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Conserved domains on  [gi|1622883474|ref|XP_028693004|]
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fibronectin type-III domain-containing protein 3A isoform X2 [Macaca mulatta]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10047016)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to fibronectin type-III domain-containing protein 3A/3B

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
570-820 8.42e-20

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 95.07  E-value: 8.42e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  570 DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPK-AKEIQLRWGPPlvdGGSPISCYSVEMSPI 648
Cdd:COG3401    197 GDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSA--PTGLTATADtPGSVTLSWDPV---TESDATGYRVYRSNS 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  649 EKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGF-GPFSEKCDITTAPGPPDqckPPQ-VTCKSATCAQV--NWE 724
Cdd:COG3401    272 GDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPA---APSgLTATAVGSSSItlSWT 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  725 VplSNGTDVTEYRLE-WGGVEGSMQ-ICYCGPGLNYEIKGLSPATTYYCRVQALSVVG-AGPFSEVVACVTPPSVPGIVT 801
Cdd:COG3401    349 A--SSDADVTGYNVYrSTSGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESL 426

                          250
                   ....*....|....*....
gi 1622883474  802 CLQEISDDEIENPHYSPST 820
Cdd:COG3401    427 TASVDAVPLTDVAGATAAA 445
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
755-1014 6.68e-15

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 79.28  E-value: 6.68e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  755 GLNYEIKGLSPATTYYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTcLQEISDDEIEnphyspstclaISWEKPCD 831
Cdd:COG3401    191 TLVDGGGDIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  832 HGseILSYSI-----DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG-AGPFSHMIKLKTKPLPPDPPR-LECV 904
Cdd:COG3401    259 SD--ATGYRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTAT 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  905 AFSHQNLKLKWGegtpKTLSADSIQYHL-QMEDKNGRFVSLYRGPC-HTYKVQRLNESTSYKFCIQACNEAG-EGPLSQE 981
Cdd:COG3401    337 AVGSSSITLSWT----ASSDADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412

                          250       260       270
                   ....*....|....*....|....*....|....
gi 1622883474  982 -YIFTTPKSVPPALKAPKIEKVNDHICEITWECL 1014
Cdd:COG3401    413 vSATTASAASGESLTASVDAVPLTDVAGATAAAS 446
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
211-555 2.05e-14

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 77.74  E-value: 2.05e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  211 SNIVKPVASDIQARTVVLTWSPPSSLINGETDESTVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPATDYHAK 290
Cdd:COG3401    129 TAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYR 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  291 VQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGskIQNFVLEWDEgKGNGEFCQCYMGSQK 370
Cdd:COG3401    209 VAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSN-SGDGPFTKVATVTTT 285

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  371 QFKITKLSPAMGCKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSG-----------TP 438
Cdd:COG3401    286 SYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDadvtgynvyrsTS 365

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  439 SDEGISYILEMEEETSgygfkpkydgedlaYTVKNLRRSTKYKFKVIAYNSEG-KSNPSEVVEFTT---CPDKPGIPVKP 514
Cdd:COG3401    366 GGGTYTKIAETVTTTS--------------YTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTasaASGESLTASVD 431

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1622883474  515 SVKGKIHSHSFKITWDPPKDNGGAAINKYVVEMAEGSNGNK 555
Cdd:COG3401    432 AVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTT 472
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 991-1088 8.33e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.71  E-value: 8.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  991 PPALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYK--GPDSSFRYSSLQLNCEYRFRVCAIRqc 1068
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAVN-- 78

                           90       100
                   ....*....|....*....|
gi 1622883474 1069 qdslghQDLVGPYSTTVLFI 1088
Cdd:cd00063     79 ------GGGESPPSESVTVT 92
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
570-820 8.42e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 95.07  E-value: 8.42e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  570 DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPK-AKEIQLRWGPPlvdGGSPISCYSVEMSPI 648
Cdd:COG3401    197 GDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSA--PTGLTATADtPGSVTLSWDPV---TESDATGYRVYRSNS 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  649 EKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGF-GPFSEKCDITTAPGPPDqckPPQ-VTCKSATCAQV--NWE 724
Cdd:COG3401    272 GDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPA---APSgLTATAVGSSSItlSWT 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  725 VplSNGTDVTEYRLE-WGGVEGSMQ-ICYCGPGLNYEIKGLSPATTYYCRVQALSVVG-AGPFSEVVACVTPPSVPGIVT 801
Cdd:COG3401    349 A--SSDADVTGYNVYrSTSGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESL 426

                          250
                   ....*....|....*....
gi 1622883474  802 CLQEISDDEIENPHYSPST 820
Cdd:COG3401    427 TASVDAVPLTDVAGATAAA 445
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
755-1014 6.68e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 79.28  E-value: 6.68e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  755 GLNYEIKGLSPATTYYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTcLQEISDDEIEnphyspstclaISWEKPCD 831
Cdd:COG3401    191 TLVDGGGDIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  832 HGseILSYSI-----DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG-AGPFSHMIKLKTKPLPPDPPR-LECV 904
Cdd:COG3401    259 SD--ATGYRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTAT 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  905 AFSHQNLKLKWGegtpKTLSADSIQYHL-QMEDKNGRFVSLYRGPC-HTYKVQRLNESTSYKFCIQACNEAG-EGPLSQE 981
Cdd:COG3401    337 AVGSSSITLSWT----ASSDADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412

                          250       260       270
                   ....*....|....*....|....*....|....
gi 1622883474  982 -YIFTTPKSVPPALKAPKIEKVNDHICEITWECL 1014
Cdd:COG3401    413 vSATTASAASGESLTASVDAVPLTDVAGATAAAS 446
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
211-555 2.05e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 77.74  E-value: 2.05e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  211 SNIVKPVASDIQARTVVLTWSPPSSLINGETDESTVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPATDYHAK 290
Cdd:COG3401    129 TAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYR 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  291 VQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGskIQNFVLEWDEgKGNGEFCQCYMGSQK 370
Cdd:COG3401    209 VAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSN-SGDGPFTKVATVTTT 285

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  371 QFKITKLSPAMGCKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSG-----------TP 438
Cdd:COG3401    286 SYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDadvtgynvyrsTS 365

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  439 SDEGISYILEMEEETSgygfkpkydgedlaYTVKNLRRSTKYKFKVIAYNSEG-KSNPSEVVEFTT---CPDKPGIPVKP 514
Cdd:COG3401    366 GGGTYTKIAETVTTTS--------------YTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTasaASGESLTASVD 431

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1622883474  515 SVKGKIHSHSFKITWDPPKDNGGAAINKYVVEMAEGSNGNK 555
Cdd:COG3401    432 AVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTT 472
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 315-406 2.12e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 2.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  315 PDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 393
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrEKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1622883474  394 GTSGFSEEVLYYT 406
Cdd:cd00063     81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 622-698 4.75e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.98  E-value: 4.75e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622883474  622 EIQLRWGPPLvDGGSPISCYSVEMSPIEKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITT 698
Cdd:cd00063     16 SVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
809-884 7.66e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 7.66e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  809 DEIENPHYSP--STCLAISWEKPCDHGSEILSYSIDF------GDKQSLTVGKVT-SYIINNLQPDTTYRIRIQALNSLG 879
Cdd:pfam00041    1 SAPSNLTVTDvtSTSLTVSWTPPPDGNGPITGYEVEYrpknsgEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1622883474  880 AGPFS 884
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 819-891 4.01e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 4.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  819 STCLAISWEKPCDHGSEILSYSIDFGDKQS-------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT 891
Cdd:cd00063     14 STSVTLSWTPPEDDGGPITGYVVEYREKGSgdwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 700-782 3.56e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 3.56e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474   700 PGPPdqcKPPQVTCKSATCAQVNWEVPLSNGTD--VTEYRLEWGGVEGSMQICYCGPGLN-YEIKGLSPATTYYCRVQAL 776
Cdd:smart00060    1 PSPP---SNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 1622883474   777 SVVGAG 782
Cdd:smart00060   78 NGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 315-396 8.33e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.39  E-value: 8.33e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474   315 PDIPNPPRIANRTKNSLTLQWKAPSDNG--SKIQNFVLEWDEGKGNGEFCQCyMGSQKQFKITKLSPAMGCKFRLSARND 392
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1622883474   393 YGTS 396
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 819-881 8.92e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.39  E-value: 8.92e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474   819 STCLAISWEKPCDHG--SEILSYSIDFGDKQSL-----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 881
Cdd:smart00060   14 STSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwkevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
318-399 1.26e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.26e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  318 PNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWdEGKGNGEFCQCYM--GSQKQFKITKLSPAMGCKFRLSARNDYGT 395
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEY-RPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 1622883474  396 SGFS 399
Cdd:pfam00041   82 GPPS 85
fn3 pfam00041
Fibronectin type III domain;
707-785 1.30e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  707 KPPQVTCK--SATCAQVNWEVPLSNGTDVTEYRLEW---GGVEGSMQICYCGPGLNYEIKGLSPATTYYCRVQALSVVGA 781
Cdd:pfam00041    2 APSNLTVTdvTSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 1622883474  782 GPFS 785
Cdd:pfam00041   82 GPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 991-1088 8.33e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.71  E-value: 8.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  991 PPALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYK--GPDSSFRYSSLQLNCEYRFRVCAIRqc 1068
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAVN-- 78

                           90       100
                   ....*....|....*....|
gi 1622883474 1069 qdslghQDLVGPYSTTVLFI 1088
Cdd:cd00063     79 ------GGGESPPSESVTVT 92
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
570-820 8.42e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 95.07  E-value: 8.42e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  570 DRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPK-AKEIQLRWGPPlvdGGSPISCYSVEMSPI 648
Cdd:COG3401    197 GDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSA--PTGLTATADtPGSVTLSWDPV---TESDATGYRVYRSNS 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  649 EKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGF-GPFSEKCDITTAPGPPDqckPPQ-VTCKSATCAQV--NWE 724
Cdd:COG3401    272 GDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPA---APSgLTATAVGSSSItlSWT 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  725 VplSNGTDVTEYRLE-WGGVEGSMQ-ICYCGPGLNYEIKGLSPATTYYCRVQALSVVG-AGPFSEVVACVTPPSVPGIVT 801
Cdd:COG3401    349 A--SSDADVTGYNVYrSTSGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESL 426

                          250
                   ....*....|....*....
gi 1622883474  802 CLQEISDDEIENPHYSPST 820
Cdd:COG3401    427 TASVDAVPLTDVAGATAAA 445
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
755-1014 6.68e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 79.28  E-value: 6.68e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  755 GLNYEIKGLSPATTYYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTcLQEISDDEIEnphyspstclaISWEKPCD 831
Cdd:COG3401    191 TLVDGGGDIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  832 HGseILSYSI-----DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG-AGPFSHMIKLKTKPLPPDPPR-LECV 904
Cdd:COG3401    259 SD--ATGYRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTAT 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  905 AFSHQNLKLKWGegtpKTLSADSIQYHL-QMEDKNGRFVSLYRGPC-HTYKVQRLNESTSYKFCIQACNEAG-EGPLSQE 981
Cdd:COG3401    337 AVGSSSITLSWT----ASSDADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412

                          250       260       270
                   ....*....|....*....|....*....|....
gi 1622883474  982 -YIFTTPKSVPPALKAPKIEKVNDHICEITWECL 1014
Cdd:COG3401    413 vSATTASAASGESLTASVDAVPLTDVAGATAAAS 446
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
211-555 2.05e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 77.74  E-value: 2.05e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  211 SNIVKPVASDIQARTVVLTWSPPSSLINGETDESTVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPATDYHAK 290
Cdd:COG3401    129 TAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYR 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  291 VQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGskIQNFVLEWDEgKGNGEFCQCYMGSQK 370
Cdd:COG3401    209 VAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSN-SGDGPFTKVATVTTT 285

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  371 QFKITKLSPAMGCKFRLSARNDYGT-SGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSG-----------TP 438
Cdd:COG3401    286 SYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDadvtgynvyrsTS 365

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  439 SDEGISYILEMEEETSgygfkpkydgedlaYTVKNLRRSTKYKFKVIAYNSEG-KSNPSEVVEFTT---CPDKPGIPVKP 514
Cdd:COG3401    366 GGGTYTKIAETVTTTS--------------YTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTasaASGESLTASVD 431

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1622883474  515 SVKGKIHSHSFKITWDPPKDNGGAAINKYVVEMAEGSNGNK 555
Cdd:COG3401    432 AVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTT 472
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 315-406 2.12e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 2.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  315 PDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 393
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrEKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1622883474  394 GTSGFSEEVLYYT 406
Cdd:cd00063     81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 411-503 2.33e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.75  E-value: 2.33e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  411 PSMPASPVLTKAGITWLSLQWSKPSGTPSdEGISYILEMEEETSGYGFK-PKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 489
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1622883474  490 EGKSNPSEVVEFTT 503
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 622-698 4.75e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.98  E-value: 4.75e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622883474  622 EIQLRWGPPLvDGGSPISCYSVEMSPIEKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITT 698
Cdd:cd00063     16 SVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 700-792 6.73e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 6.73e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  700 PGPPDQckpPQVTCKSATCAQVNWEVPLSNGTDVTEYRLEWGGV-EGSMQIC--YCGPGLNYEIKGLSPATTYYCRVQAL 776
Cdd:cd00063      1 PSPPTN---LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKgSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1622883474  777 SVVGAGPFSEVVACVT 792
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
809-884 7.66e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 7.66e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  809 DEIENPHYSP--STCLAISWEKPCDHGSEILSYSIDF------GDKQSLTVGKVT-SYIINNLQPDTTYRIRIQALNSLG 879
Cdd:pfam00041    1 SAPSNLTVTDvtSTSLTVSWTPPPDGNGPITGYEVEYrpknsgEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1622883474  880 AGPFS 884
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 819-891 4.01e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 4.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  819 STCLAISWEKPCDHGSEILSYSIDFGDKQS-------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT 891
Cdd:cd00063     14 STSVTLSWTPPEDDGGPITGYVVEYREKGSgdwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 508-601 4.55e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 4.55e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  508 PGIPVKPSVKGkIHSHSFKITWDPPKDNGGAaINKYVVEMAEgSNGNKWEMI--YSGATREHLCDRLNPGCFYRLRVYCI 585
Cdd:cd00063      1 PSPPTNLRVTD-VTSTSVTLSWTPPEDDGGP-ITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1622883474  586 SDGGQSAVSESLLVQT 601
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
816-1109 2.41e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 64.64  E-value: 2.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  816 YSPSTCLAISWEKPCDHGSEILSYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLP 895
Cdd:COG3401    153 ANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTP 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  896 PDPP-RLECVAFSHQNLKLKWGEGTPKTLSAdsiqYHL-QMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEA 973
Cdd:COG3401    233 PSAPtGLTATADTPGSVTLSWDPVTESDATG----YRVyRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  974 G-EGPLSQEYIFTTPKSVPPALKAPKIEKVNDHICEITWeclQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS-SFRYS 1050
Cdd:COG3401    309 GnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSW---TASSDADVTgYNVYRSTSGGGTYTKIAETVTTtSYTDT 385

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622883474 1051 SLQLNCEYRFRVCAIrqcqDSLGhqdLVGPYSTTVLFISQRTEPPASTNRDTVESTRTR 1109
Cdd:COG3401    386 GLTPGTTYYYKVTAV----DAAG---NESAPSEEVSATTASAASGESLTASVDAVPLTD 437
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 211-310 4.49e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.51  E-value: 4.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  211 SNIVKPVASDIQARTVVLTWSPPsslingetdESTVPELYGYEVLISSTGKDGKYK-SVYVGEETNITLNDLKPATDYHA 289
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPP---------EDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEF 72

                           90       100
                   ....*....|....*....|.
gi 1622883474  290 KVQAEYNSIKGTPSEAEIFTT 310
Cdd:cd00063     73 RVRAVNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 700-782 3.56e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 3.56e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474   700 PGPPdqcKPPQVTCKSATCAQVNWEVPLSNGTD--VTEYRLEWGGVEGSMQICYCGPGLN-YEIKGLSPATTYYCRVQAL 776
Cdd:smart00060    1 PSPP---SNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 1622883474   777 SVVGAG 782
Cdd:smart00060   78 NGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 606-688 3.89e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 3.89e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474   606 PGPclPPRLQGRPKAKE-IQLRWGPPLVDGG-SPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAAN 683
Cdd:smart00060    1 PSP--PSNLRVTDVTSTsVTLSWEPPPDDGItGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1622883474   684 KMGFG 688
Cdd:smart00060   79 GAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 315-396 8.33e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.39  E-value: 8.33e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474   315 PDIPNPPRIANRTKNSLTLQWKAPSDNG--SKIQNFVLEWDEGKGNGEFCQCyMGSQKQFKITKLSPAMGCKFRLSARND 392
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1622883474   393 YGTS 396
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 819-881 8.92e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.39  E-value: 8.92e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474   819 STCLAISWEKPCDHG--SEILSYSIDFGDKQSL-----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 881
Cdd:smart00060   14 STSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwkevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
318-399 1.26e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.26e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  318 PNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWdEGKGNGEFCQCYM--GSQKQFKITKLSPAMGCKFRLSARNDYGT 395
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEY-RPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 1622883474  396 SGFS 399
Cdd:pfam00041   82 GPPS 85
fn3 pfam00041
Fibronectin type III domain;
707-785 1.30e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  707 KPPQVTCK--SATCAQVNWEVPLSNGTDVTEYRLEW---GGVEGSMQICYCGPGLNYEIKGLSPATTYYCRVQALSVVGA 781
Cdd:pfam00041    2 APSNLTVTdvTSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 1622883474  782 GPFS 785
Cdd:pfam00041   82 GPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 411-493 1.97e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.97e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474   411 PSMPASPVLTKAGITWLSLQWSKPsgtPSDEGISYILEMEEETSGYGFKPK---YDGEDLAYTVKNLRRSTKYKFKVIAY 487
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPP---PDDGITGYIVGYRVEYREEGSEWKevnVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 1622883474   488 NSEGKS 493
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
622-691 2.21e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.42  E-value: 2.21e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622883474  622 EIQLRWGPPLvDGGSPISCYSVEMSPIEKDEPREVYQ--GSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 691
Cdd:pfam00041   15 SLTVSWTPPP-DGNGPITGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 896-986 6.56e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 6.56e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  896 PDPPR-LECVAFSHQNLKLKWGEgtPKTLSADSIQYHLQMEDKNGRFVSLYRGPC---HTYKVQRLNESTSYKFCIQACN 971
Cdd:cd00063      1 PSPPTnLRVTDVTSTSVTLSWTP--PEDDGGPITGYVVEYREKGSGDWKEVEVTPgseTSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....*
gi 1622883474  972 EAGEGPLSQEYIFTT 986
Cdd:cd00063     79 GGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
216-303 1.36e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.11  E-value: 1.36e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  216 PVASDIQARTVVLTWSPPSSLiNGEtdestvpeLYGYEVLISSTGKDGKYKSVYV-GEETNITLNDLKPATDYHAKVQAE 294
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDG-NGP--------ITGYEVEYRPKNSGEPWNEITVpGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 1622883474  295 YNSIKGTPS 303
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 508-591 3.16e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 3.16e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474   508 PGIPVKPSVKGkIHSHSFKITWDPPKDNGGAAINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISD 587
Cdd:smart00060    1 PSPPSNLRVTD-VTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1622883474   588 GGQS 591
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 895-976 4.76e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 4.76e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474   895 PPDPPRLECVAFSHQNLKLKWGEGTPKTLSADSIQYHLQMEDKNGRFVSLYRGPCHT-YKVQRLNESTSYKFCIQACNEA 973
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1622883474   974 GEG 976
Cdd:smart00060   81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
414-496 1.55e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  414 PASPVLTKAGITWLSLQWSKPSgTPSDEGISYILEMEEETSGYGFKPKYDGEDLA-YTVKNLRRSTKYKFKVIAYNSEGK 492
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPP-DGNGPITGYEVEYRPKNSGEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 1622883474  493 SNPS 496
Cdd:pfam00041   82 GPPS 85
fn3 pfam00041
Fibronectin type III domain;
522-594 2.19e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 2.19e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622883474  522 SHSFKITWDPPKDNGGAaINKYVVEMAEGSNGNKW-EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVS 594
Cdd:pfam00041   13 STSLTVSWTPPPDGNGP-ITGYEVEYRPKNSGEPWnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 211-296 2.48e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.76  E-value: 2.48e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474   211 SNIVKPVASDIQARTVVLTWSPPSslingetDESTVPELYGYEVLISSTGKDGKYKSVyVGEETNITLNDLKPATDYHAK 290
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPP-------DDGITGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFR 73


                    ....*.
gi 1622883474   291 VQAEYN 296
Cdd:smart00060   74 VRAVNG 79
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
719-879 6.76e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.78  E-value: 6.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  719 AQVNWEVPlsngTDVTEYRLEWGGVEGSMQICYCGPGLNYEIKGLsPATTYYCRVQALSVVG------AGPFSEVVACVT 792
Cdd:COG4733    554 LTVSWDAP----AGAVAYEVEWRRDDGNWVSVPRTSGTSFEVPGI-YAGDYEVRVRAINALGvssawaASSETTVTGKTA 628

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  793 PPSVP-GIVTclqEISDDEIEnphyspstclaISWEKPCDhgSEILSYSI---DFGDKQSLTV----GKVTSYIINNLQP 864
Cdd:COG4733    629 PPPAPtGLTA---TGGLGGIT-----------LSWSFPVD--ADTLRTEIrysTTGDWASATVaqalYPGNTYTLAGLKA 692

                          170
                   ....*....|....*
gi 1622883474  865 DTTYRIRIQALNSLG 879
Cdd:COG4733    693 GQTYYYRARAVDRSG 707
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
654-780 1.30e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.01  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  654 REVYQGSEVECTVSSLLPGkTYSFRLRAANKMG---FGPFSEKCDITTAPGPPdqckpPQVTCKSATC----AQVNWEVP 726
Cdd:COG4733    579 VSVPRTSGTSFEVPGIYAG-DYEVRVRAINALGvssAWAASSETTVTGKTAPP-----PAPTGLTATGglggITLSWSFP 652

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622883474  727 lsNGTDVTEYRLEWGGV---EGSMQICYCGPGLNYEIKGLSPATTYYCRVQALSVVG 780
Cdd:COG4733    653 --VDADTLRTEIRYSTTgdwASATVAQALYPGNTYTLAGLKAGQTYYYRARAVDRSG 707
fn3 pfam00041
Fibronectin type III domain;
896-979 2.92e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.78  E-value: 2.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  896 PDPPRLECVAFSHQNLKLKWGEgtPKTLSADSIQYHLQMEDKNG------RFVSlyrGPCHTYKVQRLNESTSYKFCIQA 969
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTP--PPDGNGPITGYEVEYRPKNSgepwneITVP---GTTTSVTLTGLKPGTEYEVRVQA 75

                           90
                   ....*....|
gi 1622883474  970 CNEAGEGPLS 979
Cdd:pfam00041   76 VNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 991-1088 8.33e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.71  E-value: 8.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883474  991 PPALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYK--GPDSSFRYSSLQLNCEYRFRVCAIRqc 1068
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAVN-- 78

                           90       100
                   ....*....|....*....|
gi 1622883474 1069 qdslghQDLVGPYSTTVLFI 1088
Cdd:cd00063     79 ------GGGESPPSESVTVT 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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