NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622834023|ref|XP_028693339|]
View 

GPI mannosyltransferase 2 isoform X2 [Macaca mulatta]

Protein Classification

glycosyltransferase family protein; YfhO family protein( domain architecture ID 10514647)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein| YfhO family protein is an integral membrane protein similar to Bacillus subtilis YfhO that is essential to lipoteichoic acid (LTA) glycosylation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 8-401 5.51e-179

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


:

Pssm-ID: 282094  Cd Length: 439  Bit Score: 506.76  E-value: 5.51e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834023   8 RKEVLRFAVSCRILTLMLQALFN-AIIPDHHAEAFSPPRLAPSGFVDQLVDGLLGGLSRWDAEHFLFIAEHGYLYEHNFA 86
Cdd:pfam04188   1 IKELTLYAVLFRSLQLLLVFLTPiRQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834023  87 FFPGFPLALMVGT-ELLRPLRGLLSLRSCLLISVASLNFLFFMLAAVALHDLGCLVLHCPHQAFYAALLFCLSPASVFLA 165
Cdd:pfam04188  81 FSPLWPFFVRLFIkSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834023 166 AGYSEALFALLTFSAMGQLERGRVWTSGLLFAIATGVRSNGLVSVGFLMHSQCQGFFSSLTMLNPLRQLFKLMASLFLSV 245
Cdd:pfam04188 161 SIYSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSNCVLLGIYFIDLIELTKNRKFVKAICFPFLSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834023 246 FTLGLPFALFQYYAYTQFCLPGSArpipeplvqlavdkgyriaeGNEPPWCFWDVPLIYSYIQDVYWNVGFLKYYELRQV 325
Cdd:pfam04188 241 SLMFLPFLYFQYYLYKTFCPQRSA--------------------GNEPPWCKSQLPLLYSYIQSHYWGVGFLKYWTPKQI 300

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622834023 326 PNFLLAAPVAILVVWATWTYVTTHPWLCLTLGLQRSKNNKTLEKPDLGFLSPKVFVYLVHAAVLLLFGGLCMHVQV 401
Cdd:pfam04188 301 PNFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQYPSYNKKAEKPDLGFLSPQVFVLVVHTRALVVIVCFFMHVQV 376
 
Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 8-401 5.51e-179

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


Pssm-ID: 282094  Cd Length: 439  Bit Score: 506.76  E-value: 5.51e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834023   8 RKEVLRFAVSCRILTLMLQALFN-AIIPDHHAEAFSPPRLAPSGFVDQLVDGLLGGLSRWDAEHFLFIAEHGYLYEHNFA 86
Cdd:pfam04188   1 IKELTLYAVLFRSLQLLLVFLTPiRQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834023  87 FFPGFPLALMVGT-ELLRPLRGLLSLRSCLLISVASLNFLFFMLAAVALHDLGCLVLHCPHQAFYAALLFCLSPASVFLA 165
Cdd:pfam04188  81 FSPLWPFFVRLFIkSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834023 166 AGYSEALFALLTFSAMGQLERGRVWTSGLLFAIATGVRSNGLVSVGFLMHSQCQGFFSSLTMLNPLRQLFKLMASLFLSV 245
Cdd:pfam04188 161 SIYSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSNCVLLGIYFIDLIELTKNRKFVKAICFPFLSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834023 246 FTLGLPFALFQYYAYTQFCLPGSArpipeplvqlavdkgyriaeGNEPPWCFWDVPLIYSYIQDVYWNVGFLKYYELRQV 325
Cdd:pfam04188 241 SLMFLPFLYFQYYLYKTFCPQRSA--------------------GNEPPWCKSQLPLLYSYIQSHYWGVGFLKYWTPKQI 300

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622834023 326 PNFLLAAPVAILVVWATWTYVTTHPWLCLTLGLQRSKNNKTLEKPDLGFLSPKVFVYLVHAAVLLLFGGLCMHVQV 401
Cdd:pfam04188 301 PNFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQYPSYNKKAEKPDLGFLSPQVFVLVVHTRALVVIVCFFMHVQV 376
COG5542 COG5542
Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];
66-203 2.09e-09

Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];


Pssm-ID: 444286 [Multi-domain]  Cd Length: 208  Bit Score: 57.27  E-value: 2.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834023  66 WDAEHFLFIAEHGYLY----EHNfAFFPGFPLALMVGTELlrplrGLLSLRSCLLISVaslnfLFFMLAAVALHDLgCLV 141
Cdd:COG5542     4 FLSPWYRAIATSGYFAalgkQFG-DYFPLYPYLLRLVMYL-----GLPFLLAGKLVSI-----LADLVAAYLLYRW-VKK 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622834023 142 LHCPHQAFYAALLFCLSPASVFLAAGY--SEALFALLTFSAMGQLERGRVWTSGLLFAIATGVR 203
Cdd:COG5542    72 YYGGNAALLAAAVLAFLPTVLLNSAIWgqTDSLYTLFSLAALYALLRGRYGWAALFFALATAFK 135
 
Name Accession Description Interval E-value
Mannosyl_trans2 pfam04188
Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are ...
 8-401 5.51e-179

Mannosyltransferase (PIG-V); This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI.


Pssm-ID: 282094  Cd Length: 439  Bit Score: 506.76  E-value: 5.51e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834023   8 RKEVLRFAVSCRILTLMLQALFN-AIIPDHHAEAFSPPRLAPSGFVDQLVDGLLGGLSRWDAEHFLFIAEHGYLYEHNFA 86
Cdd:pfam04188   1 IKELTLYAVLFRSLQLLLVFLTPiRQFPTSTSLALNPPCSASPSEVNSYWNKYLWNLLSWDSVFFLKISENGYQYEHEYA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834023  87 FFPGFPLALMVGT-ELLRPLRGLLSLRSCLLISVASLNFLFFMLAAVALHDLGCLVLHCPHQAFYAALLFCLSPASVFLA 165
Cdd:pfam04188  81 FSPLWPFFVRLFIkSNNDPLYHLLRLRVAIENSLFYLSILLFFLAAKILSQNIRQSLFARTISFKASLLFCLTPAAGFLT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834023 166 AGYSEALFALLTFSAMGQLERGRVWTSGLLFAIATGVRSNGLVSVGFLMHSQCQGFFSSLTMLNPLRQLFKLMASLFLSV 245
Cdd:pfam04188 161 SIYSEPLSALFAFVGIWSLECGIDISWVLWFAYSFIMRSNGLASLGRSNCVLLGIYFIDLIELTKNRKFVKAICFPFLSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834023 246 FTLGLPFALFQYYAYTQFCLPGSArpipeplvqlavdkgyriaeGNEPPWCFWDVPLIYSYIQDVYWNVGFLKYYELRQV 325
Cdd:pfam04188 241 SLMFLPFLYFQYYLYKTFCPQRSA--------------------GNEPPWCKSQLPLLYSYIQSHYWGVGFLKYWTPKQI 300

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622834023 326 PNFLLAAPVAILVVWATWTYVTTHPWLCLTLGLQRSKNNKTLEKPDLGFLSPKVFVYLVHAAVLLLFGGLCMHVQV 401
Cdd:pfam04188 301 PNFLLAVPNIILLIYSSIYYSKTHPWLCLTLGLQYPSYNKKAEKPDLGFLSPQVFVLVVHTRALVVIVCFFMHVQV 376
COG5542 COG5542
Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];
66-203 2.09e-09

Mannosyltransferase related to Gpi18 [Carbohydrate transport and metabolism];


Pssm-ID: 444286 [Multi-domain]  Cd Length: 208  Bit Score: 57.27  E-value: 2.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622834023  66 WDAEHFLFIAEHGYLY----EHNfAFFPGFPLALMVGTELlrplrGLLSLRSCLLISVaslnfLFFMLAAVALHDLgCLV 141
Cdd:COG5542     4 FLSPWYRAIATSGYFAalgkQFG-DYFPLYPYLLRLVMYL-----GLPFLLAGKLVSI-----LADLVAAYLLYRW-VKK 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622834023 142 LHCPHQAFYAALLFCLSPASVFLAAGY--SEALFALLTFSAMGQLERGRVWTSGLLFAIATGVR 203
Cdd:COG5542    72 YYGGNAALLAAAVLAFLPTVLLNSAIWgqTDSLYTLFSLAALYALLRGRYGWAALFFALATAFK 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH