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Conserved domains on  [gi|1622888833|ref|XP_028693829|]
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leucine-rich repeat-containing protein 30 [Macaca mulatta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
SCOP:  4003523

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-224 8.97e-33

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.05  E-value: 8.97e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  61 TDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQGLRVLFVNMNCLTEVPAELSLCR 140
Cdd:COG4886   126 TDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLT 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 141 KLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNLFAHIPmCVFSLKELIFLHVGSNRLENIAESIQhLTSLQIFIAEANN 220
Cdd:COG4886   206 NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNNQ 283

                  ....
gi 1622888833 221 IHSF 224
Cdd:COG4886   284 LTDL 287
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-224 8.97e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.05  E-value: 8.97e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  61 TDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQGLRVLFVNMNCLTEVPAELSLCR 140
Cdd:COG4886   126 TDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLT 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 141 KLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNLFAHIPmCVFSLKELIFLHVGSNRLENIAESIQhLTSLQIFIAEANN 220
Cdd:COG4886   206 NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNNQ 283

                  ....
gi 1622888833 221 IHSF 224
Cdd:COG4886   284 LTDL 287
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
62-229 2.47e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.18  E-value: 2.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  62 DIPDFLWGLSEVQKLNLSHNQLR-VLPPEVGKLTRIVVLNLCGNRL-KSLPREVSLLQGLRVLFVNMNCLT-EVPAELSL 138
Cdd:PLN00113  155 EIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGG 234
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 139 CRKLEVLSLSHNCLS-QLPACFADLSRLRKLNLSNNLFA-HIPMCVFSLKELIFLHVGSNRLE-NIAESIQHLTSLQIFI 215
Cdd:PLN00113  235 LTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILH 314
                         170
                  ....*....|....*
gi 1622888833 216 AEANNIH-SFPRSLC 229
Cdd:PLN00113  315 LFSNNFTgKIPVALT 329
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
93-224 8.58e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 8.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  93 LTRIVVLNLCGNRLKSLPrEVSLLQGLRVLFVNMNCLTEVPAeLSLCRKLEVLSLSHNCLSQLPAcFADLSRLRKLNLSN 172
Cdd:cd21340     1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 173 NLFAHI----------------------------PMCVFSLKE-LIFLHVGSNRLENIAEsIQHLTSLQIFIAEANNIHS 223
Cdd:cd21340    78 NRISVVeglenltnleelhienqrlppgekltfdPRSLAALSNsLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISD 156

                  .
gi 1622888833 224 F 224
Cdd:cd21340   157 L 157
LRR_8 pfam13855
Leucine rich repeat;
94-175 4.04e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 4.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  94 TRIVVLNLCGNRLKSLPREVsllqglrvlFVNMNcltevpaelslcrKLEVLSLSHNCLSQL-PACFADLSRLRKLNLSN 172
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGA---------FKGLS-------------NLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSG 58

                  ...
gi 1622888833 173 NLF 175
Cdd:pfam13855  59 NRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-224 8.97e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.05  E-value: 8.97e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  61 TDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQGLRVLFVNMNCLTEVPAELSLCR 140
Cdd:COG4886   126 TDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLT 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 141 KLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNLFAHIPmCVFSLKELIFLHVGSNRLENIAESIQhLTSLQIFIAEANN 220
Cdd:COG4886   206 NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNNQ 283

                  ....
gi 1622888833 221 IHSF 224
Cdd:COG4886   284 LTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
64-230 1.36e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.28  E-value: 1.36e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  64 PDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQGLRVLFVNMNCLTEVPAELSLCRKLE 143
Cdd:COG4886   106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLK 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 144 VLSLSHNCLSQLPACFADLSRLRKLNLSNNLFAHIPMCVFSLKELIFLHVGSNRLENIAEsIQHLTSLQIFIAEANNIHS 223
Cdd:COG4886   186 ELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTD 264

                  ....*..
gi 1622888833 224 FPRSLCL 230
Cdd:COG4886   265 LPPLANL 271
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-285 7.39e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 7.39e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  63 IPDFLWGLSEVQKLNLSHNQlrvlppEVGKLTRIVVLNLCGNRLKSLPREVSLLQGLRVLFVNMNCLTEVPAELSLCRKL 142
Cdd:COG4886    88 GLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNL 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 143 EVLSLSHNCLSQLPACFADLSRLRKLNLSNNLFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLTSLQIFiaeannih 222
Cdd:COG4886   162 KSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETL-------- 233
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622888833 223 sfprslclvtslellNLNNNDIQTLPSelhlLCRLVRIAWnpmdkgLHISHNPLSKpLPELVE 285
Cdd:COG4886   234 ---------------DLSNNQLTDLPE----LGNLTNLEE------LDLSNNQLTD-LPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-222 3.51e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.69  E-value: 3.51e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  61 TDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQGLRVLFVNMNCLTEVPaELSLCR 140
Cdd:COG4886   172 TDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLT 250
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 141 KLEVLSLSHNCLSQLPACfADLSRLRKLNLSNNLFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLTSLQIFIAEANN 220
Cdd:COG4886   251 NLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329

                  ..
gi 1622888833 221 IH 222
Cdd:COG4886   330 LK 331
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-264 1.07e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 1.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  61 TDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPrEVSLLQGLRVLFVNMNCLTEVPAELSLcR 140
Cdd:COG4886   195 TDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANL-T 272
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 141 KLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNLFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLTSLQIFIAEANN 220
Cdd:COG4886   273 NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1622888833 221 IHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLVRIAWNP 264
Cdd:COG4886   353 LLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTT 396
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
60-283 1.70e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.35  E-value: 1.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQGLRVLFVNMNCLTEVPAELSLC 139
Cdd:COG4886    16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 140 RKLEVLS-----------------LSHNCLSQLPACFADLSRLRKLNLSNNLFAHIPMCVFSLKELIFLHVGSNRLENIA 202
Cdd:COG4886    96 TNLTELDlsgneelsnltnlesldLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLP 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 203 ESIQHLTSLQIFIAEANNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELHLLCRLvriawnpmdKGLHISHNPLSKpLPE 282
Cdd:COG4886   176 EELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL---------ETLDLSNNQLTD-LPE 245

                  .
gi 1622888833 283 L 283
Cdd:COG4886   246 L 246
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
62-229 2.47e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.18  E-value: 2.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  62 DIPDFLWGLSEVQKLNLSHNQLR-VLPPEVGKLTRIVVLNLCGNRL-KSLPREVSLLQGLRVLFVNMNCLT-EVPAELSL 138
Cdd:PLN00113  155 EIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGG 234
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 139 CRKLEVLSLSHNCLS-QLPACFADLSRLRKLNLSNNLFA-HIPMCVFSLKELIFLHVGSNRLE-NIAESIQHLTSLQIFI 215
Cdd:PLN00113  235 LTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILH 314
                         170
                  ....*....|....*
gi 1622888833 216 AEANNIH-SFPRSLC 229
Cdd:PLN00113  315 LFSNNFTgKIPVALT 329
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
60-228 7.35e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.87  E-value: 7.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  60 MTDIPDFLwgLSEVQKLNLSHNQLRVLPPEVGKLTRivVLNLCGNRLKSLPREvsLLQGLRVLFVNMNCLTEVPAELSLc 139
Cdd:PRK15370  253 ITELPERL--PSALQSLDLFHNKISCLPENLPEELR--YLSVYDNSIRTLPAH--LPSGITHLNVQSNSLTALPETLPP- 325
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 140 rKLEVLSLSHNCLSQLPACFAdlSRLRKLNLSNNLFAHIPMCVfsLKELIFLHVGSNRLENIAESIQhlTSLQIFIAEAN 219
Cdd:PRK15370  326 -GLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETL--PPTITTLDVSRNALTNLPENLP--AALQIMQASRN 398

                  ....*....
gi 1622888833 220 NIHSFPRSL 228
Cdd:PRK15370  399 NLVRLPESL 407
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
93-224 8.58e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 8.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  93 LTRIVVLNLCGNRLKSLPrEVSLLQGLRVLFVNMNCLTEVPAeLSLCRKLEVLSLSHNCLSQLPAcFADLSRLRKLNLSN 172
Cdd:cd21340     1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 173 NLFAHI----------------------------PMCVFSLKE-LIFLHVGSNRLENIAEsIQHLTSLQIFIAEANNIHS 223
Cdd:cd21340    78 NRISVVeglenltnleelhienqrlppgekltfdPRSLAALSNsLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISD 156

                  .
gi 1622888833 224 F 224
Cdd:cd21340   157 L 157
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
63-198 2.53e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.02  E-value: 2.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  63 IPDFlWGLSEVQKLNLSHNQLR-VLPPEVGKLTRIVVLNLCGNRLKSlprevsllqglrvlfvnmncltEVPAELSLCRK 141
Cdd:PLN00113  468 LPDS-FGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSG----------------------EIPDELSSCKK 524
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622888833 142 LEVLSLSHNCLS-QLPACFADLSRLRKLNLS-NNLFAHIPMCVFSLKELIFLHVGSNRL 198
Cdd:PLN00113  525 LVSLDLSHNQLSgQIPASFSEMPVLSQLDLSqNQLSGEIPKNLGNVESLVQVNISHNHL 583
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
60-233 3.14e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 54.78  E-value: 3.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  60 MTDIPDFLWGLsevQKLNLSHNQLRVLPPEVGKLTRIVVLNlcgNRLKSLPrevSLLQGLRVLFVNMNCLTEVPaelSLC 139
Cdd:PRK15387  294 LTSLPVLPPGL---QELSVSDNQLASLPALPSELCKLWAYN---NQLTSLP---TLPSGLQELSVSDNQLASLP---TLP 361
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 140 RKLEVLSLSHNCLSQLPACfadLSRLRKLNLSNNLFAHIPMCVFSLKELIflhVGSNRLENIAESIQHLTSLQIFiaeAN 219
Cdd:PRK15387  362 SELYKLWAYNNRLTSLPAL---PSGLKELIVSGNRLTSLPVLPSELKELM---VSGNRLTSLPMLPSGLLSLSVY---RN 432
                         170
                  ....*....|....
gi 1622888833 220 NIHSFPRSLCLVTS 233
Cdd:PRK15387  433 QLTRLPESLIHLSS 446
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
63-284 1.49e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 1.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  63 IPDFLWGLSEVQKLNLSHNQLR-VLPPEVGKLT-RIVVLNLCGNRLK-SLPRevSLLQGLRVLFVNMNCLT-EVPAELSL 138
Cdd:PLN00113   85 ISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTgSIPR--GSIPNLETLDLSNNMLSgEIPNDIGS 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 139 CRKLEVLSLSHNCLS-QLPACFADLSRLRKLNL-SNNLFAHIPMCVFSLKELIFLHVGSNRLE-NIAESIQHLTSLQIFI 215
Cdd:PLN00113  163 FSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLaSNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLD 242
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622888833 216 AEANNIH-SFPRSLCLVTSLELLNLNNNDIQ-TLPSELHLLCRLVriawnpmdkGLHISHNPLSKPLPELV 284
Cdd:PLN00113  243 LVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLI---------SLDLSDNSLSGEIPELV 304
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
63-229 1.59e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 1.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  63 IPDFLWGLSEVQKLNLSHNQLR-VLPPEVGKLTRIVVLNLCGNRLK-SLPREVSLLQGLRVLFVNMNCLT-EVPAELSLC 139
Cdd:PLN00113  204 IPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSL 283
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 140 RKLEVLSLSHNCLS-QLPACFADLSRLRKLNL-SNNLFAHIPMCVFSLKELIFLHVGSNRLE-NIAESIQHLTSLQIFIA 216
Cdd:PLN00113  284 QKLISLDLSDNSLSgEIPELVIQLQNLEILHLfSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDL 363
                         170
                  ....*....|....
gi 1622888833 217 EANNIHS-FPRSLC 229
Cdd:PLN00113  364 STNNLTGeIPEGLC 377
PLN03150 PLN03150
hypothetical protein; Provisional
63-136 2.87e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 2.87e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622888833  63 IPDFLWGLSEVQKLNLSHNQLR-VLPPEVGKLTRIVVLNLCGNRLK-SLPREVSLLQGLRVLFVNMNCLT-EVPAEL 136
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
60-210 2.50e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.01  E-value: 2.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  60 MTDIPDFLWGLsevQKLNLSHNQLRVLPPEVGKLTRIVVLNlcgNRLKSLPrevSLLQGLRVLFVNMNCLTEVPAelsLC 139
Cdd:PRK15387  334 LTSLPTLPSGL---QELSVSDNQLASLPTLPSELYKLWAYN---NRLTSLP---ALPSGLKELIVSGNRLTSLPV---LP 401
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622888833 140 RKLEVLSLSHNCLSQLPACfadLSRLRKLNLSNNLFAHIPMCVFSLKELIFLHVGSNRL-ENIAESIQHLTS 210
Cdd:PRK15387  402 SELKELMVSGNRLTSLPML---PSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLsERTLQALREITS 470
LRR_8 pfam13855
Leucine rich repeat;
94-175 4.04e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 4.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  94 TRIVVLNLCGNRLKSLPREVsllqglrvlFVNMNcltevpaelslcrKLEVLSLSHNCLSQL-PACFADLSRLRKLNLSN 172
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGA---------FKGLS-------------NLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSG 58

                  ...
gi 1622888833 173 NLF 175
Cdd:pfam13855  59 NRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
69-179 3.94e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 3.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  69 GLSEVQKLNLSHNQLRVLppE-VGKLTRIVVLNL------CGNRLKSLPREV-SLLQGLRVLFVNMNCLTEVpAELSLCR 140
Cdd:cd21340    66 NLVNLKKLYLGGNRISVV--EgLENLTNLEELHIenqrlpPGEKLTFDPRSLaALSNSLRVLNISGNNIDSL-EPLAPLR 142
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1622888833 141 KLEVLSLSHNCLS---QLPACFADLSRLRKLNLSNNLFAHIP 179
Cdd:cd21340   143 NLEQLDASNNQISdleELLDLLSSWPSLRELDLTGNPVCKKP 184
PLN03150 PLN03150
hypothetical protein; Provisional
73-173 4.98e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.81  E-value: 4.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  73 VQKLNLSHNQLR-VLPPEVGKLTRIVVLNLCGNRLKSlprevsllqglrvlfvnmncltEVPAELSLCRKLEVLSLSHNC 151
Cdd:PLN03150  420 IDGLGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRG----------------------NIPPSLGSITSLEVLDLSYNS 477
                          90       100
                  ....*....|....*....|...
gi 1622888833 152 LS-QLPACFADLSRLRKLNLSNN 173
Cdd:PLN03150  478 FNgSIPESLGQLTSLRILNLNGN 500
LRR_8 pfam13855
Leucine rich repeat;
140-198 1.04e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.04e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622888833 140 RKLEVLSLSHNCLSQL-PACFADLSRLRKLNLSNNLFAHIPMCVFS-LKELIFLHVGSNRL 198
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
63-197 1.34e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  63 IPDFLWGLSEVQKLNLSHNQLR-VLPPEVGKLTRIVVLNLCGNRLKS-LPREVSLLQGLRVLFVNMNCL-TEVPAELSLC 139
Cdd:PLN00113  324 IPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLeGEIPKSLGAC 403
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833 140 RKLEVLSLSHNCLS-QLPACFADLSRLRKLNLS-NNLFAHIPMCVFSLKELIFLHVGSNR 197
Cdd:PLN00113  404 RSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISnNNLQGRINSRKWDMPSLQMLSLARNK 463
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
141-173 3.96e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 3.96e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1622888833 141 KLEVLSLSHNCLSQLPAcFADLSRLRKLNLSNN 173
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP-LAKLPNLETLDLSGN 33
PLN03150 PLN03150
hypothetical protein; Provisional
63-133 4.33e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 38.64  E-value: 4.33e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622888833  63 IPDFLWGLSEVQKLNLSHNQLRVLPPE-VGKLTRIVVLNLCGNRLKS-LPREVS--LLQGLRVLFVNMNCLTEVP 133
Cdd:PLN03150  458 IPPSLGSITSLEVLDLSYNSFNGSIPEsLGQLTSLRILNLNGNSLSGrVPAALGgrLLHRASFNFTDNAGLCGIP 532
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
46-253 8.95e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 37.55  E-value: 8.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833   46 RGMHHVSF-SLVTRGMTDIPDFLWGLSE--------VQKLNLSHNQLRVLP----PEvgkltRIVVLNLCGNRLKSLPRE 112
Cdd:PLN03210   555 KGMRNLLFlKFYTKKWDQKKEVRWHLPEgfdylppkLRLLRWDKYPLRCMPsnfrPE-----NLVKLQMQGSKLEKLWDG 629
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888833  113 VSLLQGLRvlfvNMNC-----LTEVPaELSLCRKLEVLSLShNC--LSQLPACFADLSRLRKLNLSnnlfahipmcvfsl 185
Cdd:PLN03210   630 VHSLTGLR----NIDLrgsknLKEIP-DLSMATNLETLKLS-DCssLVELPSSIQYLNKLEDLDMS-------------- 689
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622888833  186 keliflhvGSNRLENIAESIqHLTSL-QIFIAEANNIHSFPRslcLVTSLELLNLNNNDIQTLPSELHL 253
Cdd:PLN03210   690 --------RCENLEILPTGI-NLKSLyRLNLSGCSRLKSFPD---ISTNISWLDLDETAIEEFPSNLRL 746
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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