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Conserved domains on  [gi|1622918809|ref|XP_028700827|]
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7SK snRNA methylphosphate capping enzyme isoform X1 [Macaca mulatta]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 1008156)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tam super family cl30593
Trans-aconitate methyltransferase [Energy production and conversion];
443-486 5.59e-06

Trans-aconitate methyltransferase [Energy production and conversion];


The actual alignment was detected with superfamily member COG4106:

Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 45.20  E-value: 5.59e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622918809 443 RGRDVLDLGCNVGHLTLSIACKWGPSRMVGLDIDSRLIHSARQN 486
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARAR 44
PHA03378 super family cl33729
EBNA-3B; Provisional
 49-140 3.25e-03

EBNA-3B; Provisional


The actual alignment was detected with superfamily member PHA03378:

Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.44  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622918809  49 RGPGPCAPSAGSPAAgvgRESPGAAATPPGGPQAQQHRGGGPQAQSHGEARLSDPPGRAAPPDVGEERRGGGGTELGPPA 128
Cdd:PHA03378  699 RAPTPMRPPAAPPGR---AQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPT 775

                          90
                  ....*....|...
gi 1622918809 129 P-PRPRNGYQPHR 140
Cdd:PHA03378  776 PqPPPQAPPAPQQ 788
 
Name Accession Description Interval E-value
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
443-486 5.59e-06

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 45.20  E-value: 5.59e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622918809 443 RGRDVLDLGCNVGHLTLSIACKWGPSRMVGLDIDSRLIHSARQN 486
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARAR 44
PLN02672 PLN02672
methionine S-methyltransferase
 442-491 1.19e-05

methionine S-methyltransferase


Pssm-ID: 215360 [Multi-domain]  Cd Length: 1082  Bit Score: 48.23  E-value: 1.19e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622918809  442 FRGRDVLDLGCNVGHLTLSIACKWGPSRMVGLDIDSRLIHSARQNIrhYL 491
Cdd:PLN02672   117 FRDKTVAELGCGNGWISIAIAEKWLPSKVYGLDINPRAVKVAWINL--YL 164
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 446-505 1.23e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 44.34  E-value: 1.23e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622918809 446 DVLDLGCNVGHLTLSIAcKWGPSRMVGLDIDSRLIHSARQNIRHYLSEELRLpprtVEGD 505
Cdd:cd02440     1 RVLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKAAAALLADNVEV----LKGD 55
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 447-505 1.33e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 44.09  E-value: 1.33e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622918809 447 VLDLGCNVGHLTLSIAcKWGPSRMVGLDIDSRLIHSARQNIRhylseELRLPPRTVEGD 505
Cdd:pfam13649   1 VLDLGCGTGRLTLALA-RRGGARVTGVDLSPEMLERARERAA-----EAGLNVEFVQGD 53
PHA03378 PHA03378
EBNA-3B; Provisional
 49-140 3.25e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.44  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622918809  49 RGPGPCAPSAGSPAAgvgRESPGAAATPPGGPQAQQHRGGGPQAQSHGEARLSDPPGRAAPPDVGEERRGGGGTELGPPA 128
Cdd:PHA03378  699 RAPTPMRPPAAPPGR---AQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPT 775

                          90
                  ....*....|...
gi 1622918809 129 P-PRPRNGYQPHR 140
Cdd:PHA03378  776 PqPPPQAPPAPQQ 788
 
Name Accession Description Interval E-value
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
443-486 5.59e-06

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 45.20  E-value: 5.59e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622918809 443 RGRDVLDLGCNVGHLTLSIACKWGPSRMVGLDIDSRLIHSARQN 486
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARAR 44
PLN02672 PLN02672
methionine S-methyltransferase
 442-491 1.19e-05

methionine S-methyltransferase


Pssm-ID: 215360 [Multi-domain]  Cd Length: 1082  Bit Score: 48.23  E-value: 1.19e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622918809  442 FRGRDVLDLGCNVGHLTLSIACKWGPSRMVGLDIDSRLIHSARQNIrhYL 491
Cdd:PLN02672   117 FRDKTVAELGCGNGWISIAIAEKWLPSKVYGLDINPRAVKVAWINL--YL 164
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 446-505 1.23e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 44.34  E-value: 1.23e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622918809 446 DVLDLGCNVGHLTLSIAcKWGPSRMVGLDIDSRLIHSARQNIRHYLSEELRLpprtVEGD 505
Cdd:cd02440     1 RVLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKAAAALLADNVEV----LKGD 55
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 447-505 1.33e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 44.09  E-value: 1.33e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622918809 447 VLDLGCNVGHLTLSIAcKWGPSRMVGLDIDSRLIHSARQNIRhylseELRLPPRTVEGD 505
Cdd:pfam13649   1 VLDLGCGTGRLTLALA-RRGGARVTGVDLSPEMLERARERAA-----EAGLNVEFVQGD 53
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 447-489 2.73e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 44.33  E-value: 2.73e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622918809 447 VLDLGCNVGHLTLSIACKWGP-SRMVGLDIDSRLIHSARQNIRH 489
Cdd:pfam13847   7 VLDLGCGTGHLSFELAEELGPnAEVVGIDISEEAIEKARENAQK 50
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 431-489 4.49e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 43.08  E-value: 4.49e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622918809 431 DGRL-RVLKPEWFRGRDVLDLGCNVGHLTLSIAcKWGpSRMVGLDIDSRLIHSARQNIRH 489
Cdd:COG2227    11 DRRLaALLARLLPAGGRVLDVGCGTGRLALALA-RRG-ADVTGVDISPEALEIARERAAE 68
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
444-488 1.57e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 42.97  E-value: 1.57e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1622918809 444 GRDVLDLGCNVGhlTLSIACKW-GPSRMVGLDIDSRLIHSARQNIR 488
Cdd:COG2263    46 GKTVLDLGCGTG--MLAIGAALlGAKKVVGVDIDPEALEIARENAE 89
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 421-490 1.69e-04

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 42.98  E-value: 1.69e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622918809 421 YYGYRNPSCEDGRLRVLKPEwfRGRDVLDLGCNVGHLTLSIACKWGpSRMVGLDIDSRLIHSARQNIRHY 490
Cdd:COG0500     6 YSDELLPGLAALLALLERLP--KGGRVLDLGCGTGRNLLALAARFG-GRVIGIDLSPEAIALARARAAKA 72
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 448-490 2.51e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 40.43  E-value: 2.51e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622918809 448 LDLGCNVGHLTLSIACKWGPSRMVGLDIDSRLIHSARQNIRHY 490
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAAL 43
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 443-489 8.70e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 41.28  E-value: 8.70e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1622918809 443 RGRDVLDLGCNVGHLTLSIACKWGPSRMVGLDIDSRLIHSARQNIRH 489
Cdd:COG4123    37 KGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVAL 83
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 444-488 9.68e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 40.56  E-value: 9.68e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1622918809 444 GRDVLDLGCNVGHLTLSIACKWGPSRMVGLDIDSRLIHSARQNIR 488
Cdd:COG2813    50 GGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAA 94
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
442-488 1.24e-03

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 40.93  E-value: 1.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622918809 442 FRGRDVLDLGCnvGhlT--LSIAC-KWGPSRMVGLDIDSRLIHSARQNIR 488
Cdd:COG2264   147 KPGKTVLDVGC--G--SgiLAIAAaKLGAKRVLAVDIDPVAVEAARENAE 192
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 443-505 1.50e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 39.21  E-value: 1.50e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622918809 443 RGRDVLDLGCNVGHLTLSIAcKWGpSRMVGLDIDSRLIHSARQNIRhylseELRLPPRTVEGD 505
Cdd:COG2226    22 PGARVLDLGCGTGRLALALA-ERG-ARVTGVDISPEMLELARERAA-----EAGLNVEFVVGD 77
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 421-489 1.63e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 39.33  E-value: 1.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622918809 421 YYGYRNPSCEDGRLRVLKPEWfRGRDVLDLGCNVGHLTLSIAcKWGPSrMVGLDIDSRLIHSARQNIRH 489
Cdd:pfam13489   1 YAHQRERLLADLLLRLLPKLP-SPGRVLDFGCGTGIFLRLLR-AQGFS-VTGVDPSPIAIERALLNVRF 66
PRK08317 PRK08317
hypothetical protein; Provisional
 443-505 2.20e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 39.92  E-value: 2.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622918809 443 RGRDVLDLGCNVGHLTLSIACKWGP-SRMVGLDIDSRLIHSARQNIrhylsEELRLPPRTVEGD 505
Cdd:PRK08317   19 PGDRVLDVGCGPGNDARELARRVGPeGRVVGIDRSEAMLALAKERA-----AGLGPNVEFVRGD 77
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 443-488 3.08e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 38.73  E-value: 3.08e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1622918809 443 RGRDVLDLGCNVGHLTLSIACKWGPSRMVGLDIDSRLIHSARQNIR 488
Cdd:pfam05175  31 LSGKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLA 76
PHA03378 PHA03378
EBNA-3B; Provisional
 49-140 3.25e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.44  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622918809  49 RGPGPCAPSAGSPAAgvgRESPGAAATPPGGPQAQQHRGGGPQAQSHGEARLSDPPGRAAPPDVGEERRGGGGTELGPPA 128
Cdd:PHA03378  699 RAPTPMRPPAAPPGR---AQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPT 775

                          90
                  ....*....|...
gi 1622918809 129 P-PRPRNGYQPHR 140
Cdd:PHA03378  776 PqPPPQAPPAPQQ 788
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 45-130 4.01e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 4.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622918809  45 GGTERGPGPCAPSAGSPAAGVGRESPGAAATPPGGPQAQQHRGGGPQAQSHGEARLSDPPGRAAPPDVGEERRGGGGTEL 124
Cdd:PRK07764  400 SAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAA 479


                  ....*.
gi 1622918809 125 GPPAPP 130
Cdd:PRK07764  480 PAPAPP 485
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 435-487 4.39e-03

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 39.17  E-value: 4.39e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622918809 435 RVLKPewfrGRDVLDLGCNVGhlTLSIAC-KWGPSRMVGLDIDSRLIHSARQNI 487
Cdd:pfam06325 157 RLVKP----GESVLDVGCGSG--ILAIAAlKLGAKKVVGVDIDPVAVRAAKENA 204
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 21-138 5.84e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.58  E-value: 5.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622918809  21 KDESGGGGGPTVPPHQEAASGELCGGTERGPGPCAPSAGSPAAGvGRESPGAAATPPGGPQAQqhRGGGPQAQSHGEARL 100
Cdd:PRK07764  655 KHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAP-AQPAPAPAATPPAGQADD--PAAQPPQAAQGASAP 731

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1622918809 101 SDPPGRAAP-PDVGEERRGGGGTELGPPAPPRPRNGYQP 138
Cdd:PRK07764  732 SPAADDPVPlPPEPDDPPDPAGAPAQPPPPPAPAPAAAP 770
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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