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Conserved domains on  [gi|1622896070|ref|XP_028695185|]
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zinc finger protein 780B isoform X2 [Macaca mulatta]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-66 1.55e-35

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 128.48  E-value: 1.55e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622896070    6 VTFRDVAIDFSQEEWECLQPDQRTLYRDVMLENYSHLISLGSSISKPDVITLLEQEKEPWI 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
217-630 4.93e-18

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 87.83  E-value: 4.93e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 217 KPFECKECGKAFSLSTQLNRHKNIHTGEKLFEC--KECGKSFNRSSNLTQHQSIHAGVKPHQCK---------------- 278
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 279 ECGKAFNRGSNLIQHQKIHSNEKPFVCrecgmTFRYHYQLIEHCrihTGEKPFECKECRKAFTLLTKLVRHQKIHIGEKP 358
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLP-----DLLSISNLRNNP---LPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 359 fecrecgkafsllNQLNRHKNIHTGEKPFECKECGKSFNRSSNLIQHQSIHAGVKPYQCKECGKGFNRGANLIQHQKIHS 438
Cdd:COG5048   184 -------------LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 439 NEKPFVCRECEMAFRYHYQLIQHCQIHTG-------GKPFECKECGKAFSLLTQLARHKN--IHSGE--KPFEC--KDCG 505
Cdd:COG5048   251 SDSSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCG 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 506 KAFNRGSNLVQHQSIHTGEKPYECKEC-------GKTFRLHLQLSQHEKTHTGEKPFEC--KECGKFFRRGSNLNQHRSI 576
Cdd:COG5048   331 KLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIIT 410

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622896070 577 HTGKKP--FECKECGKAFRLHMHLIRHQKFHTGEKPFECKECGKAFSLHTQLNRHK 630
Cdd:COG5048   411 HLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
626-650 3.12e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.12e-04
                          10        20
                  ....*....|....*....|....*
gi 1622896070 626 LNRHKNIHTGEKPFECKECGKSFNR 650
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
710-733 8.47e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 8.47e-03
                          10        20
                  ....*....|....*....|....
gi 1622896070 710 LIEHYQIHTGEKPFECKECGKAFS 733
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-66 1.55e-35

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 128.48  E-value: 1.55e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622896070    6 VTFRDVAIDFSQEEWECLQPDQRTLYRDVMLENYSHLISLGSSISKPDVITLLEQEKEPWI 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 7.09e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.54  E-value: 7.09e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622896070   5 SVTFRDVAIDFSQEEWECLQPDQRTLYRDVMLENYSHLISLG 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 3.56e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.14  E-value: 3.56e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622896070   6 VTFRDVAIDFSQEEWECLQPDQRTLYRDVMLENYSHLISL 45
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
217-630 4.93e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 87.83  E-value: 4.93e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 217 KPFECKECGKAFSLSTQLNRHKNIHTGEKLFEC--KECGKSFNRSSNLTQHQSIHAGVKPHQCK---------------- 278
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 279 ECGKAFNRGSNLIQHQKIHSNEKPFVCrecgmTFRYHYQLIEHCrihTGEKPFECKECRKAFTLLTKLVRHQKIHIGEKP 358
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLP-----DLLSISNLRNNP---LPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 359 fecrecgkafsllNQLNRHKNIHTGEKPFECKECGKSFNRSSNLIQHQSIHAGVKPYQCKECGKGFNRGANLIQHQKIHS 438
Cdd:COG5048   184 -------------LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 439 NEKPFVCRECEMAFRYHYQLIQHCQIHTG-------GKPFECKECGKAFSLLTQLARHKN--IHSGE--KPFEC--KDCG 505
Cdd:COG5048   251 SDSSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCG 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 506 KAFNRGSNLVQHQSIHTGEKPYECKEC-------GKTFRLHLQLSQHEKTHTGEKPFEC--KECGKFFRRGSNLNQHRSI 576
Cdd:COG5048   331 KLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIIT 410

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622896070 577 HTGKKP--FECKECGKAFRLHMHLIRHQKFHTGEKPFECKECGKAFSLHTQLNRHK 630
Cdd:COG5048   411 HLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
374-398 3.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.12e-04
                          10        20
                  ....*....|....*....|....*
gi 1622896070 374 LNRHKNIHTGEKPFECKECGKSFNR 398
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
626-650 3.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.12e-04
                          10        20
                  ....*....|....*....|....*
gi 1622896070 626 LNRHKNIHTGEKPFECKECGKSFNR 650
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
710-733 8.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 8.47e-03
                          10        20
                  ....*....|....*....|....
gi 1622896070 710 LIEHYQIHTGEKPFECKECGKAFS 733
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-66 1.55e-35

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 128.48  E-value: 1.55e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622896070    6 VTFRDVAIDFSQEEWECLQPDQRTLYRDVMLENYSHLISLGSSISKPDVITLLEQEKEPWI 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 7.09e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.54  E-value: 7.09e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622896070   5 SVTFRDVAIDFSQEEWECLQPDQRTLYRDVMLENYSHLISLG 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 3.56e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.14  E-value: 3.56e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622896070   6 VTFRDVAIDFSQEEWECLQPDQRTLYRDVMLENYSHLISL 45
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
217-630 4.93e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 87.83  E-value: 4.93e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 217 KPFECKECGKAFSLSTQLNRHKNIHTGEKLFEC--KECGKSFNRSSNLTQHQSIHAGVKPHQCK---------------- 278
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 279 ECGKAFNRGSNLIQHQKIHSNEKPFVCrecgmTFRYHYQLIEHCrihTGEKPFECKECRKAFTLLTKLVRHQKIHIGEKP 358
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLP-----DLLSISNLRNNP---LPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 359 fecrecgkafsllNQLNRHKNIHTGEKPFECKECGKSFNRSSNLIQHQSIHAGVKPYQCKECGKGFNRGANLIQHQKIHS 438
Cdd:COG5048   184 -------------LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 439 NEKPFVCRECEMAFRYHYQLIQHCQIHTG-------GKPFECKECGKAFSLLTQLARHKN--IHSGE--KPFEC--KDCG 505
Cdd:COG5048   251 SDSSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCG 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 506 KAFNRGSNLVQHQSIHTGEKPYECKEC-------GKTFRLHLQLSQHEKTHTGEKPFEC--KECGKFFRRGSNLNQHRSI 576
Cdd:COG5048   331 KLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIIT 410

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622896070 577 HTGKKP--FECKECGKAFRLHMHLIRHQKFHTGEKPFECKECGKAFSLHTQLNRHK 630
Cdd:COG5048   411 HLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
357-771 1.84e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 86.29  E-value: 1.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 357 KPFECRECGKAFSLLNQLNRHKNIHTGEKPFEC--KECGKSFNRSSNLIQHQSIH---------AGVKPYQCK------- 418
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHhnnpsdlnsKSLPLSNSKassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 419 ECGKGFNRGANLIQHQKIHSNEKPFVCrecemAFRYHYQLIQHCQIHTGGKPFECKEcgkAFSLLTQLARHKNIHSGEKP 498
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLP-----DLLSISNLRNNPLPGNNSSSVNTPQ---SNSLHPPLPANSLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 499 FeckdcgkafnrgSNLVQHQSIHTGEKPYECKECGKTFRLHLQLSQHEKTHTgEKPFECKECGKFFRRGSNLNQHRSIHT 578
Cdd:COG5048   184 L------------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSS 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 579 GKKPFECKECGKAFRLHMHLIRHQKFHTGE-------KPFECKECGKAFSLHTQLNRHKN--IHTGE--KPFECKE--CG 645
Cdd:COG5048   251 SDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCG 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 646 KSFNRVSNLVQHQSIHAGVKPYECK--ECGKVFNRGSN-----LIQHQKIHSSEKPFVC--KECRKTFRYHYQLIEHYQI 716
Cdd:COG5048   331 KLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIIT 410

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622896070 717 HTGEKP--FECKECGKAFSLLTQLAGHQIIHNGEKPFKCkeCGKAFNHGSNLVQPRS 771
Cdd:COG5048   411 HLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
162-378 7.15e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 7.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 162 PYECKECGKHFSRGSNLIQHQSIHTGEKTYKCKECGKAFQLHIQLTRHQKFHTGE-------KPFECKECGKAFSLSTQL 234
Cdd:COG5048   226 SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPL 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 235 NRHKN--IHTGEKL--FECKE--CGKSFNRSSNLTQHQSIHAGVKPHQCK--ECGKAFNRGSN-----LIQHQKIHSNEK 301
Cdd:COG5048   306 TRHLRsvNHSGESLkpFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDK 385

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 302 PFVC----RECGMTFRYHYQLIEHCRIHTGEKPFECKECRKAFTLLTKLVRHQKIHIGEKPFECRECGKAFSLLNQLNRH 377
Cdd:COG5048   386 KSETlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465


                  .
gi 1622896070 378 K 378
Cdd:COG5048   466 K 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
161-309 3.39e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 3.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 161 KPYECKECGKHFSRGSNLIQHQ--SIHTGE--KTYKCKE--CGKAFQLHIQLTRHQKFHTGEKPFECKEC-------GKA 227
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896070 228 FSLSTQLNRHKNIHTGEKLFEC--KECGKSFNRSSNLTQHQSIHAGVKPHQCK--ECGKAFNRGSNLIQHQKIHSNEKPF 303
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                  ....*.
gi 1622896070 304 VCRECG 309
Cdd:COG5048   448 LCSILK 453
zf-H2C2_2 pfam13465
Zinc-finger double domain;
374-398 3.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.12e-04
                          10        20
                  ....*....|....*....|....*
gi 1622896070 374 LNRHKNIHTGEKPFECKECGKSFNR 398
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
626-650 3.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.12e-04
                          10        20
                  ....*....|....*....|....*
gi 1622896070 626 LNRHKNIHTGEKPFECKECGKSFNR 650
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
597-621 4.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.81e-04
                          10        20
                  ....*....|....*....|....*
gi 1622896070 597 HLIRHQKFHTGEKPFECKECGKAFS 621
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
206-229 7.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.63e-04
                          10        20
                  ....*....|....*....|....
gi 1622896070 206 LTRHQKFHTGEKPFECKECGKAFS 229
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
542-566 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|....*
gi 1622896070 542 LSQHEKTHTGEKPFECKECGKFFRR 566
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-341 1.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.94e-03
                          10        20
                  ....*....|....*....|....
gi 1622896070 318 LIEHCRIHTGEKPFECKECRKAFT 341
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
486-510 2.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.04e-03
                          10        20
                  ....*....|....*....|....*
gi 1622896070 486 LARHKNIHSGEKPFECKDCGKAFNR 510
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
346-369 2.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.06e-03
                          10        20
                  ....*....|....*....|....
gi 1622896070 346 LVRHQKIHIGEKPFECRECGKAFS 369
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
513-536 3.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.02e-03
                          10        20
                  ....*....|....*....|....
gi 1622896070 513 NLVQHQSIHTGEKPYECKECGKTF 536
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
569-592 3.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.86e-03
                          10        20
                  ....*....|....*....|....
gi 1622896070 569 NLNQHRSIHTGKKPFECKECGKAF 592
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
234-258 4.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.56e-03
                          10        20
                  ....*....|....*....|....*
gi 1622896070 234 LNRHKNIHTGEKLFECKECGKSFNR 258
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 247-269 7.55e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.55e-03
                          10        20
                  ....*....|....*....|...
gi 1622896070 247 FECKECGKSFNRSSNLTQHQSIH 269
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
710-733 8.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 8.47e-03
                          10        20
                  ....*....|....*....|....
gi 1622896070 710 LIEHYQIHTGEKPFECKECGKAFS 733
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 387-409 9.65e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 9.65e-03
                          10        20
                  ....*....|....*....|...
gi 1622896070 387 FECKECGKSFNRSSNLIQHQSIH 409
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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