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Conserved domains on  [gi|1622895751|ref|XP_028695104|]
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zinc finger protein 846 isoform X3 [Macaca mulatta]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
50-439 1.73e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 1.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751  50 SNTAEKLYDSNHCGKVFSEHPFLMTHMRTHIGEKTSEDNQSGKTLRNNFPYSFY------------------KKSHAKGK 111
Cdd:COG5048    27 LSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSrhlrthhnnpsdlnskslPLSNSKAS 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 112 TPKYFKHEKAFNKFSNLTRQNKTHTQEKLYECTDCWRTFLYQSSLKVHGRSHNGDKHYICK--------ECGKAFSNSSH 183
Cdd:COG5048   107 SSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLhpplpansLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 184 LIGHGIIHSGEKPYVCKECGKAFIQSTGLKLHIRTHTgEKPYKCKECGKAFTHS------SYLTDHTRIHSGKKPYVCME 257
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 258 CGKAFTRSTGLILHIRIHAG-EKPYECKECGKVFIHSSYLTKHVR--IHSGE--KPYLCKE--CGKAFTRSSGLVLHMRT 330
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 331 HTGEKPYECK--ECGKAFN------NSSMLSQHVRIHTgEKPYEC--KQCGKAFVQSSGLSTHFRTHTGEKGYECK--EC 398
Cdd:COG5048   346 HTSISPAKEKllNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1622895751 399 GKAFARSTNLNMHMRTHTGEKPYACKECGKAFRYSTCLNVH 439
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
50-439 1.73e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 1.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751  50 SNTAEKLYDSNHCGKVFSEHPFLMTHMRTHIGEKTSEDNQSGKTLRNNFPYSFY------------------KKSHAKGK 111
Cdd:COG5048    27 LSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSrhlrthhnnpsdlnskslPLSNSKAS 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 112 TPKYFKHEKAFNKFSNLTRQNKTHTQEKLYECTDCWRTFLYQSSLKVHGRSHNGDKHYICK--------ECGKAFSNSSH 183
Cdd:COG5048   107 SSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLhpplpansLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 184 LIGHGIIHSGEKPYVCKECGKAFIQSTGLKLHIRTHTgEKPYKCKECGKAFTHS------SYLTDHTRIHSGKKPYVCME 257
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 258 CGKAFTRSTGLILHIRIHAG-EKPYECKECGKVFIHSSYLTKHVR--IHSGE--KPYLCKE--CGKAFTRSSGLVLHMRT 330
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 331 HTGEKPYECK--ECGKAFN------NSSMLSQHVRIHTgEKPYEC--KQCGKAFVQSSGLSTHFRTHTGEKGYECK--EC 398
Cdd:COG5048   346 HTSISPAKEKllNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1622895751 399 GKAFARSTNLNMHMRTHTGEKPYACKECGKAFRYSTCLNVH 439
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
407-432 3.81e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 3.81e-05
                          10        20
                  ....*....|....*....|....*.
gi 1622895751 407 NLNMHMRTHTGEKPYACKECGKAFRY 432
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 196-243 1.48e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.70  E-value: 1.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622895751 196 PYVCKECGKAFIQSTGLKLHIRTHTGEKpyKCKECGKAFTHSSYLTDH 243
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
50-439 1.73e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 1.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751  50 SNTAEKLYDSNHCGKVFSEHPFLMTHMRTHIGEKTSEDNQSGKTLRNNFPYSFY------------------KKSHAKGK 111
Cdd:COG5048    27 LSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSrhlrthhnnpsdlnskslPLSNSKAS 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 112 TPKYFKHEKAFNKFSNLTRQNKTHTQEKLYECTDCWRTFLYQSSLKVHGRSHNGDKHYICK--------ECGKAFSNSSH 183
Cdd:COG5048   107 SSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLhpplpansLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 184 LIGHGIIHSGEKPYVCKECGKAFIQSTGLKLHIRTHTgEKPYKCKECGKAFTHS------SYLTDHTRIHSGKKPYVCME 257
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 258 CGKAFTRSTGLILHIRIHAG-EKPYECKECGKVFIHSSYLTKHVR--IHSGE--KPYLCKE--CGKAFTRSSGLVLHMRT 330
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 331 HTGEKPYECK--ECGKAFN------NSSMLSQHVRIHTgEKPYEC--KQCGKAFVQSSGLSTHFRTHTGEKGYECK--EC 398
Cdd:COG5048   346 HTSISPAKEKllNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1622895751 399 GKAFARSTNLNMHMRTHTGEKPYACKECGKAFRYSTCLNVH 439
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-470 1.75e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 169 YICKECGKAFSNSSHLIGHGIIHSGEKPYVCKECGKAFIQSTGLKL--HIRTHTGE------------------------ 222
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNpsdlnskslplsnskasssslsss 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 223 -----KPYKCKECGKAFTHSSYLTDHTRIHS---GKKPYVCMECGKAFTRSTGLILHIRIHAgekpyeckECGKVFIHSS 294
Cdd:COG5048   114 ssnsnDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSLHPPLPANS--------LSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 295 YLTKHVRIHSGEKPYLCKECGKAFTRSSGLVLHMRTHTgEKPYECKECGKAFNNSSMLSQHVRIHTGEKPYECKQCG--- 371
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrss 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 372 ---KAFVQSSGLSTHFRTHTG-EKGYECKECGKAFARSTNLNMHMRT--HTGE--KPYACKE--CGKAFRYSTCLNVHMR 441
Cdd:COG5048   265 lptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1622895751 442 THTGAKPYDCK--KCGKNFTQSSALAKHLRT 470
Cdd:COG5048   345 LHTSISPAKEKllNSSSKFSPLLNNEPPQSL 375
zf-H2C2_2 pfam13465
Zinc-finger double domain;
407-432 3.81e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 3.81e-05
                          10        20
                  ....*....|....*....|....*.
gi 1622895751 407 NLNMHMRTHTGEKPYACKECGKAFRY 432
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-236 7.63e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.63e-05
                          10        20
                  ....*....|....*....|....*
gi 1622895751 212 LKLHIRTHTGEKPYKCKECGKAFTH 236
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
351-376 1.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.20e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622895751 351 MLSQHVRIHTGEKPYECKQCGKAFVQ 376
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
324-348 1.61e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.61e-04
                          10        20
                  ....*....|....*....|....*
gi 1622895751 324 LVLHMRTHTGEKPYECKECGKAFNN 348
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 193-272 3.30e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 193 GEKPYVCK--ECGKAFIQSTGLKLHiRTHTGEKPykckecgkaFTHSSYLTDHTRIHSGK-KPYVCMECGKAFTRSTGLI 269
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQ---------KLHENPSPEKMNIFSAKdKPYRCEVCDKRYKNLNGLK 415


                  ...
gi 1622895751 270 LHI 272
Cdd:COG5189   416 YHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622895751 295 YLTKHVRIHSGEKPYLCKECGKAFTR 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 305-388 1.36e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 305 GEKPYLCK--ECGKAFTRSSGLVLHMRT-HTGEKPYECKECGKafnnssmlsqHVRIHTGEKPYECKQCGKAFVQSSGLS 381
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1622895751 382 THfRTHT 388
Cdd:COG5189   416 YH-RKHS 421
PHA00733 PHA00733
hypothetical protein
 196-243 1.48e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.70  E-value: 1.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622895751 196 PYVCKECGKAFIQSTGLKLHIRTHTGEKpyKCKECGKAFTHSSYLTDH 243
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 393-415 2.60e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.60e-03
                          10        20
                  ....*....|....*....|...
gi 1622895751 393 YECKECGKAFARSTNLNMHMRTH 415
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 138-220 2.84e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622895751 138 EKLYEC--TDCWRTFLYQSSLKVHgRSHNgdkhyickECGKAFSNSSHLIGHGIIHSGEKPYVCKECGKAFIQSTGLKLH 215
Cdd:COG5189   347 GKPYKCpvEGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ....*
gi 1622895751 216 iRTHT 220
Cdd:COG5189   418 -RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
380-404 3.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.09e-03
                          10        20
                  ....*....|....*....|....*
gi 1622895751 380 LSTHFRTHTGEKGYECKECGKAFAR 404
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
239-264 3.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622895751 239 YLTDHTRIHSGKKPYVCMECGKAFTR 264
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 281-303 5.76e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 5.76e-03
                          10        20
                  ....*....|....*....|...
gi 1622895751 281 YECKECGKVFIHSSYLTKHVRIH 303
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 225-247 7.08e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.08e-03
                          10        20
                  ....*....|....*....|...
gi 1622895751 225 YKCKECGKAFTHSSYLTDHTRIH 247
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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