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Conserved domains on  [gi|1622904805|ref|XP_028699671|]
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leucine-rich repeat-containing protein 34 isoform X3 [Macaca mulatta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 133-405 7.61e-31

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 122.98  E-value: 7.61e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 133 NLLGDVGAYYAAKLVQKQLNLIYLnlMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINSSLEKL 212
Cdd:COG5238   164 RLGLLAAISMAKALQNNSVETVYL--GCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTL 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 213 DLGDCDLEESTVH-IGRMLKENHCLVVLHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTT 291
Cdd:COG5238   242 DLSNNQIGDEGVIaLAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKT 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 292 LEVIDLSFNRIENAGANYLSETLTShNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCVAYSDLI 371
Cdd:COG5238   322 LHTLNLAYNGIGAQGAIALAKALQE-NTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL 400

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1622904805 372 QMGRLKPDNTDVEPFVVDGRVYLAEVSNGLKKHY 405
Cdd:COG5238   401 QTNRLHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 133-405 7.61e-31

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 122.98  E-value: 7.61e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 133 NLLGDVGAYYAAKLVQKQLNLIYLnlMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINSSLEKL 212
Cdd:COG5238   164 RLGLLAAISMAKALQNNSVETVYL--GCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTL 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 213 DLGDCDLEESTVH-IGRMLKENHCLVVLHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTT 291
Cdd:COG5238   242 DLSNNQIGDEGVIaLAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKT 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 292 LEVIDLSFNRIENAGANYLSETLTShNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCVAYSDLI 371
Cdd:COG5238   322 LHTLNLAYNGIGAQGAIALAKALQE-NTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL 400

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1622904805 372 QMGRLKPDNTDVEPFVVDGRVYLAEVSNGLKKHY 405
Cdd:COG5238   401 QTNRLHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 148-364 1.82e-29

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 116.69  E-value: 1.82e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 148 QKQLNLIYLNLMFNDIGPEGGELIaKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINS-SLEKLDLGDCDLE-ESTVH 225
Cdd:cd00116    78 TKGCGLQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEgASCEA 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 226 IGRMLKENHCLVVLHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENA 305
Cdd:cd00116   157 LAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDA 236

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622904805 306 GANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATC 364
Cdd:cd00116   237 GAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGA 295
LRR_8 pfam13855
Leucine rich repeat;
262-331 2.96e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.96e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 262 SSLRYLDVSCNKITHDGmvylADVLKSNTTLEVIDLSFNRIenagaNYLSETLTSHNRSLKALSVVSNNI 331
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD----DGAFKGLSNLKVLDLSNNLL-----TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
261-288 3.17e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.08  E-value: 3.17e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622904805  261 NSSLRYLDVSCNKITHDGMVYLADVLKS 288
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 133-405 7.61e-31

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 122.98  E-value: 7.61e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 133 NLLGDVGAYYAAKLVQKQLNLIYLnlMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINSSLEKL 212
Cdd:COG5238   164 RLGLLAAISMAKALQNNSVETVYL--GCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTL 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 213 DLGDCDLEESTVH-IGRMLKENHCLVVLHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTT 291
Cdd:COG5238   242 DLSNNQIGDEGVIaLAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKT 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 292 LEVIDLSFNRIENAGANYLSETLTShNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCVAYSDLI 371
Cdd:COG5238   322 LHTLNLAYNGIGAQGAIALAKALQE-NTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL 400

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1622904805 372 QMGRLKPDNTDVEPFVVDGRVYLAEVSNGLKKHY 405
Cdd:COG5238   401 QTNRLHTLILDGNLIGAEAQQRLEQLLERIKSVY 434
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 148-364 1.82e-29

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 116.69  E-value: 1.82e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 148 QKQLNLIYLNLMFNDIGPEGGELIaKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINS-SLEKLDLGDCDLE-ESTVH 225
Cdd:cd00116    78 TKGCGLQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEgASCEA 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 226 IGRMLKENHCLVVLHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENA 305
Cdd:cd00116   157 LAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDA 236

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622904805 306 GANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATC 364
Cdd:cd00116   237 GAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGA 295
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 128-346 2.91e-29

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 118.35  E-value: 2.91e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 128 LDVGYNLLGDVGAYYAAKLVQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINS 207
Cdd:COG5238   185 VYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNT 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 208 SLEKLDLGDCDLEESTV-HIGRMLKENHCLVVLHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVL 286
Cdd:COG5238   265 TVETLYLSGNQIGAEGAiALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKAL 344

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 287 KSNTTLEVIDLSFNRIENAGANYLSETLTShNRSLKALSVVSNNIEGEGLVALSQSMKTN 346
Cdd:COG5238   345 QENTTLHSLDLSDNQIGDEGAIALAKYLEG-NTTLRELNLGKNNIGKQGAEALIDALQTN 403
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 125-341 3.99e-29

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 117.97  E-value: 3.99e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 125 INGLDVGYNLLGDVGAYYAAKLVQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQ 204
Cdd:COG5238   210 VTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQ 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 205 INSSLEKLDLGDCDL-EESTVHIGRMLKENHCLVVLHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLA 283
Cdd:COG5238   290 GNTTLTSLDLSVNRIgDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALA 369

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622904805 284 DVLKSNTTLEVIDLSFNRIENAGANYLSETLtSHNRsLKALSVVSNNIEGEGLVALSQ 341
Cdd:COG5238   370 KYLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNR-LHTLILDGNLIGAEAQQRLEQ 425
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 128-329 1.06e-20

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 92.03  E-value: 1.06e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 128 LDVGYNLLGDVGAYYAAKLVQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINS 207
Cdd:cd00116   142 LVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLK 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 208 SLEKLDLGDCDleestvhigrmlkenhclvvlhmckhdIKNSGIQQLCDAL-YLNSSLRYLDVSCNKITHDGMVYLADVL 286
Cdd:cd00116   222 SLEVLNLGDNN---------------------------LTDAGAAALASALlSPNISLLTLSLSCNDITDDGAKDLAEVL 274

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1622904805 287 KSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSN 329
Cdd:cd00116   275 AEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 85-314 3.80e-20

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 92.16  E-value: 3.80e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805  85 KGLAAGITLNIAGNNrlvpverVTGEDFWILSRILKNCLYINGLDVGYNLLGDVGAYYAAKLVQKQLNLIYLNLMFNDIG 164
Cdd:COG5238   233 KGNKSLTTLDLSNNQ-------IGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIG 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 165 PEGGELIAKVLHKNQTLKYLRMTGNKIENKGGMSFAAMLQINSSLEKLDLgdcdleestvhigrmlkenhclvvlhmCKH 244
Cdd:COG5238   306 DEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDL---------------------------SDN 358

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 245 DIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNtTLEVIDLSFNRIENAGANYLSETL 314
Cdd:COG5238   359 QIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLIGAEAQQRLEQLL 427
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 212-372 1.96e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 80.99  E-value: 1.96e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 212 LDLGDCDLEESTVHIGRMLKENHCLVVLHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTT 291
Cdd:COG5238   158 LLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKS 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 292 LEVIDLSFNRIENAGANYLSETLTsHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCVAYSDLI 371
Cdd:COG5238   238 LTTLDLSNNQIGDEGVIALAEALK-NNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL 316


                  .
gi 1622904805 372 Q 372
Cdd:COG5238   317 Q 317
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 143-371 7.43e-16

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 78.17  E-value: 7.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 143 AAKLVQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIEN--KGGMSFAAMLQINSSLEKLDLGDCDLE 220
Cdd:cd00116    15 ATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRipRGLQSLLQGLTKGCGLQELDLSDNALG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 221 ESTVHIgrmlkenhclvvlhmckhdiknsgiqqlCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNT-TLEVIDLSF 299
Cdd:cd00116    95 PDGCGV----------------------------LESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGR 146

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622904805 300 NRIENAGANYLSETLtSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCVAYSDLI 371
Cdd:cd00116   147 NRLEGASCEALAKAL-RANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETL 217
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
58-332 1.28e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 1.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805  58 SNLCMEKSQKINPFILRILQEVDKEIKKGLAAGITLNIAGNNRLVPVERVTGEDFWILSRILKNCLYINGLDVGYNLLGD 137
Cdd:COG4886     3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 138 VGAYYAAKLVQKQLNLIYLNLMFNDIgpeggeliakvLHKNQTLKYLRMTGNKIEnkggmSFAAMLQINSSLEKLDLGDC 217
Cdd:COG4886    83 SLLLLGLTDLGDLTNLTELDLSGNEE-----------LSNLTNLESLDLSGNQLT-----DLPEELANLTNLKELDLSNN 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 218 DLEEstvhIGRMLKENHCLVVLhmckhDIKNSGIQQLCDALYLNSSLRYLDVSCNKIThdgmvYLADVLKSNTTLEVIDL 297
Cdd:COG4886   147 QLTD----LPEPLGNLTNLKSL-----DLSNNQLTDLPEELGNLTNLKELDLSNNQIT-----DLPEPLGNLTNLEELDL 212

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1622904805 298 SFNRIENaganyLSETLtSHNRSLKALSVVSNNIE 332
Cdd:COG4886   213 SGNQLTD-----LPEPL-ANLTNLETLDLSNNQLT 241
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 114-219 9.55e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 9.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 114 ILSRILKNCLYINGLDVGYNLLGDVGAYYAAK-LVQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNQTLKYLRMTGNKIE 192
Cdd:cd00116   212 ALAETLASLKSLEVLNLGDNNLTDAGAAALASaLLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFG 291

                          90       100
                  ....*....|....*....|....*...
gi 1622904805 193 NKG-GMSFAAMLQINSSLEKLDLGDCDL 219
Cdd:cd00116   292 EEGaQLLAESLLEPGNELESLWVKDDSF 319
LRR_8 pfam13855
Leucine rich repeat;
262-331 2.96e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.96e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 262 SSLRYLDVSCNKITHDGmvylADVLKSNTTLEVIDLSFNRIenagaNYLSETLTSHNRSLKALSVVSNNI 331
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD----DGAFKGLSNLKVLDLSNNLL-----TTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 235-302 1.28e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622904805 235 CLVVLhmckhDIKNSGIQQLCDALYLnSSLRYLDVSCNKIthDGMVYLADVLKSNTTLEVIDLSFNRI 302
Cdd:cd21340   121 SLRVL-----NISGNNIDSLEPLAPL-RNLEQLDASNNQI--SDLEELLDLLSSWPSLRELDLTGNPV 180
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
261-288 3.17e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.08  E-value: 3.17e-03
                           10        20
                   ....*....|....*....|....*...
gi 1622904805  261 NSSLRYLDVSCNKITHDGMVYLADVLKS 288
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
128-389 4.63e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.15  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 128 LDVGYNLLGDVGAYyAAKLVqkqlNLIYLNLMFNDIgpeggELIAKVLHKNQTLKYLRMTGNKIEnkggmSFAAMLQINS 207
Cdd:COG4886   164 LDLSNNQLTDLPEE-LGNLT----NLKELDLSNNQI-----TDLPEPLGNLTNLEELDLSGNQLT-----DLPEPLANLT 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 208 SLEKLDLGDCDLEeSTVHIGRMLKenhcLVVLhmckhDIKNSGIQQLCDALYLnSSLRYLDVSCNKITHDGMVYLADVLK 287
Cdd:COG4886   229 NLETLDLSNNQLT-DLPELGNLTN----LEEL-----DLSNNQLTDLPPLANL-TNLKTLDLSNNQLTDLKLKELELLLG 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622904805 288 SNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCVAY 367
Cdd:COG4886   298 LNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEA 377

                         250       260
                  ....*....|....*....|..
gi 1622904805 368 SDLIQMGRLKPDNTDVEPFVVD 389
Cdd:COG4886   378 TLLTLALLLLTLLLLLLTTTAG 399
LRR_6 pfam13516
Leucine Rich repeat;
177-200 5.61e-03

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 34.13  E-value: 5.61e-03
                          10        20
                  ....*....|....*....|....
gi 1622904805 177 KNQTLKYLRMTGNKIENKGGMSFA 200
Cdd:pfam13516   1 SNTHLTTLDLSDNDIGDEGAEALA 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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