BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  40 GSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAE 119
Cdd:cd18390     1 GGVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAE 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622914065 120 EGVLEEAEFYNITSLIKLVKDKIRERDSKTSQ 151
Cdd:cd18390    81 EGVLEEAEFYNITSLIKLVKDKIRERDSKTSQ 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  40 GSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAE 119
Cdd:cd18390     1 GGVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAE 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622914065 120 EGVLEEAEFYNITSLIKLVKDKIRERDSKTSQ 151
Cdd:cd18390    81 EGVLEEAEFYNITSLIKLVKDKIRERDSKTSQ 112

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065   45 WVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADpdldSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEgVLE 124
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDF----KESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEE-LLE 75

                           90       100
                   ....*....|....*....|.
gi 1622914065  125 EAEFYNITSLIKLVKDKIRER 145
Cdd:smart00225  76 LADYLQIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  40 GSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAE 119
Cdd:cd18390     1 GGVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAE 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622914065 120 EGVLEEAEFYNITSLIKLVKDKIRERDSKTSQ 151
Cdd:cd18390    81 EGVLEEAEFYNITSLIKLVKDKIRERDSKTSQ 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  45 WVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLE 124
Cdd:cd18362     1 WVKLNVGGTYFLTTRTTLCRDPKSFLCRLCQEDPDLPSDKDETGAYLIDRDPTYFGPILNYLRHGKLIIDKDLAEEGVLE 80

                  ....*
gi 1622914065 125 EAEFY 129
Cdd:cd18362    81 EAEFY 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 9 (KCTD9); KCTD9 is a BTB/POZ domain-containing protein that contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure. It functions as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD9 BTB domain forms a pentameric structure.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  45 WVRLNVGGTYFLTTRQTLC-RDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVL 123
Cdd:cd18368     2 WIKLNVGGRIFTTTRSTLVkKEPDSMLARMFSDDSTWPSSRDENGAYLIDRSPEYFEPILNYLRHGQLILNDGLNPLGVL 81

                          90
                  ....*....|...
gi 1622914065 124 EEAEFYNITSLIK 136
Cdd:cd18368    82 EEAKFFGIQSLIE 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYRLCqaDPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAE-EGVLE 124
Cdd:cd18316     1 VKLNVGGTLFTTSRSTLLKDPDSLLAALF--SGRWPLPRDEDGSIFIDRDPELFRHILNFLRTGKLPLPSDFVElEELLA 78

                  ....*
gi 1622914065 125 EAEFY 129
Cdd:cd18316    79 EAEFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana FH protein interacting protein FIP2 and similar proteins; FIP2 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDetGAYLIDRDPTYFGPVLNYLRHGKLVI----NKDLAEeg 121
Cdd:cd18376     1 VKLNVGGQKFTTTLDTLTKDPDSMLAAMFSGRHSLKKDED--GSYFIDRDGTHFRHILNYLRDGEVKIptedRSVLKE-- 76

                          90
                  ....*....|...
gi 1622914065 122 VLEEAEFYNITSL 134
Cdd:cd18376    77 LLEEAEYYQLRGL 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADpdLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVInKDLAEEGVLEE 125
Cdd:cd18393     4 IHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGR--ISTLKDETGAIFIDRDPTVFAPILNFLRTKELDP-RGIHVSLLLHE 80

                          90
                  ....*....|.
gi 1622914065 126 AEFYNITSLIK 136
Cdd:cd18393    81 AQFYGITPLVR 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYRLCqaDPDLDSDKDETGAYLIDRDPTYFGPVLNYLRhGKLVINKDLAEEGVLEE 125
Cdd:cd18363     4 INLNVGGKRFSTSRQTLTWIPDSFFTSLL--SGRISSLKDETGAIFIDRDPKLFSIILNYLR-TKEIDLRNVDISSLRHE 80

                  ....*.
gi 1622914065 126 AEFYNI 131
Cdd:cd18363    81 AEFYGI 86

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065   45 WVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADpdldSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEgVLE 124
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDF----KESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEE-LLE 75

                           90       100
                   ....*....|....*....|.
gi 1622914065  125 EAEFYNITSLIKLVKDKIRER 145
Cdd:smart00225  76 LADYLQIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAE-EGVLE 124
Cdd:cd18367     5 VELNVGGQVYTTSLSTLIKDPDSLLGRMFSGKNRQELARDSKGRYFLDRDGVLFRYILDYLRNQKLVLPENFPErERLKR 84

                          90
                  ....*....|....*
gi 1622914065 125 EAEFYNITSLIKLVK 139
Cdd:cd18367    85 EAEYFQLPELVKALR 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 14 (KCTD14); KCTD14 is a BTB/POZ domain-containing protein with unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  43 SKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDetGAYLIDRDPTYFGPVLNYLRHGKLviNKDLAEEgV 122
Cdd:cd18371     1 SQVVSLNVGGHIYTTTLSTLRKFPGSKLAELFNGQPKLRTDSE--GRYFIDRDGTYFRYILEYLRTNQV--PTQHIQE-V 75

                          90
                  ....*....|....*...
gi 1622914065 123 LEEAEFYNITSLIKLVKD 140
Cdd:cd18371    76 YKEALFYDIEPLVKLLEE 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYRL--CQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVL 123
Cdd:cd18398     5 VELNVGGQVYFTRHATLVSIPHSLLWKMfsPKRDTANDLAKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPEKGRL 84

                          90
                  ....*....|....*.
gi 1622914065 124 E-EAEFYNITSLIKLV 138
Cdd:cd18398    85 KrEAEYFQLPDLVKLL 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPD--LDSDKDEtgaYLIDRDPTYFGPVLNYLRHGKLVINKDLAE-EGV 122
Cdd:cd18361     1 VHIDVGGHIYTSSLETLTKYPESRLGKLFNGSIPivLDSLKQH---YFIDRDGKMFRHILNFLRTSKLLLPDDFTEfDLL 77

                          90
                  ....*....|....
gi 1622914065 123 LEEAEFYNITSLIK 136
Cdd:cd18361    78 YEEARYYELQPMVK 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYR-LCQADPDLdsdKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAE-EGVL 123
Cdd:cd18375     3 VTLNVGGKKFTTRPSTLRRFPDSRLARmLDGKDQDF---KVVNGQFFVDRDGSLFSYILDYLRTGQLTLPTEFSDyNRLA 79

                          90
                  ....*....|....*
gi 1622914065 124 EEAEFYNITSLIKLV 138
Cdd:cd18375    80 REAEFYGLYSLADLL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD8; KCTD8, a BTB/POZ domain-containing protein, is an auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. It interacts as a tetramer with GABRB1 and GABRB2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAE-EGVLE 124
Cdd:cd18396     6 VELNVGGQVYVTKHSTLLSVPDSTLASMFSRRAARELPRDNRGRFFIDRDGFLFRYVLDYLRDKQLALPDHFPEkERLLR 85

                          90
                  ....*....|....*...
gi 1622914065 125 EAEFYNITSLIKLVKDKI 142
Cdd:cd18396    86 EAEYFQLGDLVKLLTPKV 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 12 (KCTD12); KCTD12, also called predominantly fetal expressed T1 domain (Pfetin), is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. It also regulates colorectal cancer cell stemness through the ERK pathway. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLE- 124
Cdd:cd18397     5 VELNVGGQVYVTRHTTLVSVPDSLLWHMFSQQKPGELARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRLQr 84

                          90
                  ....*....|....
gi 1622914065 125 EAEFYNITSLIKLV 138
Cdd:cd18397    85 EAEFFQLPELVKRL 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2); This subfamily of KCTD proteins, also called the BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein (BACURD) subfamily, includes KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2). KCTD10 is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. KCTD13 is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. TNFAIP1, also called protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair, cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD10 and KCTD13 BTB domains form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDpKSFLYRLCQADPDLDSDKDetGAYLIDRDPTYFGPVLNYLRHGKLVI---NKDLAEegV 122
Cdd:cd18369     1 VKLNVGGSLHYTTIGTLTKQ-DTMLRAMFSGRMEVLTDSE--GWILIDRCGKHFGTILNYLRDGSVPLpesRRELAE--L 75

                          90
                  ....*....|....*.
gi 1622914065 123 LEEAEFYNITSLIKLV 138
Cdd:cd18369    76 LAEAKYYLVQGLVEQC 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDEtgaYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEE 125
Cdd:cd18416     4 VVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPVLNE---YFFDRHPGVFAQILNYYRTGKLHYPTDVCGPLFEEE 80

                  ....*...
gi 1622914065 126 AEFYNITS 133
Cdd:cd18416    81 LEFWGLDA 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNB/Kv2 subfamily of Shab-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains two alpha subunit members, Kv2.1 (KCNB1) and Kv2.2 (KCNB2), which are orthologs of the Shab gene in Drosophila. They are delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Kv2/KCNB subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  43 SKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADP---------DLDSDKDEtgaYLIDRDPTYFGPVLNYLRHGKLVI 113
Cdd:cd18378     1 SRRVLLNVGGVRHEVLWRTLDRLPRTRLGRLRECNThesllelcdDYDLEDNE---YFFDRHPGAFTSILNFYRTGKLHM 77

                          90
                  ....*....|....*...
gi 1622914065 114 NKDLAEEGVLEEAEFYNI 131
Cdd:cd18378    78 PEEMCVLSFSQELEYWGI 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYrlcqadpdlDSDKD-----ETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEE 120
Cdd:cd18418     2 IVLNVSGTRFQTWRNTLERYPDTLLG---------SSERDffyheETQEYFFDRDPDIFRHILNFYRTGKLHYPRHECIS 72

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622914065 121 GVLEEAEFYNITSLI------KLVKDKIRE 144
Cdd:cd18418    73 AYDEELAFFGIIPEIigdccyEEYKDRRRE 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  48 LNVGGTYFLTTRQTLCRDPKSFLYRlcqadpdldSDK-----DETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGV 122
Cdd:cd18419    39 LNVSGRRFQTWRTTLERYPDTLLGS---------TEKefffnEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAY 109

                          90       100
                  ....*....|....*....|....*...
gi 1622914065 123 LEEAEFYNITSLI------KLVKDKIRE 144
Cdd:cd18419   110 DEELAFYGILPEIigdccyEEYKDRKRE 137

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  48 LNVGGTYFLTTRQTLCRDPKSFLYRL--CQADPDLDSDKDE---TGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGV 122
Cdd:cd18424     3 INVGGSRFVLSQQVLSSHPETRLGKLavSVRDSVLELCDDAnfvDNEYFFDRSSQAFKYIMNYYKTGHLHVMEELCAISF 82

                          90
                  ....*....|..
gi 1622914065 123 LEEAEFYNITSL 134
Cdd:cd18424    83 LQEIEYWGIDEL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYRL--CQADPDL-------DSDKDEtgaYLIDRDPTYFGPVLNYLRHGKLVINKD 116
Cdd:cd18382     1 VIINVGGARYSLPWSTLDRFPLTRLSRLkaCRSEDDIlrvcddyDVERNE---FFFDRSPEAFGVILLFLRAGKLRLLRE 77

                          90
                  ....*....|....*
gi 1622914065 117 LAEEGVLEEAEFYNI 131
Cdd:cd18382    78 MCALSFQEELAYWGI 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  48 LNVGGTYFLTTRQTLCRDPKSFLyrlCQADPDLDSDKDeTGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAE 127
Cdd:cd18417    39 VNVSGRRFQTWKNTLDRYPDTLL---GSSEKEFFYNED-TQEYFFDRDPEMFRHILNFYRTGRLHYPRHECIQAFDEELS 114

                  ....
gi 1622914065 128 FYNI 131
Cdd:cd18417   115 FYGI 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 1 (KCNB1); KCNB1, also called delayed rectifier potassium channel 1 (DRK1) or voltage-gated potassium channel subunit Kv2.1, mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB1 is involved in the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  38 RPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRL--CQADPDL----DSDKDETGAYLIDRDPTYFGPVLNYLRHGKL 111
Cdd:cd18411     4 RSKACSRRVKLNVGGLAHEVLWRTLDRLPRTRLGKLrdCNTHESLmeicDDYNLEENEYFFDRHPGAFTSILNFYRTGKL 83

                          90       100
                  ....*....|....*....|...
gi 1622914065 112 VINKDLAEEGVLEEAEFYNITSL 134
Cdd:cd18411    84 HMMEEMCALSFSQELDYWGIDEI 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADP---------DLDSDKDETGA---YLIDRDPTYFGPVLNYLRHGKLVI 113
Cdd:cd18415     4 IILNVGGTRHETYRSTLKTLPGTRLALLASSDPqgdcltqcsQVGGSDGSPGGgneFFFDRHPGVFAYVLNYYRTGKLHC 83

                          90
                  ....*....|....*...
gi 1622914065 114 NKDLAEEGVLEEAEFYNI 131
Cdd:cd18415    84 PADVCGPLFEEELAFWGI 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 4 (KCNG4); KCNG4, also called voltage-gated potassium channel subunit Kv6.4, is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG4 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYRL---------CQADPDLDSDKDEtgaYLIDRDPTYFGPVLNYLRHGKLVINKD 116
Cdd:cd18423     4 IIINVGGIKYLMPWSTLDEFPLTRLGKLkfcssyeeiVQICDDYDEDTNE---FFFDRNPCAFRMIVSFLAAGKLRLLRE 80

                          90
                  ....*....|....*
gi 1622914065 117 LAEEGVLEEAEFYNI 131
Cdd:cd18423    81 MCALSFQEELTYWGI 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPD-----LDSDKDETG-AYLIDRDPTYFGPVLNYLRHGKLVINKDLAE 119
Cdd:cd18384     1 IRINVGGFRRRLSASALLRFPGTRLGRLLACHSEeaileLCDDYDVAArEFYFDRNPGFFLYVLHFYRTGKLHVMDELCV 80

                          90
                  ....*....|....*
gi 1622914065 120 EGVLEEAEFYNITSL 134
Cdd:cd18384    81 FSFSQEIEYWGINEF 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 1 (KCNS1); KCNS1, also called delayed-rectifier K(+) channel alpha subunit 1 or voltage-gated potassium channel subunit Kv9.1, is a modulatory alpha subunit of voltage-gated potassium channel that mediates neuropathic pain following nerve injury. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  46 VRLNVGGTYFLTTRQTLCRDPKSFLYRL--CQADPDL-----DSDKDETGAYLiDRDPTYFGPVLNYLRHGKLVINKDLA 118
Cdd:cd18426     1 ININVGGLKRRLSSSTLSKFPDTRLGRLlsCDSEESIlqicdDYDVSAKEFYF-DRNPGLFPYVLHFYQTGKLHIMEELC 79

                          90
                  ....*....|....
gi 1622914065 119 EEGVLEEAEFYNIT 132
Cdd:cd18426    80 VFSFSQEIEYWGIN 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shab and similar proteins; Shab is a slow delayed rectifier voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shab is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622914065  43 SKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADP-----DLDSDKD-ETGAYLIDRDPTYFGPVLNYLRHGKLVINKD 116
Cdd:cd18413     1 NRRVVINVGGVKHEVLWRTLDRMPHTRLGKLRDSNTheaivELCDDYSlADNEYFFDRHPRSFASILNFYRTGKLHLVEE 80

                          90
                  ....*....|....*...
gi 1622914065 117 LAEEGVLEEAEFYNITSL 134
Cdd:cd18413    81 MCVLAFSDDLEYWGVDEL 98