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Conserved domains on  [gi|1622911028|ref|XP_028696404|]
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RNA polymerase I-specific transcription initiation factor RRN3 isoform X1 [Macaca mulatta]

Protein Classification

RNA polymerase I-specific transcription initiation factor RRN3 family protein( domain architecture ID 10526375)

RNA polymerase I-specific transcription initiation factor RRN3 family protein similar to human RRN3 that is required for efficient transcription initiation by RNA polymerase I, and for the formation of the competent preinitiation complex (PIC).

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 60-569 9.08e-144

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


:

Pssm-ID: 461623  Cd Length: 548  Bit Score: 426.64  E-value: 9.08e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028  60 LLKYKKGETNDFELLKNQL-LDPD----IKDDQIINWLLEFRSSIMYLTKDFEQLISIILRLPWLNRSQTVVEEYLAFLG 134
Cdd:pfam05327  16 LEEHEKGDSEQYDELKEQFsPDPEspdaPSTALLKQLLKALSSNVSRLDRSCSGLVEAILSLSWLGRDESFVKAYIRFLG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028 135 NLVSAQTVFLRPCLSMIASHFVPPRVIIKEGDVDVSDSEDEDdnlpanFDTCHRALQIIARYVPSTPWFLMPILVEKFPF 214
Cdd:pfam05327  96 VLASAHPKYLSLVLSMLVSNFTPQPESSGRLPGYPPVTRREV------YERVHEALKYILRLIPTAPSVLLPILSRKFPH 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028 215 VQKSERTLECYVHNLLRISVYFPTLRHEILELIIEKLLKLDVnasrqDI--------EDAEETATQTCGGTDSTEGLFNM 286
Cdd:pfam05327 170 KRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDV-----EIqveledldDDEDEELLEQLDEDDDDDDDDDS 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028 287 D-----EDEETEHDTKAGPARLDQMVHPVAERLDILMSLVLSYMKDVCY--VDGKVDNSKTKDLYRDLINIFDKLLLPTH 359
Cdd:pfam05327 245 DddsdsSDDGLDDDEEDDEVQRIKKIKELVEKLDAILDLLFEHLDSKFSsgSPEELNEGEGVEVFNTLLSLFKSTILPTY 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028 360 ASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPSNPAIIRQAAGNYIGSFLARAKFIPLITVKSCLDLLVNWLHIYLNN 439
Cdd:pfam05327 325 RSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFVARAKFVSRSQVRFVLSYLCDWLNRYVDE 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028 440 QDSGTKAfCDVALHGPFYSACQAVFYTFVFRHKQLL---SGNLKEGLRYLQSLN--FERIVMSQLNPLKVCLPSVVNFFA 514
Cdd:pfam05327 405 REEECRG-PDLKRHGVFYAVCQALLYIFCFRWRDLTdadDDEEGGDLEWLPGLDefLQRAIYSKLNPLKVCSPNVVTEFA 483

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622911028 515 AITNKYQLVFCYTIIERNNRqmlpviRSTAGGDSVQTcTNPLDTFFPFDPCVLKR 569
Cdd:pfam05327 484 RIAHHLQFAYCFSIIESNKR------EETAGTATGQE-FEQLDAYFPFDPYLLPR 531
 
Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 60-569 9.08e-144

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 426.64  E-value: 9.08e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028  60 LLKYKKGETNDFELLKNQL-LDPD----IKDDQIINWLLEFRSSIMYLTKDFEQLISIILRLPWLNRSQTVVEEYLAFLG 134
Cdd:pfam05327  16 LEEHEKGDSEQYDELKEQFsPDPEspdaPSTALLKQLLKALSSNVSRLDRSCSGLVEAILSLSWLGRDESFVKAYIRFLG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028 135 NLVSAQTVFLRPCLSMIASHFVPPRVIIKEGDVDVSDSEDEDdnlpanFDTCHRALQIIARYVPSTPWFLMPILVEKFPF 214
Cdd:pfam05327  96 VLASAHPKYLSLVLSMLVSNFTPQPESSGRLPGYPPVTRREV------YERVHEALKYILRLIPTAPSVLLPILSRKFPH 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028 215 VQKSERTLECYVHNLLRISVYFPTLRHEILELIIEKLLKLDVnasrqDI--------EDAEETATQTCGGTDSTEGLFNM 286
Cdd:pfam05327 170 KRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDV-----EIqveledldDDEDEELLEQLDEDDDDDDDDDS 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028 287 D-----EDEETEHDTKAGPARLDQMVHPVAERLDILMSLVLSYMKDVCY--VDGKVDNSKTKDLYRDLINIFDKLLLPTH 359
Cdd:pfam05327 245 DddsdsSDDGLDDDEEDDEVQRIKKIKELVEKLDAILDLLFEHLDSKFSsgSPEELNEGEGVEVFNTLLSLFKSTILPTY 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028 360 ASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPSNPAIIRQAAGNYIGSFLARAKFIPLITVKSCLDLLVNWLHIYLNN 439
Cdd:pfam05327 325 RSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFVARAKFVSRSQVRFVLSYLCDWLNRYVDE 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028 440 QDSGTKAfCDVALHGPFYSACQAVFYTFVFRHKQLL---SGNLKEGLRYLQSLN--FERIVMSQLNPLKVCLPSVVNFFA 514
Cdd:pfam05327 405 REEECRG-PDLKRHGVFYAVCQALLYIFCFRWRDLTdadDDEEGGDLEWLPGLDefLQRAIYSKLNPLKVCSPNVVTEFA 483

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622911028 515 AITNKYQLVFCYTIIERNNRqmlpviRSTAGGDSVQTcTNPLDTFFPFDPCVLKR 569
Cdd:pfam05327 484 RIAHHLQFAYCFSIIESNKR------EETAGTATGQE-FEQLDAYFPFDPYLLPR 531
 
Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 60-569 9.08e-144

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 426.64  E-value: 9.08e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028  60 LLKYKKGETNDFELLKNQL-LDPD----IKDDQIINWLLEFRSSIMYLTKDFEQLISIILRLPWLNRSQTVVEEYLAFLG 134
Cdd:pfam05327  16 LEEHEKGDSEQYDELKEQFsPDPEspdaPSTALLKQLLKALSSNVSRLDRSCSGLVEAILSLSWLGRDESFVKAYIRFLG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028 135 NLVSAQTVFLRPCLSMIASHFVPPRVIIKEGDVDVSDSEDEDdnlpanFDTCHRALQIIARYVPSTPWFLMPILVEKFPF 214
Cdd:pfam05327  96 VLASAHPKYLSLVLSMLVSNFTPQPESSGRLPGYPPVTRREV------YERVHEALKYILRLIPTAPSVLLPILSRKFPH 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028 215 VQKSERTLECYVHNLLRISVYFPTLRHEILELIIEKLLKLDVnasrqDI--------EDAEETATQTCGGTDSTEGLFNM 286
Cdd:pfam05327 170 KRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDV-----EIqveledldDDEDEELLEQLDEDDDDDDDDDS 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028 287 D-----EDEETEHDTKAGPARLDQMVHPVAERLDILMSLVLSYMKDVCY--VDGKVDNSKTKDLYRDLINIFDKLLLPTH 359
Cdd:pfam05327 245 DddsdsSDDGLDDDEEDDEVQRIKKIKELVEKLDAILDLLFEHLDSKFSsgSPEELNEGEGVEVFNTLLSLFKSTILPTY 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028 360 ASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPSNPAIIRQAAGNYIGSFLARAKFIPLITVKSCLDLLVNWLHIYLNN 439
Cdd:pfam05327 325 RSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFVARAKFVSRSQVRFVLSYLCDWLNRYVDE 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622911028 440 QDSGTKAfCDVALHGPFYSACQAVFYTFVFRHKQLL---SGNLKEGLRYLQSLN--FERIVMSQLNPLKVCLPSVVNFFA 514
Cdd:pfam05327 405 REEECRG-PDLKRHGVFYAVCQALLYIFCFRWRDLTdadDDEEGGDLEWLPGLDefLQRAIYSKLNPLKVCSPNVVTEFA 483

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622911028 515 AITNKYQLVFCYTIIERNNRqmlpviRSTAGGDSVQTcTNPLDTFFPFDPCVLKR 569
Cdd:pfam05327 484 RIAHHLQFAYCFSIIESNKR------EETAGTATGQE-FEQLDAYFPFDPYLLPR 531
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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