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 197-227 1.05e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.05e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622825792 197 GERPFFCPSNGCEKTFSTQYSLKSHMK-GHDN 227
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHMLhGHQN 377
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
5-203 8.13e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 8.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825792   5 YVQHIISPDQIHLTINPGSTPMPRNIEGATlTLQSECPETKRKEVKRYQCTfeGCPRTYSTAGNLRTHQKT--HRGEY-- 80
Cdd:COG5048   244 SPSSLSSSDSSSSASESPRSSLPTASSQSS-SPNESDSSSEKGFSLPIKSK--QCNISFSRSSPLTRHLRSvnHSGESlk 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825792  81 TFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTL------YRLKAHQRLHTGKTFNCESEGCSKYFTT 154
Cdd:COG5048   321 PFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKR 400

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1622825792 155 LSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFC 203
Cdd:COG5048   401 DSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
157-183 8.95e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 8.95e-06
                          10        20
                  ....*....|....*....|....*..
gi 1622825792 157 DLRKHIRTHTGEKPFRCDHdgCGKAFA 183
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 197-227 1.05e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.05e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622825792 197 GERPFFCPSNGCEKTFSTQYSLKSHMK-GHDN 227
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHMLhGHQN 377
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
5-203 8.13e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 8.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825792   5 YVQHIISPDQIHLTINPGSTPMPRNIEGATlTLQSECPETKRKEVKRYQCTfeGCPRTYSTAGNLRTHQKT--HRGEY-- 80
Cdd:COG5048   244 SPSSLSSSDSSSSASESPRSSLPTASSQSS-SPNESDSSSEKGFSLPIKSK--QCNISFSRSSPLTRHLRSvnHSGESlk 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825792  81 TFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTL------YRLKAHQRLHTGKTFNCESEGCSKYFTT 154
Cdd:COG5048   321 PFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKR 400

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1622825792 155 LSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFC 203
Cdd:COG5048   401 DSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
84-231 2.65e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825792  84 CNQEGCGKAFLTSYSLRIHVR--VHTKE--KPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCE-SEGCSKYFTTLSDL 158
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEkLLNSSSKFSPLLNN 369

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622825792 159 RKH-----IRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGPS 231
Cdd:COG5048   370 EPPqslqqYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
zf-H2C2_2 pfam13465
Zinc-finger double domain;
157-183 8.95e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 8.95e-06
                          10        20
                  ....*....|....*....|....*..
gi 1622825792 157 DLRKHIRTHTGEKPFRCDHdgCGKAFA 183
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
187-214 9.05e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 9.05e-05
                          10        20
                  ....*....|....*....|....*...
gi 1622825792 187 HLKTHVRTHTGERPFFCPSngCEKTFST 214
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 109-196 1.57e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825792 109 EKPFECDVQGCEKAFNTLYRLKAHqRLHTgktfnceseGCSKYFTTLSDLRKHIRTHTGEKPFRCDHdgCGKAFAASHHL 188
Cdd:COG5189   347 GKPYKCPVEGCNKKYKNQNGLKYH-MLHG---------HQNQKLHENPSPEKMNIFSAKDKPYRCEV--CDKRYKNLNGL 414


                  ....*...
gi 1622825792 189 KTHvRTHT 196
Cdd:COG5189   415 KYH-RKHS 421
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 143-222 1.88e-04

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 40.87  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825792 143 CESEGCSKYFTTLSDLRKHIRTHTGE------KPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNgCEKTFSTQY 216
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKCEN-CLLRFRTHR 80


                  ....*.
gi 1622825792 217 SLKSHM 222
Cdd:pfam15909  81 SLFKHL 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
98-125 2.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.30e-04
                          10        20
                  ....*....|....*....|....*...
gi 1622825792  98 SLRIHVRVHTKEKPFECDVqgCEKAFNT 125
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 197-227 1.05e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.05e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1622825792 197 GERPFFCPSNGCEKTFSTQYSLKSHMK-GHDN 227
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHMLhGHQN 377
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
137-246 3.46e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825792 137 TGKTFNCESEGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCektfSTQY 216
Cdd:COG5048    28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP----LSNS 103

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622825792 217 SLKSHMKGHDNKGPSYSTLTQHNGSEDTNH 246
Cdd:COG5048   104 KASSSSLSSSSSNSNDNNLLSSHSLPPSSR 133
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 84-162 4.13e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 37.01  E-value: 4.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825792  84 CNQEGCGKAFLTSYSLRIHVRVHT------KEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCSKYFTTLSD 157
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCpptqslEGKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKCENCLLRFRTHRS 81


                  ....*
gi 1622825792 158 LRKHI 162
Cdd:pfam15909  82 LFKHL 86
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 171-195 7.46e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.46e-03
                          10        20
                  ....*....|....*....|....*
gi 1622825792 171 FRCDHdgCGKAFAASHHLKTHVRTH 195
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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