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Conserved domains on  [gi|1622906628|ref|XP_028699912|]
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zinc finger protein 589 isoform X2 [Macaca mulatta]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 34-74 2.32e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.67  E-value: 2.32e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622906628  34 PVTFEDVAVLFTEAEWKRLNLEQRNLFKEVMLENLRNLVSL 74
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
302-668 1.24e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 302 KPYVCSQCGRGFSCKPYLIRHQRTHTREKSFMCTVCGRGFREK--SELIKHQRIHTGDKPYVCRDCGRG--FVRRSCLNT 377
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 378 HQRIHSDEKPFvCRECGRGFRAKSTLLLHQWTHSEVKPHVCEEC-GHGFSQKSTLKSHQRTHSGEKpyvcgeCGRGFSRR 456
Cdd:COG5048   112 SSSSNSNDNNL-LSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 457 IFLSgHWRTHTGEKPYTCFECGRNFSLKSALSVHQRIHSGEKPYACAECGRGFITKSQLIRHQRTHTGEKPYVCGECGR- 535
Cdd:COG5048   185 SLLI-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRs 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 536 -----GFIAQSTLHYHRSTHSG-EKPYVCSQCGRGFRDKSALLAHEQT--HSGE--KPYVCGE--CGWGFGRKILLSRHW 603
Cdd:COG5048   264 slptaSSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622906628 604 RTHTGEKPYACMECGRNFSH------KSTLSLHQR-IHSGEKPYACT--ECGRGFRRKSQLSIHQKTHLGKSFR 668
Cdd:COG5048   344 LLHTSISPAKEKLLNSSSKFspllnnEPPQSLQQYkDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPY 417
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
167-402 4.73e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 4.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 167 FSSLFQRPPISSQGGNRILEIQLSPA-----QNASSEEVDRISKRAETPGFGAVRFGECALAFNQKSNLFR--QKAVTAE 239
Cdd:COG5048   202 NSPLSSSYSIPSSSSDQNLENSSSSLplttnSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSssPNESDSS 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 240 KSSDKRQSQVCGECGRGFSRKSQLIIHQRT--HTGE--KPYVCGE--CGRGFIVESVLRNHLSTHSGEKPYVCSQCGRGF 313
Cdd:COG5048   282 SEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSS 361

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 314 S-------CKPYLIRHQRTHTREKSFMCTV--CGRGFREKSELIKHQRIHTGDKPYVCRD--CGRGFVRRSCLNTHQRIH 382
Cdd:COG5048   362 KfspllnnEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIH 441

                         250       260
                  ....*....|....*....|
gi 1622906628 383 SDEKPFVCRECGRGFRAKST 402
Cdd:COG5048   442 TNHAPLLCSILKSFRRDLDL 461
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 34-74 2.32e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.67  E-value: 2.32e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622906628  34 PVTFEDVAVLFTEAEWKRLNLEQRNLFKEVMLENLRNLVSL 74
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
35-84 5.13e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 5.13e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1622906628   35 VTFEDVAVLFTEAEWKRLNLEQRNLFKEVMLENLRNLVSLAE--SKPEVHTC 84
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFqvPKPDLISQ 52
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 35-74 2.08e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.97  E-value: 2.08e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622906628  35 VTFEDVAVLFTEAEWKRLNLEQRNLFKEVMLENLRNLVSL 74
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
302-668 1.24e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 302 KPYVCSQCGRGFSCKPYLIRHQRTHTREKSFMCTVCGRGFREK--SELIKHQRIHTGDKPYVCRDCGRG--FVRRSCLNT 377
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 378 HQRIHSDEKPFvCRECGRGFRAKSTLLLHQWTHSEVKPHVCEEC-GHGFSQKSTLKSHQRTHSGEKpyvcgeCGRGFSRR 456
Cdd:COG5048   112 SSSSNSNDNNL-LSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 457 IFLSgHWRTHTGEKPYTCFECGRNFSLKSALSVHQRIHSGEKPYACAECGRGFITKSQLIRHQRTHTGEKPYVCGECGR- 535
Cdd:COG5048   185 SLLI-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRs 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 536 -----GFIAQSTLHYHRSTHSG-EKPYVCSQCGRGFRDKSALLAHEQT--HSGE--KPYVCGE--CGWGFGRKILLSRHW 603
Cdd:COG5048   264 slptaSSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622906628 604 RTHTGEKPYACMECGRNFSH------KSTLSLHQR-IHSGEKPYACT--ECGRGFRRKSQLSIHQKTHLGKSFR 668
Cdd:COG5048   344 LLHTSISPAKEKLLNSSSKFspllnnEPPQSLQQYkDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPY 417
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
167-402 4.73e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 4.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 167 FSSLFQRPPISSQGGNRILEIQLSPA-----QNASSEEVDRISKRAETPGFGAVRFGECALAFNQKSNLFR--QKAVTAE 239
Cdd:COG5048   202 NSPLSSSYSIPSSSSDQNLENSSSSLplttnSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSssPNESDSS 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 240 KSSDKRQSQVCGECGRGFSRKSQLIIHQRT--HTGE--KPYVCGE--CGRGFIVESVLRNHLSTHSGEKPYVCSQCGRGF 313
Cdd:COG5048   282 SEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSS 361

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 314 S-------CKPYLIRHQRTHTREKSFMCTV--CGRGFREKSELIKHQRIHTGDKPYVCRD--CGRGFVRRSCLNTHQRIH 382
Cdd:COG5048   362 KfspllnnEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIH 441

                         250       260
                  ....*....|....*....|
gi 1622906628 383 SDEKPFVCRECGRGFRAKST 402
Cdd:COG5048   442 TNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
431-455 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|....*
gi 1622906628 431 LKSHQRTHSGEKPYVCGECGRGFSR 455
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 249-270 8.42e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.42e-03
                          10        20
                  ....*....|....*....|..
gi 1622906628 249 VCGECGRGFSRKSQLIIHQRTH 270
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 34-74 2.32e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.67  E-value: 2.32e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622906628  34 PVTFEDVAVLFTEAEWKRLNLEQRNLFKEVMLENLRNLVSL 74
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
35-84 5.13e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 5.13e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1622906628   35 VTFEDVAVLFTEAEWKRLNLEQRNLFKEVMLENLRNLVSLAE--SKPEVHTC 84
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFqvPKPDLISQ 52
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 35-74 2.08e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.97  E-value: 2.08e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622906628  35 VTFEDVAVLFTEAEWKRLNLEQRNLFKEVMLENLRNLVSL 74
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
302-668 1.24e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 1.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 302 KPYVCSQCGRGFSCKPYLIRHQRTHTREKSFMCTVCGRGFREK--SELIKHQRIHTGDKPYVCRDCGRG--FVRRSCLNT 377
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 378 HQRIHSDEKPFvCRECGRGFRAKSTLLLHQWTHSEVKPHVCEEC-GHGFSQKSTLKSHQRTHSGEKpyvcgeCGRGFSRR 456
Cdd:COG5048   112 SSSSNSNDNNL-LSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 457 IFLSgHWRTHTGEKPYTCFECGRNFSLKSALSVHQRIHSGEKPYACAECGRGFITKSQLIRHQRTHTGEKPYVCGECGR- 535
Cdd:COG5048   185 SLLI-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRs 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 536 -----GFIAQSTLHYHRSTHSG-EKPYVCSQCGRGFRDKSALLAHEQT--HSGE--KPYVCGE--CGWGFGRKILLSRHW 603
Cdd:COG5048   264 slptaSSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622906628 604 RTHTGEKPYACMECGRNFSH------KSTLSLHQR-IHSGEKPYACT--ECGRGFRRKSQLSIHQKTHLGKSFR 668
Cdd:COG5048   344 LLHTSISPAKEKLLNSSSKFspllnnEPPQSLQQYkDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPY 417
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-569 4.31e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 4.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 223 AFNQKSNLFRQKavtaekSSDKRQSQVCGECGRGFSRKSQLIIHQRTHTGEKPYVCGECGRG--FIVESVLRNHLSTHSG 300
Cdd:COG5048    15 VLSSTPKSTLKS------LSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 301 EKPYVCSQCGRG---------------FSCKPYLIRHQ----------------RTHTREKSF-MCT------------- 335
Cdd:COG5048    89 NPSDLNSKSLPLsnskasssslsssssNSNDNNLLSSHslppssrdpqlpdllsISNLRNNPLpGNNsssvntpqsnslh 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 336 -------VCGRGFREKSELIKHQRIHTGDKPYVCRDCGR---------------------------GFVRRSCLNTHQRI 381
Cdd:COG5048   169 pplpansLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSsysipssssdqnlensssslplttnsqLSPKSLLSQSPSSL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 382 HSDEKPFVCRECGRGFRAKSTLLLHQWTHSEV-------KPHVCEECGHGFSQKSTLKSHQRT--HSGE--KPYVCGE-- 448
Cdd:COG5048   249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYsl 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 449 CGRGFSRRIFLSGHWRTHTGEKPYTCFECGRNFSLKSAL-------SVHQRIHSGEKPYACA--ECGRGFITKSQLIRHQ 519
Cdd:COG5048   329 CGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHI 408

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622906628 520 RTHTGEKPYVC--GECGRGFIAQSTLHYHRSTHSGEKPYVCSQCGRGFRDKS 569
Cdd:COG5048   409 ITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
274-663 5.15e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 5.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 274 KPYVCGECGRGFIVESVLRNHLSTHSGEKPYVCSQCGRGFSCKPY--LIRHQRTHTREKSFMCtvCGRGFREKSELIKHQ 351
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 352 RIHTGDKPYVCRDCgrgfvrRSCLNTHQRIHSDEKPFV------CRECGRGFRAKSTLLLHQWTHSEVKPHvcEECGHGF 425
Cdd:COG5048   110 LSSSSSNSNDNNLL------SSHSLPPSSRDPQLPDLLsisnlrNNPLPGNNSSSVNTPQSNSLHPPLPAN--SLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 426 SQKSTLKSHQRTHSGEKPYVCGECGRgFSRRIFLSGHWRTHTGEKPYTCFECGRNFSLKSALSVHQRIHSGEKPYACAEC 505
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 506 GRGFITKSQLIRHQRTHTGE-------KPYVCGECGRGFIAQSTLHYHRST--HSGE--KPYVC--SQCGRGFRDKSALL 572
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 573 AHEQTHSGEKPYVC---GECGW----GFGRKILLSRHWRTHTGEKPYACM--ECGRNFSHKSTLSLHQRIHSGEKPYAC- 642
Cdd:COG5048   341 RHILLHTSISPAKEkllNSSSKfsplLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCk 420

                         410       420
                  ....*....|....*....|..
gi 1622906628 643 -TECGRGFRRKSQLSIHQKTHL 663
Cdd:COG5048   421 nPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
167-402 4.73e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 4.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 167 FSSLFQRPPISSQGGNRILEIQLSPA-----QNASSEEVDRISKRAETPGFGAVRFGECALAFNQKSNLFR--QKAVTAE 239
Cdd:COG5048   202 NSPLSSSYSIPSSSSDQNLENSSSSLplttnSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSssPNESDSS 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 240 KSSDKRQSQVCGECGRGFSRKSQLIIHQRT--HTGE--KPYVCGE--CGRGFIVESVLRNHLSTHSGEKPYVCSQCGRGF 313
Cdd:COG5048   282 SEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSS 361

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 314 S-------CKPYLIRHQRTHTREKSFMCTV--CGRGFREKSELIKHQRIHTGDKPYVCRD--CGRGFVRRSCLNTHQRIH 382
Cdd:COG5048   362 KfspllnnEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIH 441

                         250       260
                  ....*....|....*....|
gi 1622906628 383 SDEKPFVCRECGRGFRAKST 402
Cdd:COG5048   442 TNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
414-673 2.99e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 414 KPHVCEECGHGFSQKSTLKSHQRTHSGEKPYVCGECGRG--FSRRIFLSGHWRTHTGEKPYTC----------------F 475
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 476 ECGRNFSLKSALS---------------VHQRIHSGEKPY---------------------ACAECGRGFITKSQLIRHQ 519
Cdd:COG5048   112 SSSSNSNDNNLLSshslppssrdpqlpdLLSISNLRNNPLpgnnsssvntpqsnslhpplpANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 520 RTHTGEKPYVCGECGRGFIAQSTLHYHRSTHSgEKPYVCSQCGRGFRDKSALLAHEQTHSGEKPYVCGECG------WGF 593
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 594 GRKILLSRHWRTHTG-EKPYACMECGRNFSHKSTLSLHQR--IHSGE--KPYACTE--CGRGFRRKSQLSIHQKTHLGKS 666
Cdd:COG5048   271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350


                  ....*..
gi 1622906628 667 FRGARSE 673
Cdd:COG5048   351 PAKEKLL 357
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
426-499 5.24e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 5.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 426 SQKSTLKSHQRTHSGE----KPYVCGECGRGFSRRIFLSGHWRTHTGEKPYTCFECGR--NFSLKSALSVHQRIHSGEKP 499
Cdd:COG5048    12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
431-455 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|....*
gi 1622906628 431 LKSHQRTHSGEKPYVCGECGRGFSR 455
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
515-537 2.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.32e-03
                          10        20
                  ....*....|....*....|...
gi 1622906628 515 LIRHQRTHTGEKPYVCGECGRGF 537
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
346-371 2.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622906628 346 ELIKHQRIHTGDKPYVCRDCGRGFVR 371
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 500-522 3.88e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.88e-03
                          10        20
                  ....*....|....*....|...
gi 1622906628 500 YACAECGRGFITKSQLIRHQRTH 522
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
486-511 4.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.89e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622906628 486 ALSVHQRIHSGEKPYACAECGRGFIT 511
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 640-662 4.96e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.96e-03
                          10        20
                  ....*....|....*....|...
gi 1622906628 640 YACTECGRGFRRKSQLSIHQKTH 662
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 416-438 5.21e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.21e-03
                          10        20
                  ....*....|....*....|...
gi 1622906628 416 HVCEECGHGFSQKSTLKSHQRTH 438
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
627-651 5.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.24e-03
                          10        20
                  ....*....|....*....|....*
gi 1622906628 627 LSLHQRIHSGEKPYACTECGRGFRR 651
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
599-623 5.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.72e-03
                          10        20
                  ....*....|....*....|....*
gi 1622906628 599 LSRHWRTHTGEKPYACMECGRNFSH 623
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
186-379 6.30e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 6.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 186 EIQLSPAQNASSEEVDRISKRAETPgfgavrfgeCALAFNQKSNLFRQKAVTAEKSSDKRQSQVCGE-CGRGFSRKSQLI 264
Cdd:COG5048   270 SQSSSPNESDSSSEKGFSLPIKSKQ---------CNISFSRSSPLTRHLRSVNHSGESLKPFSCPYSlCGKLFSRNDALK 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622906628 265 IHQRTHTGEKPYVC--GECGRGFIVESVLRNHLSTH-----SGEKPYVC--SQCGRGFSCKPYLIRHQRTHT--REKSFM 333
Cdd:COG5048   341 RHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLsfRPYNCK 420

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1622906628 334 CTVCGRGFREKSELIKHQRIHTGDKPYVCRDCGRGFVRRSCLNTHQ 379
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 249-270 8.42e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.42e-03
                          10        20
                  ....*....|....*....|..
gi 1622906628 249 VCGECGRGFSRKSQLIIHQRTH 270
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 332-354 9.67e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 9.67e-03
                          10        20
                  ....*....|....*....|...
gi 1622906628 332 FMCTVCGRGFREKSELIKHQRIH 354
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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