NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622835494|ref|XP_028696854|]
View 

MORN repeat-containing protein 1 isoform X4 [Macaca mulatta]

Protein Classification

MORN repeat-containing protein( domain architecture ID 11468649)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  33296386|35568981

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
23-206 8.40e-39

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 142.40  E-value: 8.40e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494  23 AEGYGVYVYPNSFFRYEGEWKGGRKHGHGKLLFKDGSYYEGAFVDGEITGEGRRHWAwSGDTFSGQFVLGEPQGHGVMEY 102
Cdd:COG4642    89 GDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFP-NGDVYEGEFKNGKPHGQGTLTY 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494 103 KAGGCYEGEVSHGMREGRGFLVDRDGQVYQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWH 182
Cdd:COG4642   168 ADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFK 247

                         170       180
                  ....*....|....*....|....
gi 1622835494 183 SDVFSGLGSMAHCSGVTYYGLWIN 206
Cdd:COG4642   248 NGKRHGQGTMTYADGSVYEGEWKN 271
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
23-206 8.40e-39

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 142.40  E-value: 8.40e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494  23 AEGYGVYVYPNSFFRYEGEWKGGRKHGHGKLLFKDGSYYEGAFVDGEITGEGRRHWAwSGDTFSGQFVLGEPQGHGVMEY 102
Cdd:COG4642    89 GDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFP-NGDVYEGEFKNGKPHGQGTLTY 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494 103 KAGGCYEGEVSHGMREGRGFLVDRDGQVYQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWH 182
Cdd:COG4642   168 ADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFK 247

                         170       180
                  ....*....|....*....|....
gi 1622835494 183 SDVFSGLGSMAHCSGVTYYGLWIN 206
Cdd:COG4642   248 NGKRHGQGTMTYADGSVYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 11-191 5.29e-25

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 108.77  E-value: 5.29e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494  11 GELMSPTGRLWAA-------EGYGVYVYPNSFFrYEGEWKGGRKHGHGKLLFKDGSYYEGAFVDGEITGEGRrHWAWSGD 83
Cdd:PLN03185    1 GELVLSNGDFYSGsllgnvpEGPGKYLWSDGCM-YEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGT-YTGTDGT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494  84 TFSGQFVLGEPQGHGVMEYKAGGCYEGEVSHGMREGRGFLVDRDGQVYQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQR 163
Cdd:PLN03185   79 TYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMM 158

                         170       180
                  ....*....|....*....|....*...
gi 1622835494 164 QGHGVLRRTDGSTYEGQWHSDVFSGLGS 191
Cdd:PLN03185  159 HGFGVYTWSDGGCYVGTWTRGLKDGKGV 186
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 38-60 8.63e-05

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 39.31  E-value: 8.63e-05
                          10        20
                  ....*....|....*....|...
gi 1622835494  38 YEGEWKGGRKHGHGKLLFKDGSY 60
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
37-57 7.90e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 36.55  E-value: 7.90e-04
                           10        20
                   ....*....|....*....|.
gi 1622835494   37 RYEGEWKGGRKHGHGKLLFKD 57
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
23-206 8.40e-39

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 142.40  E-value: 8.40e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494  23 AEGYGVYVYPNSFFRYEGEWKGGRKHGHGKLLFKDGSYYEGAFVDGEITGEGRRHWAwSGDTFSGQFVLGEPQGHGVMEY 102
Cdd:COG4642    89 GDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFP-NGDVYEGEFKNGKPHGQGTLTY 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494 103 KAGGCYEGEVSHGMREGRGFLVDRDGQVYQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWH 182
Cdd:COG4642   168 ADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFK 247

                         170       180
                  ....*....|....*....|....
gi 1622835494 183 SDVFSGLGSMAHCSGVTYYGLWIN 206
Cdd:COG4642   248 NGKRHGQGTMTYADGSVYEGEWKN 271
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
11-209 1.11e-30

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 120.06  E-value: 1.11e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494  11 GELMSPTGRLWAAEGYGVYVYPNSFFRYEGEWKGGRKHGHGKLLFKD-GSYYEGAFVDGEITGEGRRHWAwSGDTFSGQF 89
Cdd:COG4642    53 GGGGGGGTGVAGGGGGEGGVTAAGGGGGGGGGKGDGGDGGGGEGGFGgGGGGGGGKKGGGGGGGGVLEGD-DGGGYGGGT 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494  90 VLGEPQGHGVMEYKAGGCYEGEVSHGMREGRGFLVDRDGQVYQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVL 169
Cdd:COG4642   132 ADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTY 211

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1622835494 170 RRTDGSTYEGQWHSDVFSGLGSMAHCSGVTYYGLWINGHP 209
Cdd:COG4642   212 TYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKR 251
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
22-207 7.17e-28

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 112.36  E-value: 7.17e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494  22 AAEGYGVYVYPNSFFRYEGEWKGGRKHGHGKLLFKDGSYYEGAFVDGEITGEGRRHWAWS-----------GDTFSGQFV 90
Cdd:COG4642    30 GGEGGGGLGTLPGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGGGGGGKGDGGdggggeggfggGGGGGGGKK 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494  91 LGEPQGHGVMEYKAGGCYEGEVSHGMREGRGFLVDRDGQVYQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLR 170
Cdd:COG4642   110 GGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLT 189

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1622835494 171 RTDGSTYEGQWHSDVFSGLGSMAHCSGVTYYGLWING 207
Cdd:COG4642   190 YANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNG 226
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 11-191 5.29e-25

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 108.77  E-value: 5.29e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494  11 GELMSPTGRLWAA-------EGYGVYVYPNSFFrYEGEWKGGRKHGHGKLLFKDGSYYEGAFVDGEITGEGRrHWAWSGD 83
Cdd:PLN03185    1 GELVLSNGDFYSGsllgnvpEGPGKYLWSDGCM-YEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGT-YTGTDGT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494  84 TFSGQFVLGEPQGHGVMEYKAGGCYEGEVSHGMREGRGFLVDRDGQVYQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQR 163
Cdd:PLN03185   79 TYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMM 158

                         170       180
                  ....*....|....*....|....*...
gi 1622835494 164 QGHGVLRRTDGSTYEGQWHSDVFSGLGS 191
Cdd:PLN03185  159 HGFGVYTWSDGGCYVGTWTRGLKDGKGV 186
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 27-207 5.78e-23

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 102.60  E-value: 5.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494  27 GVYVYPNSFFrYEGEWKGGRKHGHGKLLFKDGSYYEGAFVDGEITGEGRRHWAwSGDTFSGQFVLGEPQGHGVMEYKAGG 106
Cdd:PLN03185    1 GELVLSNGDF-YSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWP-SGATYEGEFSGGYMHGSGTYTGTDGT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494 107 CYEGEVSHGMREGRGFLVDRDGQVYQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWHSDVF 186
Cdd:PLN03185   79 TYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMM 158

                         170       180
                  ....*....|....*....|.
gi 1622835494 187 SGLGSMAHCSGVTYYGLWING 207
Cdd:PLN03185  159 HGFGVYTWSDGGCYVGTWTRG 179
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 105-209 2.42e-12

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 69.48  E-value: 2.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494 105 GGCYEGEVSHGMREGRGFLVDRDGQVYQGSFHDNKRHGPGQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWHSD 184
Cdd:PLN03185    8 GDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLN 87

                          90       100
                  ....*....|....*....|....*
gi 1622835494 185 VFSGLGSMAHCSGVTYYGLWINGHP 209
Cdd:PLN03185   88 LKHGLGYQRYPNGDVFEGSWIQGLQ 112
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 144-208 4.99e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 45.98  E-value: 4.99e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622835494 144 GQMLFKNGDKYDGDWVRDQRQGHGVLRRTDGSTYEGQWHSDVFSGLGSMAHCSGVTYYGLWINGH 208
Cdd:PLN03185    1 GELVLSNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGY 65
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 38-60 8.63e-05

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 39.31  E-value: 8.63e-05
                          10        20
                  ....*....|....*....|...
gi 1622835494  38 YEGEWKGGRKHGHGKLLFKDGSY 60
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
24-151 2.88e-04

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 41.59  E-value: 2.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622835494  24 EGYGVYVYPNSFFRYEGEWKGGRKHGHGKLLFKDG---SYYEgafvDGEITGEGrrhwawsgdtfsgQFVLGEPQGHGVM 100
Cdd:COG2849    34 SGVKEKTEDSYNEGGKLIKKKLGKGLGKYKKGKLGewkTYYP----NGQLKSEG-------------TYKNGKLEGEWKE 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622835494 101 EYKAGG-CYEGEVSHGMREGRGFLVDRDGQV-YQGSFHDNKRHGPGQMLFKNG 151
Cdd:COG2849    97 YYENGKlKSEGNYKNGKLHGEWKEYYENGKLkEEGNYKNGKKDGVWKYYDENG 149
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
37-57 7.90e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 36.55  E-value: 7.90e-04
                           10        20
                   ....*....|....*....|.
gi 1622835494   37 RYEGEWKGGRKHGHGKLLFKD 57
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
152-173 4.02e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 34.62  E-value: 4.02e-03
                           10        20
                   ....*....|....*....|..
gi 1622835494  152 DKYDGDWVRDQRQGHGVLRRTD 173
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 131-153 9.01e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 33.54  E-value: 9.01e-03
                          10        20
                  ....*....|....*....|...
gi 1622835494 131 YQGSFHDNKRHGPGQMLFKNGDK 153
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
130-150 9.36e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 33.47  E-value: 9.36e-03
                           10        20
                   ....*....|....*....|.
gi 1622835494  130 VYQGSFHDNKRHGPGQMLFKN 150
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH