NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622825254|ref|XP_028699454|]
View 

prospero homeobox protein 1 isoform X3 [Macaca mulatta]

Protein Classification

homeo-prospero domain-containing protein( domain architecture ID 141796)

homeo-prospero domain (HPD)-containing protein similar to Drosophila melanogaster homeobox protein prospero, a homeodomain protein that controls neuronal identity

CATH:  1.10.10.500
Gene Ontology:  GO:0003677|GO:0003700
PubMed:  12429095|15837198

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
HPD super family cl20287
Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is ...
579-667 1.28e-48

Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. homologs of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.


The actual alignment was detected with superfamily member pfam05044:

Pssm-ID: 461534  Cd Length: 154  Bit Score: 167.61  E-value: 1.28e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254 579 GLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVK----------------------------------------------- 611
Cdd:pfam05044   1 GLTPMHLKKAKLMFFYTRYPSSNVLKTYFPDVKfnrcntsqlikwfsnfrefyyiqmekfarqalsegvtdaedllvsrd 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622825254 612 ------------------VPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQ 667
Cdd:pfam05044  81 selfrvlnlhynknndfeVPDRFLEVVQLTLREFFNAIQAGKDSDPSWKKAIYKVICKLDSEVPEIFKSPNFLE 154
HEC1 super family cl34933
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
95-444 5.72e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG5185:

Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 43.02  E-value: 5.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254  95 QLLKNNMNKNGGT--------EPSFQASGLSSTG--SEVHQEDICSNSSRD---------SPPECLSPFGRPTMSQFDMD 155
Cdd:COG5185   170 QELNQNLKKLEIFgltlgllkGISELKKAEPSGTvnSIKESETGNLGSESTllekakeiiNIEEALKGFQDPESELEDLA 249
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254 156 RLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREE 235
Cdd:COG5185   250 QTSDKLEKLVEQNTDLRLEKLGENAESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLAAAEAEQELEE 329
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254 236 R------------RQLKQQLEDMQKQLRQLQEKFYQIYDSTD----SENDEDGNLSEDSMRSEILDARA----------- 288
Cdd:COG5185   330 SkretetgiqnltAEIEQGQESLTENLEAIKEEIENIVGEVElsksSEELDSFKDTIESTKESLDEIPQnqrgyaqeila 409
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254 289 --QDSVGRSDNEMCELDpGQfIDRARALIREQEMAENKPKREGNNKERDHGPNS---LQPEGKHLAETLKQELNTAMSQV 363
Cdd:COG5185   410 tlEDTLKAADRQIEELQ-RQ-IEQATSSNEEVSKLLNELISELNKVMREADEESqsrLEEAYDEINRSVRSKKEDLNEEL 487
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254 364 VDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPN--PLDTFGNVQMASSTDQTEALPL 441
Cdd:COG5185   488 TQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFMRARGYAHILALENliPASELIQASNAKTDGQAANLRT 567

                  ...
gi 1622825254 442 VVR 444
Cdd:COG5185   568 AVI 570
 
Name Accession Description Interval E-value
HPD pfam05044
Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is ...
579-667 1.28e-48

Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. homologs of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.


Pssm-ID: 461534  Cd Length: 154  Bit Score: 167.61  E-value: 1.28e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254 579 GLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVK----------------------------------------------- 611
Cdd:pfam05044   1 GLTPMHLKKAKLMFFYTRYPSSNVLKTYFPDVKfnrcntsqlikwfsnfrefyyiqmekfarqalsegvtdaedllvsrd 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622825254 612 ------------------VPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQ 667
Cdd:pfam05044  81 selfrvlnlhynknndfeVPDRFLEVVQLTLREFFNAIQAGKDSDPSWKKAIYKVICKLDSEVPEIFKSPNFLE 154
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
95-444 5.72e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 43.02  E-value: 5.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254  95 QLLKNNMNKNGGT--------EPSFQASGLSSTG--SEVHQEDICSNSSRD---------SPPECLSPFGRPTMSQFDMD 155
Cdd:COG5185   170 QELNQNLKKLEIFgltlgllkGISELKKAEPSGTvnSIKESETGNLGSESTllekakeiiNIEEALKGFQDPESELEDLA 249
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254 156 RLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREE 235
Cdd:COG5185   250 QTSDKLEKLVEQNTDLRLEKLGENAESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLAAAEAEQELEE 329
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254 236 R------------RQLKQQLEDMQKQLRQLQEKFYQIYDSTD----SENDEDGNLSEDSMRSEILDARA----------- 288
Cdd:COG5185   330 SkretetgiqnltAEIEQGQESLTENLEAIKEEIENIVGEVElsksSEELDSFKDTIESTKESLDEIPQnqrgyaqeila 409
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254 289 --QDSVGRSDNEMCELDpGQfIDRARALIREQEMAENKPKREGNNKERDHGPNS---LQPEGKHLAETLKQELNTAMSQV 363
Cdd:COG5185   410 tlEDTLKAADRQIEELQ-RQ-IEQATSSNEEVSKLLNELISELNKVMREADEESqsrLEEAYDEINRSVRSKKEDLNEEL 487
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254 364 VDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPN--PLDTFGNVQMASSTDQTEALPL 441
Cdd:COG5185   488 TQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFMRARGYAHILALENliPASELIQASNAKTDGQAANLRT 567

                  ...
gi 1622825254 442 VVR 444
Cdd:COG5185   568 AVI 570
 
Name Accession Description Interval E-value
HPD pfam05044
Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is ...
579-667 1.28e-48

Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. homologs of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.


Pssm-ID: 461534  Cd Length: 154  Bit Score: 167.61  E-value: 1.28e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254 579 GLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVK----------------------------------------------- 611
Cdd:pfam05044   1 GLTPMHLKKAKLMFFYTRYPSSNVLKTYFPDVKfnrcntsqlikwfsnfrefyyiqmekfarqalsegvtdaedllvsrd 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622825254 612 ------------------VPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQ 667
Cdd:pfam05044  81 selfrvlnlhynknndfeVPDRFLEVVQLTLREFFNAIQAGKDSDPSWKKAIYKVICKLDSEVPEIFKSPNFLE 154
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
95-444 5.72e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 43.02  E-value: 5.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254  95 QLLKNNMNKNGGT--------EPSFQASGLSSTG--SEVHQEDICSNSSRD---------SPPECLSPFGRPTMSQFDMD 155
Cdd:COG5185   170 QELNQNLKKLEIFgltlgllkGISELKKAEPSGTvnSIKESETGNLGSESTllekakeiiNIEEALKGFQDPESELEDLA 249
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254 156 RLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREE 235
Cdd:COG5185   250 QTSDKLEKLVEQNTDLRLEKLGENAESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLAAAEAEQELEE 329
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254 236 R------------RQLKQQLEDMQKQLRQLQEKFYQIYDSTD----SENDEDGNLSEDSMRSEILDARA----------- 288
Cdd:COG5185   330 SkretetgiqnltAEIEQGQESLTENLEAIKEEIENIVGEVElsksSEELDSFKDTIESTKESLDEIPQnqrgyaqeila 409
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254 289 --QDSVGRSDNEMCELDpGQfIDRARALIREQEMAENKPKREGNNKERDHGPNS---LQPEGKHLAETLKQELNTAMSQV 363
Cdd:COG5185   410 tlEDTLKAADRQIEELQ-RQ-IEQATSSNEEVSKLLNELISELNKVMREADEESqsrLEEAYDEINRSVRSKKEDLNEEL 487
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825254 364 VDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPN--PLDTFGNVQMASSTDQTEALPL 441
Cdd:COG5185   488 TQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFMRARGYAHILALENliPASELIQASNAKTDGQAANLRT 567

                  ...
gi 1622825254 442 VVR 444
Cdd:COG5185   568 AVI 570
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
225-289 7.51e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 39.61  E-value: 7.51e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622825254 225 VSARKEQKREERRQLKQQLEDMQKQLRQLQEK---FYQIYDSTDSENDEDGNLSE-DSMRSEILDARAQ 289
Cdd:COG3206   166 LELRREEARKALEFLEEQLPELRKELEEAEAAleeFRQKNGLVDLSEEAKLLLQQlSELESQLAEARAE 234
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH