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Conserved domains on  [gi|1622893015|ref|XP_028694553|]
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KN motif and ankyrin repeat domain-containing protein 2 isoform X1 [Macaca mulatta]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 13778391)

ankyrin (ANK) repeat domain-containing protein may be involved in mediating protein-protein interactions; ankyrin (ANK) repeat domain-containing protein may be involved in mediating protein-protein interactions; similar to Homo sapiens ankyrin repeat and SOCS box protein 7 isoform 1; ankyrin repeat (ANK) domain-containing protein may be involved in mediating protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  15152081|17176038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
643-833 5.89e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.86  E-value: 5.89e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 643 DAHAELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIMLTALAtlk 722
Cdd:COG0666    55 ALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYN--- 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 723 tqDDIETVLQLFRLG-DVNAKASQaGQTALMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLLA 801
Cdd:COG0666   131 --GNLEIVKLLLEAGaDVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLE 207

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1622893015 802 VPScDISLTDRDGSTALMVALDAGQSEIASML 833
Cdd:COG0666   208 AGA-DVNAKDNDGKTALDLAAENGNLEIVKLL 238
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 31-69 2.96e-20

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


:

Pssm-ID: 432311  Cd Length: 39  Bit Score: 84.32  E-value: 2.96e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622893015  31 PYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPR 69
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
 189-305 6.37e-03

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 40.41  E-value: 6.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015  189 REQMAGALRK-LRQLEEQVKLIP-VLQVKLSVLQEEKRQLTVQLKSQKFLGHPTAGRGRSELCL--DLPDPPEDPVALET 264
Cdd:PTZ00108   997 KEYLLGKLEReLARLSNKVRFIKhVINGELVITNAKKKDLVKELKKLGYVRFKDIIKKKSEKITaeEEEGAEEDDEADDE 1076

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1622893015  265 RSVGTWVRERD----LGMPdgEAALTA-KVAVLETQLKKALQELQA 305
Cdd:PTZ00108  1077 DDEEELGAAVSydylLSMP--IWSLTKeKVEKLNAELEKKEKELEK 1120
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
643-833 5.89e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.86  E-value: 5.89e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 643 DAHAELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIMLTALAtlk 722
Cdd:COG0666    55 ALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYN--- 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 723 tqDDIETVLQLFRLG-DVNAKASQaGQTALMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLLA 801
Cdd:COG0666   131 --GNLEIVKLLLEAGaDVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLE 207

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1622893015 802 VPScDISLTDRDGSTALMVALDAGQSEIASML 833
Cdd:COG0666   208 AGA-DVNAKDNDGKTALDLAAENGNLEIVKLL 238
Ank_2 pfam12796
Ankyrin repeats (3 copies);
751-836 1.02e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.48  E-value: 1.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 751 LMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLtdrDGSTALMVALDAGQSEIA 830
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD---NGRTALHYAARSGHLEIV 77


                  ....*.
gi 1622893015 831 SMLYSR 836
Cdd:pfam12796  78 KLLLEK 83
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 31-69 2.96e-20

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 84.32  E-value: 2.96e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622893015  31 PYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPR 69
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 663-800 3.28e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.15  E-value: 3.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 663 LLDYV--VNIADSNGNTALHYSVS--HANFPVVQQLLDSGVcKVDKQNRAGYspimltalatlktqddietvlqLFRLG- 737
Cdd:PHA03100  127 LLDNGanVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKGV-DINAKNRVNY----------------------LLSYGv 183

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622893015 738 DVNAKaSQAGQTALMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLL 800
Cdd:PHA03100  184 PINIK-DVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 747-775 5.91e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.65  E-value: 5.91e-05
                           10        20
                   ....*....|....*....|....*....
gi 1622893015  747 GQTALMLAVSHGRVDVVKALLACEADINV 775
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 189-305 6.37e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 40.41  E-value: 6.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015  189 REQMAGALRK-LRQLEEQVKLIP-VLQVKLSVLQEEKRQLTVQLKSQKFLGHPTAGRGRSELCL--DLPDPPEDPVALET 264
Cdd:PTZ00108   997 KEYLLGKLEReLARLSNKVRFIKhVINGELVITNAKKKDLVKELKKLGYVRFKDIIKKKSEKITaeEEEGAEEDDEADDE 1076

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1622893015  265 RSVGTWVRERD----LGMPdgEAALTA-KVAVLETQLKKALQELQA 305
Cdd:PTZ00108  1077 DDEEELGAAVSydylLSMP--IWSLTKeKVEKLNAELEKKEKELEK 1120
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
643-833 5.89e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.86  E-value: 5.89e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 643 DAHAELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIMLTALAtlk 722
Cdd:COG0666    55 ALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLHLAAYN--- 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 723 tqDDIETVLQLFRLG-DVNAKASQaGQTALMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLLA 801
Cdd:COG0666   131 --GNLEIVKLLLEAGaDVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLE 207

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1622893015 802 VPScDISLTDRDGSTALMVALDAGQSEIASML 833
Cdd:COG0666   208 AGA-DVNAKDNDGKTALDLAAENGNLEIVKLL 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
636-830 2.54e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 124.30  E-value: 2.54e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 636 LRLACRSDaHAELVRRhlvtframsarLLDY--VVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPI 713
Cdd:COG0666    91 LHAAARNG-DLEIVKL-----------LLEAgaDVNARDKDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPL 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 714 MLTALatlktQDDIETVLQLFRLG-DVNAKaSQAGQTALMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGH 792
Cdd:COG0666   158 HLAAA-----NGNLEIVKLLLEAGaDVNAR-DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGN 231

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1622893015 793 KEIAGLLLAVPScDISLTDRDGSTALMVALDAGQSEIA 830
Cdd:COG0666   232 LEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIV 268
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
636-833 3.38e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.91  E-value: 3.38e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 636 LRLACRSDAHAELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIML 715
Cdd:COG0666    15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGA-DINAKDDGGNTLLHA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 716 TAlatlkTQDDIETVLQLFRLG-DVNAKASQaGQTALMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKE 794
Cdd:COG0666    94 AA-----RNGDLEIVKLLLEAGaDVNARDKD-GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLE 167

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1622893015 795 IAGLLLAVPsCDISLTDRDGSTALMVALDAGQSEIASML 833
Cdd:COG0666   168 IVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
661-833 2.45e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 101.18  E-value: 2.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 661 ARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLGDVN 740
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 741 AKASQAGQTALMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLL---AvpscDISLTDRDGSTA 817
Cdd:COG0666    81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLeagA----DVNAQDNDGNTP 156

                         170
                  ....*....|....*.
gi 1622893015 818 LMVALDAGQSEIASML 833
Cdd:COG0666   157 LHLAAANGNLEIVKLL 172
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
636-801 6.15e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 94.25  E-value: 6.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 636 LRLACRSDaHAELVRRhlvtframsarLLDY--VVNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPI 713
Cdd:COG0666   124 LHLAAYNG-NLEIVKL-----------LLEAgaDVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 714 MLTALatlktQDDIETVLQLFRLG-DVNAKaSQAGQTALMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGH 792
Cdd:COG0666   191 HLAAE-----NGHLEIVKLLLEAGaDVNAK-DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGA 264


                  ....*....
gi 1622893015 793 KEIAGLLLA 801
Cdd:COG0666   265 ALIVKLLLL 273
Ank_2 pfam12796
Ankyrin repeats (3 copies);
751-836 1.02e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 87.48  E-value: 1.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 751 LMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLtdrDGSTALMVALDAGQSEIA 830
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD---NGRTALHYAARSGHLEIV 77


                  ....*.
gi 1622893015 831 SMLYSR 836
Cdd:pfam12796  78 KLLLEK 83
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 31-69 2.96e-20

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 84.32  E-value: 2.96e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622893015  31 PYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPR 69
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
679-777 1.56e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.46  E-value: 1.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 679 LHYSVSHANFPVVQQLLDSGvCKVDKQNRAGYSPIMLTALAtlktqDDIETVLQLFRLGDVNAKASqaGQTALMLAVSHG 758
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKN-----GHLEIVKLLLEHADVNLKDN--GRTALHYAARSG 72

                          90
                  ....*....|....*....
gi 1622893015 759 RVDVVKALLACEADINVQD 777
Cdd:pfam12796  73 HLEIVKLLLEKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
749-800 7.99e-11

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 58.05  E-value: 7.99e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622893015 749 TALMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLL 800
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 663-800 3.28e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.15  E-value: 3.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 663 LLDYV--VNIADSNGNTALHYSVS--HANFPVVQQLLDSGVcKVDKQNRAGYspimltalatlktqddietvlqLFRLG- 737
Cdd:PHA03100  127 LLDNGanVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKGV-DINAKNRVNY----------------------LLSYGv 183

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622893015 738 DVNAKaSQAGQTALMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLL 800
Cdd:PHA03100  184 PINIK-DVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 668-787 3.80e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.81  E-value: 3.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 668 VNIADSNGNTALHYSVSHANFPVVQQLLDSGvCKVDKQNRAGYSPIMLtALATLKTQDDIETVLQlfRLGDVNAKASQAG 747
Cdd:PHA02878  194 VNIPDKTNNSPLHHAVKHYNKPIVHILLENG-ASTDARDKCGNTPLHI-SVGYCKDYDILKLLLE--HGVDVNAKSYILG 269

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1622893015 748 QTALMLAVSHGRvdVVKALLACEADINVQDDDGSTALMCA 787
Cdd:PHA02878  270 LTALHSSIKSER--KLKLLLEYGADINSLNSYKLTPLSSA 307
Ank_5 pfam13857
Ankyrin repeats (many copies);
731-784 6.34e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 49.65  E-value: 6.34e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622893015 731 LQLFRLGDVNAKaSQAGQTALMLAVSHGRVDVVKALLACEADINVQDDDGSTAL 784
Cdd:pfam13857   1 LLEHGPIDLNRL-DGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 668-822 2.57e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 53.81  E-value: 2.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 668 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIMLTAlatlkTQDDIETVLQLFRLGDVNAKASQAG 747
Cdd:PHA02874  150 VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGA-YANVKDNNGESPLHNAA-----EYGDYACIKLLIDHGNHIMNKCKNG 223

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622893015 748 QTALMLAVSHGRVDVvkALLACEADINVQDDDGSTALMCACEHG-HKEIAGLLLaVPSCDISLTDRDGSTALMVAL 822
Cdd:PHA02874  224 FTPLHNAIIHNRSAI--ELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILL-YHKADISIKDNKGENPIDTAF 296
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 763-835 5.88e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 53.36  E-value: 5.88e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622893015 763 VKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLLAVpSCDISLTDRDGSTALMVALDAGQSEIASMLYS 835
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEF-GADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
PHA03095 PHA03095
ankyrin-like protein; Provisional
 652-768 6.79e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.72  E-value: 6.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 652 HLVTFRAMSA---RLLDYVVNIA--DSNGNTALHYSVSHANF--PVVQQLLDSGVcKVDKQNRAGYSPIMLTAlatlkTQ 724
Cdd:PHA03095  194 HLQSFKPRARivrELIRAGCDPAatDMLGNTPLHSMATGSSCkrSLVLPLLIAGI-SINARNRYGQTPLHYAA-----VF 267

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1622893015 725 DDIETVLQLFRLG-DVNAkASQAGQTALMLAVSHGRVDVVKALLA 768
Cdd:PHA03095  268 NNPRACRRLIALGaDINA-VSSDGNTPLSLMVRNNNGRAVRAALA 311
Ank_2 pfam12796
Ankyrin repeats (3 copies);
784-841 1.08e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 1.08e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622893015 784 LMCACEHGHKEIAGLLLAVPsCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKC 841
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL 57
PHA03095 PHA03095
ankyrin-like protein; Provisional
 637-786 2.40e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.79  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 637 RLACRSDAHAELVRRHLvtfrAMSARlldyvVNIADSNGNTALHYSVSHANFP---VVQQLLDSGVcKVDKQNRAGYSPI 713
Cdd:PHA03095   18 YLLNASNVTVEEVRRLL----AAGAD-----VNFRGEYGKTPLHLYLHYSSEKvkdIVRLLLEAGA-DVNAPERCGFTPL 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622893015 714 MLTALAtlktqDDIETVLQLF-RLG-DVNAKaSQAGQTAL--MLAVSHGRVDVVKALLACEADINVQDDDGSTALMC 786
Cdd:PHA03095   88 HLYLYN-----ATTLDVIKLLiKAGaDVNAK-DKVGRTPLhvYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAV 158
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 679-840 3.16e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.43  E-value: 3.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 679 LHYSVSHANFPVVQQLLDSGvCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLG--------------------- 737
Cdd:PHA03100   39 LYLAKEARNIDVVKILLDNG-ADINSSTKNNSTPLHYLSNIKYNLTDVKEIVKLLLEYGanvnapdnngitpllyaiskk 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 738 ---------------DVNAKASQaGQTALMLAVSHGRVDV------------------VKALLACEADINVQDDDGSTAL 784
Cdd:PHA03100  118 snsysiveylldngaNVNIKNSD-GENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVPINIKDVYGFTPL 196

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622893015 785 MCACEHGHKEIAGLLLAVpSCDISLTDRDGSTALMVALDAGQSEIASM-LYSRMNIK 840
Cdd:PHA03100  197 HYAVYNNNPEFVKYLLDL-GANPNLVNKYGDTPLHIAILNNNKEIFKLlLNNGPSIK 252
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 747-778 3.91e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 44.20  E-value: 3.91e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1622893015 747 GQTALMLAVSH-GRVDVVKALLACEADINVQDD 778
Cdd:pfam00023   2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 679-836 4.96e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.99  E-value: 4.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 679 LHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLtalATLKTQDDIETVLqLFRLGDVNAKASQAgQTALMLAVSHG 758
Cdd:PHA02875   72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHL---ATILKKLDIMKLL-IARGADPDIPNTDK-FSPLHLAVMMG 146

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622893015 759 RVDVVKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLLAvPSCDISLTDRDGSTALM-VALDAGQSEIASMLYSR 836
Cdd:PHA02875  147 DIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD-SGANIDYFGKNGCVAALcYAIENNKIDIVRLFIKR 224
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 747-775 5.51e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 43.79  E-value: 5.51e-06
                          10        20
                  ....*....|....*....|....*....
gi 1622893015 747 GQTALMLAVSHGRVDVVKALLACEADINV 775
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 669-800 1.61e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.71  E-value: 1.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 669 NIADSNGNTALHYSVSHANFPVVQQLLDSGvCKVDKQNRAGYSPiMLTALATlkTQDDIETVLQLFrlgdvnAKAS--QA 746
Cdd:PLN03192  552 DIGDSKGRTPLHIAASKGYEDCVLVLLKHA-CNVHIRDANGNTA-LWNAISA--KHHKIFRILYHF------ASISdpHA 621

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622893015 747 GQTALMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLL 800
Cdd:PLN03192  622 AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 747-853 1.91e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.33  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 747 GQTALMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKEI---------------AGLLLAVPS------- 804
Cdd:PLN03192  558 GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIfrilyhfasisdphaAGDLLCTAAkrndlta 637

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622893015 805 --------CDISLTDRDGSTALMVALDAGQSEIASMLYsrMN-IKCSFAPMSDDESPT 853
Cdd:PLN03192  638 mkellkqgLNVDSEDHQGATALQVAMAEDHVDMVRLLI--MNgADVDKANTDDDFSPT 693
Ank_5 pfam13857
Ankyrin repeats (many copies);
766-821 2.59e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.33  E-value: 2.59e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622893015 766 LLACE-ADINVQDDDGSTALMCACEHGHKEIAGLLLAVPsCDISLTDRDGSTALMVA 821
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG-VDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
780-833 3.62e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.88  E-value: 3.62e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622893015 780 GSTALMCACEHGHKEIAGLLLAvPSCDISLTDRDGSTALMVALDAGQSEIASML 833
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLE-KGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA03095 PHA03095
ankyrin-like protein; Provisional
 653-801 3.71e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 47.33  E-value: 3.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 653 LVTFRAMSARLLDYVVNI------ADSNGNTALHYsvsHANFP-----VVQQLLDSGvCKVDKQNRAGYSPimLTALATL 721
Cdd:PHA03095  159 LLKSRNANVELLRLLIDAgadvyaVDDRFRSLLHH---HLQSFkprarIVRELIRAG-CDPAATDMLGNTP--LHSMATG 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 722 KTQDDIeTVLQLFRLG-DVNAKaSQAGQTALMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLL 800
Cdd:PHA03095  233 SSCKRS-LVLPLLIAGiSINAR-NRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310


                  .
gi 1622893015 801 A 801
Cdd:PHA03095  311 A 311
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 668-793 3.73e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 47.27  E-value: 3.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 668 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRaGYSPIMltaLATLKTQDDIETVLQLFRLGDVNAKASQAG 747
Cdd:PHA02874  183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKN-GFTPLH---NAIIHNRSAIELLINNASINDQDIDGSTPL 258

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1622893015 748 QTALMLAVShgrVDVVKALLACEADINVQDDDGSTALMCACEHGHK 793
Cdd:PHA02874  259 HHAINPPCD---IDIIDILLYHKADISIKDNKGENPIDTAFKYINK 301
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 747-775 5.91e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.65  E-value: 5.91e-05
                           10        20
                   ....*....|....*....|....*....
gi 1622893015  747 GQTALMLAVSHGRVDVVKALLACEADINV 775
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 747-809 6.28e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.82  E-value: 6.28e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622893015 747 GQTALMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISL 809
Cdd:PTZ00322  115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 751-848 6.58e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.78  E-value: 6.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 751 LMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLLAvPSCDISLTDRDGSTALMVALDAGQSEIA 830
Cdd:PLN03192  529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLK-HACNVHIRDANGNTALWNAISAKHHKIF 607

                          90
                  ....*....|....*...
gi 1622893015 831 SMLYsrmnikcSFAPMSD 848
Cdd:PLN03192  608 RILY-------HFASISD 618
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 668-839 1.25e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.34  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 668 VNIADSNGNTALHYSVSHANFPVVQQLLDSGVcKVDKQNRAGYSPIMltaLATLKTQDDIETVLqLFRLGDVNAKaSQAG 747
Cdd:PHA02874  117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGA-DVNIEDDNGCYPIH---IAIKHNFFDIIKLL-LEKGAYANVK-DNNG 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 748 QTALMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKEIAgllLAVPSCDISLTDRDGSTALMVALDAGQS 827
Cdd:PHA02874  191 ESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIE---LLINNASINDQDIDGSTPLHHAINPPCD 267

                         170
                  ....*....|....
gi 1622893015 828 E--IASMLYSRMNI 839
Cdd:PHA02874  268 IdiIDILLYHKADI 281
PHA03095 PHA03095
ankyrin-like protein; Provisional
 668-822 1.49e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.40  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 668 VNIADSNGNTALH-Y-SVSHANFPVVQQLLDSG--VCKVDKQnraGYSPI----------------MLTALATLKTQDDI 727
Cdd:PHA03095  110 VNAKDKVGRTPLHvYlSGFNINPKVIRLLLRKGadVNALDLY---GMTPLavllksrnanvellrlLIDAGADVYAVDDR 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 728 ETVL----------------QLFRLGDVNAKASQAGQTAL--MLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACE 789
Cdd:PHA03095  187 FRSLlhhhlqsfkprarivrELIRAGCDPAATDMLGNTPLhsMATGSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAV 266

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1622893015 790 HGHKEIAGLLLAVpSCDISLTDRDGSTALMVAL 822
Cdd:PHA03095  267 FNNPRACRRLIAL-GADINAVSSDGNTPLSLMV 298
Ank_2 pfam12796
Ankyrin repeats (3 copies);
636-706 2.04e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.87  E-value: 2.04e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622893015 636 LRLACRSDaHAELVRRhlvtframsarLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGvCKVDKQN 706
Cdd:pfam12796  34 LHLAAKNG-HLEIVKL-----------LLEHADVNLKDNGRTALHYAARSGHLEIVKLLLEKG-ADINVKD 91
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 668-784 7.33e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.32  E-value: 7.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 668 VNIADSNGNTALHYSVS---HANFPVVQQLldsgvCKVDKQNRAGyspimlTALATLKTQDDIETVLQLFRLG-DVNAKA 743
Cdd:PLN03192  584 VHIRDANGNTALWNAISakhHKIFRILYHF-----ASISDPHAAG------DLLCTAAKRNDLTAMKELLKQGlNVDSED 652

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622893015 744 SQaGQTALMLAVSHGRVDVVKALLACEADI---NVQDDDGSTAL 784
Cdd:PLN03192  653 HQ-GATALQVAMAEDHVDMVRLLIMNGADVdkaNTDDDFSPTEL 695
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 728-846 8.83e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.64  E-value: 8.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 728 ETVLQLFRLG-DVNAKASQAgQTALMLAVSHGRVDVVKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLLAvPSCD 806
Cdd:PHA02874  105 DMIKTILDCGiDVNIKDAEL-KTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLE-KGAY 182

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1622893015 807 ISLTDRDGSTALMVALDAGQSEIASMLY---SRMNIKCS--FAPM 846
Cdd:PHA02874  183 ANVKDNNGESPLHNAAEYGDYACIKLLIdhgNHIMNKCKngFTPL 227
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 666-822 1.43e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 42.36  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 666 YVVNIADSNGNTALHYSVSHANFP-VVQQLLDSGVcKVDKQNRAGYSPIMLTAlatlKTQDDIETVLQLFRLG-DVNAkA 743
Cdd:PHA02876  264 FSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGA-DVNAKNIKGETPLYLMA----KNGYDTENIRTLIMLGaDVNA-A 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015 744 SQAGQTALMLAVSHGRV-DVVKALLACEADINVQDDDGSTALMCACEHGHKEIAGLLLAVpSCDISLTDRDGSTALMVAL 822
Cdd:PHA02876  338 DRLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDY-GADIEALSQKIGTALHFAL 416
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 189-305 6.37e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 40.41  E-value: 6.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622893015  189 REQMAGALRK-LRQLEEQVKLIP-VLQVKLSVLQEEKRQLTVQLKSQKFLGHPTAGRGRSELCL--DLPDPPEDPVALET 264
Cdd:PTZ00108   997 KEYLLGKLEReLARLSNKVRFIKhVINGELVITNAKKKDLVKELKKLGYVRFKDIIKKKSEKITaeEEEGAEEDDEADDE 1076

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1622893015  265 RSVGTWVRERD----LGMPdgEAALTA-KVAVLETQLKKALQELQA 305
Cdd:PTZ00108  1077 DDEEELGAAVSydylLSMP--IWSLTKeKVEKLNAELEKKEKELEK 1120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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