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Conserved domains on  [gi|1622904812|ref|XP_028699672|]
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leucine-rich repeat-containing protein 34 isoform X4 [Macaca mulatta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 72-376 1.55e-29

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 118.74  E-value: 1.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812  72 NLLGDVGAYYAAKLVQKQLNLIYLnlMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINSSLEKL 151
Cdd:COG5238   164 RLGLLAAISMAKALQNNSVETVYL--GCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTL 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 152 DLGDCDLGMQSVIAFATVLTRNQAIKAINLnrpilYGEQeestvhigrmlkenhclvvlhmckhdIKNSGIQQLCDALYL 231
Cdd:COG5238   242 DLSNNQIGDEGVIALAEALKNNTTVETLYL-----SGNQ--------------------------IGAEGAIALAKALQG 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 232 NSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTShNRSLKALSVVSNNIEGEGLVALS 311
Cdd:COG5238   291 NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQE-NTTLHSLDLSDNQIGDEGAIALA 369

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622904812 312 QSMKTNLTFSHIYIWGNKFDEATCVAYSDLIQMGRLKPDNTDVEPFVVDGRVYLAEVSNGLKKHY 376
Cdd:COG5238   370 KYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 72-376 1.55e-29

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 118.74  E-value: 1.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812  72 NLLGDVGAYYAAKLVQKQLNLIYLnlMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINSSLEKL 151
Cdd:COG5238   164 RLGLLAAISMAKALQNNSVETVYL--GCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTL 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 152 DLGDCDLGMQSVIAFATVLTRNQAIKAINLnrpilYGEQeestvhigrmlkenhclvvlhmckhdIKNSGIQQLCDALYL 231
Cdd:COG5238   242 DLSNNQIGDEGVIALAEALKNNTTVETLYL-----SGNQ--------------------------IGAEGAIALAKALQG 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 232 NSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTShNRSLKALSVVSNNIEGEGLVALS 311
Cdd:COG5238   291 NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQE-NTTLHSLDLSDNQIGDEGAIALA 369

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622904812 312 QSMKTNLTFSHIYIWGNKFDEATCVAYSDLIQMGRLKPDNTDVEPFVVDGRVYLAEVSNGLKKHY 376
Cdd:COG5238   370 KYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 67-335 5.87e-26

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 106.67  E-value: 5.87e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812  67 LDVGYNLLGDVGAYYAAKLVQKQLNLIYLNLMFNDIG--PEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQi 144
Cdd:cd00116    28 LRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLR- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 145 NSSLEKLDLGDCDLGMQSVIAFATVLTRNQ-AIKAINLNRPILYGEqeeSTVHIGRMLKENHCLVVLHMCKHDIKNSGIQ 223
Cdd:cd00116   107 SSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGA---SCEALAKALRANRDLKELNLANNGIGDAGIR 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 224 QLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIE 303
Cdd:cd00116   184 ALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDIT 263

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1622904812 304 GEGLVALSQSMKTNLTFSHIYIWGNKFDEATC 335
Cdd:cd00116   264 DDGAKDLAEVLAEKESLLELDLRGNKFGEEGA 295
LRR_8 pfam13855
Leucine rich repeat;
233-302 9.90e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 9.90e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 233 SSLRYLDVSCNKITHDGmvylADVLKSNTTLEVIDLSFNRIenagaNYLSETLTSHNRSLKALSVVSNNI 302
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD----DGAFKGLSNLKVLDLSNNLL-----TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
232-259 4.35e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.31  E-value: 4.35e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622904812  232 NSSLRYLDVSCNKITHDGMVYLADVLKS 259
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 72-376 1.55e-29

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 118.74  E-value: 1.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812  72 NLLGDVGAYYAAKLVQKQLNLIYLnlMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINSSLEKL 151
Cdd:COG5238   164 RLGLLAAISMAKALQNNSVETVYL--GCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTL 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 152 DLGDCDLGMQSVIAFATVLTRNQAIKAINLnrpilYGEQeestvhigrmlkenhclvvlhmckhdIKNSGIQQLCDALYL 231
Cdd:COG5238   242 DLSNNQIGDEGVIALAEALKNNTTVETLYL-----SGNQ--------------------------IGAEGAIALAKALQG 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 232 NSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTShNRSLKALSVVSNNIEGEGLVALS 311
Cdd:COG5238   291 NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQE-NTTLHSLDLSDNQIGDEGAIALA 369

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622904812 312 QSMKTNLTFSHIYIWGNKFDEATCVAYSDLIQMGRLKPDNTDVEPFVVDGRVYLAEVSNGLKKHY 376
Cdd:COG5238   370 KYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 67-317 4.54e-29

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 117.58  E-value: 4.54e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812  67 LDVGYNLLGDVGAYYAAKLVQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINS 146
Cdd:COG5238   185 VYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNT 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 147 SLEKLDLGDCDLGMQSVIAFATVLTRNQAIKAINLNrpilygeqeestvhigrmlkENHclvvlhmckhdIKNSGIQQLC 226
Cdd:COG5238   265 TVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLS--------------------VNR-----------IGDEGAIALA 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 227 DALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTShNRSLKALSVVSNNIEGEG 306
Cdd:COG5238   314 EGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEG-NTTLRELNLGKNNIGKQG 392

                         250
                  ....*....|.
gi 1622904812 307 LVALSQSMKTN 317
Cdd:COG5238   393 AEALIDALQTN 403
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 64-285 5.41e-27

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 111.42  E-value: 5.41e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812  64 INGLDVGYNLLGDVGAYYAAKLVQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQ 143
Cdd:COG5238   210 VTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQ 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 144 INSSLEKLDLGDCDLGMQSVIAFATVLTRNQAIKAINLNRPilyGEQEESTVHIGRMLKENHCLVVLHMCKHDIKNSGIQ 223
Cdd:COG5238   290 GNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYN---GIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAI 366

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622904812 224 QLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNtTLEVIDLSFNRIENAGANYLSETL 285
Cdd:COG5238   367 ALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLIGAEAQQRLEQLL 427
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 67-335 5.87e-26

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 106.67  E-value: 5.87e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812  67 LDVGYNLLGDVGAYYAAKLVQKQLNLIYLNLMFNDIG--PEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQi 144
Cdd:cd00116    28 LRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLR- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 145 NSSLEKLDLGDCDLGMQSVIAFATVLTRNQ-AIKAINLNRPILYGEqeeSTVHIGRMLKENHCLVVLHMCKHDIKNSGIQ 223
Cdd:cd00116   107 SSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGA---SCEALAKALRANRDLKELNLANNGIGDAGIR 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 224 QLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIE 303
Cdd:cd00116   184 ALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDIT 263

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1622904812 304 GEGLVALSQSMKTNLTFSHIYIWGNKFDEATC 335
Cdd:cd00116   264 DDGAKDLAEVLAEKESLLELDLRGNKFGEEGA 295
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 72-343 4.37e-25

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 106.03  E-value: 4.37e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812  72 NLLGDVGAYYAAKLVQKQLNLIYLNLMfndigpeggeliaKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINSSLEKL 151
Cdd:COG5238   147 LKDPLGGNAVHLLGLAARLGLLAAISM-------------AKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTL 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 152 DLGDCDLGMQSVIAFATVLTRNQAIKAINLnrpilygeqeeSTVHIGrmlkenhclvvlhmckhdikNSGIQQLCDALYL 231
Cdd:COG5238   214 WLKRNPIGDEGAEILAEALKGNKSLTTLDL-----------SNNQIG--------------------DEGVIALAEALKN 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 232 NSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLtSHNRSLKALSVVSNNIEGEGLVALS 311
Cdd:COG5238   263 NTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLHTLNLAYNGIGAQGAIALA 341

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1622904812 312 QSMKTNLTFSHIYIWGNKFDEATCVAYSDLIQ 343
Cdd:COG5238   342 KALQENTTLHSLDLSDNQIGDEGAIALAKYLE 373
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 58-300 1.10e-21

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 94.73  E-value: 1.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812  58 LKNCLYINGLDVGYNLLGD--VGAYYAAKLVQKQLNLIYLNlmfNDIGPEGGELIAKVLHKNQ-TLKYLRMTGNKIENKG 134
Cdd:cd00116    77 LTKGCGLQELDLSDNALGPdgCGVLESLLRSSSLQELKLNN---NGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGAS 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 135 GMSFAAMLQINSSLEKLDLGDCDLGMQSVIAFATVLTRNQAIKAINLNrpiLYGEQEESTVHIGRMLKENHCLVVLHMCK 214
Cdd:cd00116   154 CEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEVLNLGD 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 215 HDIKNSGIQQLCDAL-YLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLK 293
Cdd:cd00116   231 NNLTDAGAAALASALlSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELE 310


                  ....*..
gi 1622904812 294 ALSVVSN 300
Cdd:cd00116   311 SLWVKDD 317
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 113-346 9.98e-20

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 90.62  E-value: 9.98e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 113 VLHKNQTLKYLRMTGNKI-ENKGGMSFAAMLQINSSLEKLDLGDCDLGMQSVIAFATVLTRNQAIKAINLNR-PIlygeQ 190
Cdd:COG5238   146 VLKDPLGGNAVHLLGLAArLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRnPI----G 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 191 EESTVHIGRMLKENHclvvlhmckhdiknsgiqqlcdalylnsSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSF 270
Cdd:COG5238   222 DEGAEILAEALKGNK----------------------------SLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSG 273

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622904812 271 NRIENAGANYLSETLtSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCVAYSDLIQMGR 346
Cdd:COG5238   274 NQIGAEGAIALAKAL-QGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENT 348
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 24-248 1.92e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 86.77  E-value: 1.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812  24 KGLAAGITLNIAGNNrlvpverVTGEDFWILSRILKNCLYINGLDVGYNLLGDVGAYYAAKLVQKQLNLIYLNLMFNDIG 103
Cdd:COG5238   233 KGNKSLTTLDLSNNQ-------IGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIG 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 104 PEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINSSLEKLDLGDCDLGMQSVIAFATVLTRNQAIKAINLnr 183
Cdd:COG5238   306 DEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNL-- 383

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622904812 184 pilygeqeestvhigrmlkenhclvvlhmCKHDIKNSGIQQLCDALYLNsSLRYLDVSCNKITHD 248
Cdd:COG5238   384 -----------------------------GKNNIGKQGAEALIDALQTN-RLHTLILDGNLIGAE 418
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 158-343 9.23e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 78.68  E-value: 9.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 158 LGMQSVIAFATVLTRNQAIKAINLNRpiLYGEQEESTVHIGRMLKENHCLVVLHMCKHDIKNSGIQQLCDALYLNSSLRY 237
Cdd:COG5238   135 LALPRRINLIQVLKDPLGGNAVHLLG--LAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTT 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 238 LDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTsHNRSLKALSVVSNNIEGEGLVALSQSMKTN 317
Cdd:COG5238   213 LWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALK-NNTTVETLYLSGNQIGAEGAIALAKALQGN 291

                         170       180
                  ....*....|....*....|....*.
gi 1622904812 318 LTFSHIYIWGNKFDEATCVAYSDLIQ 343
Cdd:COG5238   292 TTLTSLDLSVNRIGDEGAIALAEGLQ 317
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 31-200 9.40e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 78.68  E-value: 9.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812  31 TLNIAGNnrlvpveRVTGEDFWILSRILKNCLYINGLDVGYNLLGDVGAYYAAKLVQKQLNLIYLNLMFNDIGPEGGELI 110
Cdd:COG5238   268 TLYLSGN-------QIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIAL 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 111 AKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINSSLEKLDLGDCDLGMQSVIAFATVLTRNQAIKAINLNRPILYGEQ 190
Cdd:COG5238   341 AKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAEAQ 420

                         170
                  ....*....|
gi 1622904812 191 EESTVHIGRM 200
Cdd:COG5238   421 QRLEQLLERI 430
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 148-342 8.82e-12

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 65.45  E-value: 8.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 148 LEKLDLGDCDLGMQSVIAFATVLTRNQAIKAINLnRPILYGEQEESTVHIGRMLKENHCLVVLhmckhDIKNSGIQ---- 223
Cdd:cd00116    25 LQVLRLEGNTLGEEAAKALASALRPQPSLKELCL-SLNETGRIPRGLQSLLQGLTKGCGLQEL-----DLSDNALGpdgc 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 224 QLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNT-TLEVIDLSFNRIENAGANYLSETLtSHNRSLKALSVVSNNI 302
Cdd:cd00116    99 GVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKAL-RANRDLKELNLANNGI 177

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1622904812 303 EGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCVAYSDLI 342
Cdd:cd00116   178 GDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETL 217
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 53-158 1.28e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812  53 ILSRILKNCLYINGLDVGYNLLGDVGAYYAAK-LVQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIE 131
Cdd:cd00116   212 ALAETLASLKSLEVLNLGDNNLTDAGAAALASaLLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFG 291

                          90       100
                  ....*....|....*....|....*...
gi 1622904812 132 NKG-GMSFAAMLQINSSLEKLDLGDCDL 158
Cdd:cd00116   292 EEGaQLLAESLLEPGNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
216-303 8.86e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 8.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 216 DIKNSGIQQLCDALYLNSSLRYLDVSCNKIThdgmvYLADVLKSNTTLEVIDLSFNRIENaganyLSETLtSHNRSLKAL 295
Cdd:COG4886   165 DLSNNQLTDLPEELGNLTNLKELDLSNNQIT-----DLPEPLGNLTNLEELDLSGNQLTD-----LPEPL-ANLTNLETL 233


                  ....*...
gi 1622904812 296 SVVSNNIE 303
Cdd:COG4886   234 DLSNNQLT 241
LRR_8 pfam13855
Leucine rich repeat;
233-302 9.90e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 9.90e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904812 233 SSLRYLDVSCNKITHDGmvylADVLKSNTTLEVIDLSFNRIenagaNYLSETLTSHNRSLKALSVVSNNI 302
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD----DGAFKGLSNLKVLDLSNNLL-----TTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 206-273 2.99e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 2.99e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622904812 206 CLVVLhmckhDIKNSGIQQLCDALYLnSSLRYLDVSCNKIthDGMVYLADVLKSNTTLEVIDLSFNRI 273
Cdd:cd21340   121 SLRVL-----NISGNNIDSLEPLAPL-RNLEQLDASNNQI--SDLEELLDLLSSWPSLRELDLTGNPV 180
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
232-259 4.35e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.31  E-value: 4.35e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622904812  232 NSSLRYLDVSCNKITHDGMVYLADVLKS 259
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_6 pfam13516
Leucine Rich repeat;
116-139 9.63e-03

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 33.36  E-value: 9.63e-03
                          10        20
                  ....*....|....*....|....
gi 1622904812 116 KNQTLKYLRMTGNKIENKGGMSFA 139
Cdd:pfam13516   1 SNTHLTTLDLSDNDIGDEGAEALA 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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