NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622919208|ref|XP_028700907|]
View 

endoribonuclease YbeY isoform X3 [Macaca mulatta]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PRK13963 super family cl46897
rRNA maturation RNase YbeY;
29-91 2.40e-18

rRNA maturation RNase YbeY;


The actual alignment was detected with superfamily member TIGR00043:

Pssm-ID: 481237 [Multi-domain]  Cd Length: 110  Bit Score: 76.53  E-value: 2.40e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622919208  29 AGEFPLPEFPDDYNLGDIFLGVEYIFHQCKE-DEDYNDVLTVTATHGLCHLLGFTHSTEAEWQQ 91
Cdd:TIGR00043  34 YEEEEPPGGFPEEVLGDIVISLEVAKEQAKEyGHSLERELAHLTVHGLLHLLGYDHETEDEEKE 97
 
Name Accession Description Interval E-value
TIGR00043 TIGR00043
rRNA maturation RNase YbeY; This metalloprotein family is represented by a single member ...
29-91 2.40e-18

rRNA maturation RNase YbeY; This metalloprotein family is represented by a single member sequence only in nearly every bacterium. Crystallography demonstrated metal-binding activity, possibly to nickel. It is a predicted to be a metallohydrolase, and more recently it was shown that mutants have a ribosomal RNA processing defect. [Protein synthesis, Other]


Pssm-ID: 272871 [Multi-domain]  Cd Length: 110  Bit Score: 76.53  E-value: 2.40e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622919208  29 AGEFPLPEFPDDYNLGDIFLGVEYIFHQCKE-DEDYNDVLTVTATHGLCHLLGFTHSTEAEWQQ 91
Cdd:TIGR00043  34 YEEEEPPGGFPEEVLGDIVISLEVAKEQAKEyGHSLERELAHLTVHGLLHLLGYDHETEDEEKE 97
YbeY pfam02130
Endoribonuclease YbeY; YbeY is a single strand-specific metallo-endoribonuclease involved in ...
32-91 2.28e-09

Endoribonuclease YbeY; YbeY is a single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. It acts together with the RNase R to eliminate defective 70S ribosomes, but not properly maturated 70S ribosomes or individual subunits, by a process mediated specifically by the 30S ribosomal subunit. It is involved in the processing of 16S, 23S and 5S rRNAs, with a particularly strong effect on maturation at both the 5'-and 3'-ends of 16S rRNA as well as maturation of the 5'-end of 23S and 5S rRNAs. The crystal structure of the protein from Aquifex aeolicus showed an overall fold consisting of one central alpha-helix surrounded by a four-stranded beta-sheet and four other alpha-helices.


Pssm-ID: 460455  Cd Length: 125  Bit Score: 53.24  E-value: 2.28e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622919208  32 FPLPEFPDDynLGDIFLGVEYIFHQCKEdedYN----DVLTVTATHGLCHLLGFTHSTEAEWQQ 91
Cdd:pfam02130  55 FPMDEPEEP--LGDIVISPEKAKEQAEE---YGhsleRELAFLTVHGLLHLLGYDHEEEEEAKE 113
YbeY COG0319
ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme [Translation, ribosomal structure and ...
32-91 2.65e-08

ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme [Translation, ribosomal structure and biogenesis]; ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440088  Cd Length: 144  Bit Score: 50.54  E-value: 2.65e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622919208  32 FPLPEFPDDYN--LGDIFLGVEYIFHQCKE-DEDYNDVLTVTATHGLCHLLGFTHSTEAEWQQ 91
Cdd:COG0319    66 FPYDELPEDGPplLGDIVISVETAAREAKEqGHSFEDELAHLLVHGLLHLLGYDHETEEEAEE 128
 
Name Accession Description Interval E-value
TIGR00043 TIGR00043
rRNA maturation RNase YbeY; This metalloprotein family is represented by a single member ...
29-91 2.40e-18

rRNA maturation RNase YbeY; This metalloprotein family is represented by a single member sequence only in nearly every bacterium. Crystallography demonstrated metal-binding activity, possibly to nickel. It is a predicted to be a metallohydrolase, and more recently it was shown that mutants have a ribosomal RNA processing defect. [Protein synthesis, Other]


Pssm-ID: 272871 [Multi-domain]  Cd Length: 110  Bit Score: 76.53  E-value: 2.40e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622919208  29 AGEFPLPEFPDDYNLGDIFLGVEYIFHQCKE-DEDYNDVLTVTATHGLCHLLGFTHSTEAEWQQ 91
Cdd:TIGR00043  34 YEEEEPPGGFPEEVLGDIVISLEVAKEQAKEyGHSLERELAHLTVHGLLHLLGYDHETEDEEKE 97
YbeY pfam02130
Endoribonuclease YbeY; YbeY is a single strand-specific metallo-endoribonuclease involved in ...
32-91 2.28e-09

Endoribonuclease YbeY; YbeY is a single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. It acts together with the RNase R to eliminate defective 70S ribosomes, but not properly maturated 70S ribosomes or individual subunits, by a process mediated specifically by the 30S ribosomal subunit. It is involved in the processing of 16S, 23S and 5S rRNAs, with a particularly strong effect on maturation at both the 5'-and 3'-ends of 16S rRNA as well as maturation of the 5'-end of 23S and 5S rRNAs. The crystal structure of the protein from Aquifex aeolicus showed an overall fold consisting of one central alpha-helix surrounded by a four-stranded beta-sheet and four other alpha-helices.


Pssm-ID: 460455  Cd Length: 125  Bit Score: 53.24  E-value: 2.28e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622919208  32 FPLPEFPDDynLGDIFLGVEYIFHQCKEdedYN----DVLTVTATHGLCHLLGFTHSTEAEWQQ 91
Cdd:pfam02130  55 FPMDEPEEP--LGDIVISPEKAKEQAEE---YGhsleRELAFLTVHGLLHLLGYDHEEEEEAKE 113
YbeY COG0319
ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme [Translation, ribosomal structure and ...
32-91 2.65e-08

ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme [Translation, ribosomal structure and biogenesis]; ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440088  Cd Length: 144  Bit Score: 50.54  E-value: 2.65e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622919208  32 FPLPEFPDDYN--LGDIFLGVEYIFHQCKE-DEDYNDVLTVTATHGLCHLLGFTHSTEAEWQQ 91
Cdd:COG0319    66 FPYDELPEDGPplLGDIVISVETAAREAKEqGHSFEDELAHLLVHGLLHLLGYDHETEEEAEE 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH