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Conserved domains on  [gi|1622888691|ref|XP_028693797|]
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WD repeat-containing protein 7 isoform X1 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822067)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 408-598 3.10e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 78.15  E-value: 3.10e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  408 KVTASVYIPAHGRLVCGREDGSIvivpatqtAIVQLLQGEHMlrrgwpphRTLRGHRNKVTCLLYPHqvsaryDQRYLIS 487
Cdd:cd00200     11 GVTCVAFSPDGKLLATGSGDGTI--------KVWDLETGELL--------RTLKGHTGPVRDVAASA------DGTYLAS 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  488 GGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIK 567
Cdd:cd00200     69 GSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVA 142

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1622888691  568 WRPSDDYLVVGCSDGSVYVWQMDTGaldRCV 598
Cdd:cd00200    143 FSPDGTFVASSSQDGTIKLWDLRTG---KCV 170
WD40 COG2319
WD40 repeat [General function prediction only];
1383-1443 2.13e-11

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 2.13e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622888691 1383 HRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATySNTDSHISFWQMNT 1443
Cdd:COG2319    133 KTLASGSADGTVRLWDLATGKLlRTLTGHSGAVTSVAFSPDGKLLAS-GSDDGTVRLWDLAT 193
WD40 COG2319
WD40 repeat [General function prediction only];
22-189 2.17e-11

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 2.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   22 ISAVLLTDDGATIVTGCHDGQICLWDLSvelEINPRALLFGHTASITCLSkacASSDKQYIVSASESGEMCLWDVSDGRC 101
Cdd:COG2319    123 VRSVAFSPDGKTLASGSADGTVRLWDLA---TGKLLRTLTGHSGAVTSVA---FSPDGKLLASGSDDGTVRLWDLATGKL 196

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  102 IefTKLACTHTGIQFYQFSVGNQregRLLCHGHYPEILVVDATSLEVLYSLvsKISPDWISSMSIirSHrtQEDTVVALS 181
Cdd:COG2319    197 L--RTLTGHTGAVRSVAFSPDGK---LLASGSADGTVRLWDLATGKLLRTL--TGHSGSVRSVAF--SP--DGRLLASGS 265


                   ....*...
gi 1622888691  182 VTGILKVW 189
Cdd:COG2319    266 ADGTVRLW 273
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 408-598 3.10e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.15  E-value: 3.10e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  408 KVTASVYIPAHGRLVCGREDGSIvivpatqtAIVQLLQGEHMlrrgwpphRTLRGHRNKVTCLLYPHqvsaryDQRYLIS 487
Cdd:cd00200     11 GVTCVAFSPDGKLLATGSGDGTI--------KVWDLETGELL--------RTLKGHTGPVRDVAASA------DGTYLAS 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  488 GGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIK 567
Cdd:cd00200     69 GSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVA 142

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1622888691  568 WRPSDDYLVVGCSDGSVYVWQMDTGaldRCV 598
Cdd:cd00200    143 FSPDGTFVASSSQDGTIKLWDLRTG---KCV 170
WD40 COG2319
WD40 repeat [General function prediction only];
420-596 1.46e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 1.46e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  420 RLVCGREDGSIVIVPATQTAIVqllqgehmlrrgwpphRTLRGHRNKVTCLlyphQVSAryDQRYLISGGVDFSVIIWDI 499
Cdd:COG2319    134 TLASGSADGTVRLWDLATGKLL----------------RTLTGHSGAVTSV----AFSP--DGKLLASGSDDGTVRLWDL 191

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  500 FSGEMKHIFCVHGGEITQLLVPPENcsarvqHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGC 579
Cdd:COG2319    192 ATGKLLRTLTGHTGAVRSVAFSPDG------KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                          170
                   ....*....|....*..
gi 1622888691  580 SDGSVYVWQMDTGALDR 596
Cdd:COG2319    266 ADGTVRLWDLATGELLR 282
WD40 COG2319
WD40 repeat [General function prediction only];
1383-1443 2.13e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 2.13e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622888691 1383 HRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATySNTDSHISFWQMNT 1443
Cdd:COG2319    133 KTLASGSADGTVRLWDLATGKLlRTLTGHSGAVTSVAFSPDGKLLAS-GSDDGTVRLWDLAT 193
WD40 COG2319
WD40 repeat [General function prediction only];
22-189 2.17e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 2.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   22 ISAVLLTDDGATIVTGCHDGQICLWDLSvelEINPRALLFGHTASITCLSkacASSDKQYIVSASESGEMCLWDVSDGRC 101
Cdd:COG2319    123 VRSVAFSPDGKTLASGSADGTVRLWDLA---TGKLLRTLTGHSGAVTSVA---FSPDGKLLASGSDDGTVRLWDLATGKL 196

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  102 IefTKLACTHTGIQFYQFSVGNQregRLLCHGHYPEILVVDATSLEVLYSLvsKISPDWISSMSIirSHrtQEDTVVALS 181
Cdd:COG2319    197 L--RTLTGHTGAVRSVAFSPDGK---LLASGSADGTVRLWDLATGKLLRTL--TGHSGSVRSVAF--SP--DGRLLASGS 265


                   ....*...
gi 1622888691  182 VTGILKVW 189
Cdd:COG2319    266 ADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-274 1.28e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 1.28e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   16 KAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELEINPralLFGHTASITCLSkacASSDKQYIVSASESGEMCLWD 95
Cdd:cd00200     48 KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSVA---FSPDGRILSSSSRDKTIKVWD 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   96 VSDGRCIefTKLACtHTG-IQFYQFSvgnqREGRLLCHGHYP-EILVVDATSLEVLYSLvsKISPDWISSMSIIRShrtq 173
Cdd:cd00200    122 VETGKCL--TTLRG-HTDwVNSVAFS----PDGTFVASSSQDgTIKLWDLRTGKCVATL--TGHTGEVNSVAFSPD---- 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  174 EDTVVALSVTGILKVWivtseisDMQDTEPI--FEEESKPIYCqncqsisfCAFTQRSLLVVCSKYW---RVFDAGDYSL 248
Cdd:cd00200    189 GEKLLSSSSDGTIKLW-------DLSTGKCLgtLRGHENGVNS--------VAFSPDGYLLASGSEDgtiRVWDLRTGEC 253

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 1622888691  249 LCSGPSENGQTW------TGGDFVSA--DK-VIIW 274
Cdd:cd00200    254 VQTLSGHTNSVTslawspDGKRLASGsaDGtIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1374-1443 6.57e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.97  E-value: 6.57e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622888691 1374 YMVSYYERNHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNtDSHISFWQMNT 1443
Cdd:cd00200    181 NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKClGTLRGHENGVNSVAFSPDGYLLASGSE-DGTIRVWDLRT 250
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1401-1439 2.75e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 2.75e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1622888691  1401 TGKC-QTIHGHKGPITAVAFAPDGRYLATYSNtDSHISFW 1439
Cdd:smart00320    1 SGELlKTLKGHTGPVTSVAFSPDGKYLASGSD-DGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
1405-1439 1.01e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 1.01e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622888691 1405 QTIHGHKGPITAVAFAPDGRYLATySNTDSHISFW 1439
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSPDGKLLAS-GSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
454-498 1.86e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622888691  454 WPPHRTLRGHRNKVTCLLYPHqvsaryDQRYLISGGVDFSVIIWD 498
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 454-498 2.64e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 2.64e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622888691   454 WPPHRTLRGHRNKVTCLLYPHqvsaryDQRYLISGGVDFSVIIWD 498
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSP------DGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 22-189 1.12e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 43.14  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   22 ISAVLLTDDGATIVTGCHDGQICLWDL----SVELEI----------------NPRALLFGHTASITCLskaCASSDKQY 81
Cdd:pfam20426  127 VSCVAVTSDGSILATGSYDTTVMVWEVlrgrSSEKRSrntqtefprkdhviaeTPFHILCGHDDIITCL---YVSVELDI 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   82 IVSASESGEMCLWDVSDGRCIE---------FTKLACTHTG-IQFYQ--------FSVGNQR------EGRL-------- 129
Cdd:pfam20426  204 VISGSKDGTCIFHTLREGRYVRsirhpsgcpLSKLVASRHGrIVLYAdddlslhlYSINGKHiassesNGRLncielssc 283

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622888691  130 ----LCHGHYPEILVVDATSLEVL--YSLVSKIspdwISSMSIirshrTQEDTVVALSVTGILKVW 189
Cdd:pfam20426  284 geflVCAGDQGQIVVRSMNSLEVVrrYNGIGKI----ITSLTV-----TPEECFLAGTKDGSLLVY 340
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 55-95 1.20e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 1.20e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1622888691    55 NPRALLFGHTASITCLskaCASSDKQYIVSASESGEMCLWD 95
Cdd:smart00320    3 ELLKTLKGHTGPVTSV---AFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 408-598 3.10e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.15  E-value: 3.10e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  408 KVTASVYIPAHGRLVCGREDGSIvivpatqtAIVQLLQGEHMlrrgwpphRTLRGHRNKVTCLLYPHqvsaryDQRYLIS 487
Cdd:cd00200     11 GVTCVAFSPDGKLLATGSGDGTI--------KVWDLETGELL--------RTLKGHTGPVRDVAASA------DGTYLAS 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  488 GGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIK 567
Cdd:cd00200     69 GSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVA 142

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1622888691  568 WRPSDDYLVVGCSDGSVYVWQMDTGaldRCV 598
Cdd:cd00200    143 FSPDGTFVASSSQDGTIKLWDLRTG---KCV 170
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 456-603 3.63e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 3.63e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  456 PHRTLRGHRNKVTCllyphqVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLvppenCSARvQHCICS 535
Cdd:cd00200      1 LRRTLKGHTGGVTC------VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA-----ASAD-GTYLAS 68

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622888691  536 VASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITA 603
Cdd:cd00200     69 GSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD 136
WD40 COG2319
WD40 repeat [General function prediction only];
420-596 1.46e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 1.46e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  420 RLVCGREDGSIVIVPATQTAIVqllqgehmlrrgwpphRTLRGHRNKVTCLlyphQVSAryDQRYLISGGVDFSVIIWDI 499
Cdd:COG2319    134 TLASGSADGTVRLWDLATGKLL----------------RTLTGHSGAVTSV----AFSP--DGKLLASGSDDGTVRLWDL 191

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  500 FSGEMKHIFCVHGGEITQLLVPPENcsarvqHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGC 579
Cdd:COG2319    192 ATGKLLRTLTGHTGAVRSVAFSPDG------KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                          170
                   ....*....|....*..
gi 1622888691  580 SDGSVYVWQMDTGALDR 596
Cdd:COG2319    266 ADGTVRLWDLATGELLR 282
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-597 1.47e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.14  E-value: 1.47e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  407 LKVTASVYIPAHGRLVCGREDGSIVIVPATQTAIVqllqgehmlrrgwpphRTLRGHRNKVTCLLYpHQvsaryDQRYLI 486
Cdd:cd00200     52 GPVRDVAASADGTYLASGSSDKTIRLWDLETGECV----------------RTLTGHTSYVSSVAF-SP-----DGRILS 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  487 SGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPEN---------CSARV---------------QHCICSVA----- 537
Cdd:cd00200    110 SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtfvasssqdGTIKLwdlrtgkcvatltghTGEVNSVAfspdg 189

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622888691  538 -------SDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRC 597
Cdd:cd00200    190 ekllsssSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
458-594 2.51e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 2.51e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  458 RTLRGHRNKVTCLlyphQVSAryDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCICSVA 537
Cdd:COG2319    198 RTLTGHTGAVRSV----AFSP--DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG------RLLASGS 265

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622888691  538 SDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGAL 594
Cdd:COG2319    266 ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
409-604 5.71e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 5.71e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  409 VTASVYIPAHGRLVCGREDGSIVIVPATQTAIVqllqgehmlrrgwpphRTLRGHRNKVTCLLYphqvSAryDQRYLISG 488
Cdd:COG2319    207 VRSVAFSPDGKLLASGSADGTVRLWDLATGKLL----------------RTLTGHSGSVRSVAF----SP--DGRLLASG 264

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  489 GVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvQHcICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKW 568
Cdd:COG2319    265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG-----KL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1622888691  569 RPSDDYLVVGCSDGSVYVWQMDTGALDRCVMG----ITAV 604
Cdd:COG2319    339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGhtgaVTSV 378
WD40 COG2319
WD40 repeat [General function prediction only];
1383-1443 2.13e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 2.13e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622888691 1383 HRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATySNTDSHISFWQMNT 1443
Cdd:COG2319    133 KTLASGSADGTVRLWDLATGKLlRTLTGHSGAVTSVAFSPDGKLLAS-GSDDGTVRLWDLAT 193
WD40 COG2319
WD40 repeat [General function prediction only];
22-189 2.17e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 2.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   22 ISAVLLTDDGATIVTGCHDGQICLWDLSvelEINPRALLFGHTASITCLSkacASSDKQYIVSASESGEMCLWDVSDGRC 101
Cdd:COG2319    123 VRSVAFSPDGKTLASGSADGTVRLWDLA---TGKLLRTLTGHSGAVTSVA---FSPDGKLLASGSDDGTVRLWDLATGKL 196

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  102 IefTKLACTHTGIQFYQFSVGNQregRLLCHGHYPEILVVDATSLEVLYSLvsKISPDWISSMSIirSHrtQEDTVVALS 181
Cdd:COG2319    197 L--RTLTGHTGAVRSVAFSPDGK---LLASGSADGTVRLWDLATGKLLRTL--TGHSGSVRSVAF--SP--DGRLLASGS 265


                   ....*...
gi 1622888691  182 VTGILKVW 189
Cdd:COG2319    266 ADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
1383-1443 3.92e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.86  E-value: 3.92e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622888691 1383 HRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNtDSHISFWQMNT 1443
Cdd:COG2319    259 RLLASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAFSPDGKLLASGSD-DGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
1383-1446 4.43e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.86  E-value: 4.43e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622888691 1383 HRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNtDSHISFWQMNTSLL 1446
Cdd:COG2319    217 KLLASGSADGTVRLWDLATGKLlRTLTGHSGSVRSVAFSPDGRLLASGSA-DGTVRLWDLATGEL 280
WD40 COG2319
WD40 repeat [General function prediction only];
10-189 4.75e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.47  E-value: 4.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   10 IVLW----GR-----KAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSvelEINPRALLFGHTASITCLSkacASSDKQ 80
Cdd:COG2319    144 VRLWdlatGKllrtlTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA---TGKLLRTLTGHTGAVRSVA---FSPDGK 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   81 YIVSASESGEMCLWDVSDGRCIEFTKlacTHTG-IQFYQFSvgnqREGRLLCHGHY-PEILVVDATSLEVLYSLvsKISP 158
Cdd:COG2319    218 LLASGSADGTVRLWDLATGKLLRTLT---GHSGsVRSVAFS----PDGRLLASGSAdGTVRLWDLATGELLRTL--TGHS 288

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1622888691  159 DWISSMSIIRSHRtqedTVVALSVTGILKVW 189
Cdd:COG2319    289 GGVNSVAFSPDGK----LLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
16-189 5.24e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.47  E-value: 5.24e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   16 KAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELEInprALLFGHTASITCLskaCASSDKQYIVSASESGEMCLWD 95
Cdd:COG2319    243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL---RTLTGHSGGVNSV---AFSPDGKLLASGSDDGTVRLWD 316

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   96 VSDGRCIEftklacTHTGIQFYQFSVGNQREGRLLCHGHYPE-ILVVDATSLEVLYSLVSkiSPDWISSMSIIRSHRtqe 174
Cdd:COG2319    317 LATGKLLR------TLTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLTG--HTGAVTSVAFSPDGR--- 385

                          170
                   ....*....|....*
gi 1622888691  175 dTVVALSVTGILKVW 189
Cdd:COG2319    386 -TLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-274 1.28e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 1.28e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   16 KAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELEINPralLFGHTASITCLSkacASSDKQYIVSASESGEMCLWD 95
Cdd:cd00200     48 KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSVA---FSPDGRILSSSSRDKTIKVWD 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   96 VSDGRCIefTKLACtHTG-IQFYQFSvgnqREGRLLCHGHYP-EILVVDATSLEVLYSLvsKISPDWISSMSIIRShrtq 173
Cdd:cd00200    122 VETGKCL--TTLRG-HTDwVNSVAFS----PDGTFVASSSQDgTIKLWDLRTGKCVATL--TGHTGEVNSVAFSPD---- 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  174 EDTVVALSVTGILKVWivtseisDMQDTEPI--FEEESKPIYCqncqsisfCAFTQRSLLVVCSKYW---RVFDAGDYSL 248
Cdd:cd00200    189 GEKLLSSSSDGTIKLW-------DLSTGKCLgtLRGHENGVNS--------VAFSPDGYLLASGSEDgtiRVWDLRTGEC 253

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 1622888691  249 LCSGPSENGQTW------TGGDFVSA--DK-VIIW 274
Cdd:cd00200    254 VQTLSGHTNSVTslawspDGKRLASGsaDGtIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
409-594 1.55e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 1.55e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  409 VTASVYIPAHGRLVCGREDGSIVIVPATQTAIVqllqgehmlrrgwpphRTLRGHRNKVTCLlyphQVSAryDQRYLISG 488
Cdd:COG2319     81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLL----------------RTLTGHTGAVRSV----AFSP--DGKTLASG 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  489 GVDFSVIIWDIFSGEMKHIFCVHGGEIT--------QLLVppencsarvqhcicSVASDHSVGLLSLREKKCIMLASRHL 560
Cdd:COG2319    139 SADGTVRLWDLATGKLLRTLTGHSGAVTsvafspdgKLLA--------------SGSDDGTVRLWDLATGKLLRTLTGHT 204

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1622888691  561 FPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGAL 594
Cdd:COG2319    205 GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238
WD40 COG2319
WD40 repeat [General function prediction only];
1383-1443 3.18e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 3.18e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622888691 1383 HRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNtDSHISFWQMNT 1443
Cdd:COG2319    175 KLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKLLASGSA-DGTVRLWDLAT 235
WD40 COG2319
WD40 repeat [General function prediction only];
1383-1443 5.63e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 5.63e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622888691 1383 HRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNtDSHISFWQMNT 1443
Cdd:COG2319    343 KTLASGSDDGTVRLWDLATGELlRTLTGHTGAVTSVAFSPDGRTLASGSA-DGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
11-98 5.78e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 5.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   11 VLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELEINPralLFGHTASITCLSkacASSDKQYIVSASESGE 90
Cdd:COG2319    322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT---LTGHTGAVTSVA---FSPDGRTLASGSADGT 395


                   ....*...
gi 1622888691   91 MCLWDVSD 98
Cdd:COG2319    396 VRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1374-1443 6.57e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.97  E-value: 6.57e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622888691 1374 YMVSYYERNHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNtDSHISFWQMNT 1443
Cdd:cd00200    181 NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKClGTLRGHENGVNSVAFSPDGYLLASGSE-DGTIRVWDLRT 250
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 458-588 9.82e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.58  E-value: 9.82e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  458 RTLRGHRNKVTCllyphqVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENcsarvqHCICSVA 537
Cdd:cd00200    171 ATLTGHTGEVNS------VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG------YLLASGS 238

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622888691  538 SDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQ 588
Cdd:cd00200    239 EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
1384-1446 1.23e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 1.23e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622888691 1384 RIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNtDSHISFWQMNTSLL 1446
Cdd:COG2319    302 LLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSD-DGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1381-1443 1.30e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 1.30e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622888691 1381 RNHRIAVGA-RHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNtDSHISFWQMNT 1443
Cdd:cd00200    103 PDGRILSSSsRDKTIKVWDVETGKClTTLRGHTDWVNSVAFSPDGTFVASSSQ-DGTIKLWDLRT 166
WD40 COG2319
WD40 repeat [General function prediction only];
22-102 1.69e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 1.69e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   22 ISAVLLTDDGATIVTGCHDGQICLWDLSVELeinPRALLFGHTASITCLSkacASSDKQYIVSASESGEMCLWDVSDGRC 101
Cdd:COG2319     81 VLSVAFSPDGRLLASASADGTVRLWDLATGL---LLRTLTGHTGAVRSVA---FSPDGKTLASGSADGTVRLWDLATGKL 154


                   .
gi 1622888691  102 I 102
Cdd:COG2319    155 L 155
WD40 COG2319
WD40 repeat [General function prediction only];
1383-1443 1.75e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 1.75e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622888691 1383 HRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNtDSHISFWQMNT 1443
Cdd:COG2319     91 RLLASASADGTVRLWDLATGLLlRTLTGHTGAVRSVAFSPDGKTLASGSA-DGTVRLWDLAT 151
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1382-1443 1.05e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.42  E-value: 1.05e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622888691 1382 NHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATySNTDSHISFWQMNT 1443
Cdd:cd00200    147 GTFVASSSQDGTIKLWDLRTGKCvATLTGHTGEVNSVAFSPDGEKLLS-SSSDGTIKLWDLST 208
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1376-1443 6.24e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 6.24e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622888691 1376 VSYYERNHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATySNTDSHISFWQMNT 1443
Cdd:cd00200     57 VAASADGTYLASGSSDKTIRLWDLETGECvRTLTGHTSYVSSVAFSPDGRILSS-SSRDKTIKVWDVET 124
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1385-1440 8.94e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 8.94e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622888691 1385 IAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSnTDSHISFWQ 1440
Cdd:cd00200    234 LASGSEDGTIRVWDLRTGECvQTLSGHTNSVTSLAWSPDGKRLASGS-ADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1401-1439 2.75e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 2.75e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1622888691  1401 TGKC-QTIHGHKGPITAVAFAPDGRYLATYSNtDSHISFW 1439
Cdd:smart00320    1 SGELlKTLKGHTGPVTSVAFSPDGKYLASGSD-DGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
476-594 2.71e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 2.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  476 VSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARvqhcicSVASDHSVGLLSLREKKCIML 555
Cdd:COG2319     42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLA------SASADGTVRLWDLATGLLLRT 115

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1622888691  556 ASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGAL 594
Cdd:COG2319    116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154
WD40 pfam00400
WD domain, G-beta repeat;
1405-1439 1.01e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 1.01e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622888691 1405 QTIHGHKGPITAVAFAPDGRYLATySNTDSHISFW 1439
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSPDGKLLAS-GSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-95 1.24e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 1.24e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622888691   22 ISAVLLTDDGATIVTGCHDGQICLWDLsveLEINPRALLFGHTASITCLskaCASSDKQYIVSASESGEMCLWD 95
Cdd:cd00200    222 VNSVAFSPDGYLLASGSEDGTIRVWDL---RTGECVQTLSGHTNSVTSL---AWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
454-498 1.86e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622888691  454 WPPHRTLRGHRNKVTCLLYPHqvsaryDQRYLISGGVDFSVIIWD 498
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 454-498 2.64e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 2.64e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622888691   454 WPPHRTLRGHRNKVTCLLYPHqvsaryDQRYLISGGVDFSVIIWD 498
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSP------DGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-237 5.64e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.86  E-value: 5.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   60 LFGHTASITCLskaCASSDKQYIVSASESGEMCLWDVSDGRCIEFTKLactHTG-IQFYQFSVGNQregRLLCHGHYPEI 138
Cdd:cd00200      5 LKGHTGGVTCV---AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGpVRDVAASADGT---YLASGSSDKTI 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691  139 LVVDATSLEVLYSLVSkiSPDWISSMSIIRSHRtqedTVVALSVTGILKVWivtseisDMQDTEPIFEEE--SKPIYCqn 216
Cdd:cd00200     76 RLWDLETGECVRTLTG--HTSYVSSVAFSPDGR----ILSSSSRDKTIKVW-------DVETGKCLTTLRghTDWVNS-- 140

                          170       180
                   ....*....|....*....|.
gi 1622888691  217 cqsisfCAFTQRSLLVVCSKY 237
Cdd:cd00200    141 ------VAFSPDGTFVASSSQ 155
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1382-1443 6.85e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 6.85e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622888691 1382 NHRIAVGARHGSVALYDIRTGKCQ-TIHGHKGPITAVAFAPDGRYLATYSNtDSHISFWQMNT 1443
Cdd:cd00200     21 GKLLATGSGDGTIKVWDLETGELLrTLKGHTGPVRDVAASADGTYLASGSS-DKTIRLWDLET 82
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 22-189 1.12e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 43.14  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   22 ISAVLLTDDGATIVTGCHDGQICLWDL----SVELEI----------------NPRALLFGHTASITCLskaCASSDKQY 81
Cdd:pfam20426  127 VSCVAVTSDGSILATGSYDTTVMVWEVlrgrSSEKRSrntqtefprkdhviaeTPFHILCGHDDIITCL---YVSVELDI 203

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622888691   82 IVSASESGEMCLWDVSDGRCIE---------FTKLACTHTG-IQFYQ--------FSVGNQR------EGRL-------- 129
Cdd:pfam20426  204 VISGSKDGTCIFHTLREGRYVRsirhpsgcpLSKLVASRHGrIVLYAdddlslhlYSINGKHiassesNGRLncielssc 283

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622888691  130 ----LCHGHYPEILVVDATSLEVL--YSLVSKIspdwISSMSIirshrTQEDTVVALSVTGILKVW 189
Cdd:pfam20426  284 geflVCAGDQGQIVVRSMNSLEVVrrYNGIGKI----ITSLTV-----TPEECFLAGTKDGSLLVY 340
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 55-95 1.20e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 1.20e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1622888691    55 NPRALLFGHTASITCLskaCASSDKQYIVSASESGEMCLWD 95
Cdd:smart00320    3 ELLKTLKGHTGPVTSV---AFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 550-587 1.39e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 1.39e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1622888691   550 KKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVW 587
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 1381-1443 1.86e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 42.21  E-value: 1.86e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622888691 1381 RNHRIAVGARHGSVALYDIRTGKcqTIHGHKG----PITAVAFAPDGRYLATYSnTDSHISFWQMNT 1443
Cdd:cd22857    234 DGHTVYVGDTSGDLASIDLRTGK--LLGCFKGkcggSIRSIARHPELPLIASCG-LDRYLRIWDTET 297
WD40 pfam00400
WD domain, G-beta repeat;
55-95 4.39e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 4.39e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622888691   55 NPRALLFGHTASITCLskaCASSDKQYIVSASESGEMCLWD 95
Cdd:pfam00400    2 KLLKTLEGHTGSVTSL---AFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 16-47 6.42e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 6.42e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1622888691    16 KAPTHCISAVLLTDDGATIVTGCHDGQICLWD 47
Cdd:smart00320    9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1405-1443 9.67e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 9.67e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1622888691 1405 QTIHGHKGPITAVAFAPDGRYLATYSnTDSHISFWQMNT 1443
Cdd:cd00200      3 RTLKGHTGGVTCVAFSPDGKLLATGS-GDGTIKVWDLET 40
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 1380-1426 9.85e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 39.90  E-value: 9.85e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1622888691 1380 ERNHRIAVGARHGSVALYDIRTGK--CQTIHGHKGPITAVAFAPDGRYL 1426
Cdd:cd22857    190 DDHRKIVTGTGYHQVRLYDTRAQRrpVVSVDFGETPIKAVAEDPDGHTV 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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