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Conserved domains on  [gi|1622905258|ref|XP_028699730|]
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dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X1 [Macaca mulatta]

Protein Classification

glycosyltransferase family 58 protein( domain architecture ID 3605)

glycosyltransferase family 58 protein similar to Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol

CAZY:  GT58
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  11308030|11042447|21592771

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ALG3 super family cl04986
ALG3 protein; The formation of N-glycosidic linkages of glycoproteins involves the ordered ...
 96-283 2.78e-109

ALG3 protein; The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl pyrophosphate. Whereas early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9GlcNAc2-PP-Dol on the lumenal side use Dol-P-Man. ALG3 gene encodes the Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase.


The actual alignment was detected with superfamily member pfam05208:

Pssm-ID: 461587  Cd Length: 358  Bit Score: 327.12  E-value: 2.78e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905258  96 YPAGFVYIFMGLYYATGRGTDIRMAQNIFAVLYLATLLLVFLIYHQtCKVPPFVFFFMCCaSYRVHSIFVLRLFNDPVAM 175
Cdd:pfam05208  54 YPAGHVYIYSALYYLTDGGRNIRLAQYIFAGLYLLTLALVFAIYRR-AKVPPYVLPLLCL-SKRLHSIFVLRLFNDCFAM 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905258 176 VLLFLSINFLLAQRWGWGCCFFSLAVSVKMNVLLFAPGLLFLLLTQFGFRGALPKLGICAGLQVVLGLPFLLENPIGYLS 255
Cdd:pfam05208 132 LFLYLAILLFQRRRWTLGSLLYSLAVSIKMNALLFLPALLVLLLLNLGLLGTLRQLAVIALVQVLLGLPFLLTNPRSYLS 211

                         170       180
                  ....*....|....*....|....*...
gi 1622905258 256 RSFDLGRQFLFRWTVNWRFLPEALFLHR 283
Cdd:pfam05208 212 RAFDFSRQFLYKWTVNWRFVPEEIFLSK 239
 
Name Accession Description Interval E-value
ALG3 pfam05208
ALG3 protein; The formation of N-glycosidic linkages of glycoproteins involves the ordered ...
 96-283 2.78e-109

ALG3 protein; The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl pyrophosphate. Whereas early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9GlcNAc2-PP-Dol on the lumenal side use Dol-P-Man. ALG3 gene encodes the Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase.


Pssm-ID: 461587  Cd Length: 358  Bit Score: 327.12  E-value: 2.78e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905258  96 YPAGFVYIFMGLYYATGRGTDIRMAQNIFAVLYLATLLLVFLIYHQtCKVPPFVFFFMCCaSYRVHSIFVLRLFNDPVAM 175
Cdd:pfam05208  54 YPAGHVYIYSALYYLTDGGRNIRLAQYIFAGLYLLTLALVFAIYRR-AKVPPYVLPLLCL-SKRLHSIFVLRLFNDCFAM 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905258 176 VLLFLSINFLLAQRWGWGCCFFSLAVSVKMNVLLFAPGLLFLLLTQFGFRGALPKLGICAGLQVVLGLPFLLENPIGYLS 255
Cdd:pfam05208 132 LFLYLAILLFQRRRWTLGSLLYSLAVSIKMNALLFLPALLVLLLLNLGLLGTLRQLAVIALVQVLLGLPFLLTNPRSYLS 211

                         170       180
                  ....*....|....*....|....*...
gi 1622905258 256 RSFDLGRQFLFRWTVNWRFLPEALFLHR 283
Cdd:pfam05208 212 RAFDFSRQFLYKWTVNWRFVPEEIFLSK 239
 
Name Accession Description Interval E-value
ALG3 pfam05208
ALG3 protein; The formation of N-glycosidic linkages of glycoproteins involves the ordered ...
 96-283 2.78e-109

ALG3 protein; The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl pyrophosphate. Whereas early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9GlcNAc2-PP-Dol on the lumenal side use Dol-P-Man. ALG3 gene encodes the Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase.


Pssm-ID: 461587  Cd Length: 358  Bit Score: 327.12  E-value: 2.78e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905258  96 YPAGFVYIFMGLYYATGRGTDIRMAQNIFAVLYLATLLLVFLIYHQtCKVPPFVFFFMCCaSYRVHSIFVLRLFNDPVAM 175
Cdd:pfam05208  54 YPAGHVYIYSALYYLTDGGRNIRLAQYIFAGLYLLTLALVFAIYRR-AKVPPYVLPLLCL-SKRLHSIFVLRLFNDCFAM 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622905258 176 VLLFLSINFLLAQRWGWGCCFFSLAVSVKMNVLLFAPGLLFLLLTQFGFRGALPKLGICAGLQVVLGLPFLLENPIGYLS 255
Cdd:pfam05208 132 LFLYLAILLFQRRRWTLGSLLYSLAVSIKMNALLFLPALLVLLLLNLGLLGTLRQLAVIALVQVLLGLPFLLTNPRSYLS 211

                         170       180
                  ....*....|....*....|....*...
gi 1622905258 256 RSFDLGRQFLFRWTVNWRFLPEALFLHR 283
Cdd:pfam05208 212 RAFDFSRQFLYKWTVNWRFVPEEIFLSK 239
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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