NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622905306|ref|XP_028699732|]
View 

eukaryotic translation initiation factor 4 gamma 1 isoform X9 [Macaca mulatta]

Protein Classification

eukaryotic translation initiation factor 4 gamma( domain architecture ID 10501430)

eukaryotic translation initiation factor 4 gamma (EIF4G) plays a key functional role in the initiation of cap-dependent translation by acting as an adapter to nucleate the assembly of eIF4F complex

CATH:  1.25.40.180
Gene Ontology:  GO:0003743|GO:0031369|GO:0003723|GO:0003729|GO:0060090|GO:0006446
PubMed:  27694156|9019810|12867079|10872469
SCOP:  4000569

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 672-897 4.83e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


:

Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.46  E-value: 4.83e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  672 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 751
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  752 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 831
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622905306  832 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 897
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1349-1481 2.66e-57

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


:

Pssm-ID: 211397  Cd Length: 134  Bit Score: 194.04  E-value: 2.66e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306 1349 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIASNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1427
Cdd:cd11559      1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622905306 1428 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1481
Cdd:cd11559     81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1153-1265 6.97e-37

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


:

Pssm-ID: 397128  Cd Length: 113  Bit Score: 135.10  E-value: 6.97e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306 1153 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1232
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1622905306 1233 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1265
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 4-482 2.49e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 2.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306    4 PSQISYPASQGAYYIPGQGRStyvvPTQQYPVQPG--APGFYPGASPTEfgtyagAYYP-----AQGVQQFPTGVA--PA 74
Cdd:PHA03247  2483 PAEARFPFAAGAAPDPGGGGP----PDPDAPPAPSrlAPAILPDEPVGE------PVHPrmltwIRGLEELASDDAgdPP 2552

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306   75 PVLMNQPPQIAPKRERKTIRIRdPNQGGKDITeeimsgARTASTPTPPQTGGGLEPQANGETPQVAVivrPDDRSQGAII 154
Cdd:PHA03247  2553 PPLPPAAPPAAPDRSVPPPRPA-PRPSEPAVT------SRARRPDAPPQSARPRAPVDDRGDPRGPA---PPSPLPPDTH 2622

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  155 ADRPGLPGPEHSPSESQPSSPSPTPSPSpvlEPGSEPNLAVLSIPGDTMATIQMSVEESTP------ISRETGEPYRLS- 227
Cdd:PHA03247  2623 APDPPPPSPSPAANEPDPHPPPTVPPPE---RPRDDPAPGRVSRPRRARRLGRAAQASSPPqrprrrAARPTVGSLTSLa 2699

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  228 ----PEPTPLAEPILEVEVTLSKPVPESEFSSSPLQASTPLASHTveihePNGMV----PSEDLEPEVESSPELALPPAC 299
Cdd:PHA03247  2700 dpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-----PAGPAtpggPARPARPPTTAGPPAPAPPAA 2774

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  300 PSESP---VPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEvTASVAPATILSATPAMAPSATSPAqeeemeeeEEE 376
Cdd:PHA03247  2775 PAAGPprrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL-PPAASPAGPLPPPTSAQPTAPPPP--------PGP 2845

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  377 EEEGEAGEAESEKGGE--ELLPSESTPVPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEavgdlLDAFKEANPAVPE 454
Cdd:PHA03247  2846 PPPSLPLGGSVAPGGDvrRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPER-----PPQPQAPPPPQPQ 2920

                          490       500
                   ....*....|....*....|....*...
gi 1622905306  455 VENQPPAGSNPGPESEGSGVPPRPEEAD 482
Cdd:PHA03247  2921 PQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 672-897 4.83e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.46  E-value: 4.83e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  672 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 751
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  752 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 831
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622905306  832 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 897
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1349-1481 2.66e-57

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 194.04  E-value: 2.66e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306 1349 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIASNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1427
Cdd:cd11559      1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622905306 1428 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1481
Cdd:cd11559     81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 673-900 1.68e-53

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 186.03  E-value: 1.68e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306   673 RRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlKVPttekptvtvNFRK 752
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNA-KNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306   753 LLLNRCQKEFEKDkdddevfekkqkemdeaataeergrlkeeLEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV 832
Cdd:smart00543   72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622905306   833 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKT---SSRIRFMLQDVLDLRGSN 900
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELRKNK 200
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1153-1265 6.97e-37

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 135.10  E-value: 6.97e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306 1153 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1232
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1622905306 1233 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1265
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1153-1265 8.13e-36

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 131.98  E-value: 8.13e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  1153 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1232
Cdd:smart00544    1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80

                            90       100       110
                    ....*....|....*....|....*....|...
gi 1622905306  1233 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1265
Cdd:smart00544   81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
1420-1503 1.84e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 104.29  E-value: 1.84e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  1420 KLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqqGKGVALKSVTAFFKW 1499
Cdd:smart00515    2 PLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVTW 79


                    ....
gi 1622905306  1500 LREA 1503
Cdd:smart00515   80 LQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 1432-1508 3.43e-23

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 94.52  E-value: 3.43e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622905306 1432 ELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqQGKGVALKSVTAFFKWLREAEEESD 1508
Cdd:pfam02020    1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAE-KGMKKVRKQAKPFVEWLEEAEEESD 76
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-482 2.49e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 2.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306    4 PSQISYPASQGAYYIPGQGRStyvvPTQQYPVQPG--APGFYPGASPTEfgtyagAYYP-----AQGVQQFPTGVA--PA 74
Cdd:PHA03247  2483 PAEARFPFAAGAAPDPGGGGP----PDPDAPPAPSrlAPAILPDEPVGE------PVHPrmltwIRGLEELASDDAgdPP 2552

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306   75 PVLMNQPPQIAPKRERKTIRIRdPNQGGKDITeeimsgARTASTPTPPQTGGGLEPQANGETPQVAVivrPDDRSQGAII 154
Cdd:PHA03247  2553 PPLPPAAPPAAPDRSVPPPRPA-PRPSEPAVT------SRARRPDAPPQSARPRAPVDDRGDPRGPA---PPSPLPPDTH 2622

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  155 ADRPGLPGPEHSPSESQPSSPSPTPSPSpvlEPGSEPNLAVLSIPGDTMATIQMSVEESTP------ISRETGEPYRLS- 227
Cdd:PHA03247  2623 APDPPPPSPSPAANEPDPHPPPTVPPPE---RPRDDPAPGRVSRPRRARRLGRAAQASSPPqrprrrAARPTVGSLTSLa 2699

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  228 ----PEPTPLAEPILEVEVTLSKPVPESEFSSSPLQASTPLASHTveihePNGMV----PSEDLEPEVESSPELALPPAC 299
Cdd:PHA03247  2700 dpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-----PAGPAtpggPARPARPPTTAGPPAPAPPAA 2774

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  300 PSESP---VPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEvTASVAPATILSATPAMAPSATSPAqeeemeeeEEE 376
Cdd:PHA03247  2775 PAAGPprrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL-PPAASPAGPLPPPTSAQPTAPPPP--------PGP 2845

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  377 EEEGEAGEAESEKGGE--ELLPSESTPVPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEavgdlLDAFKEANPAVPE 454
Cdd:PHA03247  2846 PPPSLPLGGSVAPGGDvrRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPER-----PPQPQAPPPPQPQ 2920

                          490       500
                   ....*....|....*....|....*...
gi 1622905306  455 VENQPPAGSNPGPESEGSGVPPRPEEAD 482
Cdd:PHA03247  2921 PQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 53-364 8.37e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.80  E-value: 8.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306   53 TYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDiTEEIMSGARTA--STPTPPQTGGGLEP 130
Cdd:pfam17823  116 AAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASA-PHAASPAPRTAasSTTAASSTTAASSA 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  131 QANGETPQVAVIVRPDDRSQGAIIADRPGLpGPEHSPSESQPSSPSPTPSPSPVLEPGSepnLAVLSIPGDTMATIQMSV 210
Cdd:pfam17823  195 PTTAASSAPATLTPARGISTAATATGHPAA-GTALAAVGNSSPAAGTVTAAVGTVTPAA---LATLAAAAGTVASAAGTI 270

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  211 EESTPISRetgepyRLSPeptplaepilevevtlSKPVPESEFSSSPLQASTPLASHTVeihepngMVPSEDlEPEVESS 290
Cdd:pfam17823  271 NMGDPHAR------RLSP----------------AKHMPSDTMARNPAAPMGAQAQGPI-------IQVSTD-QPVHNTA 320

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622905306  291 PElalppacpsESPVPIAPTAQPeellNGAPSPPAVDLSPVSEPEEQAKEVTASVAPATILSATPAMapSATSP 364
Cdd:pfam17823  321 GE---------PTPSPSNTTLEP----NTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEV--EATSP 379
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 672-897 4.83e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.46  E-value: 4.83e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  672 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 751
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  752 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 831
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622905306  832 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 897
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1349-1481 2.66e-57

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 194.04  E-value: 2.66e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306 1349 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIASNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1427
Cdd:cd11559      1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622905306 1428 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1481
Cdd:cd11559     81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 673-900 1.68e-53

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 186.03  E-value: 1.68e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306   673 RRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlKVPttekptvtvNFRK 752
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNA-KNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306   753 LLLNRCQKEFEKDkdddevfekkqkemdeaataeergrlkeeLEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV 832
Cdd:smart00543   72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622905306   833 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKT---SSRIRFMLQDVLDLRGSN 900
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELRKNK 200
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1153-1265 6.97e-37

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 135.10  E-value: 6.97e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306 1153 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1232
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1622905306 1233 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1265
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1153-1265 8.13e-36

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 131.98  E-value: 8.13e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  1153 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1232
Cdd:smart00544    1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80

                            90       100       110
                    ....*....|....*....|....*....|...
gi 1622905306  1233 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1265
Cdd:smart00544   81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
1420-1503 1.84e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 104.29  E-value: 1.84e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  1420 KLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqqGKGVALKSVTAFFKW 1499
Cdd:smart00515    2 PLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVTW 79


                    ....
gi 1622905306  1500 LREA 1503
Cdd:smart00515   80 LQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 1432-1508 3.43e-23

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 94.52  E-value: 3.43e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622905306 1432 ELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqQGKGVALKSVTAFFKWLREAEEESD 1508
Cdd:pfam02020    1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAE-KGMKKVRKQAKPFVEWLEEAEEESD 76
W2 cd11473
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 1350-1475 3.64e-23

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211395  Cd Length: 135  Bit Score: 96.78  E-value: 3.64e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306 1350 PSEELNRQLEKLLKEG-SSNQRVFDWIEANLSEQQIASNTLVRALMTAVCYSAIIFE----TPLRVDVAVLKARAKLLQK 1424
Cdd:cd11473      2 KNKKLRDSLLKELEEDkSSDVESVKAAKSKLDLDPISLEEVVKVLLTAVVNAVESADsislTQKEQLVLVLKKYGPVLRE 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622905306 1425 YLCD-EQKELQALYALQALVVT--LEQPPNLLRMFFDALYDEDVVKEDAFYSWE 1475
Cdd:cd11473     82 LLKLiKKDQLYLLLKIEKLCLQlkLSELISLLEKILDLLYDADVLSEEAILSWF 135
W2_eIF2B_epsilon cd11558
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ...
 1378-1508 2.48e-15

C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211396  Cd Length: 169  Bit Score: 75.37  E-value: 2.48e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306 1378 NLSEQQIASNTlVRALMTAVCYSAIIFETPLRVDVAVLKARAK-LLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMF 1456
Cdd:cd11558     39 NVTDHDVRRAV-VKALLELILEVSSTSTAELLEALKKLLSKWGpLLENYVKSQDDQVELLLALEEFCLESEEGGPLFAKL 117

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1622905306 1457 FDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESD 1508
Cdd:cd11558    118 LHALYDLDILEEEAILEWWEEPDAGADEEMKKVRELVKKFIEWLEEAEEESD 169
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 1357-1508 4.26e-09

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 56.86  E-value: 4.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306 1357 QLEKLLKEGSSNQRVFDwIEANLSEQQIASNTLVRALmtavcysAIIFETPLRVD-VAVLKARAKLLQKYLCDEQKELQA 1435
Cdd:cd11561     10 ELGEFLKKNKDESGLSE-LKEILKEAERLDVVKDKAV-------LVLAEVLFDENiVKEIKKRKALLLKLVTDEKAQKAL 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622905306 1436 LYALQALVVtlEQPPNLLRMF---FDALYDEDVVKEDAFYSW---ESSKDPAEQQGKGVaLKSVTAFFKWLREAEEESD 1508
Cdd:cd11561     82 LGGIERFCG--KHSPELLKKVpliLKALYDNDILEEEVILKWyekVSKKYVSKEKSKKV-RKAAEPFVEWLEEAEEEEE 157
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 1346-1506 9.06e-08

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 54.14  E-value: 9.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306 1346 QRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIASN--------TLVRALMTAVCYSA---IIFETPLRVdvav 1414
Cdd:cd11560     29 YRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSSlpehevvgLLWTALMDAVEWSKkedQIAEQALRH---- 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306 1415 LKARAKLLQKYLCDEQKELQALYALQalVVTLEQPpNLLRMFFD---ALYDEDVVKEDAFYSWesSKDPAEQQGKGVALK 1491
Cdd:cd11560    105 LKKYAPLLAAFCTTARAELALLNKIQ--EYCYENM-KFMKVFQKivkLLYKADVLSEDAILKW--YKKGHSPKGKQVFLK 179

                          170
                   ....*....|....*
gi 1622905306 1492 SVTAFFKWLREAEEE 1506
Cdd:cd11560    180 QMEPFVEWLQEAEEE 194
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-482 2.49e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 2.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306    4 PSQISYPASQGAYYIPGQGRStyvvPTQQYPVQPG--APGFYPGASPTEfgtyagAYYP-----AQGVQQFPTGVA--PA 74
Cdd:PHA03247  2483 PAEARFPFAAGAAPDPGGGGP----PDPDAPPAPSrlAPAILPDEPVGE------PVHPrmltwIRGLEELASDDAgdPP 2552

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306   75 PVLMNQPPQIAPKRERKTIRIRdPNQGGKDITeeimsgARTASTPTPPQTGGGLEPQANGETPQVAVivrPDDRSQGAII 154
Cdd:PHA03247  2553 PPLPPAAPPAAPDRSVPPPRPA-PRPSEPAVT------SRARRPDAPPQSARPRAPVDDRGDPRGPA---PPSPLPPDTH 2622

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  155 ADRPGLPGPEHSPSESQPSSPSPTPSPSpvlEPGSEPNLAVLSIPGDTMATIQMSVEESTP------ISRETGEPYRLS- 227
Cdd:PHA03247  2623 APDPPPPSPSPAANEPDPHPPPTVPPPE---RPRDDPAPGRVSRPRRARRLGRAAQASSPPqrprrrAARPTVGSLTSLa 2699

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  228 ----PEPTPLAEPILEVEVTLSKPVPESEFSSSPLQASTPLASHTveihePNGMV----PSEDLEPEVESSPELALPPAC 299
Cdd:PHA03247  2700 dpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-----PAGPAtpggPARPARPPTTAGPPAPAPPAA 2774

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  300 PSESP---VPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEvTASVAPATILSATPAMAPSATSPAqeeemeeeEEE 376
Cdd:PHA03247  2775 PAAGPprrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL-PPAASPAGPLPPPTSAQPTAPPPP--------PGP 2845

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  377 EEEGEAGEAESEKGGE--ELLPSESTPVPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEavgdlLDAFKEANPAVPE 454
Cdd:PHA03247  2846 PPPSLPLGGSVAPGGDvrRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPER-----PPQPQAPPPPQPQ 2920

                          490       500
                   ....*....|....*....|....*...
gi 1622905306  455 VENQPPAGSNPGPESEGSGVPPRPEEAD 482
Cdd:PHA03247  2921 PQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
189-475 7.43e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 50.62  E-value: 7.43e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  189 SEPNLAVLSIPGDTMATIQMSVEE------STPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAST 262
Cdd:PRK07003   336 GELGLAPDEYAGFTMTLLRMLAFEpavtggGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAA 415

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  263 PLASHTVEIHEPNGMVPSEDLEPEVESSPElalPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVS--------EP 334
Cdd:PRK07003   416 AAAAATRAEAPPAAPAPPATADRGDDAADG---DAPVPAKANARASADSRCDERDAQPPADSGSASAPASdappdaafEP 492

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  335 EEQAKEVTASVAPATILSATPAMAPSATSPAQEEEMEEEEEEEEEGEAGEAESEKGGEELL----------------PSE 398
Cdd:PRK07003   493 APRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAALdvlrnagmrvssdrgaRAA 572

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622905306  399 STPVPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVP 475
Cdd:PRK07003   573 AAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPPPWEDIPPDDYVPLSADEGFGGP 649
PHA03247 PHA03247
large tegument protein UL36; Provisional
 10-476 7.55e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 7.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306   10 PASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQ--FPTGVAPAPVLMNQPPQIAPK 87
Cdd:PHA03247  2629 PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRraARPTVGSLTSLADPPPPPPTP 2708

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306   88 RERktirirdPNQGGKDITEEIMSGARTASTPTPPQTGGglePQANGETPQVAVIVRPDDRSQGAIIADRPGLP----GP 163
Cdd:PHA03247  2709 EPA-------PHALVSATPLPPGPAAARQASPALPAAPA---PPAVPAGPATPGGPARPARPPTTAGPPAPAPPaapaAG 2778

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  164 EHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMATIQMSVEESTPISRETGEPYRLSPEPTPLAEPilevevT 243
Cdd:PHA03247  2779 PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP------L 2852

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  244 LSKPVPESEFSSSPLQASTPlASHTVEIHEPNGMVPSEDLEPEVESSPELALPPACPSESPVPIAPTAQPEELLNGAPSP 323
Cdd:PHA03247  2853 GGSVAPGGDVRRRPPSRSPA-AKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  324 -------PAVDLSPVSEPEEQAKEVTASVAP---ATILSATPAMAPSATSPAQEEEMEEEEEEEEEGEAGEAESEKGGEE 393
Cdd:PHA03247  2932 pppppprPQPPLAPTTDPAGAGEPSGAVPQPwlgALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSL 3011

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  394 LLPSESTPVPANLSQNL------EAAAATQVAVSVPKRrrkikelNKKEAVgDLLDAFKEANPAVPEVENQPPAGSNPGP 467
Cdd:PHA03247  3012 ALHEETDPPPVSLKQTLwppddtEDSDADSLFDSDSER-------SDLEAL-DPLPPEPHDPFAHEPDPATPEAGARESP 3083


                   ....*....
gi 1622905306  468 ESEgSGVPP 476
Cdd:PHA03247  3084 SSQ-FGPPP 3091
PHA03247 PHA03247
large tegument protein UL36; Provisional
 28-487 1.13e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306   28 VPTQQYPVQPGAPGF-----YPGASPTEfgtyAGAYYPAQGVQQFPTGVAPAPVlmnqPPQIAPKRERKTIRIRDPNQGG 102
Cdd:PHA03247  2568 VPPPRPAPRPSEPAVtsrarRPDAPPQS----ARPRAPVDDRGDPRGPAPPSPL----PPDTHAPDPPPPSPSPAANEPD 2639

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  103 KDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQV-AVIVRPDDRSQGAIIAD-----RPGLPGPEhSPSESQPSSPS 176
Cdd:PHA03247  2640 PHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAsSPPQRPRRRAARPTVGSltslaDPPPPPPT-PEPAPHALVSA 2718

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  177 PTPSPSPVLEPGSEPNLAVLSIPGDTMATIQMSVEESTPISRETGEPyrlSPEPTPLAEPILEVEVTLSKPVPESEFSSS 256
Cdd:PHA03247  2719 TPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG---PPAPAPPAAPAAGPPRRLTRPAVASLSESR 2795

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  257 PLQASTP-LASHTVEIHEPNGMVPSEDlEPEVESSPELALPPACPSESPVPIAPTAQPeellnGAPSPPAVDLSPVSEPE 335
Cdd:PHA03247  2796 ESLPSPWdPADPPAAVLAPAAALPPAA-SPAGPLPPPTSAQPTAPPPPPGPPPPSLPL-----GGSVAPGGDVRRRPPSR 2869

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  336 EQAKEVTASVAPATILSATPAMAPSATSPAQEEEMEEEEEEEEEGEAGEAESEKGGEEL-LPSESTPV--PANLSQNLEA 412
Cdd:PHA03247  2870 SPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQpQPPPPPPPrpQPPLAPTTDP 2949

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622905306  413 AAATQVAVSVPKRRrkikelnkkeavgdlLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDS 487
Cdd:PHA03247  2950 AGAGEPSGAVPQPW---------------LGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWAS 3009
rne PRK10811
ribonuclease E; Reviewed
 213-366 6.30e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 44.65  E-value: 6.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  213 STPISR-ETGEPYRLSPEPTPLAEPILeVEVTLSKPVPESEfSSSPLQASTPLASHTVEIHEPN--GMVPSEDLEPEVES 289
Cdd:PRK10811   844 RYPVVRpQDVQVEEQREAEEVQVQPVV-AEVPVAAAVEPVV-SAPVVEAVAEVVEEPVVVAEPQpeEVVVVETTHPEVIA 921

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  290 SPELALPP-------ACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASVAPATILSATPAMAPSAT 362
Cdd:PRK10811   922 APVTEQPQvitesdvAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEV 1001


                   ....
gi 1622905306  363 SPAQ 366
Cdd:PRK10811  1002 APAQ 1005
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
318-484 7.12e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 7.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  318 NGAPSPPAVDLSPVSEPEEQAKEVTASVAPATILSATPAMAPS----ATSPAQEEEMEEEEEEEEEGEAGEAESEKGGEE 393
Cdd:PRK12323   369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAaaaaARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  394 LLPSESTPVPANLSQNLEAAAATQVAVSVPKRRRKIKElNKKEAVGDLLDAFKEANPAVPEVenqPPAGSNPGPESEGSG 473
Cdd:PRK12323   449 APAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPA-AAPAPADDDPPPWEELPPEFASP---APAQPDAAPAGWVAE 524

                          170
                   ....*....|.
gi 1622905306  474 VPPRPEEADET 484
Cdd:PRK12323   525 SIPDPATADPD 535
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 53-364 8.37e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.80  E-value: 8.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306   53 TYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDiTEEIMSGARTA--STPTPPQTGGGLEP 130
Cdd:pfam17823  116 AAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASA-PHAASPAPRTAasSTTAASSTTAASSA 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  131 QANGETPQVAVIVRPDDRSQGAIIADRPGLpGPEHSPSESQPSSPSPTPSPSPVLEPGSepnLAVLSIPGDTMATIQMSV 210
Cdd:pfam17823  195 PTTAASSAPATLTPARGISTAATATGHPAA-GTALAAVGNSSPAAGTVTAAVGTVTPAA---LATLAAAAGTVASAAGTI 270

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  211 EESTPISRetgepyRLSPeptplaepilevevtlSKPVPESEFSSSPLQASTPLASHTVeihepngMVPSEDlEPEVESS 290
Cdd:pfam17823  271 NMGDPHAR------RLSP----------------AKHMPSDTMARNPAAPMGAQAQGPI-------IQVSTD-QPVHNTA 320

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622905306  291 PElalppacpsESPVPIAPTAQPeellNGAPSPPAVDLSPVSEPEEQAKEVTASVAPATILSATPAMapSATSP 364
Cdd:pfam17823  321 GE---------PTPSPSNTTLEP----NTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEV--EATSP 379
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 97-361 1.49e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 1.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306   97 DPNQGGKDITEEIMSGARTAS------------TPTPPQTGgglePQANGETPQVAVIVRPDDRSQGAIIADRP------ 158
Cdd:PRK10263   308 DPLLNGAPITEPVAVAAAATTatqswaapvepvTQTPPVAS----VDVPPAQPTVAWQPVPGPQTGEPVIAPAPegypqq 383

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  159 ---GLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMATIQMSVEESTPISRETGEPyrlsPEPTPLAE 235
Cdd:PRK10263   384 sqyAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEE----QQSTFAPQ 459

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  236 PILEVEVTLSKPVPESEFSSSPLQASTPLASHTV-EIHEPNGMVPSEDLEPEVESS-----PELAL---PPACPSESPVP 306
Cdd:PRK10263   460 STYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEpVVEETKPARPPLYYFEEVEEKrarerEQLAAwyqPIPEPVKEPEP 539

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622905306  307 IAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAkevtASVAPATILSATPAMAPSA 361
Cdd:PRK10263   540 IKSSLKAPSVAAVPPVEAAAAVSPLASGVKKA----TLATGAAATVAAPVFSLAN 590
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 200-335 3.10e-03

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 42.18  E-value: 3.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  200 GDTMATIQMSVEESTPISRETGEPYRLSPEPTPLAEPilevevTLSKPVPESEfsssPLQASTPLASHTVEIHEpngMVP 279
Cdd:pfam15324  959 GDREAQREPPVAASVPGDLPTKETLLPTPVPTPQPTP------PCSPPSPLKE----PSPVKTPDSSPCVSEHD---FFP 1025

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622905306  280 SEDLEPEVESSPELALPPA-CPSESPVPIAPTAqpeellnGAPSPP----AVDLSPVSEPE 335
Cdd:pfam15324 1026 VKEIPPEKGADTGPAVSLViTPTVTPIATPPPA-------ATPTPPlsenSIDKLKSPSPE 1079
PHA03325 PHA03325
nuclear-egress-membrane-like protein; Provisional
 204-364 5.01e-03

nuclear-egress-membrane-like protein; Provisional


Pssm-ID: 223044  Cd Length: 418  Bit Score: 41.02  E-value: 5.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  204 ATIQMSVEESTPISRETG-EPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQASTplashtveihepnGMVPSED 282
Cdd:PHA03325   262 FMLNSSLPTSAPKRRSRRaGAMRAAAGETADLADDDGSEHSDPEPLPASLPPPPVRRPRV-------------KHPEAGK 328

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905306  283 LEPEVESSPElALPPACPSESP-VPIAPTAQPEEllnGAPSPPAVDLSPVSEPEEQAKEVTASVAPATILSATPaMAPSA 361
Cdd:PHA03325   329 EEPDGARNAE-AKEPAQPATSTsSKGSSSAQNKD---SGSTGPGSSLAAASSFLEDDDFGSPPLDLTTSLRHMP-SPSVT 403


                   ...
gi 1622905306  362 TSP 364
Cdd:PHA03325   404 SAP 406
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH