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Conserved domains on  [gi|1622908521|ref|XP_028700259|]
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Fanconi anemia group D2 protein isoform X2 [Macaca mulatta]

Protein Classification

fanconi anemia group D2 protein( domain architecture ID 11235073)

fanconi anemia group D2 protein (FANCD2) is required for maintenance of chromosomal stability, promotion of accurate and efficient pairing of homologs during meiosis, and the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing

Gene Ontology:  GO:0006281|GO:0031573|GO:1990918|GO:0070182

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 42-1422 0e+00

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


:

Pssm-ID: 464225  Cd Length: 1346  Bit Score: 2493.47  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521   42 SHIANEVEENDSIFVKLLKTSGIILKTGENQNQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCL 121
Cdd:pfam14631    1 SHAQNEVEENGSVFVKLLKTAGVILKTGENQNEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  122 LPCERLQDEEA-SMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINVPRLIVSQLKWLDRVVDGKDLT 200
Cdd:pfam14631   81 LPCVPLQSEEAsSMVTSYQESLIKLLLGIEILQPAIIKTLFEKLPEFMFESVNSDGLNMPRLIINQLKWLDRIVDGKDLT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  201 AKIMQLISIAPENLQHDIITSLPEILGDSQHTDVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVMDKLSSI 280
Cdd:pfam14631  161 SKLMQLISVAPVELQHDIITSLPEILEDSQHNDVARELSSLLVENTQLTVPILDALSSLNLDPTLLSEVRQAVMGTLSAV 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  281 RLEDLPVIIKFILHSITAMDALEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSDQSCIILLFDVIKSA 360
Cdd:pfam14631  241 QLEDLPVVVKFILHSVSATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSSGNQASSSQDCISLVFDVIKSA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  361 IRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIERVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMCS 440
Cdd:pfam14631  321 VRFQKTISEAWLKAIENIDSVSDHKVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHALVLRDYFP 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  441 SILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVF 520
Cdd:pfam14631  401 SILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSYCQQEVVGALVTHVCSGNEAEVDVALELLLELVVLKPSAMRLYAVF 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  521 VKGILDYLDNISPQQIRKLFYVLSTLAFSKQNEASSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRTESc 600
Cdd:pfam14631  481 VKGILDYMDNLTPQQIRKLFHILSTLAFSQQHEQSSHIQDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGSMAADRSKS- 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  601 SLTQERANLSNEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQQEKLDPKALERVGHTICSDFQDAFVVDSCVVPE 680
Cdd:pfam14631  560 GSSSQSASLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGKLDPKVLEWIGQSVLNDFQDDFVVDLGPDIE 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  681 GDFPFPVKALYGLEEYNTQDGIAINLLPLLFSQDFAKDGGPVTPQESGQKLVSPLCLAPYFRLLRLCVERQHNGNLEEID 760
Cdd:pfam14631  640 GDFPFPVKALYGLEEEESQGGIAINLLPLLAKDEQAKDEGEVTAQEKGQKRVSPLCLSPFFRLLRLCVEKQHDGDLEEID 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  761 GLLDCPIFLTDLEPGEKLESMSAKERAFMCSLLFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVT 840
Cdd:pfam14631  720 GLLGCPLILTDLEVGEKLESLSKKEREFLCSLLFHTINWFREVVNAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLAVT 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  841 PDYIPPLGNFDvetlditphtvtaisakirkkgkierkqkadgsktssSDTISEEKNSECDPTPSHRGQLNKEFTGKEEK 920
Cdd:pfam14631  800 PGYVPPLANFD-------------------------------------LDSSQKEEASEAEESQSEKSQLEKEFKGKEGK 842

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  921 TSLLLHNYRAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPELLFLLEDLSQKLESMLTPPIARRVPFFKN 1000
Cdd:pfam14631  843 TGVSLQSYRAFFRELDIEVFSVLHCGLLTKSLLDTEMHTKAREEVQLGPAELLFLLEDLSRKLEFMLTPAPAKRAPFLKG 922

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1001 KGSRNIGFSHLQQRSAQEIVHCVFQLVTPMCNHLENIHNYFQCLAAENHGVVDGPGMKVQEYHIMSSCYQRLLQIFHGLF 1080
Cdd:pfam14631  923 KGDRNVGFSHLQQRSAQEIAHCVVQLLPPLCNHLENIHNYFQCLLAENHGVVDGPGVDVQEHQLMSSCYQLLLQVLHTLF 1002

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1081 AWSGFSQPENQNLLYSALHVLSSRLKQGEHSQPLEELLSQSFHYLQNFHQSIPSFQCALYLIRLLMVILEKSTASTQNKE 1160
Cdd:pfam14631 1003 AWSGFSQPENRSLLKSALGVLAGRLKEGEAELTLEELVSHSFEYLQNFRSSVPSFQCALCLIQLLIVIAEKSGNPAAKRE 1082

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1161 KIASLARQFLCRVW--PSGDKEKSSISNDQLHALLCIYLEHTDSILKAIEEIAGVGVPELINSPKDVSSSTFPTLTRHTF 1238
Cdd:pfam14631 1083 KIASLARQFLCQVWvtPSGEKEKGNKFNDALHTLLCIYLEHTDDVLKAIEEIAGEGVPELINSSKDASSSTFPTLTRQTF 1162

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1239 VVFFRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMP 1318
Cdd:pfam14631 1163 LVFFRVMMAELEKSVRKIQPGTASDSQEVQEEKLLYWNMAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLKLGMP 1242

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1319 LLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGNLKN 1398
Cdd:pfam14631 1243 LLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLGNLKN 1322

                         1370      1380
                   ....*....|....*....|....
gi 1622908521 1399 RDLQGEEIKSQNSQESTADESEDD 1422
Cdd:pfam14631 1323 RDLQGEEILSQRSQESDEEEEEDS 1346
 
Name Accession Description Interval E-value
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 42-1422 0e+00

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


Pssm-ID: 464225  Cd Length: 1346  Bit Score: 2493.47  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521   42 SHIANEVEENDSIFVKLLKTSGIILKTGENQNQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCL 121
Cdd:pfam14631    1 SHAQNEVEENGSVFVKLLKTAGVILKTGENQNEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  122 LPCERLQDEEA-SMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINVPRLIVSQLKWLDRVVDGKDLT 200
Cdd:pfam14631   81 LPCVPLQSEEAsSMVTSYQESLIKLLLGIEILQPAIIKTLFEKLPEFMFESVNSDGLNMPRLIINQLKWLDRIVDGKDLT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  201 AKIMQLISIAPENLQHDIITSLPEILGDSQHTDVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVMDKLSSI 280
Cdd:pfam14631  161 SKLMQLISVAPVELQHDIITSLPEILEDSQHNDVARELSSLLVENTQLTVPILDALSSLNLDPTLLSEVRQAVMGTLSAV 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  281 RLEDLPVIIKFILHSITAMDALEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSDQSCIILLFDVIKSA 360
Cdd:pfam14631  241 QLEDLPVVVKFILHSVSATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSSGNQASSSQDCISLVFDVIKSA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  361 IRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIERVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMCS 440
Cdd:pfam14631  321 VRFQKTISEAWLKAIENIDSVSDHKVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHALVLRDYFP 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  441 SILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVF 520
Cdd:pfam14631  401 SILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSYCQQEVVGALVTHVCSGNEAEVDVALELLLELVVLKPSAMRLYAVF 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  521 VKGILDYLDNISPQQIRKLFYVLSTLAFSKQNEASSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRTESc 600
Cdd:pfam14631  481 VKGILDYMDNLTPQQIRKLFHILSTLAFSQQHEQSSHIQDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGSMAADRSKS- 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  601 SLTQERANLSNEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQQEKLDPKALERVGHTICSDFQDAFVVDSCVVPE 680
Cdd:pfam14631  560 GSSSQSASLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGKLDPKVLEWIGQSVLNDFQDDFVVDLGPDIE 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  681 GDFPFPVKALYGLEEYNTQDGIAINLLPLLFSQDFAKDGGPVTPQESGQKLVSPLCLAPYFRLLRLCVERQHNGNLEEID 760
Cdd:pfam14631  640 GDFPFPVKALYGLEEEESQGGIAINLLPLLAKDEQAKDEGEVTAQEKGQKRVSPLCLSPFFRLLRLCVEKQHDGDLEEID 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  761 GLLDCPIFLTDLEPGEKLESMSAKERAFMCSLLFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVT 840
Cdd:pfam14631  720 GLLGCPLILTDLEVGEKLESLSKKEREFLCSLLFHTINWFREVVNAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLAVT 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  841 PDYIPPLGNFDvetlditphtvtaisakirkkgkierkqkadgsktssSDTISEEKNSECDPTPSHRGQLNKEFTGKEEK 920
Cdd:pfam14631  800 PGYVPPLANFD-------------------------------------LDSSQKEEASEAEESQSEKSQLEKEFKGKEGK 842

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  921 TSLLLHNYRAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPELLFLLEDLSQKLESMLTPPIARRVPFFKN 1000
Cdd:pfam14631  843 TGVSLQSYRAFFRELDIEVFSVLHCGLLTKSLLDTEMHTKAREEVQLGPAELLFLLEDLSRKLEFMLTPAPAKRAPFLKG 922

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1001 KGSRNIGFSHLQQRSAQEIVHCVFQLVTPMCNHLENIHNYFQCLAAENHGVVDGPGMKVQEYHIMSSCYQRLLQIFHGLF 1080
Cdd:pfam14631  923 KGDRNVGFSHLQQRSAQEIAHCVVQLLPPLCNHLENIHNYFQCLLAENHGVVDGPGVDVQEHQLMSSCYQLLLQVLHTLF 1002

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1081 AWSGFSQPENQNLLYSALHVLSSRLKQGEHSQPLEELLSQSFHYLQNFHQSIPSFQCALYLIRLLMVILEKSTASTQNKE 1160
Cdd:pfam14631 1003 AWSGFSQPENRSLLKSALGVLAGRLKEGEAELTLEELVSHSFEYLQNFRSSVPSFQCALCLIQLLIVIAEKSGNPAAKRE 1082

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1161 KIASLARQFLCRVW--PSGDKEKSSISNDQLHALLCIYLEHTDSILKAIEEIAGVGVPELINSPKDVSSSTFPTLTRHTF 1238
Cdd:pfam14631 1083 KIASLARQFLCQVWvtPSGEKEKGNKFNDALHTLLCIYLEHTDDVLKAIEEIAGEGVPELINSSKDASSSTFPTLTRQTF 1162

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1239 VVFFRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMP 1318
Cdd:pfam14631 1163 LVFFRVMMAELEKSVRKIQPGTASDSQEVQEEKLLYWNMAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLKLGMP 1242

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1319 LLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGNLKN 1398
Cdd:pfam14631 1243 LLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLGNLKN 1322

                         1370      1380
                   ....*....|....*....|....
gi 1622908521 1399 RDLQGEEIKSQNSQESTADESEDD 1422
Cdd:pfam14631 1323 RDLQGEEILSQRSQESDEEEEEDS 1346
FANCD2 cd11721
Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
 97-1410 0e+00

Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.


Pssm-ID: 212595  Cd Length: 1161  Bit Score: 1333.10  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521   97 PKIIEEFVSGLESYIEDEDSFRNCLLPCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFE-NKNSD 175
Cdd:cd11721      1 PENVDEFLSGLEDFLADRDRLRKALLPCNLLTTESSSASSVPQDSLIRLLLQVDPLQPKVIELLLEKLPEFLDEdASVPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  176 EINVPRLIVSQLKWLDRVVDGKDLTAKIMQLISIAPENLQHDIITSLPEILGDSQHTDVGKELSDLLIENTSLTVPILDV 255
Cdd:cd11721     81 EDNLPRLILNQFKWLDHIVDSEDLTEKLLELLSVAPSELQKEIITSLPEIIGDSQHEDVAEELCKLLQENSELTVPILDA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  256 LSSLRLDPNFLLKVRQLVMDKLSSIRLEDLPVIIKFILHSITAMDALEVISELREKLDLQHCVLPSRLqasqvklkskgr 335
Cdd:cd11721    161 LSNLNLSPELLSEIREKVLSCLKTVPLEDLPVLVKFLLQSITATEALEIISKLRKNLDFSPLSDPSSS------------ 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  336 aSSSGNQESSDQSCIILLFDVIKSAIRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIERVLRNKIR 415
Cdd:cd11721    229 -GSSDKSKASANSCQSLILEAIKSALRFSKLLAEAWIKVISSIDAPQDHKVIDLILLLILYSTNEDKRKSIESLLKKKIK 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  416 SGCIQEQLLQSTFSVHYLVLKDMCSSILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAE 495
Cdd:cd11721    308 SGFIRTSLLDLAFTGHSQVLKDYFKSLLSLADNLLRSAEPVVREFGSHLYKLLFKHFDRYYQQEVVGALITHIGSGNSSE 387

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  496 VDTALDVLLELVVLNPSAMMMNAVFVKGILDYLDNISPQQIRKLFYVLSTLAFS-KQNEASSHIQDDMHLVIRKQLSSTV 574
Cdd:cd11721    388 VDAALDVLRELAEKNPDELLPYATFIKGILDYLDSLNLKQIRQLFDILCHLAFSeRPLSEGSSIQDDLHIIVRKQLSNSS 467

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  575 FKYKLIGIIGAVTMAGIMAADRTE---SCSLTQERANLSNEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQQE-K 650
Cdd:cd11721    468 PKYKRMGIIGAVTLVKHLASANSSddaVERSSSNGSSLPDERLKQAANLLELVLSSCKNSPEALALFYDELANIISQAsN 547

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  651 LDPKALERVGHTICSDFQDAFVVDscvvpegdfpfpvkalygLEEYntqdgiainllpllfsqdfakdggpvtpqesgqk 730
Cdd:cd11721    548 LDPKFLEWLGETITEDFQESFVVD------------------LDET---------------------------------- 575

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  731 lvSPLCLAPYFRLLRLCVERQHNGNLEEIDGLLDCPIFLTDLEPGEKLESMSAKERAFMCSLLFLTLNWFREIVNAFCQE 810
Cdd:cd11721    576 --SSAILASLFRLLRLLERSQQGGSLDEIDALLGCPLVLPDFEVDEKFDSLSTEQRSVVLDCLFYAINWFREVINAFATQ 653

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  811 TSPEMKGKVLTRLKHIVELQIILEKYLAVtpdyipplgnfdvetlditphtvtaisakirkkgkierkqkadgsktsssd 890
Cdd:cd11721    654 KDASTKKKVLKRLRNLIELEGRLSKLLAH--------------------------------------------------- 682

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  891 tiseeknsecdptpshrgqlnkeftgkeektslllhnyrAFFRELDIEVFSILHCGLVTKFILdtemHTEATEVVQLGPP 970
Cdd:cd11721    683 ---------------------------------------CYFRELDLEVFSLLKSGLVTDTSL----ELSEEEGVHLGPK 719

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  971 ELLFLLEDLSQKLESMLTPPIARRvPFFKNKGSRNIGFSHLQQRSAQEIVHCVFQLVTPMCNHLENIHNYFQCLAAENHG 1050
Cdd:cd11721    720 ELRFLLEDLNRKLEHVLTSPKKKR-MPLLKPLKKGQGFSSLSQKSPKEVLKALVPLLPHLCKHLEKIHNYLQNLLLSNAG 798

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1051 VVDGPGMKVQEYHIMSSCYQRLLQIFHGLFAWSGFSQPENQNLLYSALHVLSSRLKQGEHS-QPLEELLSQSFHYLQNFH 1129
Cdd:cd11721    799 QLDAPGPFVQENQYAKSCYGLLLQCLRLLFAWPGFSSQSNRVLLKSALRAIASRLKESTGKdLPLKELVSSLFKYLKSFE 878

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1130 QSIPSFQCALYLIRLLMVILEKSTASTQNKEKIASLARQFLCRVWP--SGDKEKSSISNDQLHALLCIYLEHTDSILKAI 1207
Cdd:cd11721    879 PSVPSLSTAVSLVQLLQALMEKSPDRPQLREKLADLARNFLCRQWPdlSGESEKGQKYNDLIDTLLRIYLEHSDDPLKKL 958

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1208 EEIAGVGVPELINSPKDVS-SSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGtAADSQQIHEEKLLYWNMAVRDFSILI 1286
Cdd:cd11721    959 EEIAGEALPELLEKKKDKDaLETFPTLSKSTFPIFFRVLMEALIESVKKILSS-AADTGGGEMERLLLWQSAVRVFKALV 1037

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1287 NLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPL 1366
Cdd:cd11721   1038 NLVKTFDKRPVLAICLKYGRLFLKLFLKLGMPLLEKLFKNHKEEVQELLKTLQQSTRYLHHICCHSKIHKDTALTNHVPA 1117

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....
gi 1622908521 1367 LKKTLELLVCRVKAMLTLNNCREAFWLGNLKNRDLQGEEIKSQN 1410
Cdd:cd11721   1118 LKKSLETLVYRVKAMLVANNCSEAFWMGNLKNKDLQGEEILSQR 1161
 
Name Accession Description Interval E-value
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 42-1422 0e+00

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


Pssm-ID: 464225  Cd Length: 1346  Bit Score: 2493.47  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521   42 SHIANEVEENDSIFVKLLKTSGIILKTGENQNQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCL 121
Cdd:pfam14631    1 SHAQNEVEENGSVFVKLLKTAGVILKTGENQNEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  122 LPCERLQDEEA-SMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINVPRLIVSQLKWLDRVVDGKDLT 200
Cdd:pfam14631   81 LPCVPLQSEEAsSMVTSYQESLIKLLLGIEILQPAIIKTLFEKLPEFMFESVNSDGLNMPRLIINQLKWLDRIVDGKDLT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  201 AKIMQLISIAPENLQHDIITSLPEILGDSQHTDVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVMDKLSSI 280
Cdd:pfam14631  161 SKLMQLISVAPVELQHDIITSLPEILEDSQHNDVARELSSLLVENTQLTVPILDALSSLNLDPTLLSEVRQAVMGTLSAV 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  281 RLEDLPVIIKFILHSITAMDALEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSDQSCIILLFDVIKSA 360
Cdd:pfam14631  241 QLEDLPVVVKFILHSVSATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSSGNQASSSQDCISLVFDVIKSA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  361 IRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIERVLRNKIRSGCIQEQLLQSTFSVHYLVLKDMCS 440
Cdd:pfam14631  321 VRFQKTISEAWLKAIENIDSVSDHKVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHALVLRDYFP 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  441 SILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVF 520
Cdd:pfam14631  401 SILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSYCQQEVVGALVTHVCSGNEAEVDVALELLLELVVLKPSAMRLYAVF 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  521 VKGILDYLDNISPQQIRKLFYVLSTLAFSKQNEASSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRTESc 600
Cdd:pfam14631  481 VKGILDYMDNLTPQQIRKLFHILSTLAFSQQHEQSSHIQDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGSMAADRSKS- 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  601 SLTQERANLSNEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQQEKLDPKALERVGHTICSDFQDAFVVDSCVVPE 680
Cdd:pfam14631  560 GSSSQSASLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGKLDPKVLEWIGQSVLNDFQDDFVVDLGPDIE 639

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  681 GDFPFPVKALYGLEEYNTQDGIAINLLPLLFSQDFAKDGGPVTPQESGQKLVSPLCLAPYFRLLRLCVERQHNGNLEEID 760
Cdd:pfam14631  640 GDFPFPVKALYGLEEEESQGGIAINLLPLLAKDEQAKDEGEVTAQEKGQKRVSPLCLSPFFRLLRLCVEKQHDGDLEEID 719

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  761 GLLDCPIFLTDLEPGEKLESMSAKERAFMCSLLFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVT 840
Cdd:pfam14631  720 GLLGCPLILTDLEVGEKLESLSKKEREFLCSLLFHTINWFREVVNAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLAVT 799

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  841 PDYIPPLGNFDvetlditphtvtaisakirkkgkierkqkadgsktssSDTISEEKNSECDPTPSHRGQLNKEFTGKEEK 920
Cdd:pfam14631  800 PGYVPPLANFD-------------------------------------LDSSQKEEASEAEESQSEKSQLEKEFKGKEGK 842

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  921 TSLLLHNYRAFFRELDIEVFSILHCGLVTKFILDTEMHTEATEVVQLGPPELLFLLEDLSQKLESMLTPPIARRVPFFKN 1000
Cdd:pfam14631  843 TGVSLQSYRAFFRELDIEVFSVLHCGLLTKSLLDTEMHTKAREEVQLGPAELLFLLEDLSRKLEFMLTPAPAKRAPFLKG 922

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1001 KGSRNIGFSHLQQRSAQEIVHCVFQLVTPMCNHLENIHNYFQCLAAENHGVVDGPGMKVQEYHIMSSCYQRLLQIFHGLF 1080
Cdd:pfam14631  923 KGDRNVGFSHLQQRSAQEIAHCVVQLLPPLCNHLENIHNYFQCLLAENHGVVDGPGVDVQEHQLMSSCYQLLLQVLHTLF 1002

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1081 AWSGFSQPENQNLLYSALHVLSSRLKQGEHSQPLEELLSQSFHYLQNFHQSIPSFQCALYLIRLLMVILEKSTASTQNKE 1160
Cdd:pfam14631 1003 AWSGFSQPENRSLLKSALGVLAGRLKEGEAELTLEELVSHSFEYLQNFRSSVPSFQCALCLIQLLIVIAEKSGNPAAKRE 1082

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1161 KIASLARQFLCRVW--PSGDKEKSSISNDQLHALLCIYLEHTDSILKAIEEIAGVGVPELINSPKDVSSSTFPTLTRHTF 1238
Cdd:pfam14631 1083 KIASLARQFLCQVWvtPSGEKEKGNKFNDALHTLLCIYLEHTDDVLKAIEEIAGEGVPELINSSKDASSSTFPTLTRQTF 1162

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1239 VVFFRVMMAELEKTVKKIEPGTAADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMP 1318
Cdd:pfam14631 1163 LVFFRVMMAELEKSVRKIQPGTASDSQEVQEEKLLYWNMAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLKLGMP 1242

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1319 LLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKAMLTLNNCREAFWLGNLKN 1398
Cdd:pfam14631 1243 LLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLGNLKN 1322

                         1370      1380
                   ....*....|....*....|....
gi 1622908521 1399 RDLQGEEIKSQNSQESTADESEDD 1422
Cdd:pfam14631 1323 RDLQGEEILSQRSQESDEEEEEDS 1346
FANCD2 cd11721
Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
 97-1410 0e+00

Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.


Pssm-ID: 212595  Cd Length: 1161  Bit Score: 1333.10  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521   97 PKIIEEFVSGLESYIEDEDSFRNCLLPCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFE-NKNSD 175
Cdd:cd11721      1 PENVDEFLSGLEDFLADRDRLRKALLPCNLLTTESSSASSVPQDSLIRLLLQVDPLQPKVIELLLEKLPEFLDEdASVPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  176 EINVPRLIVSQLKWLDRVVDGKDLTAKIMQLISIAPENLQHDIITSLPEILGDSQHTDVGKELSDLLIENTSLTVPILDV 255
Cdd:cd11721     81 EDNLPRLILNQFKWLDHIVDSEDLTEKLLELLSVAPSELQKEIITSLPEIIGDSQHEDVAEELCKLLQENSELTVPILDA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  256 LSSLRLDPNFLLKVRQLVMDKLSSIRLEDLPVIIKFILHSITAMDALEVISELREKLDLQHCVLPSRLqasqvklkskgr 335
Cdd:cd11721    161 LSNLNLSPELLSEIREKVLSCLKTVPLEDLPVLVKFLLQSITATEALEIISKLRKNLDFSPLSDPSSS------------ 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  336 aSSSGNQESSDQSCIILLFDVIKSAIRYEKTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIERVLRNKIR 415
Cdd:cd11721    229 -GSSDKSKASANSCQSLILEAIKSALRFSKLLAEAWIKVISSIDAPQDHKVIDLILLLILYSTNEDKRKSIESLLKKKIK 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  416 SGCIQEQLLQSTFSVHYLVLKDMCSSILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGALVTHICSGNEAE 495
Cdd:cd11721    308 SGFIRTSLLDLAFTGHSQVLKDYFKSLLSLADNLLRSAEPVVREFGSHLYKLLFKHFDRYYQQEVVGALITHIGSGNSSE 387

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  496 VDTALDVLLELVVLNPSAMMMNAVFVKGILDYLDNISPQQIRKLFYVLSTLAFS-KQNEASSHIQDDMHLVIRKQLSSTV 574
Cdd:cd11721    388 VDAALDVLRELAEKNPDELLPYATFIKGILDYLDSLNLKQIRQLFDILCHLAFSeRPLSEGSSIQDDLHIIVRKQLSNSS 467

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  575 FKYKLIGIIGAVTMAGIMAADRTE---SCSLTQERANLSNEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQQE-K 650
Cdd:cd11721    468 PKYKRMGIIGAVTLVKHLASANSSddaVERSSSNGSSLPDERLKQAANLLELVLSSCKNSPEALALFYDELANIISQAsN 547

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  651 LDPKALERVGHTICSDFQDAFVVDscvvpegdfpfpvkalygLEEYntqdgiainllpllfsqdfakdggpvtpqesgqk 730
Cdd:cd11721    548 LDPKFLEWLGETITEDFQESFVVD------------------LDET---------------------------------- 575

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  731 lvSPLCLAPYFRLLRLCVERQHNGNLEEIDGLLDCPIFLTDLEPGEKLESMSAKERAFMCSLLFLTLNWFREIVNAFCQE 810
Cdd:cd11721    576 --SSAILASLFRLLRLLERSQQGGSLDEIDALLGCPLVLPDFEVDEKFDSLSTEQRSVVLDCLFYAINWFREVINAFATQ 653

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  811 TSPEMKGKVLTRLKHIVELQIILEKYLAVtpdyipplgnfdvetlditphtvtaisakirkkgkierkqkadgsktsssd 890
Cdd:cd11721    654 KDASTKKKVLKRLRNLIELEGRLSKLLAH--------------------------------------------------- 682

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  891 tiseeknsecdptpshrgqlnkeftgkeektslllhnyrAFFRELDIEVFSILHCGLVTKFILdtemHTEATEVVQLGPP 970
Cdd:cd11721    683 ---------------------------------------CYFRELDLEVFSLLKSGLVTDTSL----ELSEEEGVHLGPK 719

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  971 ELLFLLEDLSQKLESMLTPPIARRvPFFKNKGSRNIGFSHLQQRSAQEIVHCVFQLVTPMCNHLENIHNYFQCLAAENHG 1050
Cdd:cd11721    720 ELRFLLEDLNRKLEHVLTSPKKKR-MPLLKPLKKGQGFSSLSQKSPKEVLKALVPLLPHLCKHLEKIHNYLQNLLLSNAG 798

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1051 VVDGPGMKVQEYHIMSSCYQRLLQIFHGLFAWSGFSQPENQNLLYSALHVLSSRLKQGEHS-QPLEELLSQSFHYLQNFH 1129
Cdd:cd11721    799 QLDAPGPFVQENQYAKSCYGLLLQCLRLLFAWPGFSSQSNRVLLKSALRAIASRLKESTGKdLPLKELVSSLFKYLKSFE 878

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1130 QSIPSFQCALYLIRLLMVILEKSTASTQNKEKIASLARQFLCRVWP--SGDKEKSSISNDQLHALLCIYLEHTDSILKAI 1207
Cdd:cd11721    879 PSVPSLSTAVSLVQLLQALMEKSPDRPQLREKLADLARNFLCRQWPdlSGESEKGQKYNDLIDTLLRIYLEHSDDPLKKL 958

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1208 EEIAGVGVPELINSPKDVS-SSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGtAADSQQIHEEKLLYWNMAVRDFSILI 1286
Cdd:cd11721    959 EEIAGEALPELLEKKKDKDaLETFPTLSKSTFPIFFRVLMEALIESVKKILSS-AADTGGGEMERLLLWQSAVRVFKALV 1037

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1287 NLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPL 1366
Cdd:cd11721   1038 NLVKTFDKRPVLAICLKYGRLFLKLFLKLGMPLLEKLFKNHKEEVQELLKTLQQSTRYLHHICCHSKIHKDTALTNHVPA 1117

                         1290      1300      1310      1320
                   ....*....|....*....|....*....|....*....|....
gi 1622908521 1367 LKKTLELLVCRVKAMLTLNNCREAFWLGNLKNRDLQGEEIKSQN 1410
Cdd:cd11721   1118 LKKSLETLVYRVKAMLVANNCSEAFWMGNLKNKDLQGEEILSQR 1161
FANC cd11719
Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of ...
 138-1287 0e+00

Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome.


Pssm-ID: 212593  Cd Length: 977  Bit Score: 1011.38  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  138 YSKSLIKLLLGID----ILQPAIIKTLFEKLPEYFFENKN-SDEINVPRLIVSQLKWLDRVVDGKDLTAKIMQLISIAPE 212
Cdd:cd11719      2 AVGTLLRAVLKGSpcseEDGALRRYKIYSCCIQLVESGDLqQDVASEIIGLLMLEVHHFPGPLLVDLASDFVGAVREDRL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  213 NLQHDIITSLPEILG-----------------DSQHTDVGKELSDLLiENTSLTVPILDVLSSLRLDPNFLLKVRQLVMD 275
Cdd:cd11719     82 VNGKSLELLPIILTAlatkkevlacgkgdlngEEYKRQLIDTLCSVR-WPQRYMIQLTSVFKDVCLTPEEMNLVVAKVLT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  276 KLSSIRLEDLPVIIKFILHS---ITAMDALEVISELREKLDLQHCVLPSRLQAsqvklkskgrASSSGNQESSDQSCIIL 352
Cdd:cd11719    161 MFSKLNLQEIPPLVYQLLVLsskGSRRSVLDGIIAFFRELDKQHREEQSSDEL----------SELITAPADELYHVEGT 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  353 LFDVIKSAIRYE-KTISEAWIKAIE--NTASVSEHKVFDLVMLFIIYSTNTQTKKYIERVLRNKIRSGC----------- 418
Cdd:cd11719    231 VILHIVFAIKLDcELGRELLKHLKAgqQGDPSKCLCPFSIALLLSLTRIQRFEEQVFDLLKTSVVKSFKdlqllqgskfl 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  419 --------IQEQLLQSTFSVHYLVLKDMCSSILSLAQSLLHSL---------------------DQSIISFGSLLYKYAF 469
Cdd:cd11719    311 qtlvpqrtCVSTMILEVVRNSVHSWDHVTQGLIEFGFILMDSYgpkkildgkaveigtslskmtNQHACKLGANILLETF 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  470 KfFDTYCQQEVVGALVTHICSGNEAEVDTALDVLLELVVLNPSAmMMNAVFVKGILDYLDNISPQQIRKLFYVLSTLAFS 549
Cdd:cd11719    391 K-IHEMIRQEILEQVLNRVVTRTSSPINHFLDLFSDIIMYAPLI-LQNCSKVTETFDYLTFLPLQTVQGLLKAVQPLLKI 468

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  550 KqneasSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRT------------ESCSLTQERANLSNEQCTQV 617
Cdd:cd11719    469 S-----MSMRDSLILVLRKAMFASQLDARKSAVAGFLLLLKNFKVLGSlpssqctqsigvTQVRVDVHSRYSAVANETFC 543

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  618 TSLLQLVHSCSEQSPQASALYYDEfanliqqEKLDPKALERVGHTICSDFQDAFVVDSCVVPEGDFPFPVKAlygleeyn 697
Cdd:cd11719    544 LEIIDSLKRSLGQQADIRLMLYDG-------FYDVLRRNSQLASSIMQTLFSQLKQFYEPEPDLLPPLKLGA-------- 608

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  698 tqdgiainllpllfsqdfakdggpvTPQESGQKLVSPLCLAPYFRLLRLCVERQhngnleeidglldcpifltdlepgek 777
Cdd:cd11719    609 -------------------------CVLTQGSQIFLQEPLDHLLSCIQHCLAWY-------------------------- 637

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  778 lesmsakerafmcsllflTLNWFREIVNAFCQETSPE-----MKGKVLTRLKHIVELQIIlekylavtpdyipplgnfdv 852
Cdd:cd11719    638 ------------------ACLIMGVCEVLMEYNFSISnfsksKFEEILSLFTCYKKFSDI-------------------- 679

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  853 etlditphtvtaisakirkkgkierkqkadgsktsssdtiseeknsecdptpshrgqlnkeftgkeektslllhnyraff 932
Cdd:cd11719        --------------------------------------------------------------------------------

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521  933 relDIEVFSILHCGLVTKFILDT---EMHTEATEVVQLGPPELLFLLEDLSQKLESmltppiarrvpffknkgsrnigfs 1009
Cdd:cd11719    680 ---IFQNLCDITRVLLWRYTSIPtsvEESGKKEKGKSISLLCLEGLQKTFSVVLQF------------------------ 732

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1010 hlqqrsaqeIVHCVFQLV-----------------TPMCNHLENIHNYFQCLAAENHGVvdgpgmkVQEYHIMSSCYQRL 1072
Cdd:cd11719    733 ---------YQPKVQQFLqaldvmgteeeeagvtvTQRASFQIRQFQRSLLNLLSSEED-------DFNSKEALLLIAVL 796

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1073 LQIFHGLFAwsgfsqpenqnllysalhvlssrlkqgehsqpleelLSQSFHYLQNFHQ----------SIPSFQCALYLI 1142
Cdd:cd11719    797 STLSRLLEP------------------------------------TSPQFVQMLSWTSkickeysqedASFCKSLMNLFF 840

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1143 RLLMVILEkstastqnkekiASLARQFLCRVWPSGDK-----------------EKSSISNDQLHALLCIYLEhtDSILK 1205
Cdd:cd11719    841 SLHVLYKS------------PVTLLRDLSQDIHGQLGdidqdveiektdhfavvNLRTAAPTVCLLVLSQAEK--VMQLG 906

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908521 1206 AIEEIAGVGVPElinspkdvssSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGTaADSQQIHEEKLLYWNMAVRDFSIL 1285
Cdd:cd11719    907 TLVTFFHELVQT----------ALPSGSCVDTLLKGLSKIYSTLTAFVKYYLQVC-QSSRGIPNTVEKLVKLSGSHLTPV 975


                   ..
gi 1622908521 1286 IN 1287
Cdd:cd11719    976 CY 977
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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