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Conserved domains on  [gi|1622835718|ref|XP_028697417|]
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matrix remodeling-associated protein 8 isoform X4 [Macaca mulatta]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10542315)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets, similar to Homo sapiens T-cell antigen CD7 and voltage-gated sodium channel beta3 subunit Ig Domain

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
188-307 1.01e-15

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 72.88  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835718 188 EVLAVARGAPALLTCVNRGHMwtdrhvEEAQQVVHWDRQPPGVPHDRadrLLDLYASGerraYGPLFLRDRVAVGADaFE 267
Cdd:pfam07686   4 REVTVALGGSVTLPCTYSSSM------SEASTSVYWYRQPPGKGPTF---LIAYYSNG----SEEGVKKGRFSGRGD-PS 69
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1622835718 268 RGDFSLRIEPLEAADEGTYSCHLHHHYCGlHERRVFHLTV 307
Cdd:pfam07686  70 NGDGSLTIQNLTLSDSGTYTCAVIPSGEG-VFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
60-173 3.08e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.39  E-value: 3.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835718  60 WAAGARAVLRCQ-SPRMVWTQDRLHdrqrvlhWdLRGPGGGPARRLLDLYSAGEQrvyEARDRGRLELSASaFDDGNFSL 138
Cdd:pfam07686   8 VALGGSVTLPCTySSSMSEASTSVY-------W-YRQPPGKGPTFLIAYYSNGSE---EGVKKGRFSGRGD-PSNGDGSL 75
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1622835718 139 LIRAVEETDAGLYTCNLHHHYCHlYESLAVRLEVT 173
Cdd:pfam07686  76 TIQNLTLSDSGTYTCAVIPSGEG-VFGKGTRLTVL 109
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
188-307 1.01e-15

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 72.88  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835718 188 EVLAVARGAPALLTCVNRGHMwtdrhvEEAQQVVHWDRQPPGVPHDRadrLLDLYASGerraYGPLFLRDRVAVGADaFE 267
Cdd:pfam07686   4 REVTVALGGSVTLPCTYSSSM------SEASTSVYWYRQPPGKGPTF---LIAYYSNG----SEEGVKKGRFSGRGD-PS 69
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1622835718 268 RGDFSLRIEPLEAADEGTYSCHLHHHYCGlHERRVFHLTV 307
Cdd:pfam07686  70 NGDGSLTIQNLTLSDSGTYTCAVIPSGEG-VFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
60-173 3.08e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.39  E-value: 3.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835718  60 WAAGARAVLRCQ-SPRMVWTQDRLHdrqrvlhWdLRGPGGGPARRLLDLYSAGEQrvyEARDRGRLELSASaFDDGNFSL 138
Cdd:pfam07686   8 VALGGSVTLPCTySSSMSEASTSVY-------W-YRQPPGKGPTFLIAYYSNGSE---EGVKKGRFSGRGD-PSNGDGSL 75
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1622835718 139 LIRAVEETDAGLYTCNLHHHYCHlYESLAVRLEVT 173
Cdd:pfam07686  76 TIQNLTLSDSGTYTCAVIPSGEG-VFGKGTRLTVL 109
IGv smart00406
Immunoglobulin V-Type;
219-288 9.33e-08

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 49.30  E-value: 9.33e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835718  219 QVVHWDRQPPGvphdRADRLLdLYASGERRAYGPLFLRDRVAVGADaFERGDFSLRIEPLEAADEGTYSC 288
Cdd:smart00406  16 YYVSWVRQPPG----KGLEWL-GYIGSNGSSYYQESYKGRFTISKD-TSKNDVSLTISNLRVEDTGTYYC 79
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
231-288 9.41e-06

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 44.75  E-value: 9.41e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835718 231 PHDRADRLLDLYASGerRAYGPLF--LRDRVAVgADAFERGDFSLRIEPLEAADEGTYSC 288
Cdd:cd20960    42 PSDKVEKVVITYSGD--RVYNHYYpaLKGRVAF-TSNDLSGDASLNISNLKLSDTGTYQC 98
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
119-153 1.19e-03

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 38.52  E-value: 1.19e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1622835718 119 RDRGRLELSASAFDDGNFSLLIRAVEETDAGLYTC 153
Cdd:cd16091    56 RYRNRTSLFKDQISNGNASLLLRRVQLQDEGRYKC 90
IGv smart00406
Immunoglobulin V-Type;
88-153 1.23e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 37.75  E-value: 1.23e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622835718   88 VLHWDLRGPGGGParRLLDLYSAGEQRVYEARDRGRLELSASaFDDGNFSLLIRAVEETDAGLYTC 153
Cdd:smart00406  17 YVSWVRQPPGKGL--EWLGYIGSNGSSYYQESYKGRFTISKD-TSKNDVSLTISNLRVEDTGTYYC 79
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
188-307 1.01e-15

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 72.88  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835718 188 EVLAVARGAPALLTCVNRGHMwtdrhvEEAQQVVHWDRQPPGVPHDRadrLLDLYASGerraYGPLFLRDRVAVGADaFE 267
Cdd:pfam07686   4 REVTVALGGSVTLPCTYSSSM------SEASTSVYWYRQPPGKGPTF---LIAYYSNG----SEEGVKKGRFSGRGD-PS 69
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1622835718 268 RGDFSLRIEPLEAADEGTYSCHLHHHYCGlHERRVFHLTV 307
Cdd:pfam07686  70 NGDGSLTIQNLTLSDSGTYTCAVIPSGEG-VFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
60-173 3.08e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 54.39  E-value: 3.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835718  60 WAAGARAVLRCQ-SPRMVWTQDRLHdrqrvlhWdLRGPGGGPARRLLDLYSAGEQrvyEARDRGRLELSASaFDDGNFSL 138
Cdd:pfam07686   8 VALGGSVTLPCTySSSMSEASTSVY-------W-YRQPPGKGPTFLIAYYSNGSE---EGVKKGRFSGRGD-PSNGDGSL 75
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1622835718 139 LIRAVEETDAGLYTCNLHHHYCHlYESLAVRLEVT 173
Cdd:pfam07686  76 TIQNLTLSDSGTYTCAVIPSGEG-VFGKGTRLTVL 109
IGv smart00406
Immunoglobulin V-Type;
219-288 9.33e-08

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 49.30  E-value: 9.33e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835718  219 QVVHWDRQPPGvphdRADRLLdLYASGERRAYGPLFLRDRVAVGADaFERGDFSLRIEPLEAADEGTYSC 288
Cdd:smart00406  16 YYVSWVRQPPG----KGLEWL-GYIGSNGSSYYQESYKGRFTISKD-TSKNDVSLTISNLRVEDTGTYYC 79
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
231-288 9.41e-06

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 44.75  E-value: 9.41e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835718 231 PHDRADRLLDLYASGerRAYGPLF--LRDRVAVgADAFERGDFSLRIEPLEAADEGTYSC 288
Cdd:cd20960    42 PSDKVEKVVITYSGD--RVYNHYYpaLKGRVAF-TSNDLSGDASLNISNLKLSDTGTYQC 98
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
190-288 6.39e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 39.24  E-value: 6.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835718 190 LAVARGAPALLTCVNRGHMWTDRhveeaqqvVHWDRQPPGVPHdradRLLdLYASGERRAYGPLFlRDRVAVGADafERG 269
Cdd:cd00099     8 LSVQEGESVTLSCEVSSSFSSTY--------IYWYRQKPGQGP----EFL-IYLSSSKGKTKGGV-PGRFSGSRD--GTS 71
                          90
                  ....*....|....*....
gi 1622835718 270 DFSLRIEPLEAADEGTYSC 288
Cdd:cd00099    72 SFSLTISNLQPEDSGTYYC 90
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
119-153 1.19e-03

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 38.52  E-value: 1.19e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1622835718 119 RDRGRLELSASAFDDGNFSLLIRAVEETDAGLYTC 153
Cdd:cd16091    56 RYRNRTSLFKDQISNGNASLLLRRVQLQDEGRYKC 90
IGv smart00406
Immunoglobulin V-Type;
88-153 1.23e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 37.75  E-value: 1.23e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622835718   88 VLHWDLRGPGGGParRLLDLYSAGEQRVYEARDRGRLELSASaFDDGNFSLLIRAVEETDAGLYTC 153
Cdd:smart00406  17 YVSWVRQPPGKGL--EWLGYIGSNGSSYYQESYKGRFTISKD-TSKNDVSLTISNLRVEDTGTYYC 79
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
61-153 4.70e-03

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 36.93  E-value: 4.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835718  61 AAGARAVLRCqSPRMVWTQDRLHdrqrvlhWdLRGPGGGPARRLLDLYSAGEQRVYEARDRgrleLSASAFDDGNFSLLI 140
Cdd:cd00099    11 QEGESVTLSC-EVSSSFSSTYIY-------W-YRQKPGQGPEFLIYLSSSKGKTKGGVPGR----FSGSRDGTSSFSLTI 77
                          90
                  ....*....|...
gi 1622835718 141 RAVEETDAGLYTC 153
Cdd:cd00099    78 SNLQPEDSGTYYC 90
IgV_1_CD4 cd07690
First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of ...
251-290 4.90e-03

First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains; The members here are composed of the first immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy.


Pssm-ID: 409487  Cd Length: 97  Bit Score: 36.37  E-value: 4.90e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622835718 251 GPLFLRDRVAVGADAFERGDFSLRIEPLEAADEGTYSCHL 290
Cdd:cd07690    47 GPSKLNDRADSRRNLWDQGSFPLIIKNLKIEDSDTYICEV 86
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
61-159 6.05e-03

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 36.21  E-value: 6.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835718  61 AAGARAVLRCQSPRMVWTQDrlhdrqrvLHWDLRGPGGGParRLLdlysageqrVYEARDR-----GRLELSASAFDdgn 135
Cdd:cd04980    13 SPGERVTISCKASQSISSNY--------LAWYQQKPGQAP--KLL---------IYYASTLhsgvpSRFSGSGSGTD--- 70
                          90       100
                  ....*....|....*....|....
gi 1622835718 136 FSLLIRAVEETDAGLYTCNLHHHY 159
Cdd:cd04980    71 FTLTISSVEPEDAAVYYCQQGYTF 94
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
61-153 8.51e-03

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 36.27  E-value: 8.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835718  61 AAGARAVLRCQSPRMVWTQDRLHdrqrvLHWDLRGPGGGpaRRLLDLYSAGeqRVYEARD---RGRLELsASAFDDGNFS 137
Cdd:cd20960    13 VAGENVTLPCHHQLGLEDQGTLD-----IEWLLLPSDKV--EKVVITYSGD--RVYNHYYpalKGRVAF-TSNDLSGDAS 82
                          90
                  ....*....|....*.
gi 1622835718 138 LLIRAVEETDAGLYTC 153
Cdd:cd20960    83 LNISNLKLSDTGTYQC 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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