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Conserved domains on  [gi|1622883214|ref|XP_028692957|]
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lambda-crystallin homolog isoform X9 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK06129 super family cl35428
3-hydroxyacyl-CoA dehydrogenase; Validated
 1-262 1.01e-90

3-hydroxyacyl-CoA dehydrogenase; Validated


The actual alignment was detected with superfamily member PRK06129:

Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 270.76  E-value: 1.01e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214   1 MKLLEQAGALKGSlSAEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLF 80
Cdd:PRK06129   49 LEDLAAFDLLDGE-APDAVLARIRVTDSLADAVADADYVQESAPENLELKRALFAELDALAPPHAILASSTSALLASAFT 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  81 AGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEE 160
Cdd:PRK06129  128 EHLAGRERCLVAHPINPPYLIPVVEVVPAPWTAPATLARAEALYRAAGQSPVRLRREIDGFVLNRLQGALLREAFRLVAD 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214 161 GIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNA-EGMLSYCDRYsegmkhvlktfGPIpeFSRATAEK------------ 227
Cdd:PRK06129  208 GVASVDDIDAVIRDGLGLRWSFMGPFETIDLNApGGVADYAQRY-----------GPM--YRRMAAERgqpvpwdgelva 274

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1622883214 228 -VNQDMCVKVPDDpeHLAARRQWRDECLMRLAKLKS 262
Cdd:PRK06129  275 rVEAERRAALPLD--QLAARQAWRDRRLMALAAHRR 308
 
Name Accession Description Interval E-value
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 1-262 1.01e-90

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 270.76  E-value: 1.01e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214   1 MKLLEQAGALKGSlSAEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLF 80
Cdd:PRK06129   49 LEDLAAFDLLDGE-APDAVLARIRVTDSLADAVADADYVQESAPENLELKRALFAELDALAPPHAILASSTSALLASAFT 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  81 AGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEE 160
Cdd:PRK06129  128 EHLAGRERCLVAHPINPPYLIPVVEVVPAPWTAPATLARAEALYRAAGQSPVRLRREIDGFVLNRLQGALLREAFRLVAD 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214 161 GIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNA-EGMLSYCDRYsegmkhvlktfGPIpeFSRATAEK------------ 227
Cdd:PRK06129  208 GVASVDDIDAVIRDGLGLRWSFMGPFETIDLNApGGVADYAQRY-----------GPM--YRRMAAERgqpvpwdgelva 274

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1622883214 228 -VNQDMCVKVPDDpeHLAARRQWRDECLMRLAKLKS 262
Cdd:PRK06129  275 rVEAERRAALPLD--QLAARQAWRDRRLMALAAHRR 308
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 2-191 7.74e-62

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 196.10  E-value: 7.74e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214   2 KLLEQAGAlKGSLSAEE---QLSLISGCPNIqEAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSK 78
Cdd:COG1250    47 KLLDKLVK-KGKLTEEEadaALARITPTTDL-AALADADLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITE 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  79 LFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVqKEVAGFVLNRLQYAIISEAWRLV 158
Cdd:COG1250   125 LAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDETVATAVAFARRLGKTPVVV-KDTPGFIVNRILVPYLNEAIRLL 203

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1622883214 159 EEGIVSPSDLDLVMSEGLGMRyafIGPLETMHL 191
Cdd:COG1250   204 EEGVASPEDIDAAMRLGFGFP---MGPFELADL 233
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 1-134 5.48e-44

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 146.91  E-value: 5.48e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214   1 MKLLEQAGALKGSlSAEEQLSLISGCPNIQEAVeGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLF 80
Cdd:pfam02737  46 LERLVEKGRITEE-EVDAALARISFTTDLAAAV-DADLVIEAVPENLELKRKLFAELDAIAPPDAILATNTSSLSITELA 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622883214  81 AGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRV 134
Cdd:pfam02737 124 AATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPETVATTVELAKKIGKTPVVV 177
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 11-169 1.14e-12

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 67.55  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  11 KGSLSAEEQLSLISGC-PNIQ-EAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQ 88
Cdd:TIGR02441 388 RKKITSLERDSILSNLtPTLDySGFKNADMVIEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSRPEK 467

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  89 CIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVqKEVAGFVLNRLQYAIISEAWRLVEEGiVSPSDL 168
Cdd:TIGR02441 468 VIGMHYFSPVDKMQLLEIITHDGTSKDTLASAVAVGLKQGKVVIVV-KDGPGFYTTRCLGPMLAEVIRLLQEG-VDPKKL 545


                  .
gi 1622883214 169 D 169
Cdd:TIGR02441 546 D 546
 
Name Accession Description Interval E-value
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 1-262 1.01e-90

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 270.76  E-value: 1.01e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214   1 MKLLEQAGALKGSlSAEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLF 80
Cdd:PRK06129   49 LEDLAAFDLLDGE-APDAVLARIRVTDSLADAVADADYVQESAPENLELKRALFAELDALAPPHAILASSTSALLASAFT 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  81 AGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEE 160
Cdd:PRK06129  128 EHLAGRERCLVAHPINPPYLIPVVEVVPAPWTAPATLARAEALYRAAGQSPVRLRREIDGFVLNRLQGALLREAFRLVAD 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214 161 GIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNA-EGMLSYCDRYsegmkhvlktfGPIpeFSRATAEK------------ 227
Cdd:PRK06129  208 GVASVDDIDAVIRDGLGLRWSFMGPFETIDLNApGGVADYAQRY-----------GPM--YRRMAAERgqpvpwdgelva 274

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1622883214 228 -VNQDMCVKVPDDpeHLAARRQWRDECLMRLAKLKS 262
Cdd:PRK06129  275 rVEAERRAALPLD--QLAARQAWRDRRLMALAAHRR 308
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 2-191 7.74e-62

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 196.10  E-value: 7.74e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214   2 KLLEQAGAlKGSLSAEE---QLSLISGCPNIqEAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSK 78
Cdd:COG1250    47 KLLDKLVK-KGKLTEEEadaALARITPTTDL-AALADADLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITE 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  79 LFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVqKEVAGFVLNRLQYAIISEAWRLV 158
Cdd:COG1250   125 LAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDETVATAVAFARRLGKTPVVV-KDTPGFIVNRILVPYLNEAIRLL 203

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1622883214 159 EEGIVSPSDLDLVMSEGLGMRyafIGPLETMHL 191
Cdd:COG1250   204 EEGVASPEDIDAAMRLGFGFP---MGPFELADL 233
PRK06130 PRK06130
3-hydroxybutyryl-CoA dehydrogenase; Validated
 6-192 1.93e-50

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 235707 [Multi-domain]  Cd Length: 311  Bit Score: 167.64  E-value: 1.93e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214   6 QAGALKGSLSAEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVH 85
Cdd:PRK06130   50 ALGVYAPLGIASAGMGRIRMEAGLAAAVSGADLVIEAVPEKLELKRDVFARLDGLCDPDTIFATNTSGLPITAIAQAVTR 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  86 VKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSP 165
Cdd:PRK06130  130 PERFVGTHFFTPADVIPLVEVVRGDKTSPQTVATTMALLRSIGKRPVLVKKDIPGFIANRIQHALAREAISLLEKGVASA 209

                         170       180
                  ....*....|....*....|....*..
gi 1622883214 166 SDLDLVMSEGLGMRYAFIGPLETMHLN 192
Cdd:PRK06130  210 EDIDEVVKWSLGIRLALTGPLEQRDMN 236
PRK07531 PRK07531
carnitine 3-dehydrogenase;
23-228 5.53e-50

carnitine 3-dehydrogenase;


Pssm-ID: 236044 [Multi-domain]  Cd Length: 495  Bit Score: 171.07  E-value: 5.53e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  23 ISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIP 102
Cdd:PRK07531   68 LTFCASLAEAVAGADWIQESVPERLDLKRRVLAEIDAAARPDALIGSSTSGFLPSDLQEGMTHPERLFVAHPYNPVYLLP 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214 103 LVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAF 182
Cdd:PRK07531  148 LVELVGGGKTSPETIRRAKEILREIGMKPVHIAKEIDAFVGDRLLEALWREALWLVKDGIATTEEIDDVIRYSFGLRWAQ 227

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622883214 183 IGPLETMHLnAEGmlsycdrySEGMKHVLKTFGP-----------IPEFSRATAEKV 228
Cdd:PRK07531  228 MGLFETYRI-AGG--------EAGMRHFLAQFGPclkwpwtklmdVPDLDDALVDKI 275
PRK07066 PRK07066
L-carnitine dehydrogenase;
4-255 3.74e-45

L-carnitine dehydrogenase;


Pssm-ID: 168796 [Multi-domain]  Cd Length: 321  Bit Score: 154.22  E-value: 3.74e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214   4 LEQAGALKGSlsAEEQLSLIsgcPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGL 83
Cdd:PRK07066   57 LERQGLAPGA--SPARLRFV---ATIEACVADADFIQESAPEREALKLELHERISRAAKPDAIIASSTSGLLPTDFYARA 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  84 VHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIV 163
Cdd:PRK07066  132 THPERCVVGHPFNPVYLLPLVEVLGGERTAPEAVDAAMGIYRALGMRPLHVRKEVPGFIADRLLEALWREALHLVNEGVA 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214 164 SPSDLDLVMSEGLGMRYAFIGPLETMHLnAEGmlsycdrySEGMKHVLKTFGPIPE--FSRATAEKVNQDMCVKVPD--- 238
Cdd:PRK07066  212 TTGEIDDAIRFGAGIRWSFMGTFLTYTL-AGG--------DAGMRHFMQQFGPALElpWTKLVAPELTDALIDRVVEgta 282

                         250       260
                  ....*....|....*....|
gi 1622883214 239 ---DPEHLAARRQWRDECLM 255
Cdd:PRK07066  283 eqqGPRSIKALERYRDECIT 302
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 1-134 5.48e-44

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 146.91  E-value: 5.48e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214   1 MKLLEQAGALKGSlSAEEQLSLISGCPNIQEAVeGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLF 80
Cdd:pfam02737  46 LERLVEKGRITEE-EVDAALARISFTTDLAAAV-DADLVIEAVPENLELKRKLFAELDAIAPPDAILATNTSSLSITELA 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622883214  81 AGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRV 134
Cdd:pfam02737 124 AATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPETVATTVELAKKIGKTPVVV 177
PRK08269 PRK08269
3-hydroxybutyryl-CoA dehydrogenase; Validated
 31-206 7.30e-35

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181340 [Multi-domain]  Cd Length: 314  Bit Score: 127.10  E-value: 7.30e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  31 EAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHP 110
Cdd:PRK08269   75 DALADADLVFEAVPEVLDAKREALRWLGRHVDADAIIASTTSTFLVTDLQRHVAHPERFLNAHWLNPAYLMPLVEVSPSD 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214 111 ETAPTTVDRTHALMKKIGQCPMrVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMH 190
Cdd:PRK08269  155 ATDPAVVDRLAALLERIGKVPV-VCGPSPGYIVPRIQALAMNEAARMVEEGVASAEDIDKAIRTGFGLRFAVLGLLEFID 233

                         170
                  ....*....|....*.
gi 1622883214 191 LNAEGMLSYCDRYSEG 206
Cdd:PRK08269  234 WGGCDILYYASRYLAG 249
PRK05808 PRK05808
3-hydroxybutyryl-CoA dehydrogenase; Validated
 11-186 1.99e-27

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 180269 [Multi-domain]  Cd Length: 282  Bit Score: 106.97  E-value: 1.99e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  11 KGSLSAEEQ---LSLISGCPNIQEAVEGAMHIqECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVK 87
Cdd:PRK05808   56 KGKMTEADKeaaLARITGTTDLDDLKDADLVI-EAATENMDLKKKIFAQLDEIAKPEAILATNTSSLSITELAAATKRPD 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  88 QCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVqKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSD 167
Cdd:PRK05808  135 KVIGMHFFNPVPVMKLVEIIRGLATSDATHEAVEALAKKIGKTPVEV-KNAPGFVVNRILIPMINEAIFVLAEGVATAED 213

                         170
                  ....*....|....*....
gi 1622883214 168 LDLVMSegLGMRYAfIGPL 186
Cdd:PRK05808  214 IDEGMK--LGCNHP-IGPL 229
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 5-191 8.22e-27

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 108.40  E-value: 8.22e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214   5 EQAGALKGSLSAEEQLSLISGCPNIQEAVegamhiqecvPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLV 84
Cdd:PRK08268   66 EQADAALARLRPVEALADLADCDLVVEAI----------VERLDVKQALFAQLEAIVSPDCILATNTSSLSITAIAAALK 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  85 HVKQciVA--HPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVqKEVAGFVLNRLQYAIISEAWRLVEEGI 162
Cdd:PRK08268  136 HPER--VAglHFFNPVPLMKLVEVVSGLATDPAVADALYALARAWGKTPVRA-KDTPGFIVNRAARPYYTEALRVLEEGV 212

                         170       180
                  ....*....|....*....|....*....
gi 1622883214 163 VSPSDLDLVMSEGLGMRyafIGPLETMHL 191
Cdd:PRK08268  213 ADPATIDAILREAAGFR---MGPFELMDL 238
PLN02545 PLN02545
3-hydroxybutyryl-CoA dehydrogenase
 11-187 3.72e-25

3-hydroxybutyryl-CoA dehydrogenase


Pssm-ID: 215300 [Multi-domain]  Cd Length: 295  Bit Score: 100.96  E-value: 3.72e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  11 KGSLS---AEEQLSLISGCPNIQEaVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVK 87
Cdd:PLN02545   57 KGKMSqeeADATLGRIRCTTNLEE-LRDADFIIEAIVESEDLKKKLFSELDRICKPSAILASNTSSISITRLASATQRPQ 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  88 QCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQkEVAGFVLNRLQYAIISEAWRLVEEGIVSPSD 167
Cdd:PLN02545  136 QVIGMHFMNPPPIMKLVEIIRGADTSDEVFDATKALAERFGKTVVCSQ-DYPGFIVNRILMPMINEAFYALYTGVASKED 214

                         170       180
                  ....*....|....*....|
gi 1622883214 168 LDLVMSEGLGMRyafIGPLE 187
Cdd:PLN02545  215 IDTGMKLGTNHP---MGPLH 231
PRK08293 PRK08293
3-hydroxyacyl-CoA dehydrogenase;
6-189 1.34e-23

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 181359 [Multi-domain]  Cd Length: 287  Bit Score: 96.55  E-value: 1.34e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214   6 QAGALKGSLSAEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKL------ 79
Cdd:PRK08293   55 RDLEATKEAPAEAALNRITLTTDLAEAVKDADLVIEAVPEDPEIKGDFYEELAKVAPEKTIFATNSSTLLPSQFaeatgr 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  80 ---FAGLvhvkqcivaHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWR 156
Cdd:PRK08293  135 pekFLAL---------HFANEIWKNNTAEIMGHPGTDPEVFDTVVAFAKAIGMVPIVLKKEQPGYILNSLLVPFLSAALA 205

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1622883214 157 LVEEGIVSPSDLDLVMSEGLGMRyafIGPLETM 189
Cdd:PRK08293  206 LWAKGVADPETIDKTWMIATGAP---MGPFGIL 235
PRK06035 PRK06035
3-hydroxyacyl-CoA dehydrogenase; Validated
 31-191 1.33e-21

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 180361 [Multi-domain]  Cd Length: 291  Bit Score: 91.47  E-value: 1.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  31 EAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHP 110
Cdd:PRK06035   81 ESLSDADFIVEAVPEKLDLKRKVFAELERNVSPETIIASNTSGIMIAEIATALERKDRFIGMHWFNPAPVMKLIEVVRAA 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214 111 ETAPTTVDRTHALMKKIGQCPMRVqKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDlVMSEglgMRYAF-IGPLETM 189
Cdd:PRK06035  161 LTSEETFNTTVELSKKIGKIPIEV-ADVPGFFTTRFIEGWLLEAIRSFEIGIATIKDID-EMCK---LAFGFpMGPFELM 235


                  ..
gi 1622883214 190 HL 191
Cdd:PRK06035  236 DI 237
PRK09260 PRK09260
3-hydroxyacyl-CoA dehydrogenase;
7-187 1.38e-21

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 236434 [Multi-domain]  Cd Length: 288  Bit Score: 91.39  E-value: 1.38e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214   7 AGALKGSLSAEEQLSLISGCP---NIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGL 83
Cdd:PRK09260   50 QGVARGKLTEAARQAALARLSyslDLKAAVADADLVIEAVPEKLELKKAVFETADAHAPAECYIATNTSTMSPTEIASFT 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  84 VHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQkEVAGFVLNRLQYAIISEAWRLVEEGIV 163
Cdd:PRK09260  130 KRPERVIAMHFFNPVHKMKLVELIRGLETSDETVQVAKEVAEQMGKETVVVN-EFPGFVTSRISALVGNEAFYMLQEGVA 208

                         170       180
                  ....*....|....*....|....
gi 1622883214 164 SPSDLDLVMSegLGMRYAfIGPLE 187
Cdd:PRK09260  209 TAEDIDKAIR--LGLNFP-MGPLE 229
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 140-228 9.96e-20

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 81.49  E-value: 9.96e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214 140 GFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAE--GMLSYCDRYSEGMKH---VLKTF 214
Cdd:pfam00725   1 GFVVNRLLAPYLNEAIRLVEEGVATPEDIDAAMRLGLGLPMGPFELSDLVGLDVGyhILEVLAEEFGDRAYRpppLLEKL 80

                          90
                  ....*....|....
gi 1622883214 215 GPIPEFSRATAEKV 228
Cdd:pfam00725  81 VEAGRLGRKTGKGF 94
PRK07819 PRK07819
3-hydroxybutyryl-CoA dehydrogenase; Validated
 41-196 8.26e-19

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181133 [Multi-domain]  Cd Length: 286  Bit Score: 83.50  E-value: 8.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  41 ECVPEDLELKKKIFAQLDSIV-DDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDR 119
Cdd:PRK07819   90 EAVVEDEAVKTEIFAELDKVVtDPDAVLASNTSSIPIMKLAAATKRPGRVLGLHFFNPVPVLPLVELVPTLVTSEATVAR 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214 120 THALMKKI-GQCPMRVQKEvAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLG-----MRYA-FIGpLETMHLN 192
Cdd:PRK07819  170 AEEFASDVlGKQVVRAQDR-SGFVVNALLVPYLLSAIRMVESGFATAEDIDKAMVLGCAhpmgpLRLSdLVG-LDTVKAI 247


                  ....
gi 1622883214 193 AEGM 196
Cdd:PRK07819  248 ADSM 251
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
41-161 7.66e-14

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 71.08  E-value: 7.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  41 ECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRT 120
Cdd:PRK11154  395 EAVFEDLALKQQMVAEVEQNCAPHTIFASNTSSLPIGQIAAAAARPEQVIGLHYFSPVEKMPLVEVIPHAKTSAETIATT 474

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1622883214 121 HALMKKIGQCPMrVQKEVAGFVLNRLQYAIISEAWRLVEEG 161
Cdd:PRK11154  475 VALAKKQGKTPI-VVRDGAGFYVNRILAPYINEAARLLLEG 514
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 11-169 1.14e-12

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 67.55  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  11 KGSLSAEEQLSLISGC-PNIQ-EAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQ 88
Cdd:TIGR02441 388 RKKITSLERDSILSNLtPTLDySGFKNADMVIEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSRPEK 467

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  89 CIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVqKEVAGFVLNRLQYAIISEAWRLVEEGiVSPSDL 168
Cdd:TIGR02441 468 VIGMHYFSPVDKMQLLEIITHDGTSKDTLASAVAVGLKQGKVVIVV-KDGPGFYTTRCLGPMLAEVIRLLQEG-VDPKKL 545


                  .
gi 1622883214 169 D 169
Cdd:TIGR02441 546 D 546
PRK07530 PRK07530
3-hydroxybutyryl-CoA dehydrogenase; Validated
 11-187 3.64e-11

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181018 [Multi-domain]  Cd Length: 292  Bit Score: 61.95  E-value: 3.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  11 KGSLSAEEQ---LSLISGCPNIQEAVEGAMHIqECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVK 87
Cdd:PRK07530   57 KGKISEEARaaaLARISTATDLEDLADCDLVI-EAATEDETVKRKIFAQLCPVLKPEAILATNTSSISITRLASATDRPE 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214  88 QCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMrVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSD 167
Cdd:PRK07530  136 RFIGIHFMNPVPVMKLVELIRGIATDEATFEAAKEFVTKLGKTIT-VAEDFPAFIVNRILLPMINEAIYTLYEGVGSVEA 214

                         170       180
                  ....*....|....*....|
gi 1622883214 168 LDLVMSegLGMRYAfIGPLE 187
Cdd:PRK07530  215 IDTAMK--LGANHP-MGPLE 231
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 102-187 1.15e-05

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 45.99  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883214 102 PLVELVPHPETAPTTVDRTHALMKKIGQcPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGmrYA 181
Cdd:PRK08268  379 KRRTLMAAPATSPAARDAAHALFQQDGK-AVSVIRDSPGFVAQRTVAMIVNEAADIAQQGIASPADIDLAMRLGLN--YP 455


                  ....*.
gi 1622883214 182 FiGPLE 187
Cdd:PRK08268  456 L-GPLA 460
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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