NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622912403|ref|XP_028696643|]
View 

sulfotransferase 1A1 isoform X2 [Macaca mulatta]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-278 1.39e-95

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 281.92  E-value: 1.39e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403  38 PDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFM---RVPFLEFKVP----GIPSGMETLKDTPAPRLLKTHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403 111 LALLPQTLLDQKVK---------DVAVSYYHFYHMAKVYPEPGTWDSFLEKFMAGEVSYGSWYQHVREWWELSHTHPVLY 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKiiylvrnpkDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403 182 LFYEDMKENPKREIRKILEFVGRSLPEETVDLMVQHTSFKEMKKNPMANYTTVPQEfmdhsISPFMRKGMTGDWKTTFTV 261
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235
                         250
                  ....*....|....*..
gi 1622912403 262 AQNERFDADYAEKMAGC 278
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-278 1.39e-95

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 281.92  E-value: 1.39e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403  38 PDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFM---RVPFLEFKVP----GIPSGMETLKDTPAPRLLKTHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403 111 LALLPQTLLDQKVK---------DVAVSYYHFYHMAKVYPEPGTWDSFLEKFMAGEVSYGSWYQHVREWWELSHTHPVLY 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKiiylvrnpkDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403 182 LFYEDMKENPKREIRKILEFVGRSLPEETVDLMVQHTSFKEMKKNPMANYTTVPQEfmdhsISPFMRKGMTGDWKTTFTV 261
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235
                         250
                  ....*....|....*..
gi 1622912403 262 AQNERFDADYAEKMAGC 278
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
34-280 4.71e-25

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 102.31  E-value: 4.71e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403  34 FRARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRaPIFMR-----VPFLEFKVPGIPSgMETLKDTPAPrLLKTH 108
Cdd:PLN02164   75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIEIDFPFFPS-VDVLKDKGNT-LFSTH 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403 109 LPLALLPQTLLD---------QKVKDVAVSYYHFYHMAKVY--PEPGTWDSFlEKFMAGEVSYGSWYQHVREWWELSHTH 177
Cdd:PLN02164  152 IPYGLLPDSVVKsgckmvyiwRDPKDTFISMWTFLHKERSQqgPLNSLEESF-DMFCRGLSVYGPYLDHVLGYWKAYQEN 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403 178 P--VLYLFYEDMKENPKREIRKILEFVGRSLPEE-----TVDLMVQHTSFkEMKKNPMANYTTVPQEFMD--HSISPFMR 248
Cdd:PLN02164  231 PdrILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSF-ETLKNLEANKGEKDREDRPavYANSAYFR 309
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1622912403 249 KGMTGDWKTTFTVAQNERFDADYAEKMAGCSL 280
Cdd:PLN02164  310 KGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-278 1.39e-95

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 281.92  E-value: 1.39e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403  38 PDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFM---RVPFLEFKVP----GIPSGMETLKDTPAPRLLKTHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403 111 LALLPQTLLDQKVK---------DVAVSYYHFYHMAKVYPEPGTWDSFLEKFMAGEVSYGSWYQHVREWWELSHTHPVLY 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKiiylvrnpkDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403 182 LFYEDMKENPKREIRKILEFVGRSLPEETVDLMVQHTSFKEMKKNPMANYTTVPQEfmdhsISPFMRKGMTGDWKTTFTV 261
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235
                         250
                  ....*....|....*..
gi 1622912403 262 AQNERFDADYAEKMAGC 278
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
34-280 4.71e-25

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 102.31  E-value: 4.71e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403  34 FRARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRaPIFMR-----VPFLEFKVPGIPSgMETLKDTPAPrLLKTH 108
Cdd:PLN02164   75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIEIDFPFFPS-VDVLKDKGNT-LFSTH 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403 109 LPLALLPQTLLD---------QKVKDVAVSYYHFYHMAKVY--PEPGTWDSFlEKFMAGEVSYGSWYQHVREWWELSHTH 177
Cdd:PLN02164  152 IPYGLLPDSVVKsgckmvyiwRDPKDTFISMWTFLHKERSQqgPLNSLEESF-DMFCRGLSVYGPYLDHVLGYWKAYQEN 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403 178 P--VLYLFYEDMKENPKREIRKILEFVGRSLPEE-----TVDLMVQHTSFkEMKKNPMANYTTVPQEFMD--HSISPFMR 248
Cdd:PLN02164  231 PdrILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSF-ETLKNLEANKGEKDREDRPavYANSAYFR 309
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1622912403 249 KGMTGDWKTTFTVAQNERFDADYAEKMAGCSL 280
Cdd:PLN02164  310 KGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
Sulfotransfer_3 pfam13469
Sulfotransferase family;
47-208 2.91e-07

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 49.60  E-value: 2.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403  47 PKSGTTWVSQILDmiyqggdlekCHRAPIFMR-----VPFLEFKVPGIPSGMETLKDTPAPR---------------LLK 106
Cdd:pfam13469   7 PRSGTTLLHRLLA----------AHPDVRPPEetwfvIPRILALLQAWGKSLEALARVPSYArwlcdkspshlfhldLLL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912403 107 THLPLALLPQTLLDqkVKDVAVSyyHFYHMAKVYPEPgtWDSFLEKFMAGEVSYgsWYQHVREWWELSHTHP---VLYLF 183
Cdd:pfam13469  77 KAFPDAKFIHLHRD--PVDTVIS--SYCSLFGFTLSS--YSTAFLRDIGLALAR--WSRAYERLMAARARVPpgrFLDVR 148
                         170       180
                  ....*....|....*....|....*
gi 1622912403 184 YEDMKENPKREIRKILEFVGRSLPE 208
Cdd:pfam13469 149 YEDLVADPEGTLRRILEFLGLPWDD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure