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Conserved domains on  [gi|1622919280|ref|XP_028700926|]
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equilibrative nucleoside transporter 4 isoform X1 [Macaca mulatta]

Protein Classification

nucleoside transporter family protein( domain architecture ID 68369)

nucleoside transporter family protein is involved in transport, similar to equilibrative nucleoside transporters and battenin

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Nucleoside_tran super family cl15430
Nucleoside transporter; This is a family of nucleoside transporters. In mammalian cells ...
75-503 5.70e-57

Nucleoside transporter; This is a family of nucleoside transporters. In mammalian cells nucleoside transporters transport nucleoside across the plasma membrane and are essential for nucleotide synthesis via the salvage pathways for cells that lack their own de novo synthesis pathways. Also in this family is mouse and human nucleolar protein HNP36, a protein of unknown function; although it has been hypothesized to be a plasma membrane nucleoside transporter.


The actual alignment was detected with superfamily member TIGR00939:

Pssm-ID: 472807  Cd Length: 437  Bit Score: 196.48  E-value: 5.70e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280  75 LLAGVGFLLPYNSFITDVDYLHHKYPGTSIVFDMSLTYI--------LVALAAVLLNNVL-VERLTLHTRI--TAGYLLA 143
Cdd:TIGR00939   2 FMLGVGVLLPWNAFITAPQYFIEYYKYAQNIPEAIPSSSkmwkhfntYYTLASQLPSLLFnSLNLFLIFRIpvTVRLLGG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 144 LGPLLFISICDVWLQLFSRDQ--AYAINLAAVGTVAFGCTVQQSSFYGYTGMLPKRYTQGVMTGESTAGVMISLSRILTK 221
Cdd:TIGR00939  82 LVILLVVVILVMVLVKVQTSEtgFFVTTMASVVIINSGMALLQGSLFGLAGVFPSTYSSAVMSGQGLAGVLTSLAMILVK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 222 LLLPDE---RASTLIFFLVSVALELLCFLLHLLVRRSRFVLFYTTRprdsrrgrpGLGKGSGyrvhHDVTAGDvhfehpa 298
Cdd:TIGR00939 162 ASGNDShglKKSALGYFGTPCVVQLICIVCYLLLPKLPFARYYLQK---------KLDKGAG----EDETKGE------- 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 299 paLASSGSPKDSPAHEVTGSGGaymrfDVPRPRVQRSWPTFRALLLHR--YVVARVIWADMLSIAVTYFITLCLFPGLES 376
Cdd:TIGR00939 222 --LRSKAEQNGIPHGGDQPSPT-----LVLDWEKEPESPDEPQKPLKTsvWVVFTKVWLLAFSVVFVFTVTLSVFPAITT 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 377 EIRHCILGE---WLPILIMAVFNLSDFVGKILAALP--VDWRGTHLLACSCLRIVFIPLFILCVYPSGTPA---LRHPAW 448
Cdd:TIGR00939 295 AVTSSGLGLsnwFYPIICFLLFNLFDWLGRSLTSKFmwPDEDSRWLPILSFLRVLFIPLFLLCNYPQRSRLpvfFPGDAY 374
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622919280 449 PCIFSLLMGISNGYFGSVPMILAAGKVSPKQRELAGNTMTVSYMSGLTLGSAVAY 503
Cdd:TIGR00939 375 FIILMLLFGFSNGYLGSLSMCLAPRQVDPHEREVAGALMVIFLLVGLALGAVLSF 429
 
Name Accession Description Interval E-value
2a57 TIGR00939
Equilibrative Nucleoside Transporter (ENT); [Transport and binding proteins, Nucleosides, ...
75-503 5.70e-57

Equilibrative Nucleoside Transporter (ENT); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 273352  Cd Length: 437  Bit Score: 196.48  E-value: 5.70e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280  75 LLAGVGFLLPYNSFITDVDYLHHKYPGTSIVFDMSLTYI--------LVALAAVLLNNVL-VERLTLHTRI--TAGYLLA 143
Cdd:TIGR00939   2 FMLGVGVLLPWNAFITAPQYFIEYYKYAQNIPEAIPSSSkmwkhfntYYTLASQLPSLLFnSLNLFLIFRIpvTVRLLGG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 144 LGPLLFISICDVWLQLFSRDQ--AYAINLAAVGTVAFGCTVQQSSFYGYTGMLPKRYTQGVMTGESTAGVMISLSRILTK 221
Cdd:TIGR00939  82 LVILLVVVILVMVLVKVQTSEtgFFVTTMASVVIINSGMALLQGSLFGLAGVFPSTYSSAVMSGQGLAGVLTSLAMILVK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 222 LLLPDE---RASTLIFFLVSVALELLCFLLHLLVRRSRFVLFYTTRprdsrrgrpGLGKGSGyrvhHDVTAGDvhfehpa 298
Cdd:TIGR00939 162 ASGNDShglKKSALGYFGTPCVVQLICIVCYLLLPKLPFARYYLQK---------KLDKGAG----EDETKGE------- 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 299 paLASSGSPKDSPAHEVTGSGGaymrfDVPRPRVQRSWPTFRALLLHR--YVVARVIWADMLSIAVTYFITLCLFPGLES 376
Cdd:TIGR00939 222 --LRSKAEQNGIPHGGDQPSPT-----LVLDWEKEPESPDEPQKPLKTsvWVVFTKVWLLAFSVVFVFTVTLSVFPAITT 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 377 EIRHCILGE---WLPILIMAVFNLSDFVGKILAALP--VDWRGTHLLACSCLRIVFIPLFILCVYPSGTPA---LRHPAW 448
Cdd:TIGR00939 295 AVTSSGLGLsnwFYPIICFLLFNLFDWLGRSLTSKFmwPDEDSRWLPILSFLRVLFIPLFLLCNYPQRSRLpvfFPGDAY 374
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622919280 449 PCIFSLLMGISNGYFGSVPMILAAGKVSPKQRELAGNTMTVSYMSGLTLGSAVAY 503
Cdd:TIGR00939 375 FIILMLLFGFSNGYLGSLSMCLAPRQVDPHEREVAGALMVIFLLVGLALGAVLSF 429
Nucleoside_tran pfam01733
Nucleoside transporter; This is a family of nucleoside transporters. In mammalian cells ...
170-503 8.61e-31

Nucleoside transporter; This is a family of nucleoside transporters. In mammalian cells nucleoside transporters transport nucleoside across the plasma membrane and are essential for nucleotide synthesis via the salvage pathways for cells that lack their own de novo synthesis pathways. Also in this family is mouse and human nucleolar protein HNP36, a protein of unknown function; although it has been hypothesized to be a plasma membrane nucleoside transporter.


Pssm-ID: 396340  Cd Length: 286  Bit Score: 120.99  E-value: 8.61e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 170 LAAVGTVAFGCTVQQSSFYGYTGMLPKRYTQGVMTGESTAGVMISLSRILTKLLLPDERASTLIFFLVSVALELLCFLLH 249
Cdd:pfam01733   1 MGMIVLINSFNALLQNSLFGLAGVFPSTYTQAVMSGQGLAGVLVSVVMILTKASNSDLSESALLYFGTSIVVVIVCAICL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 250 LLVRRSRFVLFYttrprdsrrgrpglgkgsgyrvhhdvtagdvhfehpapalassgspkdspaHEVTGSGGAymrFDVPR 329
Cdd:pfam01733  81 NVLKKLRFYKYH---------------------------------------------------WQLKLEGPT---FDNSD 106
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 330 PRVQRSWPTFRALLlhryvvaRVIWADMLSIAVTYFITLCLFPGlESEIRHCILGEW----LPILIMAVFNLSDFVGKIL 405
Cdd:pfam01733 107 EQEENLKVLFFVIL-------AKIKVLALSVVLIFTVTLSVFPA-VTAEVVSSLPTWeayfIPVLCFLLFNLFDWLGRSL 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 406 AALPVdWRGTH---LLACSCLRIVFIPLFILCVYPSGTPAL----RHPAWPCIFSLLMGISNGYFGSVPMILAAGKVSPK 478
Cdd:pfam01733 179 AAWFM-WPGQDprwLPVLVILRFLFIPLFLLCNYKPQSRALpvlfESDAWFIIFMCLFAFSNGYLSSLCMCYAPKSVPPH 257
                         330       340
                  ....*....|....*....|....*
gi 1622919280 479 QRELAGNTMTVSYMSGLTLGSAVAY 503
Cdd:pfam01733 258 ESETAGAIMVFFLCLGLALGAVISF 282
 
Name Accession Description Interval E-value
2a57 TIGR00939
Equilibrative Nucleoside Transporter (ENT); [Transport and binding proteins, Nucleosides, ...
75-503 5.70e-57

Equilibrative Nucleoside Transporter (ENT); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 273352  Cd Length: 437  Bit Score: 196.48  E-value: 5.70e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280  75 LLAGVGFLLPYNSFITDVDYLHHKYPGTSIVFDMSLTYI--------LVALAAVLLNNVL-VERLTLHTRI--TAGYLLA 143
Cdd:TIGR00939   2 FMLGVGVLLPWNAFITAPQYFIEYYKYAQNIPEAIPSSSkmwkhfntYYTLASQLPSLLFnSLNLFLIFRIpvTVRLLGG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 144 LGPLLFISICDVWLQLFSRDQ--AYAINLAAVGTVAFGCTVQQSSFYGYTGMLPKRYTQGVMTGESTAGVMISLSRILTK 221
Cdd:TIGR00939  82 LVILLVVVILVMVLVKVQTSEtgFFVTTMASVVIINSGMALLQGSLFGLAGVFPSTYSSAVMSGQGLAGVLTSLAMILVK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 222 LLLPDE---RASTLIFFLVSVALELLCFLLHLLVRRSRFVLFYTTRprdsrrgrpGLGKGSGyrvhHDVTAGDvhfehpa 298
Cdd:TIGR00939 162 ASGNDShglKKSALGYFGTPCVVQLICIVCYLLLPKLPFARYYLQK---------KLDKGAG----EDETKGE------- 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 299 paLASSGSPKDSPAHEVTGSGGaymrfDVPRPRVQRSWPTFRALLLHR--YVVARVIWADMLSIAVTYFITLCLFPGLES 376
Cdd:TIGR00939 222 --LRSKAEQNGIPHGGDQPSPT-----LVLDWEKEPESPDEPQKPLKTsvWVVFTKVWLLAFSVVFVFTVTLSVFPAITT 294
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 377 EIRHCILGE---WLPILIMAVFNLSDFVGKILAALP--VDWRGTHLLACSCLRIVFIPLFILCVYPSGTPA---LRHPAW 448
Cdd:TIGR00939 295 AVTSSGLGLsnwFYPIICFLLFNLFDWLGRSLTSKFmwPDEDSRWLPILSFLRVLFIPLFLLCNYPQRSRLpvfFPGDAY 374
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622919280 449 PCIFSLLMGISNGYFGSVPMILAAGKVSPKQRELAGNTMTVSYMSGLTLGSAVAY 503
Cdd:TIGR00939 375 FIILMLLFGFSNGYLGSLSMCLAPRQVDPHEREVAGALMVIFLLVGLALGAVLSF 429
Nucleoside_tran pfam01733
Nucleoside transporter; This is a family of nucleoside transporters. In mammalian cells ...
170-503 8.61e-31

Nucleoside transporter; This is a family of nucleoside transporters. In mammalian cells nucleoside transporters transport nucleoside across the plasma membrane and are essential for nucleotide synthesis via the salvage pathways for cells that lack their own de novo synthesis pathways. Also in this family is mouse and human nucleolar protein HNP36, a protein of unknown function; although it has been hypothesized to be a plasma membrane nucleoside transporter.


Pssm-ID: 396340  Cd Length: 286  Bit Score: 120.99  E-value: 8.61e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 170 LAAVGTVAFGCTVQQSSFYGYTGMLPKRYTQGVMTGESTAGVMISLSRILTKLLLPDERASTLIFFLVSVALELLCFLLH 249
Cdd:pfam01733   1 MGMIVLINSFNALLQNSLFGLAGVFPSTYTQAVMSGQGLAGVLVSVVMILTKASNSDLSESALLYFGTSIVVVIVCAICL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 250 LLVRRSRFVLFYttrprdsrrgrpglgkgsgyrvhhdvtagdvhfehpapalassgspkdspaHEVTGSGGAymrFDVPR 329
Cdd:pfam01733  81 NVLKKLRFYKYH---------------------------------------------------WQLKLEGPT---FDNSD 106
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 330 PRVQRSWPTFRALLlhryvvaRVIWADMLSIAVTYFITLCLFPGlESEIRHCILGEW----LPILIMAVFNLSDFVGKIL 405
Cdd:pfam01733 107 EQEENLKVLFFVIL-------AKIKVLALSVVLIFTVTLSVFPA-VTAEVVSSLPTWeayfIPVLCFLLFNLFDWLGRSL 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622919280 406 AALPVdWRGTH---LLACSCLRIVFIPLFILCVYPSGTPAL----RHPAWPCIFSLLMGISNGYFGSVPMILAAGKVSPK 478
Cdd:pfam01733 179 AAWFM-WPGQDprwLPVLVILRFLFIPLFLLCNYKPQSRALpvlfESDAWFIIFMCLFAFSNGYLSSLCMCYAPKSVPPH 257
                         330       340
                  ....*....|....*....|....*
gi 1622919280 479 QRELAGNTMTVSYMSGLTLGSAVAY 503
Cdd:pfam01733 258 ESETAGAIMVFFLCLGLALGAVISF 282
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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