BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622908866  97 RRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYT 175
Cdd:cd18295     2 RRDYYDEFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYT 80

Ankyrin repeat [Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866   6 LFASCRKGDVGRVRYLLEqRDVEVNVRDKWDSTPLYYACLCGHEELVLYLLANGARCEANTFDGERCLYGALSDPIRRAL 85
Cdd:COG0666   157 LHLAAANGNLEIVKLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1622908866  86 RDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVV 118
Cdd:COG0666   236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIV 268

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622908866  97 RRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYT 175
Cdd:cd18295     2 RRDYYDEFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYT 80

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866  234 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTELSPEAAYDV 313
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSE-------IYLDDVSPEDFRALLNFLYTGKLDLPEENVEEL 73

                           90       100
                   ....*....|....*....|..
gi 1622908866  314 LSIADMYLLPGLKRLCGRSLAQ 335
Cdd:smart00225  74 LELADYLQIPGLVELCEEFLLK 95

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 234 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTeLSPEAAYDV 313
Cdd:pfam00651  12 DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSE-------ITLDDVSPEDFEALLEFMYTGKL-ISEENVDDL 83

                          90       100
                  ....*....|....*....|..
gi 1622908866 314 LSIADMYLLPGLKRLCGRSLAQ 335
Cdd:pfam00651  84 LAAADKLQIPSLVDKCEEFLIK 105

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622908866  116 DVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWK--GKSVVVLRHplINPVAFGALLQYLYT 175
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDD--VSPEDFRALLNFLYT 60

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 232 CPD-VCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEepetsggppaITLHgISPDIFTHVLYYVYSDHTELSPEAA 310
Cdd:PHA03098   10 CDEsIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENE----------INLN-IDYDSFNEVIKYIYTGKINITSNNV 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622908866 311 YDVLSIADMYLLPGLKRLCGRSLAQVLDEDSVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDF 378
Cdd:PHA03098   79 KDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDF 146

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.

                           10        20
                   ....*....|....*....|....*....
gi 1622908866   36 DSTPLYYACLCGHEELVLYLLANGARCEA 64
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622908866  97 RRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYT 175
Cdd:cd18295     2 RRDYYDEFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYT 80

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 232 CPDVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTELSPEA-A 310
Cdd:cd18286    17 DSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSE-------ITLTGVSHAAVSFVLLFIYGGVLDLPDDVnL 89

                          90
                  ....*....|....*...
gi 1622908866 311 YDVLSIADMYLLPGLKRL 328
Cdd:cd18286    90 GELLSLADMYGLDGLKDV 107

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 231 SCPDVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTELSPEAA 310
Cdd:cd18314     5 EFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKE-------VTLEDVEPEIFETVLKYMYTGQVTLSEENV 77

                          90
                  ....*....|....*....
gi 1622908866 311 YDVLSIADMYLLPGLKRLC 329
Cdd:cd18314    78 LDLLMLASKYQVPDLEKLC 96

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622908866 105 LQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYT 175
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYT 71

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 234 DVCFRV--AGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPETsggppaITLHGISPDIFTHVLYYVYSDHTELSPEAAY 311
Cdd:cd18294    16 DVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSP------LVLSDIEPEVFRAVLEFIYTNCVTLSNHTVI 89

                          90       100
                  ....*....|....*....|..
gi 1622908866 312 DVLSIADMYLLPGLKRLCGRSL 333
Cdd:cd18294    90 EVLAAAVEYGLDELRKLCERFI 111

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 234 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTeLSPEAAYDV 313
Cdd:pfam00651  12 DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSE-------ITLDDVSPEDFEALLEFMYTGKL-ISEENVDDL 83

                          90       100
                  ....*....|....*....|..
gi 1622908866 314 LSIADMYLLPGLKRLCGRSLAQ 335
Cdd:pfam00651  84 LAAADKLQIPSLVDKCEEFLIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622908866 103 DFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWK--GKSVVVLRHplINPVAFGALLQYLYT 175
Cdd:cd18287    11 EDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMResQQSEIELKD--TNAEAFKALLKYIYT 83

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 102 DDFLQrLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYT-VVSKP 180
Cdd:cd18286     6 KDLLQ-LFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGgVLDLP 84

                  ...
gi 1622908866 181 GTC 183
Cdd:cd18286    85 DDV 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 207 DCALPPELrGDLWElpfpcpdgfNSC-PDVCFRVAGCSFLCHKAFFCGRSDYFRALLddhfrESEEPETSGGPPAItlHG 285
Cdd:cd18279     2 ECRLAEDL-GNLWE---------NSRfTDCCLCVGGQEFQAHKAILAARSPVFSAMF-----EHEMEESKKNRVEI--ND 64

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622908866 286 ISPDIFTHVLYYVYSDHTELSPEAAYDVLSIADMYLLPGLKRLCGRSLAQVLDEDS 341
Cdd:cd18279    65 VDPEVFKEMMRFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 234 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTELSPEAAYDV 313
Cdd:cd18256    22 DVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDV-------VQIHGVEPDIFHILLDFIYTGVVEVTVSNVQEL 94

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622908866 314 LSIADMYLLPGLKRLCGRSLAQVLDEDSVVG 344
Cdd:cd18256    95 LVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 234 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSD-------HTELS 306
Cdd:cd18280    16 DVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGE-------IVIEDVEPPVFKALLHFIYKDelpddvePAGSD 88

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622908866 307 PEAAYD-----VLSIADMYLLPGLKRLCGRSL 333
Cdd:cd18280    89 SSSLDTtmaqhLLAAADRYALERLRLLCESRL 120

Ankyrin repeat [Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866   6 LFASCRKGDVGRVRYLLEqRDVEVNVRDKWDSTPLYYACLCGHEELVLYLLANGARCEANTFDGERCLYGALSDPIRRAL 85
Cdd:COG0666   157 LHLAAANGNLEIVKLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1622908866  86 RDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVV 118
Cdd:COG0666   236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIV 268

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 241 GCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppAITLHgISPDIFTHVLYYVYSDHTELSP-----EAAYDVLS 315
Cdd:cd18302    15 GKEFPCHKCVLVARLEYFHSMLSSSWIEASSCS------ALTMP-IPSDILEIILDYLYTDEASAVKesqnvEFLCNVLV 87

                          90       100
                  ....*....|....*....|..
gi 1622908866 316 IADMYLLPGLKRLCGRSLAQVL 337
Cdd:cd18302    88 IADQLLITRLKEICEVALVELL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 234 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTELSPEAAYDV 313
Cdd:cd18250    23 DVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADR-------VVLHGVSAEILGLLLDFSYTGRVTVTQDNVEAL 95

                          90       100
                  ....*....|....*....|....*....
gi 1622908866 314 LSIADMYLLPGLKRLCGRSLAQVLDEDSV 342
Cdd:cd18250    96 LRAADLFQFPSVKEACCAYLQQRLDVSNC 124

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 234 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTELSPEA-AYD 312
Cdd:cd18300    11 DVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKE-------VELPGVSKETFLALLEYLYTDQAPILEDGdCVG 83

                          90
                  ....*....|....*..
gi 1622908866 313 VLSIADMYLLPGLKRLC 329
Cdd:cd18300    84 LIVLANRLCLPRLVALC 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622908866 114 HSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYT 175
Cdd:cd18298    12 TSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYT 73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 234 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTELSPEAAYDV 313
Cdd:cd18242    23 DVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSE-------VELQGLTASTMEILLDFVYTETVHVTVENVQEL 95

                          90       100
                  ....*....|....*....|....*
gi 1622908866 314 LSIADMYLLPGLKRLCGRSLAQVLD 338
Cdd:cd18242    96 LPAACLLQLKGVKQACCEFLESQLD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622908866 115 SDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYT 175
Cdd:cd18297    13 SDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYT 73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 106 QRLleQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKwkgKSVVVLRHPLINPVAFGALLQYLYT 175
Cdd:cd18290    21 QRL--QGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSS---RSAVVELPAAVQPQSFQQILSFCYT 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 229 FNSC--PDVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESeEPETsggppaITLHGISPDIFTHVLYYVYSDHTELS 306
Cdd:cd18298     7 FNDPrtSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNED-DKNV------IEIDQYSYPVYYAFLRYLYTDQVDLP 79

                          90       100
                  ....*....|....*....|....*....
gi 1622908866 307 PEAAYDVLSIADMYLLPGLKRLCGRSLAQ 335
Cdd:cd18298    80 PEDAIGLLDLANSYCEERLKKLCEDIIKQ 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 207 DCALPPELrGDLWElpfpcPDGFNSCPdvcFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGI 286
Cdd:cd18343     5 ECRLAEDL-GNLWE-----NSRFTDCS---LFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNR-------VEINDV 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622908866 287 SPDIFTHVLYYVYSDHTELSPEAAYDVLSIADMYLLPGLKRLCGRSLAQVL 337
Cdd:cd18343    69 DPEVFKEMMRFIYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCNNL 119

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622908866 115 SDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSV--VVLRHplINPVAFGALLQYLYT 175
Cdd:cd18314     7 SDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLkeVTLED--VEPEIFETVLKYMYT 67

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908866 234 DVCFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPEtsggppaITLHGISPDIFTHVLYYVYSDHTELSPEAAYDV 313
Cdd:cd18255    20 DVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDE-------IELKGVSAKGLKHILDFAYTSELTLDLDCIQDV 92

                          90       100
                  ....*....|....*....|....*.
gi 1622908866 314 LSIAD-MYLLPGLKrLCGRSLAQVLD 338
Cdd:cd18255    93 LGAAVhLQMLPVVE-LCEEFLKSAMS 117