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Conserved domains on  [gi|1622908135|ref|XP_028700173|]
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ataxin-7 isoform X5 [Macaca mulatta]

Protein Classification

SCA7 domain-containing protein( domain architecture ID 10550843)

SCA7 domain-containing protein similar to protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 188-249 2.72e-27

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


:

Pssm-ID: 462422  Cd Length: 61  Bit Score: 104.99  E-value: 2.72e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622908135 188 NKRLSEREFDPDIHCGVIdLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTR 249
Cdd:pfam08313   1 KKPKAKRPVDVDKQCGVI-LPNGGPCTRSLTCKTHSMGAKRAVPGRSKPFDVLLAEYQKKNQ 61
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 258-343 1.93e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908135  258 DSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfvaskPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLP 337
Cdd:PHA03247  2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP-----ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771


                   ....*.
gi 1622908135  338 ATEPAS 343
Cdd:PHA03247  2772 PAAPAA 2777
 
Name Accession Description Interval E-value
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 188-249 2.72e-27

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


Pssm-ID: 462422  Cd Length: 61  Bit Score: 104.99  E-value: 2.72e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622908135 188 NKRLSEREFDPDIHCGVIdLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTR 249
Cdd:pfam08313   1 KKPKAKRPVDVDKQCGVI-LPNGGPCTRSLTCKTHSMGAKRAVPGRSKPFDVLLAEYQKKNQ 61
PHA03247 PHA03247
large tegument protein UL36; Provisional
 258-343 1.93e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908135  258 DSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfvaskPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLP 337
Cdd:PHA03247  2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP-----ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771


                   ....*.
gi 1622908135  338 ATEPAS 343
Cdd:PHA03247  2772 PAAPAA 2777
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 262-337 9.48e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 9.48e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622908135 262 PPQPlrDPHPAPPRTSQEPHQNPHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIdPPPVHESPHPPLP 337
Cdd:pfam03154 207 PPQG--SPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPL-PQPSLHGQMPPMP 279
 
Name Accession Description Interval E-value
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 188-249 2.72e-27

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


Pssm-ID: 462422  Cd Length: 61  Bit Score: 104.99  E-value: 2.72e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622908135 188 NKRLSEREFDPDIHCGVIdLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTR 249
Cdd:pfam08313   1 KKPKAKRPVDVDKQCGVI-LPNGGPCTRSLTCKTHSMGAKRAVPGRSKPFDVLLAEYQKKNQ 61
PHA03247 PHA03247
large tegument protein UL36; Provisional
 258-343 1.93e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908135  258 DSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfvaskPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLP 337
Cdd:PHA03247  2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP-----ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771


                   ....*.
gi 1622908135  338 ATEPAS 343
Cdd:PHA03247  2772 PAAPAA 2777
PHA03247 PHA03247
large tegument protein UL36; Provisional
 258-521 4.90e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 4.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908135  258 DSQQPPQPLR-DPHPAPPRTSQEPHQNPhgviPSESKPFVASK-------PKPHTPSLPR-PPGCPAqqGGSAPIDPPPV 328
Cdd:PHA03247  2547 DAGDPPPPLPpAAPPAAPDRSVPPPRPA----PRPSEPAVTSRarrpdapPQSARPRAPVdDRGDPR--GPAPPSPLPPD 2620

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908135  329 HESPHPPLPatEPASRLSSEEGEGDDKEESVEKLDCHYSGHHPQPASFCTFGSRQIGRGYYVFDSRWNRLRCALNLMVEk 408
Cdd:PHA03247  2621 THAPDPPPP--SPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTS- 2697

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908135  409 hlnaqlWKKIPPVPSTTSPISTRIPQRTNSVPTSQCGVSYLAAATVSTSPVLLSSTCISPNSKSVPAHGTTLNAQPAASG 488
Cdd:PHA03247  2698 ------LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1622908135  489 AMDPVCSMQSRQVSSSSSSPSTPSGLSSVPSSP 521
Cdd:PHA03247  2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDP 2804
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 262-337 9.48e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 9.48e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622908135 262 PPQPlrDPHPAPPRTSQEPHQNPHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIdPPPVHESPHPPLP 337
Cdd:pfam03154 207 PPQG--SPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPL-PQPSLHGQMPPMP 279
PHA03247 PHA03247
large tegument protein UL36; Provisional
 257-341 3.07e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 3.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908135  257 PDSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfvaSKPKPHTPSLPRPPGCPAQQGGSAPIdPPPVHESPHPPL 336
Cdd:PHA03247  2889 PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPP---PQPQPPPPPPPRPQPPLAPTTDPAGA-GEPSGAVPQPWL 2964


                   ....*
gi 1622908135  337 PATEP 341
Cdd:PHA03247  2965 GALVP 2969
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 260-344 5.45e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 5.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908135 260 QQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLPAT 339
Cdd:PRK07764  616 AAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAG 695


                  ....*
gi 1622908135 340 EPASR 344
Cdd:PRK07764  696 AAPAQ 700
PHA03247 PHA03247
large tegument protein UL36; Provisional
 255-346 5.74e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 5.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908135  255 RHPDSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfVASKPKPHTPSLPRPPGCPAQQGGSAP-IDPPPVHESPH 333
Cdd:PHA03247  2865 RPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQ-PERPPQPQAPPPPQPQPQPPPPPQPQPpPPPPPRPQPPL 2943

                           90
                   ....*....|...
gi 1622908135  334 PPLPATEPASRLS 346
Cdd:PHA03247  2944 APTTDPAGAGEPS 2956
PHA03247 PHA03247
large tegument protein UL36; Provisional
 262-346 7.15e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 7.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908135  262 PPQPLRDPHPAPPRTSQEP-HQNPHGVIPSESKPFVASKPKPHTPSLPR-PPGCPAQQGGSAPIDPPPVHESPHPPLPAT 339
Cdd:PHA03247  2801 PWDPADPPAAVLAPAAALPpAASPAGPLPPPTSAQPTAPPPPPGPPPPSlPLGGSVAPGGDVRRRPPSRSPAAKPAAPAR 2880


                   ....*..
gi 1622908135  340 EPASRLS 346
Cdd:PHA03247  2881 PPVRRLA 2887
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 252-342 9.55e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 38.69  E-value: 9.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908135 252 ELIRHPDSQQPPQPlrDPHPAPPRTsQEPHQNPHGVIPSESKPFVASKPKPHT-PSLPRPPGCPAQQGGSAPIDPPPVHE 330
Cdd:PHA02682   71 ACMQRPSGQSPLAP--SPACAAPAP-ACPACAPAAPAPAVTCPAPAPACPPATaPTCPPPAVCPAPARPAPACPPSTRQC 147

                          90
                  ....*....|..
gi 1622908135 331 SPHPPLPATEPA 342
Cdd:PHA02682  148 PPAPPLPTPKPA 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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