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Conserved domains on  [gi|1622907650|ref|XP_028700071|]
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voltage-dependent L-type calcium channel subunit alpha-1D isoform X2 [Macaca mulatta]

Protein Classification

Ca_chan_IQ domain-containing protein; Ca_chan_IQ domain-containing protein; voltage-dependent L-type calcium channel subunit alpha-1; voltage-dependent L-type calcium channel subunit alpha-1( domain architecture ID 11999372)

Ca_chan_IQ domain-containing protein; Ca_chan_IQ domain-containing protein; voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death; voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
125-417 9.44e-70

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 234.47  E-value: 9.44e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  125 WKPFDIFILLAIFANCVALAIYIPFPEDDSnsTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHpnaYVRNGWNLLDFVI 204
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  205 VIVGLFSVILeqltketeggnhsSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Cdd:pfam00520   76 VLPSLISLVL-------------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  285 YAIIGLELFIGKMHKtcffadsdivaeedpapcafsgngrqctangtecrsgWVGPNGGITNFDNFAFAMLTVFQCITME 364
Cdd:pfam00520  143 FAIIGYQLFGGKLKT-------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTE 185
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622907650  365 GWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAK 417
Cdd:pfam00520  186 GWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1224-1523 2.59e-61

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 210.59  E-value: 2.59e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1224 SSPFEYMMFVLIMLNTLCLAMQHYEQSKM-FNDAMDILNMVFTGVFTVEMVLKVIAFKPKG-YFSDAWNTFDSLIVIGSI 1301
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1302 IDVALSEADHYFtdawntfdalivvgsvvdiaitevnptesenvpvptatpgnseesnriSITFFRLFRVMRLVKLLSRG 1381
Cdd:pfam00520   81 ISLVLSSVGSLS------------------------------------------------GLRVLRLLRLLRLLRLIRRL 112
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1382 EGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIML 1461
Cdd:pfam00520  113 EGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMY 192
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622907650 1462 ACLPGKlcdpesdynpgeeytcGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1523
Cdd:pfam00520  193 DTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
CAC1F_C super family cl25181
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1690-2208 2.01e-54

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


The actual alignment was detected with superfamily member pfam16885:

Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 194.84  E-value: 2.01e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1690 AGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDdvfkrngallgnhvnhvnsdrrdsLQQTNTTHRPLHVQrpsiPPA 1769
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEEEEEGQEGEE------------------------EEDSKDPKAPIGSQ----PPS 52
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1770 SDTEKPLFPpagnsvchnhhnhnsIGKQVPTSTNANLNNANmSKAAHGKRPSIGNlehvsenghHSSHKHdrepqRRSSV 1849
Cdd:pfam16885   53 RSRISVSLP---------------VGDRLPDSLSLGPSDDD-GGAPNSRQPSVPQ---------TGSHTH-----RRSSG 102
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1850 KRTryyetYIRSDSGDEQLPTICREDPEihgyfrdprcfgeqeyfsseecYEDDSSPTWsRQNYGYYSRYPGRNVDFERP 1929
Cdd:pfam16885  103 VLM-----FTIPEEGSSQPKGTKGQDKQ----------------------DEEEEVPDQ-LSYLDEQAGTPSRPVLLPPH 154
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1930 RGYHHPQGFLEDddspicydsrrspRRRLLPPTPAShRRSSFNFECLRRQSSQEEVPSSPTFpHRtalplhlmqqqimav 2009
Cdd:pfam16885  155 RPQHYPLREPVD-------------RRRLLPPTPAG-RKPSFNIQCLRRQGSCEDLPIPGTY-HR--------------- 204
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 2010 agldsskAQKYSPSHSTRSWATPPatppyRDWTPCYTPLIQVEQSEALDQMNGSLPSlhrsswytdepdiSYRTFTpaSL 2089
Cdd:pfam16885  205 -------GRNSGPSRAQGSWATPP-----QRGRLLYAPLLLVEEGAAGEGYLGKSPG-------------PLRTFT--CL 257
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 2090 TVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNgnvcprangdvgp 2169
Cdd:pfam16885  258 RVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLLA------------- 324
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 1622907650 2170 lshrqdyelQDFGPGYSDEEPD-PGRDEEDLADEMICITT 2208
Cdd:pfam16885  325 ---------QGTSSLYSDEESIlSSFDEEDLGDEMACVHA 355
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
905-1182 3.76e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 187.09  E-value: 3.76e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  905 HHVFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHkgaFCRNYFNLLDMLVVG 984
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  985 VSLVSFGIQS-SAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYR 1063
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1064 CTDEaksnpeecrglfilykdgdvdspvvreriwQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYn 1143
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1622907650 1144 hrveisifFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKE 1182
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
545-780 1.85e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 182.08  E-value: 1.85e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  545 FYWLVIVLVFLNTLTISSEHYNQPDW-LTQIQDIANKVLLALFTCEMLVKMYSLGL-QAYFVSLFNRFDCFVVCGGITEt 622
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSLIS- 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  623 iLVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-NFDET 701
Cdd:pfam00520   83 -LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTWENP 161
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622907650  702 QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGgpsssGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 780
Cdd:pfam00520  162 DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1595-1669 3.04e-37

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


:

Pssm-ID: 462591  Cd Length: 77  Bit Score: 135.03  E-value: 3.04e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622907650 1595 NATLFALVRTALKIKTE--GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKK 1669
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1532-1585 9.59e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 115.83  E-value: 9.59e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622907650 1532 EFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMP 1585
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
125-417 9.44e-70

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 234.47  E-value: 9.44e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  125 WKPFDIFILLAIFANCVALAIYIPFPEDDSnsTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHpnaYVRNGWNLLDFVI 204
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  205 VIVGLFSVILeqltketeggnhsSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Cdd:pfam00520   76 VLPSLISLVL-------------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  285 YAIIGLELFIGKMHKtcffadsdivaeedpapcafsgngrqctangtecrsgWVGPNGGITNFDNFAFAMLTVFQCITME 364
Cdd:pfam00520  143 FAIIGYQLFGGKLKT-------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTE 185
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622907650  365 GWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAK 417
Cdd:pfam00520  186 GWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1224-1523 2.59e-61

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 210.59  E-value: 2.59e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1224 SSPFEYMMFVLIMLNTLCLAMQHYEQSKM-FNDAMDILNMVFTGVFTVEMVLKVIAFKPKG-YFSDAWNTFDSLIVIGSI 1301
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1302 IDVALSEADHYFtdawntfdalivvgsvvdiaitevnptesenvpvptatpgnseesnriSITFFRLFRVMRLVKLLSRG 1381
Cdd:pfam00520   81 ISLVLSSVGSLS------------------------------------------------GLRVLRLLRLLRLLRLIRRL 112
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1382 EGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIML 1461
Cdd:pfam00520  113 EGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMY 192
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622907650 1462 ACLPGKlcdpesdynpgeeytcGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1523
Cdd:pfam00520  193 DTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1690-2208 2.01e-54

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 194.84  E-value: 2.01e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1690 AGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDdvfkrngallgnhvnhvnsdrrdsLQQTNTTHRPLHVQrpsiPPA 1769
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEEEEEGQEGEE------------------------EEDSKDPKAPIGSQ----PPS 52
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1770 SDTEKPLFPpagnsvchnhhnhnsIGKQVPTSTNANLNNANmSKAAHGKRPSIGNlehvsenghHSSHKHdrepqRRSSV 1849
Cdd:pfam16885   53 RSRISVSLP---------------VGDRLPDSLSLGPSDDD-GGAPNSRQPSVPQ---------TGSHTH-----RRSSG 102
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1850 KRTryyetYIRSDSGDEQLPTICREDPEihgyfrdprcfgeqeyfsseecYEDDSSPTWsRQNYGYYSRYPGRNVDFERP 1929
Cdd:pfam16885  103 VLM-----FTIPEEGSSQPKGTKGQDKQ----------------------DEEEEVPDQ-LSYLDEQAGTPSRPVLLPPH 154
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1930 RGYHHPQGFLEDddspicydsrrspRRRLLPPTPAShRRSSFNFECLRRQSSQEEVPSSPTFpHRtalplhlmqqqimav 2009
Cdd:pfam16885  155 RPQHYPLREPVD-------------RRRLLPPTPAG-RKPSFNIQCLRRQGSCEDLPIPGTY-HR--------------- 204
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 2010 agldsskAQKYSPSHSTRSWATPPatppyRDWTPCYTPLIQVEQSEALDQMNGSLPSlhrsswytdepdiSYRTFTpaSL 2089
Cdd:pfam16885  205 -------GRNSGPSRAQGSWATPP-----QRGRLLYAPLLLVEEGAAGEGYLGKSPG-------------PLRTFT--CL 257
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 2090 TVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNgnvcprangdvgp 2169
Cdd:pfam16885  258 RVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLLA------------- 324
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 1622907650 2170 lshrqdyelQDFGPGYSDEEPD-PGRDEEDLADEMICITT 2208
Cdd:pfam16885  325 ---------QGTSSLYSDEESIlSSFDEEDLGDEMACVHA 355
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
905-1182 3.76e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 187.09  E-value: 3.76e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  905 HHVFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHkgaFCRNYFNLLDMLVVG 984
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  985 VSLVSFGIQS-SAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYR 1063
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1064 CTDEaksnpeecrglfilykdgdvdspvvreriwQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYn 1143
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1622907650 1144 hrveisifFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKE 1182
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
545-780 1.85e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 182.08  E-value: 1.85e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  545 FYWLVIVLVFLNTLTISSEHYNQPDW-LTQIQDIANKVLLALFTCEMLVKMYSLGL-QAYFVSLFNRFDCFVVCGGITEt 622
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSLIS- 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  623 iLVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-NFDET 701
Cdd:pfam00520   83 -LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTWENP 161
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622907650  702 QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGgpsssGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 780
Cdd:pfam00520  162 DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1595-1669 3.04e-37

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 135.03  E-value: 3.04e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622907650 1595 NATLFALVRTALKIKTE--GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKK 1669
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1532-1585 9.59e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 115.83  E-value: 9.59e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622907650 1532 EFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMP 1585
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1647-1677 1.66e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 66.09  E-value: 1.66e-13
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1622907650  1647 DEVTVGKFYATFLIQDYFRKFKKRKEQGLVG 1677
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
125-417 9.44e-70

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 234.47  E-value: 9.44e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  125 WKPFDIFILLAIFANCVALAIYIPFPEDDSnsTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHpnaYVRNGWNLLDFVI 204
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  205 VIVGLFSVILeqltketeggnhsSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Cdd:pfam00520   76 VLPSLISLVL-------------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  285 YAIIGLELFIGKMHKtcffadsdivaeedpapcafsgngrqctangtecrsgWVGPNGGITNFDNFAFAMLTVFQCITME 364
Cdd:pfam00520  143 FAIIGYQLFGGKLKT-------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTE 185
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622907650  365 GWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAK 417
Cdd:pfam00520  186 GWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1224-1523 2.59e-61

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 210.59  E-value: 2.59e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1224 SSPFEYMMFVLIMLNTLCLAMQHYEQSKM-FNDAMDILNMVFTGVFTVEMVLKVIAFKPKG-YFSDAWNTFDSLIVIGSI 1301
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1302 IDVALSEADHYFtdawntfdalivvgsvvdiaitevnptesenvpvptatpgnseesnriSITFFRLFRVMRLVKLLSRG 1381
Cdd:pfam00520   81 ISLVLSSVGSLS------------------------------------------------GLRVLRLLRLLRLLRLIRRL 112
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1382 EGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIML 1461
Cdd:pfam00520  113 EGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMY 192
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622907650 1462 ACLPGKlcdpesdynpgeeytcGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1523
Cdd:pfam00520  193 DTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1690-2208 2.01e-54

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 194.84  E-value: 2.01e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1690 AGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDdvfkrngallgnhvnhvnsdrrdsLQQTNTTHRPLHVQrpsiPPA 1769
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEEEEEGQEGEE------------------------EEDSKDPKAPIGSQ----PPS 52
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1770 SDTEKPLFPpagnsvchnhhnhnsIGKQVPTSTNANLNNANmSKAAHGKRPSIGNlehvsenghHSSHKHdrepqRRSSV 1849
Cdd:pfam16885   53 RSRISVSLP---------------VGDRLPDSLSLGPSDDD-GGAPNSRQPSVPQ---------TGSHTH-----RRSSG 102
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1850 KRTryyetYIRSDSGDEQLPTICREDPEihgyfrdprcfgeqeyfsseecYEDDSSPTWsRQNYGYYSRYPGRNVDFERP 1929
Cdd:pfam16885  103 VLM-----FTIPEEGSSQPKGTKGQDKQ----------------------DEEEEVPDQ-LSYLDEQAGTPSRPVLLPPH 154
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1930 RGYHHPQGFLEDddspicydsrrspRRRLLPPTPAShRRSSFNFECLRRQSSQEEVPSSPTFpHRtalplhlmqqqimav 2009
Cdd:pfam16885  155 RPQHYPLREPVD-------------RRRLLPPTPAG-RKPSFNIQCLRRQGSCEDLPIPGTY-HR--------------- 204
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 2010 agldsskAQKYSPSHSTRSWATPPatppyRDWTPCYTPLIQVEQSEALDQMNGSLPSlhrsswytdepdiSYRTFTpaSL 2089
Cdd:pfam16885  205 -------GRNSGPSRAQGSWATPP-----QRGRLLYAPLLLVEEGAAGEGYLGKSPG-------------PLRTFT--CL 257
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 2090 TVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNgnvcprangdvgp 2169
Cdd:pfam16885  258 RVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLLA------------- 324
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 1622907650 2170 lshrqdyelQDFGPGYSDEEPD-PGRDEEDLADEMICITT 2208
Cdd:pfam16885  325 ---------QGTSSLYSDEESIlSSFDEEDLGDEMACVHA 355
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
905-1182 3.76e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 187.09  E-value: 3.76e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  905 HHVFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHkgaFCRNYFNLLDMLVVG 984
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  985 VSLVSFGIQS-SAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYR 1063
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1064 CTDEaksnpeecrglfilykdgdvdspvvreriwQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYn 1143
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1622907650 1144 hrveisifFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKE 1182
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
545-780 1.85e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 182.08  E-value: 1.85e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  545 FYWLVIVLVFLNTLTISSEHYNQPDW-LTQIQDIANKVLLALFTCEMLVKMYSLGL-QAYFVSLFNRFDCFVVCGGITEt 622
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSLIS- 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  623 iLVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-NFDET 701
Cdd:pfam00520   83 -LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTWENP 161
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622907650  702 QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGgpsssGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 780
Cdd:pfam00520  162 DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1595-1669 3.04e-37

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 135.03  E-value: 3.04e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622907650 1595 NATLFALVRTALKIKTE--GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKK 1669
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1532-1585 9.59e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 115.83  E-value: 9.59e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622907650 1532 EFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMP 1585
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1647-1677 1.66e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 66.09  E-value: 1.66e-13
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1622907650  1647 DEVTVGKFYATFLIQDYFRKFKKRKEQGLVG 1677
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1248-1516 3.10e-06

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 50.35  E-value: 3.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1248 EQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKgYFSDAWNTFDSLIVIGSIIDVALSeadhyftdAWNTFDALIVVG 1327
Cdd:pfam08016    4 TNRSLFILLCEIVFVVFFLYFVVEEILKIRKHRPS-YLRSVWNLLDLAIVILSVVLIVLN--------IYRDFLADRLIK 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1328 SVVDiaitevnpteSENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAM 1407
Cdd:pfam08016   75 SVEA----------SPVTFIDFDRVAQLDNLYRIILAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVI 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650 1408 LFFIYAVIGMQMFGKVAmrdnnqinrnNNFQTFPQAVLLLFRcatgeawqeIMLaclpgklcdpeSDYNPGEEYTCGSNF 1487
Cdd:pfam08016  145 FFFAYAQFGYLLFGTQA----------PNFSNFVKSILTLFR---------TIL-----------GDFGYNEIFSGNRVL 194
                          250       260
                   ....*....|....*....|....*....
gi 1622907650 1488 AIVYFISFYMLCAFLIINLFVAVIMDNFD 1516
Cdd:pfam08016  195 GPLLFLTFVFLVIFILLNLFLAIINDSYV 223
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
168-293 3.91e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 41.11  E-value: 3.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622907650  168 FLIIFTVETFLKIiayglLLHPNAYVRNGWNLLDFVIVIVGLFSVIL--------EQLTKETEggnHSSGKSGGFD---- 235
Cdd:pfam08016   20 FFLYFVVEEILKI-----RKHRPSYLRSVWNLLDLAIVILSVVLIVLniyrdflaDRLIKSVE---ASPVTFIDFDrvaq 91
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622907650  236 -------VKALRAFRV-LRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 293
Cdd:pfam08016   92 ldnlyriILAFLVFLTwLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLF 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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