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Conserved domains on  [gi|1622825215|ref|XP_028699343|]
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arginine-glutamic acid dipeptide repeats protein isoform X3 [Macaca mulatta]

Protein Classification

atrophin-1 family protein( domain architecture ID 1002132)

atrophin-1 family protein similar to Homo sapiens atrophin-1 which acts as a transcriptional corepressor that recruits NR2E1 to repress transcription

Gene Ontology:  GO:0140110|GO:0005515

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 14-1011 0e+00

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 1006.60  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   14 GKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSGKKVKEEASSPLKST 93
Cdd:pfam03154    1 GKHSMRTRRSRGSMSTLRSGRKKQTASPDGRASPTNEDLRSSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   94 KRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 173
Cdd:pfam03154   81 KRQREKGASDTEEPERATAKKSKTQEISRPNSPSEGEGESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  174 SAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTAPvpHTHIQQAPALH 253
Cdd:pfam03154  161 SAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAP--HTLIQQTPTLH 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  254 PQRPPSPHPPPHPSPHPPLQPltgsagQPSAPSHAQPTLHGQGPPGPHSLQTGP-LLQHPGPPQPFGLPPQASQGQAPLG 332
Cdd:pfam03154  239 PQRLPSPHPPLQPMTQPPPPS------QVSPQPLPQPSLHGQMPPMPHSLQTGPsHMQHPVPPQPFPLTPQSSQSQVPPG 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  333 TSPAAAHP-HTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPP 411
Cdd:pfam03154  313 PSPAAPGQsQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPP 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  412 PPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTG-LHQVAPQPPFAQHPFVPGGP 490
Cdd:pfam03154  393 PPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSgLHQVPSQSPFPQHPFVPGGP 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  491 PPITPPTCPSTSTPPAGPGTsaQPPCSAAVASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTP 570
Cdd:pfam03154  473 PPITPPSGPPTSTSSAMPGI--QPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTP 550

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  571 SHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAER 650
Cdd:pfam03154  551 SHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEALEKAKREAEQKAREEKEREKEKEKEREREREREREAER 630

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  651 AAKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDPL 730
Cdd:pfam03154  631 AAKASSSSHEGRMGDPQLAGPAHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFFVPLNPTDPL 710

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  731 LAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPAANPMEHFARHSALTIPPTAGPHPF 810
Cdd:pfam03154  711 LAYHMPGLYNVDPAIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPATNPMEHFARHGALTLPPMAGPHPF 790

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  811 ASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPL 890
Cdd:pfam03154  791 ASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERLHAERMASLTNDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPL 870

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  891 HQGSAGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQS 970
Cdd:pfam03154  871 HQGSGGPVHPLVDPLAAGPHLARFPYPPGAIPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGGLPPPMSAAHQLQAMHAQS 950

                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|.
gi 1622825215  971 AELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQ 1011
Cdd:pfam03154  951 AELQRLAMEQQWLHGHPHMHGGHLPGQEDYYSRLKKESDKQ 991
 
Name Accession Description Interval E-value
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 14-1011 0e+00

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 1006.60  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   14 GKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSGKKVKEEASSPLKST 93
Cdd:pfam03154    1 GKHSMRTRRSRGSMSTLRSGRKKQTASPDGRASPTNEDLRSSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   94 KRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 173
Cdd:pfam03154   81 KRQREKGASDTEEPERATAKKSKTQEISRPNSPSEGEGESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  174 SAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTAPvpHTHIQQAPALH 253
Cdd:pfam03154  161 SAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAP--HTLIQQTPTLH 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  254 PQRPPSPHPPPHPSPHPPLQPltgsagQPSAPSHAQPTLHGQGPPGPHSLQTGP-LLQHPGPPQPFGLPPQASQGQAPLG 332
Cdd:pfam03154  239 PQRLPSPHPPLQPMTQPPPPS------QVSPQPLPQPSLHGQMPPMPHSLQTGPsHMQHPVPPQPFPLTPQSSQSQVPPG 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  333 TSPAAAHP-HTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPP 411
Cdd:pfam03154  313 PSPAAPGQsQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPP 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  412 PPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTG-LHQVAPQPPFAQHPFVPGGP 490
Cdd:pfam03154  393 PPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSgLHQVPSQSPFPQHPFVPGGP 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  491 PPITPPTCPSTSTPPAGPGTsaQPPCSAAVASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTP 570
Cdd:pfam03154  473 PPITPPSGPPTSTSSAMPGI--QPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTP 550

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  571 SHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAER 650
Cdd:pfam03154  551 SHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEALEKAKREAEQKAREEKEREKEKEKEREREREREREAER 630

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  651 AAKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDPL 730
Cdd:pfam03154  631 AAKASSSSHEGRMGDPQLAGPAHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFFVPLNPTDPL 710

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  731 LAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPAANPMEHFARHSALTIPPTAGPHPF 810
Cdd:pfam03154  711 LAYHMPGLYNVDPAIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPATNPMEHFARHGALTLPPMAGPHPF 790

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  811 ASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPL 890
Cdd:pfam03154  791 ASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERLHAERMASLTNDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPL 870

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  891 HQGSAGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQS 970
Cdd:pfam03154  871 HQGSGGPVHPLVDPLAAGPHLARFPYPPGAIPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGGLPPPMSAAHQLQAMHAQS 950

                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|.
gi 1622825215  971 AELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQ 1011
Cdd:pfam03154  951 AELQRLAMEQQWLHGHPHMHGGHLPGQEDYYSRLKKESDKQ 991
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 36-175 2.70e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 54.92  E-value: 2.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   36 KQPASPdGRTSPINEDIRS---SGRNSPSAASTSSNDSKAETVKKSGKKVKEEASSPLKSTKRQREKVASDTEEADRTSS 112
Cdd:NF033609   546 EQPDEP-GEIEPIPEDSDSdpgSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDS 624

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622825215  113 KKTKTQEiSRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 175
Cdd:NF033609   625 ASDSDSA-SDSDSASDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 686
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 182-362 4.05e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 54.22  E-value: 4.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  182 AQPPALQAPTGVTPAPSSAPPGTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPH 261
Cdd:PRK07764   595 AGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAG 674

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  262 PPPHPSPHPPLQPLTGSAGQPSAPSHAQPTLHGQGPPGPHSlqtGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAA--AH 339
Cdd:PRK07764   675 GAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQAD---DPAAQPPQAAQGASAPSPAADDPVPLPPEPDDppDP 751

                          170       180
                   ....*....|....*....|...
gi 1622825215  340 PHTSLQLPASQSALQSQQPPREQ 362
Cdd:PRK07764   752 AGAPAQPPPPPAPAPAAAPAAAP 774
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 3-175 4.23e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 51.06  E-value: 4.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215    3 KPVKEEDDGLSGKHS--MRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSGK 80
Cdd:NF033609   555 EPIPEDSDSDPGSDSgsDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDS 634

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   81 KVKEEASSPLKSTKRQREKVASDTE-EADRTSSKKTKTQEISRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTS 158
Cdd:NF033609   635 DSASDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDS 714

                          170
                   ....*....|....*..
gi 1622825215  159 PSiPSPQDNESDSDSSA 175
Cdd:NF033609   715 DS-DSDSDSDSDSDSDS 730
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 3-250 1.21e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 49.24  E-value: 1.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215    3 KPVKEEDDGLSGKHSMRTRRSRGSMStlrsgrkkQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKsgkkv 82
Cdd:NF033838   246 KEAVEKNVATSEQDKPKRRAKRGVLG--------EPATPDKKENDAKSSDSSVGEETLPSPSLKPEKKVAEAEKK----- 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   83 KEEAssplkstkrqrEKVASDTEEADR----TSSKKTKTQEISRPNSP-SEGE-----GESSDSRsvNDEGSSDPKDIDQ 152
Cdd:NF033838   313 VEEA-----------KKKAKDQKEEDRrnypTNTYKTLELEIAESDVKvKEAElelvkEEAKEPR--NEEKIKQAKAKVE 379

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  153 DNRSTSPSIPSPQDNESDSDSSAQQQMlqaqppALQAPTGVTPAPSSAPPGTPQLPAPGPMPSATAVPPQGSPTASQAPN 232
Cdd:NF033838   380 SKKAEATRLEKIKTDRKKAEEEAKRKA------AEEDKVKEKPAEQPQPAPAPQPEKPAPKPEKPAEQPKAEKPADQQAE 453

                          250
                   ....*....|....*....
gi 1622825215  233 QPQAPTAP-VPHTHIQQAP 250
Cdd:NF033838   454 EDYARRSEeEYNRLTQQQP 472
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 26-175 1.36e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 46.06  E-value: 1.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   26 SMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSGKKVKEEASSPLKSTKRQREKVASDTE 105
Cdd:NF033609   606 SASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 685

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622825215  106 -EADRTSSKKTKTQEISRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 175
Cdd:NF033609   686 sDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 756
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 26-175 2.39e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 45.29  E-value: 2.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   26 SMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSGKKVKEEASSPLKSTKRQREKVASDTE 105
Cdd:NF033609   630 SASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 709

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622825215  106 -EADRTSSKKTKTQEISRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 175
Cdd:NF033609   710 sDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 780
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 46-244 2.43e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 45.29  E-value: 2.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   46 SPINEDIRSSGRNSPSAASTSSNDSKAETVKKSGKKVKEEASSPLKSTKRQREKVASDTE-EADRTSSKKTKTQEISRPN 124
Cdd:NF033609   714 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSD 793

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  125 SPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSAQQQMLQAQPPALQAPTGvtpapSSAPPG 203
Cdd:NF033609   794 SDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSESDSN-----SDSESG 867

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622825215  204 TpqlpapgpmpSATAVPPQGSPTASQAPNQPQAPTA--PVPHT 244
Cdd:NF033609   868 S----------NNNVVPPNSPKNGTNASNKNEAKDSkePLPDT 900
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 26-175 4.67e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 44.13  E-value: 4.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   26 SMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSGKKVKEEASSPLKSTKRQREKVASDTE 105
Cdd:NF033609   648 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 727

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622825215  106 ---EADRTSSKKTKTQEISRPNSPSEGEGES---SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 175
Cdd:NF033609   728 sdsDSDSDSDSDSDSDSDSDSDSDSDSDSDSdsdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 802
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 202-362 4.89e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 40.56  E-value: 4.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  202 PGTPQLPAPGPMPSATAVPPQGSPtasqapnQPQAPTAPVPHTHIQQAPalhpqrppsphppphpsphpplqplTGSAGQ 281
Cdd:TIGR01628  380 PRMRQLPMGSPMGGAMGQPPYYGQ-------GPQQQFNGQPLGWPRMSM-------------------------MPTPMG 427

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  282 PSAPSHAQ--PTLHGQGPPGPHSLQtgplLQHPGPPQPFGLPPQASQGQAPLGTSPAAAHPHTSLQLPASQSALQSqQPP 359
Cdd:TIGR01628  428 PGGPLRPNglAPMNAVRAPSRNAQN----AAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLAS-ATP 502


                   ...
gi 1622825215  360 REQ 362
Cdd:TIGR01628  503 QMQ 505
COG5373 COG5373
Uncharacterized membrane protein [Function unknown];
174-251 5.98e-03

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444140 [Multi-domain]  Cd Length: 854  Bit Score: 40.75  E-value: 5.98e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622825215  174 SAQQQMLQAQPPAlqAPTGVTPAPSSAPPGTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTAPVPhthiQQAPA 251
Cdd:COG5373     31 EELEAELAEAAEA--ASAPAEPEPEAAAAATAAAPEAAPAPVPEAPAAPPAAAEAPAPAAAAPPAEAEP----AAAPA 102
 
Name Accession Description Interval E-value
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 14-1011 0e+00

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 1006.60  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   14 GKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSGKKVKEEASSPLKST 93
Cdd:pfam03154    1 GKHSMRTRRSRGSMSTLRSGRKKQTASPDGRASPTNEDLRSSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   94 KRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 173
Cdd:pfam03154   81 KRQREKGASDTEEPERATAKKSKTQEISRPNSPSEGEGESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  174 SAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTAPvpHTHIQQAPALH 253
Cdd:pfam03154  161 SAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAP--HTLIQQTPTLH 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  254 PQRPPSPHPPPHPSPHPPLQPltgsagQPSAPSHAQPTLHGQGPPGPHSLQTGP-LLQHPGPPQPFGLPPQASQGQAPLG 332
Cdd:pfam03154  239 PQRLPSPHPPLQPMTQPPPPS------QVSPQPLPQPSLHGQMPPMPHSLQTGPsHMQHPVPPQPFPLTPQSSQSQVPPG 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  333 TSPAAAHP-HTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPP 411
Cdd:pfam03154  313 PSPAAPGQsQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPP 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  412 PPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTG-LHQVAPQPPFAQHPFVPGGP 490
Cdd:pfam03154  393 PPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSgLHQVPSQSPFPQHPFVPGGP 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  491 PPITPPTCPSTSTPPAGPGTsaQPPCSAAVASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTP 570
Cdd:pfam03154  473 PPITPPSGPPTSTSSAMPGI--QPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTP 550

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  571 SHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAER 650
Cdd:pfam03154  551 SHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEALEKAKREAEQKAREEKEREKEKEKEREREREREREAER 630

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  651 AAKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDPL 730
Cdd:pfam03154  631 AAKASSSSHEGRMGDPQLAGPAHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFFVPLNPTDPL 710

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  731 LAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPAANPMEHFARHSALTIPPTAGPHPF 810
Cdd:pfam03154  711 LAYHMPGLYNVDPAIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPATNPMEHFARHGALTLPPMAGPHPF 790

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  811 ASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPL 890
Cdd:pfam03154  791 ASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERLHAERMASLTNDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPL 870

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  891 HQGSAGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQS 970
Cdd:pfam03154  871 HQGSGGPVHPLVDPLAAGPHLARFPYPPGAIPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGGLPPPMSAAHQLQAMHAQS 950

                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|.
gi 1622825215  971 AELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQ 1011
Cdd:pfam03154  951 AELQRLAMEQQWLHGHPHMHGGHLPGQEDYYSRLKKESDKQ 991
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 36-175 2.70e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 54.92  E-value: 2.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   36 KQPASPdGRTSPINEDIRS---SGRNSPSAASTSSNDSKAETVKKSGKKVKEEASSPLKSTKRQREKVASDTEEADRTSS 112
Cdd:NF033609   546 EQPDEP-GEIEPIPEDSDSdpgSDSGSDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDS 624

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622825215  113 KKTKTQEiSRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 175
Cdd:NF033609   625 ASDSDSA-SDSDSASDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 686
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 192-401 3.56e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 54.27  E-value: 3.56e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  192 GVTPAPSSAPPGTPQLPA-PGPMPSAT-----------AVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPalhpqrpps 259
Cdd:pfam09770  164 GVAPKKAAAPAPAPQPAAqPASLPAPSrkmmsleeveaAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQ--------- 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  260 phppphpsphpPLQPLTGSAGQPSAPSHAQPTLHGQGPPgPHSLQtGPLLQHPGPPQPFGLPPQASQGQAPlgtSPAAAH 339
Cdd:pfam09770  235 -----------QFPPQIQQQQQPQQQPQQPQQHPGQGHP-VTILQ-RPQSPQPDPAQPSIQPQAQQFHQQP---PPVPVQ 298

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622825215  340 PHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHikppPTTPIPQLPAPQAHKHPPHLSGPS 401
Cdd:pfam09770  299 PTQILQNPNRLSAARVGYPQNPQPGVQPAPAHQA----HRQQGSFGRQAPIITHPQQLAQLS 356
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 182-362 4.05e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 54.22  E-value: 4.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  182 AQPPALQAPTGVTPAPSSAPPGTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPH 261
Cdd:PRK07764   595 AGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAG 674

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  262 PPPHPSPHPPLQPLTGSAGQPSAPSHAQPTLHGQGPPGPHSlqtGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAA--AH 339
Cdd:PRK07764   675 GAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQAD---DPAAQPPQAAQGASAPSPAADDPVPLPPEPDDppDP 751

                          170       180
                   ....*....|....*....|...
gi 1622825215  340 PHTSLQLPASQSALQSQQPPREQ 362
Cdd:PRK07764   752 AGAPAQPPPPPAPAPAAAPAAAP 774
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 184-352 1.49e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 52.35  E-value: 1.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  184 PPALQAPTGVTPAPSSAPPGTPQLP----------------APGPMPSATAVPPQgSPTASQAPNQPQAPTAPVPHTHIQ 247
Cdd:pfam09770  166 APKKAAAPAPAPQPAAQPASLPAPSrkmmsleeveaamraqAKKPAQQPAPAPAQ-PPAAPPAQQAQQQQQFPPQIQQQQ 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  248 QAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPTLHGQGPPGPHSLQ-----------------TGPLLQ 310
Cdd:pfam09770  245 QPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQilqnpnrlsaarvgypqNPQPGV 324

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1622825215  311 HPGPPQPfGLPPQASQGQAPlgtsPAAAHPHTSLQLPASQSA 352
Cdd:pfam09770  325 QPAPAHQ-AHRQQGSFGRQA----PIITHPQQLAQLSEEEKA 361
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 3-175 4.23e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 51.06  E-value: 4.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215    3 KPVKEEDDGLSGKHS--MRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSGK 80
Cdd:NF033609   555 EPIPEDSDSDPGSDSgsDSSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDS 634

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   81 KVKEEASSPLKSTKRQREKVASDTE-EADRTSSKKTKTQEISRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTS 158
Cdd:NF033609   635 DSASDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDS 714

                          170
                   ....*....|....*..
gi 1622825215  159 PSiPSPQDNESDSDSSA 175
Cdd:NF033609   715 DS-DSDSDSDSDSDSDS 730
PHA03247 PHA03247
large tegument protein UL36; Provisional
 60-450 5.91e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 5.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   60 PSAASTSSNDSKAETVKKSGKKVKEEASSPLKSTKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSV 139
Cdd:PHA03247  2560 PPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPD 2639

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  140 NDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQA-QPPALQAPTG-VTPAPSSAPPGTPQLPAPGPMPSAT 217
Cdd:PHA03247  2640 PHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRpRRRAARPTVGsLTSLADPPPPPPTPEPAPHALVSAT 2719

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  218 AVPP------QGSPTASQAPNQPQAPTAPV-PHTHIQQAPALHPQRPPSPHPP-----PHPSPHPPLQPLTGSAGQPSAP 285
Cdd:PHA03247  2720 PLPPgpaaarQASPALPAAPAPPAVPAGPAtPGGPARPARPPTTAGPPAPAPPaapaaGPPRRLTRPAVASLSESRESLP 2799

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  286 SHAQPTLHGQGPPGPHSlqTGPLLQHPGPPQPfglPPQASQGQAPLGTSPAAAHPHTSLQLPASQSALQSQQPPReqPLP 365
Cdd:PHA03247  2800 SPWDPADPPAAVLAPAA--ALPPAASPAGPLP---PPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSR--SPA 2872

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  366 PAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPS 445
Cdd:PHA03247  2873 AKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGA 2952


                   ....*
gi 1622825215  446 SPAQP 450
Cdd:PHA03247  2953 GEPSG 2957
PHA03247 PHA03247
large tegument protein UL36; Provisional
 22-489 6.77e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 6.77e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   22 RSRGSMSTLRSGRKKQPASPDGRTSPINE--DIRSSGRNSPSAASTSSNDSKAETVKKSGKKVKEEASSPLKSTKRQREK 99
Cdd:PHA03247  2576 RPSEPAVTSRARRPDAPPQSARPRAPVDDrgDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD 2655

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  100 VASDTEEADRTSSKKTKTqeiSRPNSPSEGEGESSDSRSVNDEGSS-----DPKDIDQDNRSTSPSIPSPQDNESDSDSS 174
Cdd:PHA03247  2656 PAPGRVSRPRRARRLGRA---AQASSPPQRPRRRAARPTVGSLTSLadpppPPPTPEPAPHALVSATPLPPGPAAARQAS 2732

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  175 AQQQMLQAQPPALQAP-TGVTPAPSSAPPGTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTAPVPhthiqQAPALH 253
Cdd:PHA03247  2733 PALPAAPAPPAVPAGPaTPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSP-----WDPADP 2807

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  254 PQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPTLHGQGPPGPHSLQTGPLLQHPGPPQPFGLPPQASQGQAPLGT 333
Cdd:PHA03247  2808 PAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLA 2887

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  334 SPAAAHPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQA-HKHPPHLSGPSPFSMN------ 406
Cdd:PHA03247  2888 RPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLApTTDPAGAGEPSGAVPQpwlgal 2967

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  407 -----------ANLPPPPALKPLSSLSTHHPPSAH-----PPPLQLMPQSQPLPSSPAQ----PPGLTQSQNLPPPPASH 466
Cdd:PHA03247  2968 vpgrvavprfrVPQPAPSREAPASSTPPLTGHSLSrvsswASSLALHEETDPPPVSLKQtlwpPDDTEDSDADSLFDSDS 3047

                          490       500
                   ....*....|....*....|...
gi 1622825215  467 PPTGLHQVAPQPPFAQHPFVPGG 489
Cdd:PHA03247  3048 ERSDLEALDPLPPEPHDPFAHEP 3070
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 3-250 1.21e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 49.24  E-value: 1.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215    3 KPVKEEDDGLSGKHSMRTRRSRGSMStlrsgrkkQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKsgkkv 82
Cdd:NF033838   246 KEAVEKNVATSEQDKPKRRAKRGVLG--------EPATPDKKENDAKSSDSSVGEETLPSPSLKPEKKVAEAEKK----- 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   83 KEEAssplkstkrqrEKVASDTEEADR----TSSKKTKTQEISRPNSP-SEGE-----GESSDSRsvNDEGSSDPKDIDQ 152
Cdd:NF033838   313 VEEA-----------KKKAKDQKEEDRrnypTNTYKTLELEIAESDVKvKEAElelvkEEAKEPR--NEEKIKQAKAKVE 379

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  153 DNRSTSPSIPSPQDNESDSDSSAQQQMlqaqppALQAPTGVTPAPSSAPPGTPQLPAPGPMPSATAVPPQGSPTASQAPN 232
Cdd:NF033838   380 SKKAEATRLEKIKTDRKKAEEEAKRKA------AEEDKVKEKPAEQPQPAPAPQPEKPAPKPEKPAEQPKAEKPADQQAE 453

                          250
                   ....*....|....*....
gi 1622825215  233 QPQAPTAP-VPHTHIQQAP 250
Cdd:NF033838   454 EDYARRSEeEYNRLTQQQP 472
PHA03247 PHA03247
large tegument protein UL36; Provisional
 154-547 2.54e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  154 NRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGvtpaPSSAPPGTPQlpaPGPMPSATAVPPQGSPTASQAPNQ 233
Cdd:PHA03247  2565 DRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVD----DRGDPRGPAP---PSPLPPDTHAPDPPPPSPSPAANE 2637

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  234 PQAPTApvphthiqqAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQP----------TLHGQGPPGPHSL 303
Cdd:PHA03247  2638 PDPHPP---------PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRraarptvgslTSLADPPPPPPTP 2708

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  304 QTGPLLQHPGPPQPFGlPPQASQGQAPLGTSPAAAHPHTSLQLPASQSAlqsqqPPREQPLPPAPLAMPHIKPPPTTPIP 383
Cdd:PHA03247  2709 EPAPHALVSATPLPPG-PAAARQASPALPAAPAPPAVPAGPATPGGPAR-----PARPPTTAGPPAPAPPAAPAAGPPRR 2782

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  384 QLPAPQAHKHPPHLSGPSPfSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPgLTQSQNLPPPP 463
Cdd:PHA03247  2783 LTRPAVASLSESRESLPSP-WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPS-LPLGGSVAPGG 2860

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  464 ASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPgtsAQPPCSAAVASGGSIAGGSSCPLPTVQIKEEA 543
Cdd:PHA03247  2861 DVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP---ERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937


                   ....
gi 1622825215  544 LDDA 547
Cdd:PHA03247  2938 RPQP 2941
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 156-338 2.87e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.06  E-value: 2.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  156 STSPSIPSPQDNESDSDSSAQQQM-LQAQPPALQAPTGVTPAPSSAPPGTPQLPAPGPMPSATaVPPQGSPTASQAPNQP 234
Cdd:PRK07764   603 PASSGPPEEAARPAAPAAPAAPAApAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDG-GDGWPAKAGGAAPAAP 681

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  235 QAPTAPVPhthiQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPTLHGQGPPGPHSLQTGPLLQHPGP 314
Cdd:PRK07764   682 PPAPAPAA----PAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQ 757

                          170       180
                   ....*....|....*....|....
gi 1622825215  315 PQPFGLPPQASQGQAPLGTSPAAA 338
Cdd:PRK07764   758 PPPPPAPAPAAAPAAAPPPSPPSE 781
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 106-290 3.02e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.06  E-value: 3.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  106 EADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPP 185
Cdd:PRK07764   598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA 677

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  186 ALQAPTGVTPAPSSAPPGTPQlPAPGPMPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPH 265
Cdd:PRK07764   678 PAAPPPAPAPAAPAAPAGAAP-AQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPA 756

                          170       180
                   ....*....|....*....|....*
gi 1622825215  266 PSPHPPLQPLTGSAGQPSAPSHAQP 290
Cdd:PRK07764   757 QPPPPPAPAPAAAPAAAPPPSPPSE 781
PLN02967 PLN02967
kinase
 4-133 5.45e-05

kinase


Pssm-ID: 215521 [Multi-domain]  Cd Length: 581  Bit Score: 46.96  E-value: 5.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215    4 PVKEEDDGLSGKHSMRTRRSRgsmstlRSGRKKQPASPDGRTSPINEDIRssgrNSPSAASTSSNDSKAETVKK---SGK 80
Cdd:PLN02967    57 AVDEEPDENGAVSKKKPTRSV------KRATKKTVVEISEPLEEGSELVV----NEDAALDKESKKTPRRTRRKaaaASS 126

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622825215   81 KVKEEASSPLKSTKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGES 133
Cdd:PLN02967   127 DVEEEKTEKKVRKRRKVKKMDEDVEDQGSESEVSDVEESEFVTSLENESEEEL 179
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 179-356 7.93e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 46.63  E-value: 7.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  179 MLQAQPPAlqAPTGVTPAPSSAP-PGTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPAlhpqrp 257
Cdd:PRK14951   361 LLAFKPAA--AAEAAAPAEKKTPaRPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAA------ 432

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  258 psphppphPSPHPPLQPLTGSAGQPSAPSHAQP---TLHGQGPPGPHSLQTGPllqHPGPPQPFGLPPQASQGQAPLGTS 334
Cdd:PRK14951   433 --------APAAAPAAAPAAVALAPAPPAQAAPetvAIPVRVAPEPAVASAAP---APAAAPAAARLTPTEEGDVWHATV 501

                          170       180
                   ....*....|....*....|....
gi 1622825215  335 P--AAAHPHTSLqlpASQSALQSQ 356
Cdd:PRK14951   502 QqlAAAEAITAL---ARELALQSE 522
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 162-340 1.09e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 1.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  162 PSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTAPV 241
Cdd:PRK07764   597 GEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGA 676

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  242 PHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLtgSAGQPSAPSHAQPTLHGQGPPGPHSLQTGPLLQHPG-PPQPFGL 320
Cdd:PRK07764   677 APAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPP--AGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDdPPDPAGA 754

                          170       180
                   ....*....|....*....|
gi 1622825215  321 PPQASQGQAPLGTSPAAAHP 340
Cdd:PRK07764   755 PAQPPPPPAPAPAAAPAAAP 774
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 26-175 1.36e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 46.06  E-value: 1.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   26 SMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSGKKVKEEASSPLKSTKRQREKVASDTE 105
Cdd:NF033609   606 SASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 685

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622825215  106 -EADRTSSKKTKTQEISRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 175
Cdd:NF033609   686 sDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 756
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 206-459 2.36e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.03  E-value: 2.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  206 QLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTAPV-----------PHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQP 274
Cdd:pfam09770  105 QQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVrtgyekykepePIPDLQVDASLWGVAPKKAAAPAPAPQPAAQPA 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  275 LTGSAG---------------QPSAPSHAQPTLHgQGPPGPHSLQTGPLLQHPGPPQPFGLPPQASQGQAPLGtsPAAAH 339
Cdd:pfam09770  185 SLPAPSrkmmsleeveaamraQAKKPAQQPAPAP-AQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQH--PGQGH 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  340 PHTSLQLPASQSALQSQQPPREQplppaplamphikpppttpipqlpaPQAHKHPPHLSGPSPFSMNANLPPPPALKPLs 419
Cdd:pfam09770  262 PVTILQRPQSPQPDPAQPSIQPQ-------------------------AQQFHQQPPPVPVQPTQILQNPNRLSAARVG- 315

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 1622825215  420 sLSTHHPPSAHPPPLQLMPQSQplPSSPAQPPGLTQSQNL 459
Cdd:pfam09770  316 -YPQNPQPGVQPAPAHQAHRQQ--GSFGRQAPIITHPQQL 352
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 26-175 2.39e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 45.29  E-value: 2.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   26 SMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSGKKVKEEASSPLKSTKRQREKVASDTE 105
Cdd:NF033609   630 SASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 709

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622825215  106 -EADRTSSKKTKTQEISRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 175
Cdd:NF033609   710 sDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 780
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 46-244 2.43e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 45.29  E-value: 2.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   46 SPINEDIRSSGRNSPSAASTSSNDSKAETVKKSGKKVKEEASSPLKSTKRQREKVASDTE-EADRTSSKKTKTQEISRPN 124
Cdd:NF033609   714 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSD 793

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  125 SPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSAQQQMLQAQPPALQAPTGvtpapSSAPPG 203
Cdd:NF033609   794 SDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSESDSN-----SDSESG 867

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622825215  204 TpqlpapgpmpSATAVPPQGSPTASQAPNQPQAPTA--PVPHT 244
Cdd:NF033609   868 S----------NNNVVPPNSPKNGTNASNKNEAKDSkePLPDT 900
PRK13042 PRK13042
superantigen-like protein SSL4; Reviewed;
156-242 2.65e-04

superantigen-like protein SSL4; Reviewed;


Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 44.24  E-value: 2.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  156 STSPSIPSPQDNESDSDSSAQQQMLQAQPPALQaPTGVTPAPSSAPPGTPQLPAPGPMPSATaVPPQGSPTASQAPNQPQ 235
Cdd:PRK13042    17 TTGVITTTTQAANATTPSSTKVEAPQSTPPSTK-VEAPQSKPNATTPPSTKVEAPQQTPNAT-TPSSTKVETPQSPTTKQ 94


                   ....*..
gi 1622825215  236 APTAPVP 242
Cdd:PRK13042    95 VPTEINP 101
PRK10856 PRK10856
cytoskeleton protein RodZ;
132-236 2.86e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 44.25  E-value: 2.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  132 ESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPAPG 211
Cdd:PRK10856   149 QSSAELSQNSGQSVPLDTSTTTDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPAAP 228

                           90       100
                   ....*....|....*....|....*
gi 1622825215  212 PMPSATAVPPQGSPTASQAPNQPQA 236
Cdd:PRK10856   229 ATPDGAAPLPTDQAGVSTPAADPNA 253
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 193-400 3.39e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.59  E-value: 3.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  193 VTPAPSSAPPGTPQLPAPGPMPsatavPPQGSPTASQAPNQPQAPTAPVPHThiqqAPALHPQRPPSPHPPPHPSPHPPL 272
Cdd:PRK07764   588 VGPAPGAAGGEGPPAPASSGPP-----EEAARPAAPAAPAAPAAPAPAGAAA----APAEASAAPAPGVAAPEHHPKHVA 658

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  273 QPLTGSAGQPSAPSHAQPTLHGQGPPGPHSLQTGPLLQHPGPPQPfGLPPQASQGQAPLGTSPAAAHPHTSLQLPASQSA 352
Cdd:PRK07764   659 VPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAP-APAATPPAGQADDPAAQPPQAAQGASAPSPAADD 737

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1622825215  353 lqsQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGP 400
Cdd:PRK07764   738 ---PVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEE 782
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 132-243 4.04e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 44.69  E-value: 4.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  132 ESSDSRSVNDEGSSDP---KDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLP 208
Cdd:PRK10263   728 EFSPMKALLDDGPHEPlftPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQP 807

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1622825215  209 APGPMPSATAVPPQGSPTASQAPNQPQAPTAPVPH 243
Cdd:PRK10263   808 QQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ 842
SEEEED pfam14797
Serine-rich region of AP3B1, clathrin-adaptor complex; This short low-complexity, highly ...
 63-174 4.11e-04

Serine-rich region of AP3B1, clathrin-adaptor complex; This short low-complexity, highly serine-rich region lies on clathrin-adaptor complex 3 beta-1 subunit proteins, between family Adaptin_N, pfam01602 and a C-terminal domain, AP3B1_C,pfam14796.


Pssm-ID: 434218 [Multi-domain]  Cd Length: 111  Bit Score: 41.07  E-value: 4.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   63 ASTSSNDSKAETVKKSGKKVKEEASSplkstkrqrekvasdtEEADRTSSKKTKTQeisrpnSPSEGEGESSDSRSVNDE 142
Cdd:pfam14797   15 SSDSSSDSESESGSESEEEGKEGSSS----------------EDSSEDSSSEQESE------SGSESEKKRTAKRNSKAK 72

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1622825215  143 GSSDPKDIDQDNRSTSPSIPSPQDNESDSDSS 174
Cdd:pfam14797   73 GKSDSEDGEKKNEKSKTSDSSDTESSSSEESS 104
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 1-154 4.18e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 44.65  E-value: 4.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215    1 MFKPVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSGK 80
Cdd:PTZ00108  1236 KKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVKKRLE 1315

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622825215   81 KVKEEASSPLKSTKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEgESSDSRSVNDEGSSDPKDIDQDN 154
Cdd:PTZ00108  1316 GSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSS-EDDDDSEVDDSEDEDDEDDEDDD 1388
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 26-175 4.67e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 44.13  E-value: 4.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   26 SMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSGKKVKEEASSPLKSTKRQREKVASDTE 105
Cdd:NF033609   648 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 727

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622825215  106 ---EADRTSSKKTKTQEISRPNSPSEGEGES---SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 175
Cdd:NF033609   728 sdsDSDSDSDSDSDSDSDSDSDSDSDSDSDSdsdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 802
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
137-234 5.14e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 44.00  E-value: 5.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  137 RSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPAlqAPTGVTPAPSSAPPGTPQLPAPGPMPSA 216
Cdd:PRK14971   363 TQKGDDASGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPS--APQSATQPAGTPPTVSVDPPAAVPVNPP 440

                           90
                   ....*....|....*...
gi 1622825215  217 TAVPPQGSPTASQAPNQP 234
Cdd:PRK14971   441 STAPQAVRPAQFKEEKKI 458
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 169-338 5.36e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 5.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  169 SDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQ 248
Cdd:PRK07764   367 ASDDERGLLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAG 446

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  249 APALHPQRPPSPhppphpsphpplqpltgsAGQPSAPSHAQPTlhgqgPPGPHSLQTGPllQHPGPPQPFGLPPQASQGQ 328
Cdd:PRK07764   447 NAPAGGAPSPPP------------------AAAPSAQPAPAPA-----AAPEPTAAPAP--APPAAPAPAAAPAAPAAPA 501

                          170
                   ....*....|
gi 1622825215  329 APLGTSPAAA 338
Cdd:PRK07764   502 APAGADDAAT 511
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 180-359 5.73e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 5.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  180 LQAQPPALQAPTGVTPAPSSAPPGTPQLPAPG---PMPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQR 256
Cdd:PRK07764   580 GDWQVEAVVGPAPGAAGGEGPPAPASSGPPEEaarPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAV 659

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  257 PPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPTLHGQGPPGPHSLQTGPLLQHPGPPQPfglPPQASQGQAPLGTSPA 336
Cdd:PRK07764   660 PDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQ---PPQAAQGASAPSPAAD 736

                          170       180
                   ....*....|....*....|....*.
gi 1622825215  337 AA---HPHTSLQLPASQSALQSQQPP 359
Cdd:PRK07764   737 DPvplPPEPDDPPDPAGAPAQPPPPP 762
PHA03378 PHA03378
EBNA-3B; Provisional
 185-328 6.62e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.90  E-value: 6.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  185 PALQAPTGV-TPAPSSAPPGTPQLP--APGPMPsatavPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPH 261
Cdd:PHA03378   673 PYQPSPTGAnTMLPIQWAPGTMQPPprAPTPMR-----PPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPP 747

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  262 PPPHPSPHPPLQPLTGSAGQPSAPSHAQPTLHGQGPPGPHSLQTG---PLLQHPGPPQPFGLPPQASQGQ 328
Cdd:PHA03378   748 AAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGaptPQPPPQAGPTSMQLMPRAAPGQ 817
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 137-251 9.01e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 43.34  E-value: 9.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  137 RSVNDEGSSDPK--DIDQDNRSTSPSIPSPQDNESDSDSSAQqqmlqaqPPALQAPTGVTPAPSSAPPGTPQlPAPGPMP 214
Cdd:PRK12270    17 QYLADPNSVDPSwrEFFADYGPGSTAAPTAAAAAAAAAASAP-------AAAPAAKAPAAPAPAPPAAAAPA-APPKPAA 88

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1622825215  215 SATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPA 251
Cdd:PRK12270    89 AAAAAAAPAAPPAAAAAAAPAAAAVEDEVTPLRGAAA 125
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 38-239 1.08e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215   38 PASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSGKKVKEEASSPLKSTKRQREKVASDTEEADRTSSKKTKT 117
Cdd:PHA03307   190 PAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRI 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  118 QEISRPNSPSEGEGESSDSRSVNDEgSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAP 197
Cdd:PHA03307   270 WEASGWNGPSSRPGPASSSSSPRER-SPSPSPSSPGSGPAPSS-PRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSP 347

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1622825215  198 SSAP-PGTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTA 239
Cdd:PHA03307   348 SRSPsPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRA 390
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
126-356 1.27e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.56  E-value: 1.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  126 PSEGEGESSDSRSVNDEgSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQ--APTGVTPAPSSAPPG 203
Cdd:PRK12323   365 PGQSGGGAGPATAAAAP-VAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRspAPEALAAARQASARG 443

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  204 TPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPS 283
Cdd:PRK12323   444 PGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVA 523

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  284 A----PSHAQPTlhGQGPPGPHSLQTGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAHPHTSLQLP----ASQSALQS 355
Cdd:PRK12323   524 EsipdPATADPD--DAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARLPvrglAQQLARQS 601


                   .
gi 1622825215  356 Q 356
Cdd:PRK12323   602 E 602
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 123-330 2.67e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 2.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  123 PNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSAQQQMLQAqPPALQAPTGVTPAPSSAPP 202
Cdd:PRK07764   591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPA-PAGAAAAPAEASAAPAPGVAA-PEHHPKHVAVPDASDGGDG 668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  203 GTPQLPAPGPMPSATAVPPQGSPT-ASQAPNQPQAPTAPVPHTHIQQAPAlhpqrppsphppPHPSPHPPLQPLTGSAGQ 281
Cdd:PRK07764   669 WPAKAGGAAPAAPPPAPAPAAPAApAGAAPAQPAPAPAATPPAGQADDPA------------AQPPQAAQGASAPSPAAD 736

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1622825215  282 PSAPSHAQPTLHGQGPPGPHSLQTGPllqHPGPPQPFGLPPQASQGQAP 330
Cdd:PRK07764   737 DPVPLPPEPDDPPDPAGAPAQPPPPP---APAPAAAPAAAPPPSPPSEE 782
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
181-405 3.05e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 3.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  181 QAQPPALQAPTGVTPAPSSAPPgTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPT-APVPHTHIQQAPALHPQRPPS 259
Cdd:PRK12323   371 GAGPATAAAAPVAQPAPAAAAP-AAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSpAPEALAAARQASARGPGGAPA 449

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  260 PHPPPHPSPHPPLQPLTGSAGQPSAPSHAqptlhgqgPPGPHSLQTGPLLQHPGPPQPFGLPPQasqgqaplgtsPAAAH 339
Cdd:PRK12323   450 PAPAPAAAPAAAARPAAAGPRPVAAAAAA--------APARAAPAAAPAPADDDPPPWEELPPE-----------FASPA 510

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622825215  340 PHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSM 405
Cdd:PRK12323   511 PAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDM 576
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 202-362 4.89e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 40.56  E-value: 4.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  202 PGTPQLPAPGPMPSATAVPPQGSPtasqapnQPQAPTAPVPHTHIQQAPalhpqrppsphppphpsphpplqplTGSAGQ 281
Cdd:TIGR01628  380 PRMRQLPMGSPMGGAMGQPPYYGQ-------GPQQQFNGQPLGWPRMSM-------------------------MPTPMG 427

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  282 PSAPSHAQ--PTLHGQGPPGPHSLQtgplLQHPGPPQPFGLPPQASQGQAPLGTSPAAAHPHTSLQLPASQSALQSqQPP 359
Cdd:TIGR01628  428 PGGPLRPNglAPMNAVRAPSRNAQN----AAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLAS-ATP 502


                   ...
gi 1622825215  360 REQ 362
Cdd:TIGR01628  503 QMQ 505
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 162-242 4.94e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 40.62  E-value: 4.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  162 PSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTAPV 241
Cdd:PRK07994   368 PEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSEPAAAS 447


                   .
gi 1622825215  242 P 242
Cdd:PRK07994   448 R 448
PRK10856 PRK10856
cytoskeleton protein RodZ;
175-284 5.54e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 40.01  E-value: 5.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  175 AQQQMLQA---QPPALQAPTGVTPAPSSAPPGTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAP---TAPVPHTHIQQ 248
Cdd:PRK10856   138 AQQEEITTmadQSSAELSQNSGQSVPLDTSTTTDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDpqqNAVVAPSQANV 217

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1622825215  249 APALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSA 284
Cdd:PRK10856   218 DTAATPAPAAPATPDGAAPLPTDQAGVSTPAADPNA 253
COG5373 COG5373
Uncharacterized membrane protein [Function unknown];
174-251 5.98e-03

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444140 [Multi-domain]  Cd Length: 854  Bit Score: 40.75  E-value: 5.98e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622825215  174 SAQQQMLQAQPPAlqAPTGVTPAPSSAPPGTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTAPVPhthiQQAPA 251
Cdd:COG5373     31 EELEAELAEAAEA--ASAPAEPEPEAAAAATAAAPEAAPAPVPEAPAAPPAAAEAPAPAAAAPPAEAEP----AAAPA 102
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
186-359 7.76e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 39.97  E-value: 7.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  186 ALQAPTGVTPAPSSAPPGTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPH 265
Cdd:PRK12727    54 ALETARSDTPATAAAPAPAPQAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDMIAAMALRQPVSVPRQAPAAAPVRAA 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  266 PSPHPPLQPLTGSAGQPSAPS--HAQPTLHGQGppGPHSLQTGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAHpHTS 343
Cdd:PRK12727   134 SIPSPAAQALAHAAAVRTAPRqeHALSAVPEQL--FADFLTTAPVPRAPVQAPVVAAPAPVPAIAAALAAHAAYAQ-DDD 210

                          170
                   ....*....|....*.
gi 1622825215  344 LQLPASQSALQSQQPP 359
Cdd:PRK12727   211 EQLDDDGFDLDDALPQ 226
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 162-290 8.00e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 8.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  162 PSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPAPGPMPSATAVPPQGSPTASQAPNQPQAPTApv 241
Cdd:PRK07764   387 VAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSA-- 464

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1622825215  242 phthiQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQP 290
Cdd:PRK07764   465 -----QPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADD 508
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 185-359 8.97e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 39.85  E-value: 8.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  185 PALQAPTGVTPAPSSAPPGTPQLPAPgpmPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPpsphppp 264
Cdd:PRK07994   361 PAAPLPEPEVPPQSAAPAASAQATAA---PTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQ------- 430

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622825215  265 hpsphpplqpltgSAGQPSAPSHAQPTLHGQGPPGPHSLQtgPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAHPHTSL 344
Cdd:PRK07994   431 -------------RAQGATKAKKSEPAAASRARPVNSALE--RLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVA 495

                          170
                   ....*....|....*
gi 1622825215  345 QLPASQSALQSQQPP 359
Cdd:PRK07994   496 TPKALKKALEHEKTP 510
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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