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Conserved domains on  [gi|1622890545|ref|XP_028694112|]
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desmocollin-2 isoform X3 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 104-208 3.06e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.16  E-value: 3.06e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545 104 TYTFTIFENCRVGTTVGQVCATDKDEPdtMHTRLKYSIIGQVPPSptLFSMHPTTGVITTTSSqLDRELIDKYQLKIKVQ 183
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKP-LDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*
gi 1622890545 184 DMDGQyfGLQTTSTCIINIDDVNDH 208
Cdd:cd11304    76 DGGGP--PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
217-319 2.15e-18

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 2.15e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545 217 YVASVEENT-VDVEILRVTVEDKDLvnTANWRANYTILKGNENGNFKIVTDAktneGILCVVKPLNYEEKQQVILQIGVV 295
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 1622890545 296 NEAPFSREassrsamSTATVTVNV 319
Cdd:pfam00028  75 DSGGPPLS-------STATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 334-430 6.86e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.50  E-value: 6.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545 334 TVRMSENAAVGTTSNGYKAYDPETRSSSGIRYKKLT-DPTEWVTIDENTGSIRVFRSLDREAetirNGIYNITVLASDQA 412
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 1622890545 413 G--RTCTGTLGIILQDVNDN 430
Cdd:cd11304    79 GppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3-91 1.30e-13

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 1.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545   3 ENSL-GPFPLFLQQVQSDTAQNYTIYYSIRGPGVDqeprNLFYVERDTGNLYCTRAVDREQYESFEIIAFATTPDGYTPE 81
Cdd:pfam00028   7 ENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 1622890545  82 LPLPLIIKIE 91
Cdd:pfam00028  83 STATVTITVL 92
CADH_Y-type_LIR super family cl03079
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 709-753 3.40e-08

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


The actual alignment was detected with superfamily member pfam01049:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 50.61  E-value: 3.40e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622890545 709 DYVLTYNYEGRGSVAG---SVGCCSERQEEDgLEFLDNLEPKFRTLAE 753
Cdd:pfam01049  11 DSLQTYAYEGDGSSAGslsSLESSTSDSDQD-YDYLSDWGPRFKKLAE 57
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 104-208 3.06e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.16  E-value: 3.06e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545 104 TYTFTIFENCRVGTTVGQVCATDKDEPdtMHTRLKYSIIGQVPPSptLFSMHPTTGVITTTSSqLDRELIDKYQLKIKVQ 183
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKP-LDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*
gi 1622890545 184 DMDGQyfGLQTTSTCIINIDDVNDH 208
Cdd:cd11304    76 DGGGP--PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
105-202 1.38e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.97  E-value: 1.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545 105 YTFTIFENCRVGTTVGQVCATDKDEPDtmHTRLKYSIIGQvpPSPTLFSMHPTTGVITTTsSQLDRELIDKYQLKIKVQD 184
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP--NGRIFYSILGG--GPGGNFRIDPDTGDISTT-KPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*...
gi 1622890545 185 MDGQyfGLQTTSTCIINI 202
Cdd:pfam00028  76 SGGP--PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
217-319 2.15e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 2.15e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545 217 YVASVEENT-VDVEILRVTVEDKDLvnTANWRANYTILKGNENGNFKIVTDAktneGILCVVKPLNYEEKQQVILQIGVV 295
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 1622890545 296 NEAPFSREassrsamSTATVTVNV 319
Cdd:pfam00028  75 DSGGPPLS-------STATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 124-210 1.40e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.40e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545  124 ATDKDEPDtmHTRLKYSIIGQVPPSPtlFSMHPTTGVITTTSsQLDRELIDKYQLKIKVQDMDGQyfGLQTTSTCIINID 203
Cdd:smart00112   2 ATDADSGE--NGKVTYSILSGNDDGL--FSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 1622890545  204 DVNDHLP 210
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 216-324 2.61e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.74  E-value: 2.61e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545 216 SYVASVEENT-VDVEILRVTVEDKDLvnTANWRANYTILKGNENGNFKIvtDAKTneGILCVVKPLNYEEKQQVILQIGV 294
Cdd:cd11304     1 SYEVSVPENApPGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622890545 295 VNEAPFSREassrsamSTATVTVNVRDQDE 324
Cdd:cd11304    75 TDGGGPPLS-------STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 334-430 6.86e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.50  E-value: 6.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545 334 TVRMSENAAVGTTSNGYKAYDPETRSSSGIRYKKLT-DPTEWVTIDENTGSIRVFRSLDREAetirNGIYNITVLASDQA 412
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 1622890545 413 G--RTCTGTLGIILQDVNDN 430
Cdd:cd11304    79 GppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
333-425 2.12e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 2.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545 333 QTVRMSENAAVGTTSNGYKAYDPETRSSSGIRYKKLTDPTE-WVTIDENTGSIRVFRSLDREAetirNGIYNITVLASDQ 411
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 1622890545 412 A--GRTCTGTLGIILQ 425
Cdd:pfam00028  77 GgpPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 351-432 1.09e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 1.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545  351 KAYDPETRSSSGIRYKKLT-DPTEWVTIDENTGSIRVFRSLDREAetirNGIYNITVLASDQAG--RTCTGTLGIILQDV 427
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREE----QPEYTLTVEATDGGGppLSSTATVTITVLDV 76


                   ....*
gi 1622890545  428 NDNGP 432
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
3-91 1.30e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 1.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545   3 ENSL-GPFPLFLQQVQSDTAQNYTIYYSIRGPGVDqeprNLFYVERDTGNLYCTRAVDREQYESFEIIAFATTPDGYTPE 81
Cdd:pfam00028   7 ENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 1622890545  82 LPLPLIIKIE 91
Cdd:pfam00028  83 STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 18-98 3.94e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.37  E-value: 3.94e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545   18 SDTAQNYTIYYSIrgpgVDQEPRNLFYVERDTGNLYCTRAVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNY 97
Cdd:smart00112   5 ADSGENGKVTYSI----LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1622890545   98 P 98
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 19-96 1.17e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.56  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545  19 DTAQNYTIYYSIrgpgVDQEPRNLFYVERDTGNLYCTRAVDREQYESFEIIAFATtpDGYTPEL--PLPLIIKIEDENDN 96
Cdd:cd11304    25 DSGENGEVTYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT--DGGGPPLssTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 234-331 1.95e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 1.95e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545  234 TVEDKDLvnTANWRANYTILKGNENGNFKIvtDAKTneGILCVVKPLNYEEKQQVILQIGVVNEAPFSREassrsamSTA 313
Cdd:smart00112   1 SATDADS--GENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPLS-------STA 67

                           90
                   ....*....|....*...
gi 1622890545  314 TVTVNVRDQDEgpecNPP 331
Cdd:smart00112  68 TVTITVLDVND----NAP 81
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 709-753 3.40e-08

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 50.61  E-value: 3.40e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622890545 709 DYVLTYNYEGRGSVAG---SVGCCSERQEEDgLEFLDNLEPKFRTLAE 753
Cdd:pfam01049  11 DSLQTYAYEGDGSSAGslsSLESSTSDSDQD-YDYLSDWGPRFKKLAE 57
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 104-208 3.06e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 103.16  E-value: 3.06e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545 104 TYTFTIFENCRVGTTVGQVCATDKDEPdtMHTRLKYSIIGQVPPSptLFSMHPTTGVITTTSSqLDRELIDKYQLKIKVQ 183
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKP-LDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*
gi 1622890545 184 DMDGQyfGLQTTSTCIINIDDVNDH 208
Cdd:cd11304    76 DGGGP--PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
105-202 1.38e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.97  E-value: 1.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545 105 YTFTIFENCRVGTTVGQVCATDKDEPDtmHTRLKYSIIGQvpPSPTLFSMHPTTGVITTTsSQLDRELIDKYQLKIKVQD 184
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP--NGRIFYSILGG--GPGGNFRIDPDTGDISTT-KPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*...
gi 1622890545 185 MDGQyfGLQTTSTCIINI 202
Cdd:pfam00028  76 SGGP--PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
217-319 2.15e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 2.15e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545 217 YVASVEENT-VDVEILRVTVEDKDLvnTANWRANYTILKGNENGNFKIVTDAktneGILCVVKPLNYEEKQQVILQIGVV 295
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 1622890545 296 NEAPFSREassrsamSTATVTVNV 319
Cdd:pfam00028  75 DSGGPPLS-------STATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 124-210 1.40e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.40e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545  124 ATDKDEPDtmHTRLKYSIIGQVPPSPtlFSMHPTTGVITTTSsQLDRELIDKYQLKIKVQDMDGQyfGLQTTSTCIINID 203
Cdd:smart00112   2 ATDADSGE--NGKVTYSILSGNDDGL--FSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 1622890545  204 DVNDHLP 210
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 216-324 2.61e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.74  E-value: 2.61e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545 216 SYVASVEENT-VDVEILRVTVEDKDLvnTANWRANYTILKGNENGNFKIvtDAKTneGILCVVKPLNYEEKQQVILQIGV 294
Cdd:cd11304     1 SYEVSVPENApPGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622890545 295 VNEAPFSREassrsamSTATVTVNVRDQDE 324
Cdd:cd11304    75 TDGGGPPLS-------STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 334-430 6.86e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.50  E-value: 6.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545 334 TVRMSENAAVGTTSNGYKAYDPETRSSSGIRYKKLT-DPTEWVTIDENTGSIRVFRSLDREAetirNGIYNITVLASDQA 412
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 1622890545 413 G--RTCTGTLGIILQDVNDN 430
Cdd:cd11304    79 GppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
333-425 2.12e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 2.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545 333 QTVRMSENAAVGTTSNGYKAYDPETRSSSGIRYKKLTDPTE-WVTIDENTGSIRVFRSLDREAetirNGIYNITVLASDQ 411
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 1622890545 412 A--GRTCTGTLGIILQ 425
Cdd:pfam00028  77 GgpPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 351-432 1.09e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 1.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545  351 KAYDPETRSSSGIRYKKLT-DPTEWVTIDENTGSIRVFRSLDREAetirNGIYNITVLASDQAG--RTCTGTLGIILQDV 427
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREE----QPEYTLTVEATDGGGppLSSTATVTITVLDV 76


                   ....*
gi 1622890545  428 NDNGP 432
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
3-91 1.30e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 1.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545   3 ENSL-GPFPLFLQQVQSDTAQNYTIYYSIRGPGVDqeprNLFYVERDTGNLYCTRAVDREQYESFEIIAFATTPDGYTPE 81
Cdd:pfam00028   7 ENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 1622890545  82 LPLPLIIKIE 91
Cdd:pfam00028  83 STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 18-98 3.94e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.37  E-value: 3.94e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545   18 SDTAQNYTIYYSIrgpgVDQEPRNLFYVERDTGNLYCTRAVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNY 97
Cdd:smart00112   5 ADSGENGKVTYSI----LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1622890545   98 P 98
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 19-96 1.17e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.56  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545  19 DTAQNYTIYYSIrgpgVDQEPRNLFYVERDTGNLYCTRAVDREQYESFEIIAFATtpDGYTPEL--PLPLIIKIEDENDN 96
Cdd:cd11304    25 DSGENGEVTYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT--DGGGPPLssTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 234-331 1.95e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 1.95e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545  234 TVEDKDLvnTANWRANYTILKGNENGNFKIvtDAKTneGILCVVKPLNYEEKQQVILQIGVVNEAPFSREassrsamSTA 313
Cdd:smart00112   1 SATDADS--GENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPLS-------STA 67

                           90
                   ....*....|....*...
gi 1622890545  314 TVTVNVRDQDEgpecNPP 331
Cdd:smart00112  68 TVTITVLDVND----NAP 81
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 709-753 3.40e-08

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 50.61  E-value: 3.40e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622890545 709 DYVLTYNYEGRGSVAG---SVGCCSERQEEDgLEFLDNLEPKFRTLAE 753
Cdd:pfam01049  11 DSLQTYAYEGDGSSAGslsSLESSTSDSDQD-YDYLSDWGPRFKKLAE 57
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 10-96 3.71e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 51.58  E-value: 3.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622890545  10 PLFLQQVQSDTAQNYTIYYSIRGPGVDQEPrNLFYVERDTGNLYCTRAVDREQYESFEIIAFATTPDGYTPELPLPLIIK 89
Cdd:cd00031    13 GSFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIE 91


                  ....*..
gi 1622890545  90 IEDENDN 96
Cdd:cd00031    92 VYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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