second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 190 RGDLWELPFPCPDGfNSCPDVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpeTSGGPPAITLHGISPDIFTHV 269
Cdd:cd18296     1 RVDLDELPFPPEQE-LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622908868 270 LYYVYSDHTELSPEAAYDVLSIADMYLLPGLKRLCGRSLAQVLD 313
Cdd:cd18296    78 LYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622908868 312 LDEDSVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHV 383
Cdd:cd18497     1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 190 RGDLWELPFPCPDGfNSCPDVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpeTSGGPPAITLHGISPDIFTHV 269
Cdd:cd18296     1 RVDLDELPFPPEQE-LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622908868 270 LYYVYSDHTELSPEAAYDVLSIADMYLLPGLKRLCGRSLAQVLD 313
Cdd:cd18296    78 LYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622908868 312 LDEDSVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHV 383
Cdd:cd18497     1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622908868  80 LQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYT 150
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYT 71

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622908868   91 DVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWK--GKSVVVLRHplINPVAFGALLQYLYT 150
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDD--VSPEDFRALLNFLYT 60

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 190 RGDLWELPFPCPDGfNSCPDVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEpeTSGGPPAITLHGISPDIFTHV 269
Cdd:cd18296     1 RVDLDELPFPPEQE-LSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEE--NNGSIPVVTLHDVSPEVFAIV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622908868 270 LYYVYSDHTELSPEAAYDVLSIADMYLLPGLKRLCGRSLAQVLD 313
Cdd:cd18296    78 LYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622908868 312 LDEDSVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHV 383
Cdd:cd18497     1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAELVREDAASVKNRQETDSIPIIDDIRYHL 72

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 209 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTELSPEAAYDV 288
Cdd:cd18186     3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSE-------IELDDVSPEAFEALLDYIYTGELELSEENVEEL 75

                  ....*..
gi 1622908868 289 LSIADMY 295
Cdd:cd18186    76 LAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 206 SCPDVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTELSPEAA 285
Cdd:cd18314     5 EFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKE-------VTLEDVEPEIFETVLKYMYTGQVTLSEENV 77

                          90
                  ....*....|....*....
gi 1622908868 286 YDVLSIADMYLLPGLKRLC 304
Cdd:cd18314    78 LDLLMLASKYQVPDLEKLC 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622908868  89 HSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYT 150
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYT 62

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 209 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTELSPEAAYDV 288
Cdd:cd18352    15 DVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARD-------IEIPNIRWEVFELMMRFIYTGSVDITNDIAKDL 87

                          90       100
                  ....*....|....*....|....*....
gi 1622908868 289 LSIADMYLLPGLKRLCGRSLAQVLDEDSV 317
Cdd:cd18352    88 LRAADQYLLEGLKRLCEYTIAQDLTLENI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 209 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTE---LSPEAA 285
Cdd:cd18297    14 DVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPV-------IEIPDIRYDIFQLMMQYLYTGGVEsldVAQDDA 86

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622908868 286 YDVLSIADMYLLPGLKRLCGRSLAQVLDEDS 316
Cdd:cd18297    87 LELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 209 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDH---TELSPEAA 285
Cdd:cd18287    24 DVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSE-------IELKDTNAEAFKALLKYIYTGRltlTDLKEDVL 96

                          90
                  ....*....|....*.
gi 1622908868 286 YDVLSIADMYLLPGLK 301
Cdd:cd18287    97 LDVLGLAHQYGFEELE 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 209 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFreseePETSGGPPAITLHGISPDIFTHVLYYVYSDHTELSPEAAYDV 288
Cdd:cd18245    16 DATLVVGGEEIPVQKNVLAAASPYFRAKLNYNP-----PKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDI 90

                          90
                  ....*....|....*.
gi 1622908868 289 LSIADMYLLPGLKRLC 304
Cdd:cd18245    91 VQAADLLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 209 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTELSPEAAYDV 288
Cdd:cd18240    19 DVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKV-------YKIPGVSPEMMELIIEYAYTRTVPITAENVEEL 91

                          90
                  ....*....|....*.
gi 1622908868 289 LSIADMYLLPGLKRLC 304
Cdd:cd18240    92 LPAADQFNIMGIVKAC 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 166 PPPADPRlredmalladCALPPELrGDLWELPFpcpdgFNSCpdvCFRVAGCSFLCHKAFFCGRSDYFRALLddhfrESE 245
Cdd:cd18344     1 PAIKDPR----------HMLTDDL-GELWENSL-----FTDC---CLLVAGHEFRAHKAILAARSPVFRAMF-----EHE 56

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622908868 246 EPETSGGPpaITLHGISPDIFTHVLYYVYSDHTEL--SPEAAYDVLSIADMYLLPGLKRLCGRSLAQVL 312
Cdd:cd18344    57 MEERLKNP--IEIHDLDPQVFKEMMGFIYTGKAPHlhSHSMACDVLAAADKYGLEGLKVLCEDALCRNL 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868  80 LQRLLEQGIHSDVVFVV--HGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVlRHPL--INPVAFGALLQYLYT--VVS 153
Cdd:cd18294     5 MKSLINNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQKESTQS-PLVLsdIEPEVFRAVLEFIYTncVTL 83

                          90
                  ....*....|.
gi 1622908868 154 KPGTCVKVLTI 164
Cdd:cd18294    84 SNHTVIEVLAA 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 209 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTELSPEAAYDV 288
Cdd:cd18250    23 DVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADR-------VVLHGVSAEILGLLLDFSYTGRVTVTQDNVEAL 95

                          90       100
                  ....*....|....*....|....*....
gi 1622908868 289 LSIADMYLLPGLKRLCGRSLAQVLDEDSV 317
Cdd:cd18250    96 LRAADLFQFPSVKEACCAYLQQRLDVSNC 124

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 209 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTELSPEA-AYD 287
Cdd:cd18300    11 DVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKE-------VELPGVSKETFLALLEYLYTDQAPILEDGdCVG 83

                          90
                  ....*....|....*..
gi 1622908868 288 VLSIADMYLLPGLKRLC 304
Cdd:cd18300    84 LIVLANRLCLPRLVALC 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622908868  89 HSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYT 150
Cdd:cd18298    12 TSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYT 73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 177 MALLADCALPPELrGDLWElpfpcPDGFNSCpdvCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaI 256
Cdd:cd18342     1 MVKVPECRLADEL-GGLWE-----NSRFTDC---CLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR-------V 64

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622908868 257 TLHGISPDIFTHVLYYVYSDHTELSPEAAYDVLSIADMYLLPGLKRLCGRSLAQVL 312
Cdd:cd18342    65 EINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 209 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTELSPEAAYDV 288
Cdd:cd18268    25 DVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAK-------VDLKGIDSDVLDQIVDYVYTGEILITRDNVLPL 97

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622908868 289 LSIADMYLLPGLKRLCGRSLAQVLDEDSVVGV 320
Cdd:cd18268    98 MEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 204 FNSC--PDVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESeEPETsggppaITLHGISPDIFTHVLYYVYSDHTELS 281
Cdd:cd18298     7 FNDPrtSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNED-DKNV------IEIDQYSYPVYYAFLRYLYTDQVDLP 79

                          90       100
                  ....*....|....*....|....*....
gi 1622908868 282 PEAAYDVLSIADMYLLPGLKRLCGRSLAQ 310
Cdd:cd18298    80 PEDAIGLLDLANSYCEERLKKLCEDIIKQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 209 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESeepetsggppaITLHGISPDIFTHVLYYVYSDHTELSPEAAYDV 288
Cdd:cd18354    22 DLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEI-----------IEMSQFSYPVYRAFLEYLYTDSISLSPEDAIGL 90

                          90       100
                  ....*....|....*....|....*..
gi 1622908868 289 LSIADMYLLPGLKRLCGRSLAQVLDED 315
Cdd:cd18354    91 LDLATFYRENRLKKLCQQTIKQGICEE 117

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622908868  80 LQRLLEQGIHSDVVFVV-HGKPFRVHRCVLGARSAYFANMLDTKwkgksVVVLRHPLINPVAFGALLQYLYT 150
Cdd:cd18299     3 LRNLLHSPSCADVVFILqGGVRIFAHRIVLAAASSVFADLFLMM-----TVVTLDSDITPEAFRRVLEFLYT 69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622908868  83 LLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYT 150
Cdd:cd18280     8 LLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYK 75

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622908868  90 SDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSV--VVLRHplINPVAFGALLQYLYT 150
Cdd:cd18314     7 SDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLkeVTLED--VEPEIFETVLKYMYT 67

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622908868  80 LQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYT 150
Cdd:cd18331    15 LNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILLDFMYT 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622908868  80 LQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKG---KSVVVLRHPLINPVAFGALLQYLYT 150
Cdd:cd18292     8 IAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSeskQSEIELVEDPECAAVFEKFLRYLYT 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908868 209 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPetsggppAITLHGISPDIFTHVLYYVYSDHTELSPEAAYDV 288
Cdd:cd18353    22 DLKFRVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKE-------VIEIDQFSYPVYRAFLEYLYTDSVDLPPEDAIGL 94

                          90
                  ....*....|....*.
gi 1622908868 289 LSIADMYLLPGLKRLC 304
Cdd:cd18353    95 LDLATSYCENRLKKLC 110