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Conserved domains on  [gi|1622900781|ref|XP_028699084|]
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aminomethyltransferase, mitochondrial isoform X1 [Macaca mulatta]

Protein Classification

aminomethyltransferase family protein( domain architecture ID 1562447)

aminomethyltransferase family protein similar to human mitochondrial aminomethyltransferase (glycine cleavage system T protein), which is part of the glycine cleavage system that catalyzes the degradation of glycine

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
gcvT super family cl39066
glycine cleavage system aminomethyltransferase GcvT;
16-400 0e+00

glycine cleavage system aminomethyltransferase GcvT;


The actual alignment was detected with superfamily member PLN02319:

Pssm-ID: 476863 [Multi-domain]  Cd Length: 404  Bit Score: 531.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781  16 QALPPALCRPLSCAQDVLRRTPLYDFHLAHGGKMVAFAGWSLPVQYRDSHTDSHLHTRQHCSLFDVSHMLQTKIFGSDRV 95
Cdd:PLN02319   15 QADKKALSRRYFASEANLKKTALYDFHVANGGKMVPFAGWSMPIQYKDSIMDSTLNCRQNGSLFDVSHMCGLSLKGKDAI 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781  96 KLMESLVVGDIAELRPNQGTLSLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVL 175
Cdd:PLN02319   95 PFLETLVVADIAGLKDGTGTLSVFTNEKGGIIDDTVITKVTDDHIYLVVNAGCRDKDLAHIEEHMKAFKAKGGDVSWHVH 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 176 DN-ALLALQGPTAAQVLQASVADDLKKLPFMTSAVMEVFGVSgCRVTRCGYTGEDGVEISVPAAEAVHLATALLKNPE-- 252
Cdd:PLN02319  175 DErSLLALQGPLAAPVLQHLTKEDLSKMYFGDFRITDINGAD-CFLTRTGYTGEDGFEISVPSEHAVDLAKALLEKSEgk 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 253 VKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAMDFPGAKVIVPQLKGKVQRRRVGLMCEGAPMRA 332
Cdd:PLN02319  254 VRLTGLGARDSLRLEAGLCLYGNDLEEHITPVEAGLAWTIGKRRRAEGGFLGADVILKQLKEGVSRRRVGFISSGAPARS 333
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622900781 333 HSPILNMEGTKIGTVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYY 400
Cdd:PLN02319  334 HSEILDESGEKIGEVTSGGFSPCLKKNIAMGYVKSGFHKAGTEVKVEVRGKMYDAVVTKMPFVPTKYY 401
 
Name Accession Description Interval E-value
PLN02319 PLN02319
aminomethyltransferase
16-400 0e+00

aminomethyltransferase


Pssm-ID: 177953 [Multi-domain]  Cd Length: 404  Bit Score: 531.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781  16 QALPPALCRPLSCAQDVLRRTPLYDFHLAHGGKMVAFAGWSLPVQYRDSHTDSHLHTRQHCSLFDVSHMLQTKIFGSDRV 95
Cdd:PLN02319   15 QADKKALSRRYFASEANLKKTALYDFHVANGGKMVPFAGWSMPIQYKDSIMDSTLNCRQNGSLFDVSHMCGLSLKGKDAI 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781  96 KLMESLVVGDIAELRPNQGTLSLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVL 175
Cdd:PLN02319   95 PFLETLVVADIAGLKDGTGTLSVFTNEKGGIIDDTVITKVTDDHIYLVVNAGCRDKDLAHIEEHMKAFKAKGGDVSWHVH 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 176 DN-ALLALQGPTAAQVLQASVADDLKKLPFMTSAVMEVFGVSgCRVTRCGYTGEDGVEISVPAAEAVHLATALLKNPE-- 252
Cdd:PLN02319  175 DErSLLALQGPLAAPVLQHLTKEDLSKMYFGDFRITDINGAD-CFLTRTGYTGEDGFEISVPSEHAVDLAKALLEKSEgk 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 253 VKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAMDFPGAKVIVPQLKGKVQRRRVGLMCEGAPMRA 332
Cdd:PLN02319  254 VRLTGLGARDSLRLEAGLCLYGNDLEEHITPVEAGLAWTIGKRRRAEGGFLGADVILKQLKEGVSRRRVGFISSGAPARS 333
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622900781 333 HSPILNMEGTKIGTVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYY 400
Cdd:PLN02319  334 HSEILDESGEKIGEVTSGGFSPCLKKNIAMGYVKSGFHKAGTEVKVEVRGKMYDAVVTKMPFVPTKYY 401
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
33-404 1.39e-151

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 434.51  E-value: 1.39e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781  33 LRRTPLYDFHLAHGGKMVAFAGWSLPVQYRDSHTDSHLHTRQHCSLFDVSHMLQTKIFGSDRVKLMESLVVGDIAELRPN 112
Cdd:COG0404     4 LRRTPLHDRHVALGAKFVDFGGWEMPVQYPGGVIAEHLAVREAVGLFDVSHMGKIEVTGPDAAAFLDRLVTNDVSKLKPG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 113 QGTLSLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRElqnqGRDVGLEVL--DNALLALQGPTAAQV 190
Cdd:COG0404    84 RARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPP----DFDVTITDVtdDWALLAVQGPKAREV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 191 LQASVADDLKKLPFMTSAVMEVFGVsGCRVTRCGYTGEDGVEISVPAAEAVHLATALLKNPE---VKLAGLAARDSLRLE 267
Cdd:COG0404   160 LAKLTDADLSALPFMSFREGTVAGV-PVRVSRTGYTGEDGFEIYVPAEDAEALWDALLEAGEefgVKPCGLGARDTLRLE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 268 AGLCLYGNDIDEHTTPVEGSLSWTLGKRRRaamDFPGAKVIVPQLKGKVQRRRVGL-MCEGAPMRAHSPILNmEGTKIGT 346
Cdd:COG0404   239 AGYPLYGHELDETTTPLEAGLGWAVKLDKG---DFIGKEALLRQKEEGPRRKLVGLeLDGRGVPRAGAPVLA-DGEVVGE 314
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622900781 347 VTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLKV 404
Cdd:COG0404   315 VTSGTFSPTLGKSIALAYVPAGLARPGTELEVEIRGKRVPAEVVKPPFYDPEGERLRG 372
gcvT TIGR00528
glycine cleavage system T protein; The glycine cleavage system T protein (GcvT) is also known ...
33-397 4.50e-109

glycine cleavage system T protein; The glycine cleavage system T protein (GcvT) is also known as aminomethyltransferase (EC 2.1.2.10). It works with the H protein (GcvH), the P protein (GcvP), and lipoamide dehydrogenase. The reported sequence of the member from Aquifex aeolicus starts about 50 residues downstream of the start of other members of the family (perhaps in error); it scores below the trusted cutoff. Eukaryotic forms are mitochondrial and have an N-terminal transit peptide. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273121 [Multi-domain]  Cd Length: 362  Bit Score: 326.01  E-value: 4.50e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781  33 LRRTPLYDFHLAHGGKMVAFAGWSLPVQYRdSHTDSHLHTRQHCSLFDVSHMLQTKIFGSDRVKLMESLVVGDIAELRPN 112
Cdd:TIGR00528   1 LKRTPLYDLHTELGGKMVDFGGWEMPVQYK-GQIEEHNAVRTNAGLFDVSHMGQVKLSGPHSLKFLQRLTPNDVNALTPG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 113 QGTLSLFTNEAGGILDDLIVTNTSEGH-LYVVSNAGCWEKDLALMQDKVRE---LQNQGRDVglevldnALLALQGPTAA 188
Cdd:TIGR00528  80 KAQYSVLLNPQGGVVDDLIIYKEGEDNrFYLVVNAATAEKDLEWFHEHLQNgstLDCQSDII-------SLLALQGPKAK 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 189 QVLQASVADDLKKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPAAEAVHLATALLKNPEVKLAGLAARDSLRLEA 268
Cdd:TIGR00528 153 TILEPLLDQTVPGLKPFFFGQEAEFALKKAFIARTGYTGEDGFEISIANEKAVEFWEQLLAAPGVKPCGLGARDTLRLEA 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 269 GLCLYGNDIDEHTTPVEGSLSWTLgKRRRAAMDFPGAKVIVPQLKGKVQRRRVGL-MCEGAPMRAHSPILNMEGTKI-GT 346
Cdd:TIGR00528 233 GMCLYGQELDESITPLEAGLGWVI-SKSRQKYDFIGRAVLMEQKENGTEKKLVGLeMLEKGIARNGYPIFLPNGETEvGI 311
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622900781 347 VTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPT 397
Cdd:TIGR00528 312 VTSGTASPTLGKNIGLAYVPKEYHKIGTKLLVQVRNKFYPIKVVKMPFVRT 362
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
39-291 1.77e-106

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 315.30  E-value: 1.77e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781  39 YDFHLAHGGKMVAFAGWSLPVQY-RDSHTDSHLHTRQHCSLFDVSHMLQTKIFGSDRVKLMESLVVGDIAELRPNQGTLS 117
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYgSNGILAEHRAVREAAGLFDVSHMGKIEVSGPDAAAFLQRLTTNDVSKLKPGRATYT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 118 LFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVldnALLALQGPTAAQVLQASV-A 196
Cdd:pfam01571  81 LMLNERGGVIDDLTVYRLGDDHFLLVVNAANREKDLAWLRKHAEKLDVVVVDVTDDY---ALLALQGPKAREVLEKLTdG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 197 DDLKKLPFMTSAVMEVFGVSgCRVTRCGYTGEDGVEISVPAAEAVHLATALLKNPE---VKLAGLAARDSLRLEAGLCLY 273
Cdd:pfam01571 158 DLLEALPFFSFREIEIGGVP-VRVSRTGYTGEDGFEIYVPAEDAVELWEALLEAGAelgLRPAGLGARDSLRLEAGLPLY 236
                         250
                  ....*....|....*...
gi 1622900781 274 GNDIDEHTTPVEGSLSWT 291
Cdd:pfam01571 237 GHDLDEETTPLEAGLGWA 254
 
Name Accession Description Interval E-value
PLN02319 PLN02319
aminomethyltransferase
16-400 0e+00

aminomethyltransferase


Pssm-ID: 177953 [Multi-domain]  Cd Length: 404  Bit Score: 531.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781  16 QALPPALCRPLSCAQDVLRRTPLYDFHLAHGGKMVAFAGWSLPVQYRDSHTDSHLHTRQHCSLFDVSHMLQTKIFGSDRV 95
Cdd:PLN02319   15 QADKKALSRRYFASEANLKKTALYDFHVANGGKMVPFAGWSMPIQYKDSIMDSTLNCRQNGSLFDVSHMCGLSLKGKDAI 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781  96 KLMESLVVGDIAELRPNQGTLSLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVL 175
Cdd:PLN02319   95 PFLETLVVADIAGLKDGTGTLSVFTNEKGGIIDDTVITKVTDDHIYLVVNAGCRDKDLAHIEEHMKAFKAKGGDVSWHVH 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 176 DN-ALLALQGPTAAQVLQASVADDLKKLPFMTSAVMEVFGVSgCRVTRCGYTGEDGVEISVPAAEAVHLATALLKNPE-- 252
Cdd:PLN02319  175 DErSLLALQGPLAAPVLQHLTKEDLSKMYFGDFRITDINGAD-CFLTRTGYTGEDGFEISVPSEHAVDLAKALLEKSEgk 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 253 VKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAMDFPGAKVIVPQLKGKVQRRRVGLMCEGAPMRA 332
Cdd:PLN02319  254 VRLTGLGARDSLRLEAGLCLYGNDLEEHITPVEAGLAWTIGKRRRAEGGFLGADVILKQLKEGVSRRRVGFISSGAPARS 333
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622900781 333 HSPILNMEGTKIGTVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYY 400
Cdd:PLN02319  334 HSEILDESGEKIGEVTSGGFSPCLKKNIAMGYVKSGFHKAGTEVKVEVRGKMYDAVVTKMPFVPTKYY 401
gcvT PRK13579
glycine cleavage system aminomethyltransferase GcvT;
33-400 7.04e-157

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 237435 [Multi-domain]  Cd Length: 370  Bit Score: 447.86  E-value: 7.04e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781  33 LRRTPLYDFHLAHGGKMVAFAGWSLPVQYRDSHTDSHLHTRQHCSLFDVSHMLQTKIFGSDRVKLMESLVVGDIAELRPN 112
Cdd:PRK13579    9 LKTLPLHALHLAAGARMVPFAGYDMPVQYPAGVLKEHLHTRAHAGLFDVSHMGQIEVSGKDAAAALERLVPVDILALKEG 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 113 QGTLSLFTNEAGGILDDLIVTNtSEGHLYVVSNAGCWEKDLALMQDKVRElqnqgrDVGLEVL-DNALLALQGPTAAQVL 191
Cdd:PRK13579   89 RQRYTFFTNEQGGILDDLMVTN-LGDHLFLVVNAACKDADIAHLREHLSD------ECEVNPLdDRALLALQGPEAEAVL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 192 qASVADDLKKLPFMTSAVMEVFGVSgCRVTRCGYTGEDGVEISVPAAEAVHLATALLKNPEVKLAGLAARDSLRLEAGLC 271
Cdd:PRK13579  162 -ADLGPPVAALRFMDGFEPRLHGVD-CFVSRSGYTGEDGFEISVPADAAEALAEALLADPRVEPIGLGARDSLRLEAGLC 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 272 LYGNDIDEHTTPVEGSLSWTLGKRRRAAMDFPGAKVIVPQLKGKVQRRRVGLMCEG-APMRAHSPILNMEGTKIGTVTSG 350
Cdd:PRK13579  240 LYGHDIDTTTTPVEAALEWAIQKARREAGGFPGAKAILAALAKGASRRRVGLKPEGrAPVREGAPLFDDAGTEIGTVTSG 319
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622900781 351 CPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYY 400
Cdd:PRK13579  320 GFGPSVGGPVAMGYVPASLAAPGTAVFAEVRGKRLPVTVHALPFVPHRYK 369
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
33-404 1.39e-151

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 434.51  E-value: 1.39e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781  33 LRRTPLYDFHLAHGGKMVAFAGWSLPVQYRDSHTDSHLHTRQHCSLFDVSHMLQTKIFGSDRVKLMESLVVGDIAELRPN 112
Cdd:COG0404     4 LRRTPLHDRHVALGAKFVDFGGWEMPVQYPGGVIAEHLAVREAVGLFDVSHMGKIEVTGPDAAAFLDRLVTNDVSKLKPG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 113 QGTLSLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRElqnqGRDVGLEVL--DNALLALQGPTAAQV 190
Cdd:COG0404    84 RARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPP----DFDVTITDVtdDWALLAVQGPKAREV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 191 LQASVADDLKKLPFMTSAVMEVFGVsGCRVTRCGYTGEDGVEISVPAAEAVHLATALLKNPE---VKLAGLAARDSLRLE 267
Cdd:COG0404   160 LAKLTDADLSALPFMSFREGTVAGV-PVRVSRTGYTGEDGFEIYVPAEDAEALWDALLEAGEefgVKPCGLGARDTLRLE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 268 AGLCLYGNDIDEHTTPVEGSLSWTLGKRRRaamDFPGAKVIVPQLKGKVQRRRVGL-MCEGAPMRAHSPILNmEGTKIGT 346
Cdd:COG0404   239 AGYPLYGHELDETTTPLEAGLGWAVKLDKG---DFIGKEALLRQKEEGPRRKLVGLeLDGRGVPRAGAPVLA-DGEVVGE 314
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622900781 347 VTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLKV 404
Cdd:COG0404   315 VTSGTFSPTLGKSIALAYVPAGLARPGTELEVEIRGKRVPAEVVKPPFYDPEGERLRG 372
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
33-400 3.94e-126

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 369.06  E-value: 3.94e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781  33 LRRTPLYDFHLAHGGKMVAFAGWSLPVQYrDSHTDSHLHTRQHCSLFDVSHMLQTKIFGSDRVKLMESLVVGDIAELRPN 112
Cdd:PRK00389    2 LKRTPLYDLHVALGAKMVDFGGWEMPVQY-GSIIEEHHAVRTDAGLFDVSHMGEVDVTGPDALAFLQYLLANDVSKLKPG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 113 QGTLSLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDkvrelQNQGRDVGLEVLDN--ALLALQGPTAAQV 190
Cdd:PRK00389   81 KAQYTCMLNEDGGVIDDLIVYKLSEDEYLLVVNAANREKDLAWIKS-----HAAGFGVEVTDRSDdlAMIAVQGPKAREK 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 191 LQASVADDLKKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPAAEAVHLATALLKNpEVKLAGLAARDSLRLEAGL 270
Cdd:PRK00389  156 LQKLTDADLSELKPFFGAQGAEVGGGDVLVARTGYTGEDGFEIYLPAEDAEALWDALLEA-GVKPCGLGARDTLRLEAGM 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 271 CLYGNDIDEHTTPVEGSLSWT--LGKRRraamDFPGAKVIVPQLKGKVQRRRVGL-MCEGAPMRAHSPILNmEGTKIGTV 347
Cdd:PRK00389  235 PLYGQDMDETITPLEAGLGWTvkLEEKR----DFIGREALEAQKEAGVERKLVGLeLEERGIPRHGYPVLA-DGEEIGEV 309
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622900781 348 TSGCPSPSLKKNVAMGYVPceySRPGTMLLVEVRRKQQMAVVSKMPFVPTNYY 400
Cdd:PRK00389  310 TSGTFSPTLGKSIALAYVP---AGVGDEVEVEIRGKQVPAKVVKPPFVRRGKR 359
gcvT TIGR00528
glycine cleavage system T protein; The glycine cleavage system T protein (GcvT) is also known ...
33-397 4.50e-109

glycine cleavage system T protein; The glycine cleavage system T protein (GcvT) is also known as aminomethyltransferase (EC 2.1.2.10). It works with the H protein (GcvH), the P protein (GcvP), and lipoamide dehydrogenase. The reported sequence of the member from Aquifex aeolicus starts about 50 residues downstream of the start of other members of the family (perhaps in error); it scores below the trusted cutoff. Eukaryotic forms are mitochondrial and have an N-terminal transit peptide. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273121 [Multi-domain]  Cd Length: 362  Bit Score: 326.01  E-value: 4.50e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781  33 LRRTPLYDFHLAHGGKMVAFAGWSLPVQYRdSHTDSHLHTRQHCSLFDVSHMLQTKIFGSDRVKLMESLVVGDIAELRPN 112
Cdd:TIGR00528   1 LKRTPLYDLHTELGGKMVDFGGWEMPVQYK-GQIEEHNAVRTNAGLFDVSHMGQVKLSGPHSLKFLQRLTPNDVNALTPG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 113 QGTLSLFTNEAGGILDDLIVTNTSEGH-LYVVSNAGCWEKDLALMQDKVRE---LQNQGRDVglevldnALLALQGPTAA 188
Cdd:TIGR00528  80 KAQYSVLLNPQGGVVDDLIIYKEGEDNrFYLVVNAATAEKDLEWFHEHLQNgstLDCQSDII-------SLLALQGPKAK 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 189 QVLQASVADDLKKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPAAEAVHLATALLKNPEVKLAGLAARDSLRLEA 268
Cdd:TIGR00528 153 TILEPLLDQTVPGLKPFFFGQEAEFALKKAFIARTGYTGEDGFEISIANEKAVEFWEQLLAAPGVKPCGLGARDTLRLEA 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 269 GLCLYGNDIDEHTTPVEGSLSWTLgKRRRAAMDFPGAKVIVPQLKGKVQRRRVGL-MCEGAPMRAHSPILNMEGTKI-GT 346
Cdd:TIGR00528 233 GMCLYGQELDESITPLEAGLGWVI-SKSRQKYDFIGRAVLMEQKENGTEKKLVGLeMLEKGIARNGYPIFLPNGETEvGI 311
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622900781 347 VTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPT 397
Cdd:TIGR00528 312 VTSGTASPTLGKNIGLAYVPKEYHKIGTKLLVQVRNKFYPIKVVKMPFVRT 362
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
39-291 1.77e-106

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 315.30  E-value: 1.77e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781  39 YDFHLAHGGKMVAFAGWSLPVQY-RDSHTDSHLHTRQHCSLFDVSHMLQTKIFGSDRVKLMESLVVGDIAELRPNQGTLS 117
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYgSNGILAEHRAVREAAGLFDVSHMGKIEVSGPDAAAFLQRLTTNDVSKLKPGRATYT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 118 LFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVldnALLALQGPTAAQVLQASV-A 196
Cdd:pfam01571  81 LMLNERGGVIDDLTVYRLGDDHFLLVVNAANREKDLAWLRKHAEKLDVVVVDVTDDY---ALLALQGPKAREVLEKLTdG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 197 DDLKKLPFMTSAVMEVFGVSgCRVTRCGYTGEDGVEISVPAAEAVHLATALLKNPE---VKLAGLAARDSLRLEAGLCLY 273
Cdd:pfam01571 158 DLLEALPFFSFREIEIGGVP-VRVSRTGYTGEDGFEIYVPAEDAVELWEALLEAGAelgLRPAGLGARDSLRLEAGLPLY 236
                         250
                  ....*....|....*...
gi 1622900781 274 GNDIDEHTTPVEGSLSWT 291
Cdd:pfam01571 237 GHDLDEETTPLEAGLGWA 254
dmdA PRK12486
dimethylsulfoniopropionate demethylase;
33-379 6.68e-23

dimethylsulfoniopropionate demethylase;


Pssm-ID: 237113 [Multi-domain]  Cd Length: 368  Bit Score: 99.44  E-value: 6.68e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781  33 LRRTPLYDFHLAHGGKmvAFAGWS---LPVQYrDSHTDSHLHTRQHCSLFDVSHMLQTKIFGSDRVKLMESLVVGDIAEL 109
Cdd:PRK12486   11 LRRTPFSDGVEAAGVK--AYTVYNhmlLPTVF-ESVEDDYAHLKEHVQVWDVAVERQVEIRGPDAARLVQMLTPRDLRGM 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 110 RPNQGTLSLFTNEAGGILDDLIVTNTSEGHLYVV---SNAGCWEKDLAlmqdkvrelQNQGRDVGLEVLDNALLALQGPT 186
Cdd:PRK12486   88 KPGQCYYVPIVDETGGMLNDPVALKLAEDRWWISiadSDLLLWVKGLA---------NGRKLDVLVVEPDVSPLAVQGPK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 187 AAQVLQASVADDLKKLPFMTSAVMEVFGVSGCrVTRCGYTGEDGVEISVpaaEAVHLATALLKNPEVKLAGLAARDSL-- 264
Cdd:PRK12486  159 ADALMARVFGEAIRDLRFFRFGYFDFEGTDLV-IARSGYSKQGGFEIYV---EGSDLGMPLWDALFEAGKDLNVRAGCpn 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 265 ---RLEAGLCLYGNDIDEHTTPVE---------GSLSWTLGKR--RRAAMDFPGAKVivpqlkgkvqrRRVGLMCEGAPM 330
Cdd:PRK12486  235 lieRIEGGLLSYGNDMTRDNTPHEcglgrfcntQTDIGCIGKDalLRVAKEGPQKQI-----------RGIKIGGERIPP 303
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1622900781 331 RAHSPILNMEGTKIGTVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVE 379
Cdd:PRK12486  304 CDRAWPLLAGDNRVGQVTSAAYSPDFQTNVAIGMVRMTHWDPGTGLEVE 352
GCV_T_C pfam08669
Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage ...
318-395 5.72e-22

Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 462554 [Multi-domain]  Cd Length: 80  Bit Score: 89.07  E-value: 5.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622900781 318 RRRVGLMCE--GAPMRAHSPILNmEGTKIGTVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFV 395
Cdd:pfam08669   1 RRLVGLELDdgDPLLRGGEPVLR-DGEVVGYVTSGAYSPTLGKSIALAYVDAELAKPGTEVEVEIRGKRVPATVVKLPFY 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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