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Conserved domains on  [gi|1622894048|ref|XP_028694738|]
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pregnancy-specific beta-1-glycoprotein 2-like [Macaca mulatta]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10146345)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_CEACAM_D1 cd05774
First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 36-138 4.96e-45

First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM); The members here are composed of the immunoglobulin (Ig)-like domain 1 in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) proteins. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface.


:

Pssm-ID: 409430  Cd Length: 105  Bit Score: 142.41  E-value: 4.96e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894048  36 VTIEAQPAKVSEGKDVLLLVHNLPQNLTGYSWYKGQIIDLQHYITAYTIDTEMIVFGPAYSGRETVYSNASLLIQNVTKN 115
Cdd:cd05774     1 LTIELVPPQVAEGENVLLLVHNLPENLLAYAWYKGKTVSPNFLIASYIISTNSSTPGPAYSGRETIYPNGSLLIQNVTQK 80

                          90       100
                  ....*....|....*....|...
gi 1622894048 116 DTGSYTIQITKRGDETKGVTGHF 138
Cdd:cd05774    81 DTGFYTLQTITADLQTEQASVHL 103
 
Name Accession Description Interval E-value
IgV_CEACAM_D1 cd05774
First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 36-138 4.96e-45

First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM); The members here are composed of the immunoglobulin (Ig)-like domain 1 in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) proteins. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface.


Pssm-ID: 409430  Cd Length: 105  Bit Score: 142.41  E-value: 4.96e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894048  36 VTIEAQPAKVSEGKDVLLLVHNLPQNLTGYSWYKGQIIDLQHYITAYTIDTEMIVFGPAYSGRETVYSNASLLIQNVTKN 115
Cdd:cd05774     1 LTIELVPPQVAEGENVLLLVHNLPENLLAYAWYKGKTVSPNFLIASYIISTNSSTPGPAYSGRETIYPNGSLLIQNVTQK 80

                          90       100
                  ....*....|....*....|...
gi 1622894048 116 DTGSYTIQITKRGDETKGVTGHF 138
Cdd:cd05774    81 DTGFYTLQTITADLQTEQASVHL 103
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 45-139 8.04e-13

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 60.55  E-value: 8.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894048  45 VSEGKDVLLLVHNLPQ---NLTGYSWYKGQIIDLQHY-ITAYTIDTEMIVFGPAYSGRETV-YSNASLLIQNVTKNDTGS 119
Cdd:pfam07686   8 VALGGSVTLPCTYSSSmseASTSVYWYRQPPGKGPTFlIAYYSNGSEEGVKKGRFSGRGDPsNGDGSLTIQNLTLSDSGT 87

                          90       100
                  ....*....|....*....|
gi 1622894048 120 YTIQITKRGDETKGVTGHFT 139
Cdd:pfam07686  88 YTCAVIPSGEGVFGKGTRLT 107
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 45-135 1.45e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.56  E-value: 1.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894048   45 VSEGKDVLLLVHNLPQNLTGYSWYKGqiidlqhyitaytiDTEMIVFGPAYSGRETvYSNASLLIQNVTKNDTGSYTIQI 124
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPEVTWYKQ--------------GGKLLAESGRFSVSRS-GSTSTLTISNVTPEDSGTYTCAA 70

                           90
                   ....*....|..
gi 1622894048  125 T-KRGDETKGVT 135
Cdd:smart00410  71 TnSSGSASSGTT 82
 
Name Accession Description Interval E-value
IgV_CEACAM_D1 cd05774
First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 36-138 4.96e-45

First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM); The members here are composed of the immunoglobulin (Ig)-like domain 1 in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) proteins. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface.


Pssm-ID: 409430  Cd Length: 105  Bit Score: 142.41  E-value: 4.96e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894048  36 VTIEAQPAKVSEGKDVLLLVHNLPQNLTGYSWYKGQIIDLQHYITAYTIDTEMIVFGPAYSGRETVYSNASLLIQNVTKN 115
Cdd:cd05774     1 LTIELVPPQVAEGENVLLLVHNLPENLLAYAWYKGKTVSPNFLIASYIISTNSSTPGPAYSGRETIYPNGSLLIQNVTQK 80

                          90       100
                  ....*....|....*....|...
gi 1622894048 116 DTGSYTIQITKRGDETKGVTGHF 138
Cdd:cd05774    81 DTGFYTLQTITADLQTEQASVHL 103
IgV_CEACAM_like cd05741
Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 45-138 1.04e-28

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409403  Cd Length: 102  Bit Score: 101.06  E-value: 1.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894048  45 VSEGKDVLLLVHNLPQNLTGYSWYKGQIIDLQHYITAYTIDTEMIVFGPAYSGRETVYSNASLLIQNVTKNDTGSYTIQI 124
Cdd:cd05741     7 GAEGKNVLLLVPNLQTPLKSVSWYKGKQVSRNDEIAEYENSSDEFRAGSAFSGREYIYTNGSLLIQNITLSDTGFYTLES 86

                          90
                  ....*....|....
gi 1622894048 125 TKRGDETKGVTGHF 138
Cdd:cd05741    87 TNIGGKTESATFQL 100
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 45-139 8.04e-13

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 60.55  E-value: 8.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894048  45 VSEGKDVLLLVHNLPQ---NLTGYSWYKGQIIDLQHY-ITAYTIDTEMIVFGPAYSGRETV-YSNASLLIQNVTKNDTGS 119
Cdd:pfam07686   8 VALGGSVTLPCTYSSSmseASTSVYWYRQPPGKGPTFlIAYYSNGSEEGVKKGRFSGRGDPsNGDGSLTIQNLTLSDSGT 87

                          90       100
                  ....*....|....*....|
gi 1622894048 120 YTIQITKRGDETKGVTGHFT 139
Cdd:pfam07686  88 YTCAVIPSGEGVFGKGTRLT 107
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 30-121 8.14e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.00  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894048  30 PPttaQVTIEAQPAKVSEGKDVLL--LVHNLPQNLtgYSWYKGQIIDLqhyitaytidtemivfGPAYSGRETVYSNASL 107
Cdd:pfam13927   1 KP---VITVSPSSVTVREGETVTLtcEATGSPPPT--ITWYKNGEPIS----------------SGSTRSRSLSGSNSTL 59

                          90
                  ....*....|....
gi 1622894048 108 LIQNVTKNDTGSYT 121
Cdd:pfam13927  60 TISNVTRSDAGTYT 73
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 45-135 1.45e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.56  E-value: 1.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894048   45 VSEGKDVLLLVHNLPQNLTGYSWYKGqiidlqhyitaytiDTEMIVFGPAYSGRETvYSNASLLIQNVTKNDTGSYTIQI 124
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPEVTWYKQ--------------GGKLLAESGRFSVSRS-GSTSTLTISNVTPEDSGTYTCAA 70

                           90
                   ....*....|..
gi 1622894048  125 T-KRGDETKGVT 135
Cdd:smart00410  71 TnSSGSASSGTT 82
I-set pfam07679
Immunoglobulin I-set domain;
35-135 1.65e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 35.70  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894048  35 QVTIEAQPAKVSEGKDVLLLVHnlpqnLTGY-----SWYKG--QIIDLQHYITAYTIDTemivfgpaysgretvysnASL 107
Cdd:pfam07679   2 KFTQKPKDVEVQEGESARFTCT-----VTGTpdpevSWFKDgqPLRSSDRFKVTYEGGT------------------YTL 58

                          90       100
                  ....*....|....*....|....*....
gi 1622894048 108 LIQNVTKNDTGSYTIQITKR-GDETKGVT 135
Cdd:pfam07679  59 TISNVQPDDSGKYTCVATNSaGEAEASAE 87
Ig5_Contactin cd04969
Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth ...
 96-123 3.01e-03

Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.


Pssm-ID: 409358 [Multi-domain]  Cd Length: 89  Bit Score: 34.74  E-value: 3.01e-03
                          10        20
                  ....*....|....*....|....*...
gi 1622894048  96 SGRETVYSNASLLIQNVTKNDTGSYTIQ 123
Cdd:cd04969    46 SSRICILPDGSLKIKNVTKSDEGKYTCF 73
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 92-121 6.85e-03

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 34.50  E-value: 6.85e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1622894048  92 GPAYSGRETVYS------NASLLIQNVTKNDTGSYT 121
Cdd:cd20934    59 GSAYANRTALFPdllaqgNASLRLQRVRVADEGSYT 94
Ig_Titin_like cd05748
Immunoglobulin (Ig)-like domain of titin and similar proteins; The members here are composed ...
 99-132 8.79e-03

Immunoglobulin (Ig)-like domain of titin and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain found in titin-like proteins and similar proteins. Titin (also called connectin) is a fibrous sarcomeric protein specifically found in vertebrate striated muscle. Titin is a giant protein; depending on isoform composition, it ranges from 2970 to 3700 kDa, and is of a length that spans half a sarcomere. Titin largely consists of multiple repeats of Ig-like and fibronectin type 3 (FN-III)-like domains. Titin connects the ends of myosin thick filaments to Z disks and extends along the thick filament to the H zone. It appears to function similarly to an elastic band, keeping the myosin filaments centered in the sarcomere during muscle contraction or stretching. Within the sarcomere, titin is also attached to or is associated with myosin binding protein C (MyBP-C). MyBP-C appears to contribute to the generation of passive tension by titin and like titin has repeated Ig-like and FN-III domains. Also included in this group are worm twitchin and insect projectin, thick filament proteins of invertebrate muscle which also have repeated Ig-like and FN-III domains.


Pssm-ID: 409406 [Multi-domain]  Cd Length: 82  Bit Score: 33.33  E-value: 8.79e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622894048  99 ETVYSNASLLIQNVTKNDTGSYTIQITKRGDETK 132
Cdd:cd05748    42 ETTASSTSLVIKNAKRSDSGKYTLTLKNSAGEKS 75
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 46-142 9.75e-03

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 33.48  E-value: 9.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894048  46 SEGKDVLLLVHNLPQNLTGYSWYKGQIIdlqhyITAYTIDTEMIVFGPaYSGRETV-YSNASLLIQNVTKNDTGSYTIQI 124
Cdd:cd05775     8 ALGGNVTLTISSLQDDIDEIKWKKTKDK-----IVEWENNIGPTYFGS-FKDRVLLdKESGSLTIKNLTKEDSGTYELEI 81

                          90
                  ....*....|....*...
gi 1622894048 125 TKRGDETKGVTghFTLYR 142
Cdd:cd05775    82 TSTNGKVLSSK--FTLEV 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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