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Conserved domains on  [gi|1622908131|ref|XP_028700171|]
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ataxin-7 isoform X3 [Macaca mulatta]

Protein Classification

SCA7 domain-containing protein( domain architecture ID 10550843)

SCA7 domain-containing protein similar to protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 326-387 1.60e-27

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


:

Pssm-ID: 462422  Cd Length: 61  Bit Score: 105.76  E-value: 1.60e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622908131 326 NKRLSEREFDPDIHCGVIdLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTR 387
Cdd:pfam08313   1 KKPKAKRPVDVDKQCGVI-LPNGGPCTRSLTCKTHSMGAKRAVPGRSKPFDVLLAEYQKKNQ 61
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 396-481 1.43e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131  396 DSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfvaskPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLP 475
Cdd:PHA03247  2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP-----ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771


                   ....*.
gi 1622908131  476 ATEPAS 481
Cdd:PHA03247  2772 PAAPAA 2777
 
Name Accession Description Interval E-value
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 326-387 1.60e-27

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


Pssm-ID: 462422  Cd Length: 61  Bit Score: 105.76  E-value: 1.60e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622908131 326 NKRLSEREFDPDIHCGVIdLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTR 387
Cdd:pfam08313   1 KKPKAKRPVDVDKQCGVI-LPNGGPCTRSLTCKTHSMGAKRAVPGRSKPFDVLLAEYQKKNQ 61
PHA03247 PHA03247
large tegument protein UL36; Provisional
 396-481 1.43e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131  396 DSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfvaskPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLP 475
Cdd:PHA03247  2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP-----ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771


                   ....*.
gi 1622908131  476 ATEPAS 481
Cdd:PHA03247  2772 PAAPAA 2777
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 400-475 2.81e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.76  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131 400 PPQPLRDPHPAPPrTSQEPHQN-----PHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIdPPPVHESPHPPL 474
Cdd:pfam03154 201 PSAPSVPPQGSPA-TSQPPNQTqstaaPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPL-PQPSLHGQMPPM 278


                  .
gi 1622908131 475 P 475
Cdd:pfam03154 279 P 279
 
Name Accession Description Interval E-value
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 326-387 1.60e-27

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


Pssm-ID: 462422  Cd Length: 61  Bit Score: 105.76  E-value: 1.60e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622908131 326 NKRLSEREFDPDIHCGVIdLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTR 387
Cdd:pfam08313   1 KKPKAKRPVDVDKQCGVI-LPNGGPCTRSLTCKTHSMGAKRAVPGRSKPFDVLLAEYQKKNQ 61
PHA03247 PHA03247
large tegument protein UL36; Provisional
 396-481 1.43e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131  396 DSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfvaskPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLP 475
Cdd:PHA03247  2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP-----ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771


                   ....*.
gi 1622908131  476 ATEPAS 481
Cdd:PHA03247  2772 PAAPAA 2777
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 400-475 2.81e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.76  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131 400 PPQPLRDPHPAPPrTSQEPHQN-----PHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIdPPPVHESPHPPL 474
Cdd:pfam03154 201 PSAPSVPPQGSPA-TSQPPNQTqstaaPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPL-PQPSLHGQMPPM 278


                  .
gi 1622908131 475 P 475
Cdd:pfam03154 279 P 279
PHA03247 PHA03247
large tegument protein UL36; Provisional
 396-659 3.75e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131  396 DSQQPPQPLR-DPHPAPPRTSQEPHQNPhgviPSESKPFVASK-------PKPHTPSLPR-PPGCPAqqGGSAPIDPPPV 466
Cdd:PHA03247  2547 DAGDPPPPLPpAAPPAAPDRSVPPPRPA----PRPSEPAVTSRarrpdapPQSARPRAPVdDRGDPR--GPAPPSPLPPD 2620

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131  467 HESPHPPLPatEPASRLSSEEGEGDDKEESVEKLDCHYSGHHPQPASFCTFGSRQIGRGYYVFDSRWNRLRCALNLMVEk 546
Cdd:PHA03247  2621 THAPDPPPP--SPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTS- 2697

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131  547 hlnaqlWKKIPPVPSTTSPISTRIPQRTNSVPTSQCGVSYLAAATVSTSPVLLSSTCISPNSKSVPAHGTTLNAQPAASG 626
Cdd:PHA03247  2698 ------LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1622908131  627 AMDPVCSMQSRQVSSSSSSPSTPSGLSSVPSSP 659
Cdd:PHA03247  2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDP 2804
PHA03247 PHA03247
large tegument protein UL36; Provisional
 395-479 2.30e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 2.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131  395 PDSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfvaSKPKPHTPSLPRPPGCPAQQGGSAPIdPPPVHESPHPPL 474
Cdd:PHA03247  2889 PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPP---PQPQPPPPPPPRPQPPLAPTTDPAGA-GEPSGAVPQPWL 2964


                   ....*
gi 1622908131  475 PATEP 479
Cdd:PHA03247  2965 GALVP 2969
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 390-480 3.08e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 40.61  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131 390 ELIRHPDSQQPPQPlrDPHPAPPRTsQEPHQNPHGVIPSESKPFVASKPKPHT-PSLPRPPGCPAQQGGSAPIDPPPVHE 468
Cdd:PHA02682   71 ACMQRPSGQSPLAP--SPACAAPAP-ACPACAPAAPAPAVTCPAPAPACPPATaPTCPPPAVCPAPARPAPACPPSTRQC 147

                          90
                  ....*....|..
gi 1622908131 469 SPHPPLPATEPA 480
Cdd:PHA02682  148 PPAPPLPTPKPA 159
PHA03247 PHA03247
large tegument protein UL36; Provisional
 393-484 4.63e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 4.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131  393 RHPDSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfVASKPKPHTPSLPRPPGCPAQQGGSAP-IDPPPVHESPH 471
Cdd:PHA03247  2865 RPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQ-PERPPQPQAPPPPQPQPQPPPPPQPQPpPPPPPRPQPPL 2943

                           90
                   ....*....|...
gi 1622908131  472 PPLPATEPASRLS 484
Cdd:PHA03247  2944 APTTDPAGAGEPS 2956
PHA03247 PHA03247
large tegument protein UL36; Provisional
 400-484 5.63e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 5.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131  400 PPQPLRDPHPAPPRTSQEP-HQNPHGVIPSESKPFVASKPKPHTPSLPR-PPGCPAQQGGSAPIDPPPVHESPHPPLPAT 477
Cdd:PHA03247  2801 PWDPADPPAAVLAPAAALPpAASPAGPLPPPTSAQPTAPPPPPGPPPPSlPLGGSVAPGGDVRRRPPSRSPAAKPAAPAR 2880


                   ....*..
gi 1622908131  478 EPASRLS 484
Cdd:PHA03247  2881 PPVRRLA 2887
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 398-482 5.70e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 5.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131 398 QQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLPAT 477
Cdd:PRK07764  616 AAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAG 695


                  ....*
gi 1622908131 478 EPASR 482
Cdd:PRK07764  696 AAPAQ 700
PHA03247 PHA03247
large tegument protein UL36; Provisional
 229-480 5.92e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 5.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131  229 RPMHPIQQSRVPHgrimtPSVKVEKIHPKMDGTLLKSAVGPTCPATVsslvkPGLNCPSIPKPTLPSPGQILNGKGLPAP 308
Cdd:PHA03247  2576 RPSEPAVTSRARR-----PDAPPQSARPRAPVDDRGDPRGPAPPSPL-----PPDTHAPDPPPPSPSPAANEPDPHPPPT 2645

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131  309 LSLEKKPEDNSNNRKFLNKRLSEREFDPDIHCGvidlDTKKPCTRSLTCKTHSLTQrravqgrrkrfdvlLAEHKNKTRE 388
Cdd:PHA03247  2646 VPPPERPRDDPAPGRVSRPRRARRLGRAAQASS----PPQRPRRRAARPTVGSLTS--------------LADPPPPPPT 2707

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131  389 KELIRHPDSQQPPQPL-----RDPHPAPPRTSQEPHQNPHGVIPSESKPfVASKPKPHTPSLPRPPGCPAqqGGSAPIDP 463
Cdd:PHA03247  2708 PEPAPHALVSATPLPPgpaaaRQASPALPAAPAPPAVPAGPATPGGPAR-PARPPTTAGPPAPAPPAAPA--AGPPRRLT 2784

                          250       260
                   ....*....|....*....|....*
gi 1622908131  464 PPVHES--------PHPPLPATEPA 480
Cdd:PHA03247  2785 RPAVASlsesreslPSPWDPADPPA 2809
PHA03247 PHA03247
large tegument protein UL36; Provisional
 387-481 8.58e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 8.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131  387 REKELIRHPDSQQPPQPLRDPHPAPPRTSQEPHQNPHgviPSESKPfvASKPKPHTPSLPRPPGCPAQQGGS-----API 461
Cdd:PHA03247  2666 RARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPP---PPPPTP--EPAPHALVSATPLPPGPAAARQASpalpaAPA 2740

                           90       100
                   ....*....|....*....|....*....
gi 1622908131  462 DPPP---------VHESPHPPLPATEPAS 481
Cdd:PHA03247  2741 PPAVpagpatpggPARPARPPTTAGPPAP 2769
PHA03247 PHA03247
large tegument protein UL36; Provisional
 401-479 9.33e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 9.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131  401 PQPLRDPHPAPPRTSQEPHQNPhgviPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAP--IDPPPVHESPHPPLPATE 478
Cdd:PHA03247  2769 PAPPAAPAAGPPRRLTRPAVAS----LSESRESLPSPWDPADPPAAVLAPAAALPPAASPagPLPPPTSAQPTAPPPPPG 2844


                   .
gi 1622908131  479 P 479
Cdd:PHA03247  2845 P 2845
PHA03247 PHA03247
large tegument protein UL36; Provisional
 393-485 9.99e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 9.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908131  393 RHPDSQQPPqPLRDPHPAPPRTSQEPHQNPHGVIPSESKPFVASKPKPHTP----SLPRPPGCP---AQQGGSAPIDPPP 465
Cdd:PHA03247   372 RHHPKRASL-PTRKRRSARHAATPFARGPGGDDQTRPAAPVPASVPTPAPTpvpaSAPPPPATPlpsAEPGSDDGPAPPP 450

                           90       100
                   ....*....|....*....|
gi 1622908131  466 VHESPHPPLPATEPASRLSS 485
Cdd:PHA03247   451 ERQPPAPATEPAPDDPDDAT 470
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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