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Conserved domains on  [gi|1622887605|ref|XP_028693628|]
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katanin p60 ATPase-containing subunit A-like 2 isoform X5 [Macaca mulatta]

Protein Classification

LisH and AAA domain-containing protein( domain architecture ID 12217995)

LisH and AAA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPT1 super family cl34191
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 223-428 3.86e-33

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG1222:

Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 127.43  E-value: 3.86e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 223 LSAFIGmnsemrELAAVVsRVLFELARYHAPSTIFLDELESVMSQRGTapGGEHEGSLRMKTELLVQMDGLAHSEDlVFV 302
Cdd:COG1222   149 VSKYIG------EGARNV-REVFELAREKAPSIIFIDEIDAIAARRTD--DGTSGEVQRTVNQLLAELDGFESRGD-VLI 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 303 LAASNLPWELDCAMLR--RLEKRILVDLPSREARQAMIYHWLppvsksRALELRTELEYSVLSQETEGYSGSDIKLVCRE 380
Cdd:COG1222   219 IAATNRPDLLDPALLRpgRFDRVIEVPLPDEEAREEILKIHL------RDMPLADDVDLDKLAKLTEGFSGADLKAIVTE 292

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1622887605 381 AAMRpvrkifdALENHRsessdlpgiqlDTVTTADFLDVLTHTKPSAK 428
Cdd:COG1222   293 AGMF-------AIREGR-----------DTVTMEDLEKAIEKVKKKTE 322
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 25-55 6.35e-04

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


:

Pssm-ID: 128913  Cd Length: 34  Bit Score: 37.03  E-value: 6.35e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622887605   25 RRKNLLILISHYLTQEGYIDTANALEQETKL 55
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
 
Name Accession Description Interval E-value
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 223-428 3.86e-33

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 127.43  E-value: 3.86e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 223 LSAFIGmnsemrELAAVVsRVLFELARYHAPSTIFLDELESVMSQRGTapGGEHEGSLRMKTELLVQMDGLAHSEDlVFV 302
Cdd:COG1222   149 VSKYIG------EGARNV-REVFELAREKAPSIIFIDEIDAIAARRTD--DGTSGEVQRTVNQLLAELDGFESRGD-VLI 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 303 LAASNLPWELDCAMLR--RLEKRILVDLPSREARQAMIYHWLppvsksRALELRTELEYSVLSQETEGYSGSDIKLVCRE 380
Cdd:COG1222   219 IAATNRPDLLDPALLRpgRFDRVIEVPLPDEEAREEILKIHL------RDMPLADDVDLDKLAKLTEGFSGADLKAIVTE 292

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1622887605 381 AAMRpvrkifdALENHRsessdlpgiqlDTVTTADFLDVLTHTKPSAK 428
Cdd:COG1222   293 AGMF-------AIREGR-----------DTVTMEDLEKAIEKVKKKTE 322
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 242-326 4.56e-32

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 119.76  E-value: 4.56e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTapgGEHEGSLRMKTELLVQMDGLAHS-EDLVFVLAASNLPWELDCAMLRRL 320
Cdd:cd19509    81 RALFALARELQPSIIFIDEIDSLLSERGS---GEHEASRRVKTEFLVQMDGVLNKpEDRVLVLGATNRPWELDEAFLRRF 157


                  ....*.
gi 1622887605 321 EKRILV 326
Cdd:cd19509   158 EKRIYI 163
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 242-444 1.25e-25

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 110.00  E-value: 1.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTAPGgeHEGSLRMKTELLVQMDGLAHSEDLVfVLAASNLPWELDCAMLR--R 319
Cdd:TIGR01243 536 REIFRKARQAAPAIIFFDEIDAIAPARGARFD--TSVTDRIVNQLLTEMDGIQELSNVV-VIAATNRPDILDPALLRpgR 612

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 320 LEKRILVDLPSREARQAMI-YHwlppvskSRALELRTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHRS 398
Cdd:TIGR01243 613 FDRLILVPPPDEEARKEIFkIH-------TRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGSPAKEKL 685

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1622887605 399 ESSDLPGIQLDTVTTADFLDVLTHTKPS-AKNLAQRYSAWQREFESV 444
Cdd:TIGR01243 686 EVGEEEFLKDLKVEMRHFLEALKKVKPSvSKEDMLRYERLAKELKRL 732
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 226-418 1.85e-20

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 92.59  E-value: 1.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 226 FIGmnsemrELAAVVsRVLFELARYHAPSTIFLDELESVMSQR---GTapGGEHEGSlRMKTELLVQMDGLAHSEDlVFV 302
Cdd:PRK03992  205 FIG------EGARLV-RELFELAREKAPSIIFIDEIDAIAAKRtdsGT--SGDREVQ-RTLMQLLAEMDGFDPRGN-VKI 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 303 LAASNLPWELDCAMLR--RLEKRILVDLPSREARqAMIY--HwlppvskSRALELRTELEYSVLSQETEGYSGSDIKLVC 378
Cdd:PRK03992  274 IAATNRIDILDPAILRpgRFDRIIEVPLPDEEGR-LEILkiH-------TRKMNLADDVDLEELAELTEGASGADLKAIC 345

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1622887605 379 REAAMRPVRkifdaleNHRSEssdlpgiqldtVTTADFLD 418
Cdd:PRK03992  346 TEAGMFAIR-------DDRTE-----------VTMEDFLK 367
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 242-328 4.91e-19

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 82.64  E-value: 4.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTapgGEHEGSLRMKTELLVQMDGLAHSEDLVFVLAASNLPWELDCAMLRRLE 321
Cdd:pfam00004  47 RELFEAAKKLAPCVIFIDEIDALAGSRGS---GGDSESRRVVNQLLTELDGFTSSNSKVIVIAATNRPDKLDPALLGRFD 123


                  ....*..
gi 1622887605 322 KRILVDL 328
Cdd:pfam00004 124 RIIEFPL 130
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 242-329 3.61e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.82  E-value: 3.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605  242 RVLFELARYHAPSTIFLDELESVMSQRGTApggehegsLRMKTELLVQMDGLAHSEDLVFVLAASNLPWELDCAMLRRLE 321
Cdd:smart00382  68 RLALALARKLKPDVLILDEITSLLDAEQEA--------LLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFD 139


                   ....*...
gi 1622887605  322 KRILVDLP 329
Cdd:smart00382 140 RRIVLLLI 147
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 25-55 6.35e-04

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 37.03  E-value: 6.35e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622887605   25 RRKNLLILISHYLTQEGYIDTANALEQETKL 55
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 28-52 5.78e-03

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 34.21  E-value: 5.78e-03
                          10        20
                  ....*....|....*....|....*
gi 1622887605  28 NLLILISHYLTQEGYIDTANALEQE 52
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
 
Name Accession Description Interval E-value
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 223-428 3.86e-33

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 127.43  E-value: 3.86e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 223 LSAFIGmnsemrELAAVVsRVLFELARYHAPSTIFLDELESVMSQRGTapGGEHEGSLRMKTELLVQMDGLAHSEDlVFV 302
Cdd:COG1222   149 VSKYIG------EGARNV-REVFELAREKAPSIIFIDEIDAIAARRTD--DGTSGEVQRTVNQLLAELDGFESRGD-VLI 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 303 LAASNLPWELDCAMLR--RLEKRILVDLPSREARQAMIYHWLppvsksRALELRTELEYSVLSQETEGYSGSDIKLVCRE 380
Cdd:COG1222   219 IAATNRPDLLDPALLRpgRFDRVIEVPLPDEEAREEILKIHL------RDMPLADDVDLDKLAKLTEGFSGADLKAIVTE 292

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1622887605 381 AAMRpvrkifdALENHRsessdlpgiqlDTVTTADFLDVLTHTKPSAK 428
Cdd:COG1222   293 AGMF-------AIREGR-----------DTVTMEDLEKAIEKVKKKTE 322
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 242-326 4.56e-32

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 119.76  E-value: 4.56e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTapgGEHEGSLRMKTELLVQMDGLAHS-EDLVFVLAASNLPWELDCAMLRRL 320
Cdd:cd19509    81 RALFALARELQPSIIFIDEIDSLLSERGS---GEHEASRRVKTEFLVQMDGVLNKpEDRVLVLGATNRPWELDEAFLRRF 157


                  ....*.
gi 1622887605 321 EKRILV 326
Cdd:cd19509   158 EKRIYI 163
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 229-326 4.61e-31

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 117.39  E-value: 4.61e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 229 MNSEMRELAAVVSRVLFELARYHAPSTIFLDELESVMSQRGTapGGEHEGSLRMKTELLVQMDGLAHSED------LVFV 302
Cdd:cd19522    69 LTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGT--SEEHEASRRVKSELLVQMDGVGGASEnddpskMVMV 146

                          90       100
                  ....*....|....*....|....
gi 1622887605 303 LAASNLPWELDCAMLRRLEKRILV 326
Cdd:cd19522   147 LAATNFPWDIDEALRRRLEKRIYI 170
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 244-429 1.62e-26

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 110.39  E-value: 1.62e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 244 LFELARYHAPSTIFLDELESVMSQRGTAPGGEHEgslRMKTELLVQMDGLAHSedlVFVLAASNLPWELDCAMLRRLEKR 323
Cdd:COG0464   242 VFDKARGLAPCVLFIDEADALAGKRGEVGDGVGR---RVVNTLLTEMEELRSD---VVVIAATNRPDLLDPALLRRFDEI 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 324 ILVDLPSREARQAMIYHWLPPVSKSRALELRTeleysvLSQETEGYSGSDIKLVCREAAMRPVRkifdalenhrsessdl 403
Cdd:COG0464   316 IFFPLPDAEERLEIFRIHLRKRPLDEDVDLEE------LAEATEGLSGADIRNVVRRAALQALR---------------- 373

                         170       180
                  ....*....|....*....|....*.
gi 1622887605 404 pgIQLDTVTTADFLDVLTHTKPSAKN 429
Cdd:COG0464   374 --LGREPVTTEDLLEALEREDIFLKR 397
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 244-326 9.44e-26

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 102.63  E-value: 9.44e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 244 LFELARYHAPSTIFLDELESVMSQRGTapgGEHEGSLRMKTELLVQMDGLAHSEDLVFVLAASNLPWELDCAMLRRLEKR 323
Cdd:cd19521    91 LFAMARENKPSIIFIDEVDSLCGTRGE---GESEASRRIKTELLVQMNGVGNDSQGVLVLGATNIPWQLDSAIRRRFEKR 167


                  ...
gi 1622887605 324 ILV 326
Cdd:cd19521   168 IYI 170
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 242-444 1.25e-25

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 110.00  E-value: 1.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTAPGgeHEGSLRMKTELLVQMDGLAHSEDLVfVLAASNLPWELDCAMLR--R 319
Cdd:TIGR01243 536 REIFRKARQAAPAIIFFDEIDAIAPARGARFD--TSVTDRIVNQLLTEMDGIQELSNVV-VIAATNRPDILDPALLRpgR 612

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 320 LEKRILVDLPSREARQAMI-YHwlppvskSRALELRTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHRS 398
Cdd:TIGR01243 613 FDRLILVPPPDEEARKEIFkIH-------TRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGSPAKEKL 685

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1622887605 399 ESSDLPGIQLDTVTTADFLDVLTHTKPS-AKNLAQRYSAWQREFESV 444
Cdd:TIGR01243 686 EVGEEEFLKDLKVEMRHFLEALKKVKPSvSKEDMLRYERLAKELKRL 732
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 242-326 1.24e-21

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 91.97  E-value: 1.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTapgGEHEGSLRMKTELLVQMDGL-AHSEDLVFVLAASNLPWELDCAMLRRL 320
Cdd:cd19525   104 RALFSVARCKQPAVIFIDEIDSLLSQRGE---GEHESSRRIKTEFLVQLDGAtTSSEDRILVVGATNRPQEIDEAARRRL 180


                  ....*.
gi 1622887605 321 EKRILV 326
Cdd:cd19525   181 VKRLYI 186
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 242-326 1.94e-21

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 90.68  E-value: 1.94e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTapgGEHEGSLRMKTELLVQMDGL-AHSEDLVFVLAASNLPWELDCAMLRRL 320
Cdd:cd19524    82 RALFAVARELQPSIIFIDEVDSLLSERSE---GEHEASRRLKTEFLIEFDGVqSNGDDRVLVMGATNRPQELDDAVLRRF 158


                  ....*.
gi 1622887605 321 EKRILV 326
Cdd:cd19524   159 TKRVYV 164
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 226-418 1.85e-20

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 92.59  E-value: 1.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 226 FIGmnsemrELAAVVsRVLFELARYHAPSTIFLDELESVMSQR---GTapGGEHEGSlRMKTELLVQMDGLAHSEDlVFV 302
Cdd:PRK03992  205 FIG------EGARLV-RELFELAREKAPSIIFIDEIDAIAAKRtdsGT--SGDREVQ-RTLMQLLAEMDGFDPRGN-VKI 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 303 LAASNLPWELDCAMLR--RLEKRILVDLPSREARqAMIY--HwlppvskSRALELRTELEYSVLSQETEGYSGSDIKLVC 378
Cdd:PRK03992  274 IAATNRIDILDPAILRpgRFDRIIEVPLPDEEGR-LEILkiH-------TRKMNLADDVDLEELAELTEGASGADLKAIC 345

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1622887605 379 REAAMRPVRkifdaleNHRSEssdlpgiqldtVTTADFLD 418
Cdd:PRK03992  346 TEAGMFAIR-------DDRTE-----------VTMEDFLK 367
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
242-387 3.89e-20

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 93.18  E-value: 3.89e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTAPGGEHEGSLRMKTELLVQMDGLAHSEDLVfVLAASNLPWELDCAMLR--R 319
Cdd:PRK10733  234 RDMFEQAKKAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGII-VIAATNRPDVLDPALLRpgR 312

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622887605 320 LEKRILVDLPSREARQAMIYHWLppvsksRALELRTELEYSVLSQETEGYSGSDIKLVCREAAMRPVR 387
Cdd:PRK10733  313 FDRQVVVGLPDVRGREQILKVHM------RRVPLAPDIDAAIIARGTPGFSGADLANLVNEAALFAAR 374
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 242-427 1.93e-19

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 91.12  E-value: 1.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTAPGgehEGSLRMKTELLVQMDGLAhSEDLVFVLAASNLPWELDCAMLR--R 319
Cdd:TIGR01243 261 REIFKEAEENAPSIIFIDEIDAIAPKREEVTG---EVEKRVVAQLLTLMDGLK-GRGRVIVIGATNRPDALDPALRRpgR 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 320 LEKRILVDLPSREARQAMiyhwLPPVSKSRALELRTELEYsvLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHrSE 399
Cdd:TIGR01243 337 FDREIVIRVPDKRARKEI----LKVHTRNMPLAEDVDLDK--LAEVTHGFVGADLAALAKEAAMAALRRFIREGKIN-FE 409

                         170       180       190
                  ....*....|....*....|....*....|
gi 1622887605 400 SSDLPGIQLDT--VTTADFLDVLTHTKPSA 427
Cdd:TIGR01243 410 AEEIPAEVLKElkVTMKDFMEALKMVEPSA 439
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 242-328 4.91e-19

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 82.64  E-value: 4.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTapgGEHEGSLRMKTELLVQMDGLAHSEDLVFVLAASNLPWELDCAMLRRLE 321
Cdd:pfam00004  47 RELFEAAKKLAPCVIFIDEIDALAGSRGS---GGDSESRRVVNQLLTELDGFTSSNSKVIVIAATNRPDKLDPALLGRFD 123


                  ....*..
gi 1622887605 322 KRILVDL 328
Cdd:pfam00004 124 RIIEFPL 130
ftsH CHL00176
cell division protein; Validated
 231-388 2.64e-18

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 87.41  E-value: 2.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 231 SEMRELAAVV--SRV--LFELARYHAPSTIFLDELESVMSQRGTAPGGEHEGSLRMKTELLVQMDGLAHSEDLVfVLAAS 306
Cdd:CHL00176  250 SEFVEMFVGVgaARVrdLFKKAKENSPCIVFIDEIDAVGRQRGAGIGGGNDEREQTLNQLLTEMDGFKGNKGVI-VIAAT 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 307 NLPWELDCAMLR--RLEKRILVDLPSREARQAMiyhwLPPVSKSRALELRTELEysVLSQETEGYSGSDIKLVCREAAMR 384
Cdd:CHL00176  329 NRVDILDAALLRpgRFDRQITVSLPDREGRLDI----LKVHARNKKLSPDVSLE--LIARRTPGFSGADLANLLNEAAIL 402


                  ....
gi 1622887605 385 PVRK 388
Cdd:CHL00176  403 TARR 406
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 241-326 3.82e-17

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 78.81  E-value: 3.82e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 241 SRV--LFELARYHAPSTIFLDELESVMSQRGTAPGGEHEGSLRMKTELLVQMDGLAHSEDlVFVLAASNLPWELDCAMLR 318
Cdd:cd19501    83 SRVrdLFEQAKKNAPCIVFIDEIDAVGRKRGAGLGGGHDEREQTLNQLLVEMDGFESNTG-VIVIAATNRPDVLDPALLR 161

                          90
                  ....*....|
gi 1622887605 319 --RLEKRILV 326
Cdd:cd19501   162 pgRFDRQVYV 171
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
223-381 2.58e-16

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 78.00  E-value: 2.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 223 LSAFIGmnSEMRELAAVVsRVLFELARyHAPSTIFLDELESVMSQRG-TAPGGEhegSLRMKTELLVQMDGLAHSedlVF 301
Cdd:COG1223    68 LDSLIG--SYLGETARNL-RKLFDFAR-RAPCVIFFDEFDAIAKDRGdQNDVGE---VKRVVNALLQELDGLPSG---SV 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 302 VLAASNLPWELDCAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELRTeleysvLSQETEGYSGSDIKLVCREA 381
Cdd:COG1223   138 VIAATNHPELLDSALWRRFDEVIEFPLPDKEERKEILELNLKKFPLPFELDLKK------LAKKLEGLSGADIEKVLKTA 211
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
241-388 3.07e-16

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 80.85  E-value: 3.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 241 SRV--LFELARYHAPSTIFLDELESVMSQRGTAPGG---EHEGSLrmkTELLVQMDGLAHSEDLVfVLAASNLPWELDCA 315
Cdd:COG0465   221 SRVrdLFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGghdEREQTL---NQLLVEMDGFEGNEGVI-VIAATNRPDVLDPA 296

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622887605 316 MLR--RLEKRILVDLPSREARQAmI--YHwlppvskSRALELRTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRK 388
Cdd:COG0465   297 LLRpgRFDRQVVVDLPDVKGREA-IlkVH-------ARKKPLAPDVDLEVIARRTPGFSGADLANLVNEAALLAARR 365
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 223-326 3.09e-16

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 75.78  E-value: 3.09e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 223 LSAFIGmNSEmrelAAVvsRVLFELARYHAPSTIFLDELESVMSQRGTAPGGehEGSLRMKTELLVQMDGLaHSEDLVFV 302
Cdd:cd19511    64 FSKYVG-ESE----RAV--REIFQKARQAAPCIIFFDEIDSLAPRRGQSDSS--GVTDRVVSQLLTELDGI-ESLKGVVV 133

                          90       100
                  ....*....|....*....|....*.
gi 1622887605 303 LAASNLPWELDCAMLR--RLEKRILV 326
Cdd:cd19511   134 IAATNRPDMIDPALLRpgRLDKLIYV 159
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 242-388 7.27e-16

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 79.04  E-value: 7.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTAPGGEHEGSLRMKTELLVQMDGLAHSEDlVFVLAASNLPWELDCAMLR--R 319
Cdd:PTZ00454  228 RDVFRLARENAPSIIFIDEVDSIATKRFDAQTGADREVQRILLELLNQMDGFDQTTN-VKVIMATNRADTLDPALLRpgR 306

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622887605 320 LEKRILVDLPSREARQaMIYHWLppVSKsraLELRTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRK 388
Cdd:PTZ00454  307 LDRKIEFPLPDRRQKR-LIFQTI--TSK---MNLSEEVDLEDFVSRPEKISAADIAAICQEAGMQAVRK 369
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 242-326 5.45e-15

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 72.16  E-value: 5.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTAPGGEHEGSLRMKTELLVQMDGLaHSEDLVFVLAASNLPWELDCAMLR--R 319
Cdd:cd19528    76 RDIFDKARAAAPCVLFFDELDSIAKARGGNIGDAGGAADRVINQILTEMDGM-NTKKNVFIIGATNRPDIIDPAILRpgR 154


                  ....*..
gi 1622887605 320 LEKRILV 326
Cdd:cd19528   155 LDQLIYI 161
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 232-326 1.05e-14

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 71.69  E-value: 1.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 232 EMRELAAVVsrvlFELARYHAPSTIFLDELESVMSQRGTapgGEHEGSLRMKTELLVQMDGLAHS-EDLVFVLAASNLPW 310
Cdd:cd19520    78 ESQKLVAAV----FSLASKLQPSIIFIDEIDSFLRQRSS---TDHEATAMMKAEFMSLWDGLSTDgNCRVIVMGATNRPQ 150

                          90
                  ....*....|....*.
gi 1622887605 311 ELDCAMLRRLEKRILV 326
Cdd:cd19520   151 DLDEAILRRMPKRFHI 166
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 244-326 6.06e-13

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 66.15  E-value: 6.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 244 LFELARYHAPSTIFLDELESVMSQRGtaPGGEHEGSLRMKTELLVQMDGLAHSEDlVFVLAASNLPWELDCAMLR--RLE 321
Cdd:cd19481    77 IFERARRLAPCILFIDEIDAIGRKRD--SSGESGELRRVLNQLLTELDGVNSRSK-VLVIAATNRPDLLDPALLRpgRFD 153


                  ....*
gi 1622887605 322 KRILV 326
Cdd:cd19481   154 EVIEF 158
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 242-326 7.14e-13

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 66.36  E-value: 7.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGtapGGEHEGSLRMKTELLVQMDGLAHSEDlVFVLAASNLPWELDCAMLR--R 319
Cdd:cd19530    79 RQVFQRARASAPCVIFFDEVDALVPKRG---DGGSWASERVVNQLLTEMDGLEERSN-VFVIAATNRPDIIDPAMLRpgR 154


                  ....*..
gi 1622887605 320 LEKRILV 326
Cdd:cd19530   155 LDKTLYV 161
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 226-324 1.49e-12

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 65.44  E-value: 1.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 226 FIGMNSEMrelaavvSRVLFELARYHAPSTIFLDELESVMSQR-GTAPGGEHEGSlRMKTELLVQMDGLAHSEDlVFVLA 304
Cdd:cd19502    77 YIGEGARL-------VRELFEMAREKAPSIIFIDEIDAIGAKRfDSGTGGDREVQ-RTMLELLNQLDGFDPRGN-IKVIM 147

                          90       100
                  ....*....|....*....|..
gi 1622887605 305 ASNLPWELDCAMLR--RLEKRI 324
Cdd:cd19502   148 ATNRPDILDPALLRpgRFDRKI 169
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 242-324 5.98e-12

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 63.46  E-value: 5.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTapgGEHEGSLRMKTELLVQMDGLAhSEDLVFVLAASNLPWELDCAMLR--R 319
Cdd:cd19503    83 REIFEEARSHAPSIIFIDEIDALAPKREE---DQREVERRVVAQLLTLMDGMS-SRGKVVVIAATNRPDAIDPALRRpgR 158


                  ....*
gi 1622887605 320 LEKRI 324
Cdd:cd19503   159 FDREV 163
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 242-326 8.57e-12

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 62.90  E-value: 8.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTapGGEHEGSLRMKTELLVQMDGLAHSEDLVfVLAASNLPWELDCAMLR--R 319
Cdd:cd19529    76 REIFRKARQVAPCVIFFDEIDSIAPRRGT--TGDSGVTERVVNQLLTELDGLEEMNGVV-VIAATNRPDIIDPALLRagR 152


                  ....*..
gi 1622887605 320 LEKRILV 326
Cdd:cd19529   153 FDRLIYI 159
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 242-326 3.11e-11

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 61.37  E-value: 3.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTapGGEHEGSL-RMKTELLVQMDGLAHSEDLVFVLAASNLPWELDCAMLR-- 318
Cdd:cd19527    75 REVFQKARDAKPCVIFFDELDSLAPSRGN--SGDSGGVMdRVVSQLLAELDGMSSSGQDVFVIGATNRPDLLDPALLRpg 152


                  ....*...
gi 1622887605 319 RLEKRILV 326
Cdd:cd19527   153 RFDKLLYL 160
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 245-326 3.72e-11

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 61.44  E-value: 3.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 245 FELARYHAPSTIFLDELESVMSQR--GTAPGGehegslRMKTELLVQMDG-LAHSEDLVFVLAASNLPWELDCAMLRRLE 321
Cdd:cd19523    85 FLAARCRQPSVLFISDLDALLSSQddEASPVG------RLQVELLAQLDGvLGSGEDGVLVVCTTSKPEEIDESLRRYFS 158


                  ....*
gi 1622887605 322 KRILV 326
Cdd:cd19523   159 KRLLV 163
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 242-387 1.03e-10

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 63.25  E-value: 1.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQR-GTAPGGEHEGSLRMkTELLVQMDGLAHSEDlVFVLAASNLPWELDCAMLR-- 318
Cdd:PTZ00361  266 RELFRVAEENAPSIVFIDEIDAIGTKRyDATSGGEKEIQRTM-LELLNQLDGFDSRGD-VKVIMATNRIESLDPALIRpg 343

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 319 RLEKRILVDLPSREARQaMIYHwlppVSKSR-ALELRTELEYSVLSQETegYSGSDIKLVCREAAMRPVR 387
Cdd:PTZ00361  344 RIDRKIEFPNPDEKTKR-RIFE----IHTSKmTLAEDVDLEEFIMAKDE--LSGADIKAICTEAGLLALR 406
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 223-325 3.74e-09

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 55.51  E-value: 3.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 223 LSAFIGMNSEmrelaAVvsRVLFELARYHAPSTIFLDELESVMSQRGTAPGGEHEgslRMKTELLVQMDGlAHSEDLVFV 302
Cdd:cd19526    64 LNKYIGASEQ-----NV--RDLFSRAQSAKPCILFFDEFDSIAPKRGHDSTGVTD---RVVNQLLTQLDG-VEGLDGVYV 132

                          90       100
                  ....*....|....*....|....*
gi 1622887605 303 LAASNLPWELDCAMLR--RLEKRIL 325
Cdd:cd19526   133 LAATSRPDLIDPALLRpgRLDKLVY 157
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 356-394 6.26e-09

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 51.39  E-value: 6.26e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622887605 356 ELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALE 394
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEAVT 39
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 242-324 1.44e-07

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 51.25  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTApggEHEGSLRMKTELLVQMDGLAHSEDL---VFVLAASNLPWELDCAMLR 318
Cdd:cd19518    83 RELFDQAISNAPCIVFIDEIDAITPKRESA---QREMERRIVSQLLTCMDELNNEKTAggpVLVIGATNRPDSLDPALRR 159


                  ....*...
gi 1622887605 319 --RLEKRI 324
Cdd:cd19518   160 agRFDREI 167
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 242-319 1.52e-07

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 50.90  E-value: 1.52e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTAPGgehEGSLRMKTELLVQMDGLAHSEDlVFVLAASNLPWELDCAmLRR 319
Cdd:cd19519    83 RKAFEEAEKNAPAIIFIDEIDAIAPKREKTHG---EVERRIVSQLLTLMDGLKQRAH-VIVMAATNRPNSIDPA-LRR 155
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 242-319 1.37e-04

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 42.50  E-value: 1.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVMSQRGTAPGGEHEGslrMKTELLVQMDGLaHSEDLVFVLAASNLPWELDCAmLRR 319
Cdd:cd19517    88 RLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHAS---IVSTLLALMDGL-DNRGQVVVIGATNRPDALDPA-LRR 160
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 242-329 3.61e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.82  E-value: 3.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605  242 RVLFELARYHAPSTIFLDELESVMSQRGTApggehegsLRMKTELLVQMDGLAHSEDLVFVLAASNLPWELDCAMLRRLE 321
Cdd:smart00382  68 RLALALARKLKPDVLILDEITSLLDAEQEA--------LLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFD 139


                   ....*...
gi 1622887605  322 KRILVDLP 329
Cdd:smart00382 140 RRIVLLLI 147
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 25-55 6.35e-04

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 37.03  E-value: 6.35e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622887605   25 RRKNLLILISHYLTQEGYIDTANALEQETKL 55
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 242-328 3.18e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 37.90  E-value: 3.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622887605 242 RVLFELARYHAPSTIFLDELESVmsqrgtaPGGEHEGSLRMktelLVQMDGLAHSEDLVFVLAASNLPWELDCAM--LRR 319
Cdd:cd00009    74 RLLFELAEKAKPGVLFIDEIDSL-------SRGAQNALLRV----LETLNDLRIDRENVRVIGATNRPLLGDLDRalYDR 142


                  ....*....
gi 1622887605 320 LEKRILVDL 328
Cdd:cd00009   143 LDIRIVIPL 151
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 28-52 5.78e-03

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 34.21  E-value: 5.78e-03
                          10        20
                  ....*....|....*....|....*
gi 1622887605  28 NLLILISHYLTQEGYIDTANALEQE 52
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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